| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:MARK2-BUB1B |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MARK2-BUB1B | FusionPDB ID: 51743 | FusionGDB2.0 ID: 51743 | Hgene | Tgene | Gene symbol | MARK2 | BUB1B | Gene ID | 2011 | 701 |
| Gene name | microtubule affinity regulating kinase 2 | BUB1 mitotic checkpoint serine/threonine kinase B | |
| Synonyms | EMK-1|EMK1|PAR-1|Par-1b|Par1b | BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1 | |
| Cytomap | 11q13.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117 | mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q7KZI7 | O60566 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000315032, ENST00000350490, ENST00000361128, ENST00000377809, ENST00000402010, ENST00000413835, ENST00000502399, ENST00000508192, ENST00000377810, ENST00000408948, ENST00000425897, ENST00000509502, ENST00000513765, | ENST00000560120, ENST00000287598, ENST00000412359, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 9 X 11=1287 | 8 X 10 X 5=400 |
| # samples | 21 | 9 | |
| ** MAII score | log2(21/1287*10)=-2.61555082055458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/400*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MARK2 [Title/Abstract] AND BUB1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MARK2(63607032)-BUB1B(40468678), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | MARK2-BUB1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MARK2-BUB1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MARK2-BUB1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MARK2-BUB1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MARK2 | GO:0006468 | protein phosphorylation | 14976552 |
| Hgene | MARK2 | GO:0010976 | positive regulation of neuron projection development | 12429843 |
| Hgene | MARK2 | GO:0018105 | peptidyl-serine phosphorylation | 10542369|16717194 |
| Hgene | MARK2 | GO:0030010 | establishment of cell polarity | 12429843 |
| Hgene | MARK2 | GO:0035556 | intracellular signal transduction | 14976552 |
| Hgene | MARK2 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 15324659 |
| Hgene | MARK2 | GO:0070507 | regulation of microtubule cytoskeleton organization | 10542369 |
| Fusion gene breakpoints across MARK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across BUB1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-94-7557-01A | MARK2 | chr11 | 63607032 | - | BUB1B | chr15 | 40468678 | + |
| ChimerDB4 | LUSC | TCGA-94-7557-01A | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + |
| ChimerDB4 | LUSC | TCGA-94-7557 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468584 | + |
| ChimerDB4 | LUSC | TCGA-94-7557 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + |
| ChimerDB4 | LUSC | TCGA-94-7557 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000377809 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000377809 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000402010 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000402010 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000413835 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000413835 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000315032 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000315032 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000508192 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3702 | 556 | 502 | 3324 | 940 |
| ENST00000508192 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3604 | 556 | 502 | 3324 | 940 |
| ENST00000361128 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3702 | 556 | 502 | 3324 | 940 |
| ENST00000361128 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3604 | 556 | 502 | 3324 | 940 |
| ENST00000350490 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3614 | 468 | 414 | 3236 | 940 |
| ENST00000350490 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3516 | 468 | 414 | 3236 | 940 |
| ENST00000502399 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468678 | + | 3412 | 266 | 212 | 3034 | 940 |
| ENST00000502399 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468678 | + | 3314 | 266 | 212 | 3034 | 940 |
| ENST00000377809 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000377809 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000402010 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000402010 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000413835 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000413835 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000315032 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3779 | 633 | 579 | 3401 | 940 |
| ENST00000315032 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3681 | 633 | 579 | 3401 | 940 |
| ENST00000508192 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3702 | 556 | 502 | 3324 | 940 |
| ENST00000508192 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3604 | 556 | 502 | 3324 | 940 |
| ENST00000361128 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3702 | 556 | 502 | 3324 | 940 |
| ENST00000361128 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3604 | 556 | 502 | 3324 | 940 |
| ENST00000350490 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3614 | 468 | 414 | 3236 | 940 |
| ENST00000350490 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3516 | 468 | 414 | 3236 | 940 |
| ENST00000502399 | MARK2 | chr11 | 63607032 | + | ENST00000287598 | BUB1B | chr15 | 40468677 | + | 3412 | 266 | 212 | 3034 | 940 |
| ENST00000502399 | MARK2 | chr11 | 63607032 | + | ENST00000412359 | BUB1B | chr15 | 40468677 | + | 3314 | 266 | 212 | 3034 | 940 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000377809 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000689511 | 0.9993105 |
| ENST00000377809 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001081738 | 0.9989183 |
| ENST00000402010 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000689511 | 0.9993105 |
| ENST00000402010 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001081738 | 0.9989183 |
| ENST00000413835 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000689511 | 0.9993105 |
| ENST00000413835 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001081738 | 0.9989183 |
