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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MARK2-BATF2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MARK2-BATF2
FusionPDB ID: 51741
FusionGDB2.0 ID: 51741
HgeneTgene
Gene symbol

MARK2

BATF2

Gene ID

2011

116071

Gene namemicrotubule affinity regulating kinase 2basic leucine zipper ATF-like transcription factor 2
SynonymsEMK-1|EMK1|PAR-1|Par-1b|Par1bSARI
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117basic leucine zipper transcriptional factor ATF-like 2B-ATF-2basic leucine zipper transcription factor, ATF-like 2suppressor of AP-1 regulated by IFN
Modification date2020032920200313
UniProtAcc

Q7KZI7

Q8N1L9

Ensembl transtripts involved in fusion geneENST idsENST00000315032, ENST00000350490, 
ENST00000361128, ENST00000377809, 
ENST00000402010, ENST00000413835, 
ENST00000502399, ENST00000508192, 
ENST00000377810, ENST00000408948, 
ENST00000425897, ENST00000509502, 
ENST00000513765, 		ENST00000435842, 
ENST00000527716, ENST00000301887, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 11=12873 X 2 X 4=24
# samples 214
** MAII scorelog2(21/1287*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MARK2 [Title/Abstract] AND BATF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MARK2(63607032)-BATF2(64762021), # samples:3
Anticipated loss of major functional domain due to fusion event.MARK2-BATF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MARK2-BATF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MARK2-BATF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MARK2-BATF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARK2

GO:0006468

protein phosphorylation

14976552

HgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

HgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

HgeneMARK2

GO:0030010

establishment of cell polarity

12429843

HgeneMARK2

GO:0035556

intracellular signal transduction

14976552

HgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

HgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369


check buttonFusion gene breakpoints across MARK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BATF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06AMARK2chr11

63607032

-BATF2chr11

64762021

-
ChimerDB4SKCMTCGA-GN-A26D-06AMARK2chr11

63607032

+BATF2chr11

64762021

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377809MARK2chr1163607032+ENST00000301887BATF2chr1164762021-2605633100855317
ENST00000402010MARK2chr1163607032+ENST00000301887BATF2chr1164762021-2605633100855317
ENST00000413835MARK2chr1163607032+ENST00000301887BATF2chr1164762021-2605633100855317
ENST00000315032MARK2chr1163607032+ENST00000301887BATF2chr1164762021-2605633100855317
ENST00000508192MARK2chr1163607032+ENST00000301887BATF2chr1164762021-25285569312310
ENST00000361128MARK2chr1163607032+ENST00000301887BATF2chr1164762021-25285569312310
ENST00000350490MARK2chr1163607032+ENST00000301887BATF2chr1164762021-24404688431281
ENST00000502399MARK2chr1163607032+ENST00000301887BATF2chr1164762021-22382662121051279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377809ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.307248030.692752
ENST00000402010ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.307248030.692752
ENST00000413835ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.307248030.692752
ENST00000315032ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.307248030.692752
ENST00000508192ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.257766070.742234
ENST00000361128ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.257766070.742234
ENST00000350490ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.270917860.7290821
ENST00000502399ENST00000301887MARK2chr1163607032+BATF2chr1164762021-0.3683830.631617

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51741_51741_1_MARK2-BATF2_MARK2_chr11_63607032_ENST00000315032_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=317AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_2_MARK2-BATF2_MARK2_chr11_63607032_ENST00000350490_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=281AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_3_MARK2-BATF2_MARK2_chr11_63607032_ENST00000361128_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=310AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_4_MARK2-BATF2_MARK2_chr11_63607032_ENST00000377809_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=317AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_5_MARK2-BATF2_MARK2_chr11_63607032_ENST00000402010_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=317AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_6_MARK2-BATF2_MARK2_chr11_63607032_ENST00000413835_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=317AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

>51741_51741_7_MARK2-BATF2_MARK2_chr11_63607032_ENST00000502399_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=279AA_BP=17
MSSARTPLPTLNERDTEQDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQSLQAELAWWSRTLHVHERLCP
MDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPL
LFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSSPDNPSSALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAFP

--------------------------------------------------------------

>51741_51741_8_MARK2-BATF2_MARK2_chr11_63607032_ENST00000508192_BATF2_chr11_64762021_ENST00000301887_length(amino acids)=310AA_BP=161
MERAAELGNRNPGSGTAPAAPGSHVVPVGQGPGAPQPGPSSPGALELSRRHNPWGTGAHARAGSGSTTPARPAGTGSPSAGRGCLFPETR
AAGAGRLPCLCASAGFAGRLPGSSASSAAFVAPWGPAPCPSRSAWVGGSERWTWRRYLGGGNREAWRKGGKGRRGARPGGASHSRSTRRM
GPGRGCGEAGQPLTPARGCAARARPRRLRAAPDRTPPTPGWAVPPFGRAAPLRLLSAAAAGRLPRSSPALSGTAPRPAHRQPPPDLLLPT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63607032/chr11:64762021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARK2

Q7KZI7

BATF2

Q8N1L9

FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBATF2chr11:63607032chr11:64762021ENST000003018870317_8013.0275.0DomainbZIP
TgeneBATF2chr11:63607032chr11:64762021ENST000004358420217_800190.0DomainbZIP
TgeneBATF2chr11:63607032chr11:64762021ENST000003018870320_4113.0275.0RegionBasic motif
TgeneBATF2chr11:63607032chr11:64762021ENST000003018870345_6613.0275.0RegionLeucine-zipper
TgeneBATF2chr11:63607032chr11:64762021ENST000004358420220_410190.0RegionBasic motif
TgeneBATF2chr11:63607032chr11:64762021ENST000004358420245_660190.0RegionLeucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARK2chr11:63607032chr11:64762021ENST00000315032+118323_36218.0780.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000315032+11853_30418.0780.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000315032+118739_78818.0780.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000350490+116323_36218.0710.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000350490+11653_30418.0710.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000350490+116739_78818.0710.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000361128+117323_36218.0720.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000361128+11753_30418.0720.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000361128+117739_78818.0720.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000377809+118323_36218.0774.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000377809+11853_30418.0774.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000377809+118739_78818.0774.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000377810+117323_3620692.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000377810+11753_3040692.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000377810+117739_7880692.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000402010+119323_36218.0789.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000402010+11953_30418.0789.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000402010+119739_78818.0789.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000408948+116323_3620692.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000408948+11653_3040692.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000408948+116739_7880692.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000413835+118323_36218.0735.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000413835+11853_30418.0735.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000413835+118739_78818.0735.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000508192+117323_36218.0725.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000508192+11753_30418.0725.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000508192+117739_78818.0725.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000509502+118323_3620746.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000509502+11853_3040746.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000509502+118739_7880746.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000513765+118323_3620756.0DomainUBA
HgeneMARK2chr11:63607032chr11:64762021ENST00000513765+11853_3040756.0DomainProtein kinase
HgeneMARK2chr11:63607032chr11:64762021ENST00000513765+118739_7880756.0DomainKA1
HgeneMARK2chr11:63607032chr11:64762021ENST00000315032+11859_6718.0780.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000350490+11659_6718.0710.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000361128+11759_6718.0720.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000377809+11859_6718.0774.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000377810+11759_670692.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000402010+11959_6718.0789.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000408948+11659_670692.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000413835+11859_6718.0735.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000508192+11759_6718.0725.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000509502+11859_670746.0Nucleotide bindingATP
HgeneMARK2chr11:63607032chr11:64762021ENST00000513765+11859_670756.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MARK2
BATF2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MARK2-BATF2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MARK2-BATF2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource