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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MBD2-DOCK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MBD2-DOCK2
	FusionPDB ID: 51961
	FusionGDB2.0 ID: 51961
		Hgene	Tgene
	Gene symbol	MBD2	DOCK2
	Gene ID	64174	1794
	Gene name	dipeptidase 2	dedicator of cytokinesis 2
	Synonyms	MBD2	IMD40
	Cytomap	16q22.1	5q35.1
	Type of gene	protein-coding	protein-coding
	Description	dipeptidase 2	dedicator of cytokinesis protein 2dedicator of cyto-kinesis 2
	Modification date	20200313	20200313
	UniProtAcc	Q9UBB5	Q92608
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256429, ENST00000398398, ENST00000579025, ENST00000583046,	ENST00000523351, ENST00000256935, ENST00000520908, ENST00000540750,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 10 X 4=320	13 X 12 X 8=1248
	# samples	10	15
	** MAII score	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1248*10)=-3.05658352836637 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MBD2 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MBD2(51715244)-DOCK2(169502951), # samples:3
Anticipated loss of major functional domain due to fusion event.	MBD2-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBD2-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBD2-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MBD2-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DOCK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A1AY-01A	MBD2	chr18	51714083	-	DOCK2	chr5	169502950	+
ChimerDB4	BRCA	TCGA-AR-A1AY-01A	MBD2	chr18	51715243	-	DOCK2	chr5	169502950	+
ChimerDB4	BRCA	TCGA-AR-A1AY-01A	MBD2	chr18	51715244	-	DOCK2	chr5	169502951	+
ChimerDB4	BRCA	TCGA-AR-A1AY	MBD2	chr18	51715243	-	DOCK2	chr5	169502950	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000256429	MBD2	chr18	51715244	-	ENST00000256935	DOCK2	chr5	169502951	+	2358	1069	151	1833	560
ENST00000256429	MBD2	chr18	51715244	-	ENST00000540750	DOCK2	chr5	169502951	+	2353	1069	151	1833	560
ENST00000256429	MBD2	chr18	51715244	-	ENST00000520908	DOCK2	chr5	169502951	+	2355	1069	151	1833	560
ENST00000256429	MBD2	chr18	51715243	-	ENST00000256935	DOCK2	chr5	169502950	+	2358	1069	151	1833	560
ENST00000256429	MBD2	chr18	51715243	-	ENST00000540750	DOCK2	chr5	169502950	+	2353	1069	151	1833	560
ENST00000256429	MBD2	chr18	51715243	-	ENST00000520908	DOCK2	chr5	169502950	+	2355	1069	151	1833	560

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000256429	ENST00000256935	MBD2	chr18	51715244	-	DOCK2	chr5	169502951	+	0.04058629	0.9594137
ENST00000256429	ENST00000540750	MBD2	chr18	51715244	-	DOCK2	chr5	169502951	+	0.041146364	0.95885366
ENST00000256429	ENST00000520908	MBD2	chr18	51715244	-	DOCK2	chr5	169502951	+	0.04133254	0.9586675
ENST00000256429	ENST00000256935	MBD2	chr18	51715243	-	DOCK2	chr5	169502950	+	0.04058629	0.9594137
ENST00000256429	ENST00000540750	MBD2	chr18	51715243	-	DOCK2	chr5	169502950	+	0.041146364	0.95885366
ENST00000256429	ENST00000520908	MBD2	chr18	51715243	-	DOCK2	chr5	169502950	+	0.04133254	0.9586675

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51961_51961_1_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000256935_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

>51961_51961_2_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000520908_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

>51961_51961_3_MBD2-DOCK2_MBD2_chr18_51715243_ENST00000256429_DOCK2_chr5_169502950_ENST00000540750_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

>51961_51961_4_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000256935_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

>51961_51961_5_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000520908_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

>51961_51961_6_MBD2-DOCK2_MBD2_chr18_51715244_ENST00000256429_DOCK2_chr5_169502951_ENST00000540750_length(amino acids)=560AA_BP=102
MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW
KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA
LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP
IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV
GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL
KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:51715244/chr5:169502951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MBD2 Q9UBB5	DOCK2 Q92608
FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269\|PubMed:10471499, ECO:0000269\|PubMed:10947852, ECO:0000269\|PubMed:12665568, ECO:0000269\|PubMed:16415179, ECO:0000269\|PubMed:24307175, ECO:0000269\|PubMed:9774669}.	FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269\|PubMed:21613211}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000256429

50_96

280.0

1015.6666666666666

Compositional bias

Note=Arg-rich

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000256429

6_140

280.0

1015.6666666666666

Compositional bias

Note=Gly-rich

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000256429

50_96

280.0

1015.6666666666666

Compositional bias

Note=Arg-rich

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000256429

6_140

280.0

1015.6666666666666

Compositional bias

Note=Gly-rich

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000256429

145_213

280.0

1015.6666666666666

Domain

MBD

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000256429

145_213

280.0

1015.6666666666666

Domain

MBD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000583046

50_96

303.0

Compositional bias

Note=Arg-rich

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000583046

6_140

303.0

Compositional bias

Note=Gly-rich

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000583046

50_96

303.0

Compositional bias

Note=Arg-rich

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000583046

6_140

303.0

Compositional bias

Note=Gly-rich

Hgene

MBD2

chr18:51715243

chr5:169502950

ENST00000583046

145_213

303.0

Domain

MBD

Hgene

MBD2

chr18:51715244

chr5:169502951

ENST00000583046

145_213

303.0

Domain

MBD

Tgene

DOCK2

chr18:51715243

chr5:169502950

ENST00000256935

1211_1622

1576.0

1831.0

Domain

DOCKER

Tgene

DOCK2

chr18:51715243

chr5:169502950

ENST00000256935

423_607

1576.0

1831.0

Domain

C2 DOCK-type

Tgene

DOCK2

chr18:51715243

chr5:169502950

ENST00000256935

8_69

1576.0

1831.0

Domain

SH3

Tgene

DOCK2

chr18:51715244

chr5:169502951

ENST00000256935

1211_1622

1576.0

1831.0

Domain

DOCKER

Tgene

DOCK2

chr18:51715244

chr5:169502951

ENST00000256935

423_607

1576.0

1831.0

Domain

C2 DOCK-type

Tgene

DOCK2

chr18:51715244

chr5:169502951

ENST00000256935

8_69

1576.0

1831.0

Domain

SH3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1200_MBD2_51715243_DOCK2_169502950_1200_MBD2_51715243_DOCK2_169502950_ranked_0.pdb	MBD2	51715243	51715243	ENST00000520908	DOCK2	chr5	169502950	+	MRAGRVSGIPRARLRKKRSAGWGGGWMRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRW KQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPA LPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLP IRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRV GRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDL KRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTM	560

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MBD2_pLDDT.png

DOCK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MBD2
DOCK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DOCK2	chr18:51715243	chr5:169502950	ENST00000256935		45	52	939_1476	1576.0	1831.0	CRKL
Tgene	DOCK2	chr18:51715244	chr5:169502951	ENST00000256935		45	52	939_1476	1576.0	1831.0	CRKL

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Related Drugs to MBD2-DOCK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MBD2-DOCK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source