| ENST00000315032 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000689511 | 0.9993105 |
| ENST00000315032 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001081738 | 0.9989183 |
| ENST00000508192 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000743276 | 0.9992567 |
| ENST00000508192 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001201857 | 0.99879813 |
| ENST00000361128 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000743276 | 0.9992567 |
| ENST00000361128 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001201857 | 0.99879813 |
| ENST00000350490 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000740056 | 0.9992599 |
| ENST00000350490 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.001188467 | 0.9988116 |
| ENST00000502399 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000604294 | 0.9993957 |
| ENST00000502399 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468678 | + | 0.000967446 | 0.9990326 |
| ENST00000377809 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000689511 | 0.9993105 |
| ENST00000377809 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001081738 | 0.9989183 |
| ENST00000402010 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000689511 | 0.9993105 |
| ENST00000402010 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001081738 | 0.9989183 |
| ENST00000413835 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000689511 | 0.9993105 |
| ENST00000413835 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001081738 | 0.9989183 |
| ENST00000315032 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000689511 | 0.9993105 |
| ENST00000315032 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001081738 | 0.9989183 |
| ENST00000508192 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000743276 | 0.9992567 |
| ENST00000508192 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001201857 | 0.99879813 |
| ENST00000361128 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000743276 | 0.9992567 |
| ENST00000361128 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001201857 | 0.99879813 |
| ENST00000350490 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000740056 | 0.9992599 |
| ENST00000350490 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.001188467 | 0.9988116 |
| ENST00000502399 | ENST00000287598 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000604294 | 0.9993957 |
| ENST00000502399 | ENST00000412359 | MARK2 | chr11 | 63607032 | + | BUB1B | chr15 | 40468677 | + | 0.000967446 | 0.9990326 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >51743_51743_1_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000315032_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_2_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000315032_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_3_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000315032_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_4_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000315032_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_5_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000350490_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_6_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000350490_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_7_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000350490_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_8_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000350490_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_9_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000361128_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_10_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000361128_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_11_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000361128_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_12_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000361128_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_13_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000377809_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_14_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000377809_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_15_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000377809_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_16_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000377809_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_17_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000402010_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_18_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000402010_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_19_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000402010_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_20_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000402010_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_21_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000413835_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_22_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000413835_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_23_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000413835_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_24_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000413835_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_25_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000502399_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_26_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000502399_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_27_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000502399_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_28_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000502399_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_29_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000508192_BUB1B_chr15_40468677_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_30_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000508192_BUB1B_chr15_40468677_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_31_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000508192_BUB1B_chr15_40468678_ENST00000287598_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- >51743_51743_32_MARK2-BUB1B_MARK2_chr11_63607032_ENST00000508192_BUB1B_chr15_40468678_ENST00000412359_length(amino acids)=940AA_BP=17 MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63607032/chr15:40468678) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MARK2 | BUB1B |
| FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. | FUNCTION: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 209_215 | 128.0 | 1051.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 209_215 | 142.0 | 1065.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 209_215 | 128.0 | 1051.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 209_215 | 142.0 | 1065.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 766_1050 | 128.0 | 1051.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 766_1050 | 142.0 | 1065.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 766_1050 | 128.0 | 1051.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 766_1050 | 142.0 | 1065.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 224_232 | 128.0 | 1051.0 | Motif | Note=D-box | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 224_232 | 142.0 | 1065.0 | Motif | Note=D-box | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 224_232 | 128.0 | 1051.0 | Motif | Note=D-box | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 224_232 | 142.0 | 1065.0 | Motif | Note=D-box | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 772_780 | 128.0 | 1051.0 | Nucleotide binding | ATP | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 772_780 | 142.0 | 1065.0 | Nucleotide binding | ATP | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 772_780 | 128.0 | 1051.0 | Nucleotide binding | ATP | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 772_780 | 142.0 | 1065.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000315032 | + | 1 | 18 | 323_362 | 18.0 | 780.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000315032 | + | 1 | 18 | 53_304 | 18.0 | 780.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000315032 | + | 1 | 18 | 739_788 | 18.0 | 780.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000350490 | + | 1 | 16 | 323_362 | 18.0 | 710.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000350490 | + | 1 | 16 | 53_304 | 18.0 | 710.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000350490 | + | 1 | 16 | 739_788 | 18.0 | 710.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000361128 | + | 1 | 17 | 323_362 | 18.0 | 720.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000361128 | + | 1 | 17 | 53_304 | 18.0 | 720.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000361128 | + | 1 | 17 | 739_788 | 18.0 | 720.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377809 | + | 1 | 18 | 323_362 | 18.0 | 774.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377809 | + | 1 | 18 | 53_304 | 18.0 | 774.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377809 | + | 1 | 18 | 739_788 | 18.0 | 774.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377810 | + | 1 | 17 | 323_362 | 0 | 692.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377810 | + | 1 | 17 | 53_304 | 0 | 692.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377810 | + | 1 | 17 | 739_788 | 0 | 692.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000402010 | + | 1 | 19 | 323_362 | 18.0 | 789.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000402010 | + | 1 | 19 | 53_304 | 18.0 | 789.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000402010 | + | 1 | 19 | 739_788 | 18.0 | 789.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000408948 | + | 1 | 16 | 323_362 | 0 | 692.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000408948 | + | 1 | 16 | 53_304 | 0 | 692.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000408948 | + | 1 | 16 | 739_788 | 0 | 692.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000413835 | + | 1 | 18 | 323_362 | 18.0 | 735.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000413835 | + | 1 | 18 | 53_304 | 18.0 | 735.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000413835 | + | 1 | 18 | 739_788 | 18.0 | 735.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000508192 | + | 1 | 17 | 323_362 | 18.0 | 725.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000508192 | + | 1 | 17 | 53_304 | 18.0 | 725.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000508192 | + | 1 | 17 | 739_788 | 18.0 | 725.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000509502 | + | 1 | 18 | 323_362 | 0 | 746.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000509502 | + | 1 | 18 | 53_304 | 0 | 746.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000509502 | + | 1 | 18 | 739_788 | 0 | 746.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000513765 | + | 1 | 18 | 323_362 | 0 | 756.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000513765 | + | 1 | 18 | 53_304 | 0 | 756.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000513765 | + | 1 | 18 | 739_788 | 0 | 756.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000315032 | + | 1 | 18 | 323_362 | 18.0 | 780.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000315032 | + | 1 | 18 | 53_304 | 18.0 | 780.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000315032 | + | 1 | 18 | 739_788 | 18.0 | 780.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000350490 | + | 1 | 16 | 323_362 | 18.0 | 710.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000350490 | + | 1 | 16 | 53_304 | 18.0 | 710.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000350490 | + | 1 | 16 | 739_788 | 18.0 | 710.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000361128 | + | 1 | 17 | 323_362 | 18.0 | 720.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000361128 | + | 1 | 17 | 53_304 | 18.0 | 720.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000361128 | + | 1 | 17 | 739_788 | 18.0 | 720.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377809 | + | 1 | 18 | 323_362 | 18.0 | 774.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377809 | + | 1 | 18 | 53_304 | 18.0 | 774.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377809 | + | 1 | 18 | 739_788 | 18.0 | 774.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377810 | + | 1 | 17 | 323_362 | 0 | 692.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377810 | + | 1 | 17 | 53_304 | 0 | 692.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377810 | + | 1 | 17 | 739_788 | 0 | 692.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000402010 | + | 1 | 19 | 323_362 | 18.0 | 789.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000402010 | + | 1 | 19 | 53_304 | 18.0 | 789.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000402010 | + | 1 | 19 | 739_788 | 18.0 | 789.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000408948 | + | 1 | 16 | 323_362 | 0 | 692.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000408948 | + | 1 | 16 | 53_304 | 0 | 692.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000408948 | + | 1 | 16 | 739_788 | 0 | 692.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000413835 | + | 1 | 18 | 323_362 | 18.0 | 735.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000413835 | + | 1 | 18 | 53_304 | 18.0 | 735.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000413835 | + | 1 | 18 | 739_788 | 18.0 | 735.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000508192 | + | 1 | 17 | 323_362 | 18.0 | 725.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000508192 | + | 1 | 17 | 53_304 | 18.0 | 725.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000508192 | + | 1 | 17 | 739_788 | 18.0 | 725.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000509502 | + | 1 | 18 | 323_362 | 0 | 746.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000509502 | + | 1 | 18 | 53_304 | 0 | 746.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000509502 | + | 1 | 18 | 739_788 | 0 | 746.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000513765 | + | 1 | 18 | 323_362 | 0 | 756.0 | Domain | UBA |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000513765 | + | 1 | 18 | 53_304 | 0 | 756.0 | Domain | Protein kinase |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000513765 | + | 1 | 18 | 739_788 | 0 | 756.0 | Domain | KA1 |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000315032 | + | 1 | 18 | 59_67 | 18.0 | 780.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000350490 | + | 1 | 16 | 59_67 | 18.0 | 710.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000361128 | + | 1 | 17 | 59_67 | 18.0 | 720.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377809 | + | 1 | 18 | 59_67 | 18.0 | 774.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000377810 | + | 1 | 17 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000402010 | + | 1 | 19 | 59_67 | 18.0 | 789.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000408948 | + | 1 | 16 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000413835 | + | 1 | 18 | 59_67 | 18.0 | 735.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000508192 | + | 1 | 17 | 59_67 | 18.0 | 725.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000509502 | + | 1 | 18 | 59_67 | 0 | 746.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468677 | ENST00000513765 | + | 1 | 18 | 59_67 | 0 | 756.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000315032 | + | 1 | 18 | 59_67 | 18.0 | 780.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000350490 | + | 1 | 16 | 59_67 | 18.0 | 710.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000361128 | + | 1 | 17 | 59_67 | 18.0 | 720.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377809 | + | 1 | 18 | 59_67 | 18.0 | 774.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000377810 | + | 1 | 17 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000402010 | + | 1 | 19 | 59_67 | 18.0 | 789.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000408948 | + | 1 | 16 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000413835 | + | 1 | 18 | 59_67 | 18.0 | 735.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000508192 | + | 1 | 17 | 59_67 | 18.0 | 725.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000509502 | + | 1 | 18 | 59_67 | 0 | 746.0 | Nucleotide binding | ATP |
| Hgene | MARK2 | chr11:63607032 | chr15:40468678 | ENST00000513765 | + | 1 | 18 | 59_67 | 0 | 756.0 | Nucleotide binding | ATP |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 62_226 | 128.0 | 1051.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 62_226 | 142.0 | 1065.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 62_226 | 128.0 | 1051.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 62_226 | 142.0 | 1065.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000287598 | 3 | 23 | 111_118 | 128.0 | 1051.0 | Motif | Nuclear localization signal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468677 | ENST00000412359 | 3 | 23 | 111_118 | 142.0 | 1065.0 | Motif | Nuclear localization signal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000287598 | 3 | 23 | 111_118 | 128.0 | 1051.0 | Motif | Nuclear localization signal | |
| Tgene | BUB1B | chr11:63607032 | chr15:40468678 | ENST00000412359 | 3 | 23 | 111_118 | 142.0 | 1065.0 | Motif | Nuclear localization signal |
Top |
Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1735_MARK2_63607032_BUB1B_40468678_ranked_0.pdb | MARK2 | 63607032 | 63607032 | ENST00000412359 | BUB1B | chr15 | 40468678 | + | MSSARTPLPTLNERDTEQGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKP TVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQ RVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEE TMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAV LKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQD GCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV QLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVS | 940 |
Top |
pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
MARK2_pLDDT.png  |
BUB1B_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
 |
Top |
Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MARK2 | |
| BUB1B |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to MARK2-BUB1B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to MARK2-BUB1B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies