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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MDM2-POLR3B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MDM2-POLR3B
	FusionPDB ID: 52414
	FusionGDB2.0 ID: 52414
		Hgene	Tgene
	Gene symbol	MDM2	POLR3B
	Gene ID	4193	55703
	Gene name	MDM2 proto-oncogene	RNA polymerase III subunit B
	Synonyms	ACTFS\|HDMX\|LSKB\|hdm2	C128\|HLD8\|INMAP\|RPC2
	Cytomap	12q15	12q23.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum	DNA-directed RNA polymerase III subunit RPC2DNA-directed RNA polymerase III 127.6 kDa polypeptideDNA-directed RNA polymerase III subunit BRNA polymerase III subunit C2interphase nucleus and mitotic apparatus associated proteinpolymerase (RNA) III (DN
	Modification date	20200329	20200313
	UniProtAcc	Q00987	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000258148, ENST00000258149, ENST00000299252, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000462284, ENST00000540827, ENST00000348801, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000478070, ENST00000517852, ENST00000544125, ENST00000544561, ENST00000545204,	ENST00000549195, ENST00000228347, ENST00000539066,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	39 X 20 X 11=8580	2 X 2 X 2=8
	# samples	47	2
	** MAII score	log2(47/8580*10)=-4.19024498582191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: MDM2 [Title/Abstract] AND POLR3B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MDM2(69230529)-POLR3B(106820975), # samples:1
Anticipated loss of major functional domain due to fusion event.	MDM2-POLR3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-POLR3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-POLR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-POLR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Hgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Hgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Hgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Hgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Hgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Hgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Hgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Hgene	MDM2	GO:0045184	establishment of protein localization	10360174
Hgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Hgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Hgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Hgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Hgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Hgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922

Fusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POLR3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A48N-01A	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000462284	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	4170	1220	266	3520	1084
ENST00000462284	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	4168	1220	266	3520	1084
ENST00000356290	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3645	695	251	2995	914
ENST00000356290	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3643	695	251	2995	914
ENST00000540827	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3570	620	251	2920	889
ENST00000540827	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3568	620	251	2920	889
ENST00000258149	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3990	1040	251	3340	1029
ENST00000258149	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3988	1040	251	3340	1029
ENST00000258148	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3717	767	14	3067	1017
ENST00000258148	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3715	767	14	3067	1017
ENST00000350057	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3775	825	0	3125	1041
ENST00000350057	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3773	825	0	3125	1041
ENST00000360430	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3265	315	0	2615	871
ENST00000360430	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3263	315	0	2615	871
ENST00000299252	MDM2	chr12	69230529	+	ENST00000228347	POLR3B	chr12	106820975	+	3340	390	0	2690	896
ENST00000299252	MDM2	chr12	69230529	+	ENST00000539066	POLR3B	chr12	106820975	+	3338	390	0	2690	896

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000462284	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000212927	0.99978703
ENST00000462284	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000214383	0.9997856
ENST00000356290	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000381864	0.99961805
ENST00000356290	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000385301	0.9996147
ENST00000540827	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000313091	0.99968696
ENST00000540827	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.00031569	0.99968433
ENST00000258149	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000222926	0.99977714
ENST00000258149	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000223708	0.9997763
ENST00000258148	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000179659	0.9998204
ENST00000258148	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000180911	0.9998191
ENST00000350057	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000167516	0.9998325
ENST00000350057	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000169131	0.99983084
ENST00000360430	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000417355	0.9995827
ENST00000360430	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000421122	0.9995789
ENST00000299252	ENST00000228347	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000344014	0.99965596
ENST00000299252	ENST00000539066	MDM2	chr12	69230529	+	POLR3B	chr12	106820975	+	0.000346151	0.9996538

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52414_52414_1_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1017AA_BP=251
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVS
EHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKK
IADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQW
GMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAG
YINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTH
LEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSY
SGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVT
QIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPD
IIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMV
LDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRI

--------------------------------------------------------------

>52414_52414_2_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258148_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1017AA_BP=251
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVS
EHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKK
IADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQW
GMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAG
YINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTH
LEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSY
SGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVT
QIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPD
IIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMV
LDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRI

--------------------------------------------------------------

>52414_52414_3_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1029AA_BP=263
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTG
TPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFE
DLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRK
VSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKK
LVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIA
LYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLP
AGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENK
QVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQE
DMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYF
GPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHY

--------------------------------------------------------------

>52414_52414_4_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000258149_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1029AA_BP=263
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTG
TPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFE
DLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRK
VSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKK
LVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIA
LYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLP
AGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENK
QVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQE
DMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYF
GPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHY

--------------------------------------------------------------

>52414_52414_5_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=896AA_BP=130
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYS
LSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVN
AISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDME
DGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYI
IVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQC
AMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKC
TLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIE
KVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGR
FHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRL

--------------------------------------------------------------

>52414_52414_6_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000299252_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=896AA_BP=130
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYS
LSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVN
AISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDME
DGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYI
IVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQC
AMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKC
TLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIE
KVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGR
FHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRL

--------------------------------------------------------------

>52414_52414_7_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1041AA_BP=275
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI
CCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDP
EISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMM
TRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLN
GNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEY
LDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKT
KTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDAD
GICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHG
QKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSG
ITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ

--------------------------------------------------------------

>52414_52414_8_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000350057_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1041AA_BP=275
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI
CCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDP
EISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMM
TRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLN
GNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEY
LDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKT
KTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDAD
GICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHG
QKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSG
ITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ

--------------------------------------------------------------

>52414_52414_9_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=914AA_BP=148
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQ
FDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEA
CGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLT
DRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCA
GLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNK
ASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQP
QYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMT
VGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRA
VLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS

--------------------------------------------------------------

>52414_52414_10_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000356290_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=914AA_BP=148
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQ
FDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEA
CGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLT
DRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCA
GLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNK
ASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQP
QYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMT
VGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRA
VLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS

--------------------------------------------------------------

>52414_52414_11_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=871AA_BP=105
MCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGE
SDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSR
LSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELS
YPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFE
DFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLL
AYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKP
IWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPE
IGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYN
YLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISS

--------------------------------------------------------------

>52414_52414_12_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000360430_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=871AA_BP=105
MCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGE
SDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSR
LSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELS
YPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFE
DFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLL
AYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKP
IWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPE
IGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYN
YLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISS

--------------------------------------------------------------

>52414_52414_13_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=1084AA_BP=318
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQD
QITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALM
THITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDG
GRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQ
SPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRC
LVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYK
GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAG
KAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGR
SRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLS

--------------------------------------------------------------

>52414_52414_14_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000462284_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=1084AA_BP=318
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQD
QITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALM
THITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDG
GRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQ
SPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRC
LVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYK
GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAG
KAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGR
SRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLS

--------------------------------------------------------------

>52414_52414_15_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000228347_length(amino acids)=889AA_BP=123
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQE
LSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW
SLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKL
ASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKP
AVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAM
GTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTN
QTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSN
AEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAF
GGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC

--------------------------------------------------------------

>52414_52414_16_MDM2-POLR3B_MDM2_chr12_69230529_ENST00000540827_POLR3B_chr12_106820975_ENST00000539066_length(amino acids)=889AA_BP=123
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQE
LSDEDDEVYQVTVYQAGESDTDSFEEDPEISLALLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW
SLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKL
ASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKP
AVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAM
GTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTN
QTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSN
AEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAF
GGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69230529/chr12:106820975)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDM2 Q00987	.
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:30879903}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

210_215

245.0

437.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

210_215

306.0

498.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

243_301

306.0

498.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

26_109

245.0

437.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

26_109

130.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

26_109

130.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

26_109

306.0

498.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

179_185

245.0

437.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

190_202

245.0

437.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

179_185

306.0

498.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

190_202

306.0

498.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

1_101

245.0

437.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

1_101

130.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

1_101

130.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

1_101

105.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

1_101

306.0

498.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

210_304

306.0

498.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

1_101

105.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Tgene

POLR3B

chr12:69230529

chr12:106820975

ENST00000228347

1080_1095

367.0

1134.0

Zinc finger

Note=C4-type

Tgene

POLR3B

chr12:69230529

chr12:106820975

ENST00000539066

1080_1095

309.0

1076.0

Zinc finger

Note=C4-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

243_301

245.0

437.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

210_215

130.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

243_301

130.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

210_215

0.0

266.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

243_301

0.0

266.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

210_215

130.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

243_301

130.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

210_215

105.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

243_301

105.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

210_215

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

243_301

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

210_215

0.0

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

243_301

0.0

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

210_215

271.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

243_301

271.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

210_215

105.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

243_301

105.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

26_109

0.0

266.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

26_109

105.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

26_109

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

26_109

0.0

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

26_109

271.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

26_109

105.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

466_473

245.0

437.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

179_185

130.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

190_202

130.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

466_473

130.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

179_185

0.0

266.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

190_202

0.0

266.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

466_473

0.0

266.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

179_185

130.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

190_202

130.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

466_473

130.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

179_185

105.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

190_202

105.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

466_473

105.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

179_185

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

190_202

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

466_473

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

179_185

0.0

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

190_202

0.0

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

466_473

0.0

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

179_185

271.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

190_202

271.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

466_473

271.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

466_473

306.0

498.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

179_185

105.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

190_202

105.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

466_473

105.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

210_304

245.0

437.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

242_331

245.0

437.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

210_304

130.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

242_331

130.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

1_101

0.0

266.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

210_304

0.0

266.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

242_331

0.0

266.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

210_304

130.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

242_331

130.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

210_304

105.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

242_331

105.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

1_101

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

210_304

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

242_331

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

1_101

0.0

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

210_304

0.0

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

242_331

0.0

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

1_101

271.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

210_304

271.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

242_331

271.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

242_331

306.0

498.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

210_304

105.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

242_331

105.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

299_328

245.0

437.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000258149

438_479

245.0

437.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

299_328

130.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000299252

438_479

130.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

299_328

0.0

266.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000348801

438_479

0.0

266.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

299_328

130.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000356290

438_479

130.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

299_328

105.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000360430

438_479

105.0

297.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

299_328

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393412

438_479

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

299_328

0.0

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000393413

438_479

0.0

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

299_328

271.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000428863

438_479

271.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

299_328

306.0

498.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000462284

438_479

306.0

498.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

299_328

105.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69230529

chr12:106820975

ENST00000540827

438_479

105.0

297.0

Zinc finger

RING-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MDM2
POLR3B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000258149	+	8	9	170_306	245.0	437.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000299252	+	4	5	170_306	130.0	322.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000348801	+	1	3	170_306	0.0	266.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000356290	+	5	6	170_306	130.0	322.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000360430	+	3	4	170_306	105.0	297.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393412	+	1	3	170_306	0	219.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393413	+	1	2	170_306	0.0	219.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000428863	+	1	4	170_306	0	271.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000540827	+	4	5	170_306	105.0	297.0	MTBP
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000299252	+	4	5	150_230	130.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000348801	+	1	3	150_230	0.0	266.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000356290	+	5	6	150_230	130.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000360430	+	3	4	150_230	105.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393412	+	1	3	150_230	0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393413	+	1	2	150_230	0.0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000428863	+	1	4	150_230	0	271.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000540827	+	4	5	150_230	105.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000299252	+	4	5	223_232	130.0	322.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000348801	+	1	3	223_232	0.0	266.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000356290	+	5	6	223_232	130.0	322.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000360430	+	3	4	223_232	105.0	297.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393412	+	1	3	223_232	0	219.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000393413	+	1	2	223_232	0.0	219.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000428863	+	1	4	223_232	0	271.0	USP7
Hgene	MDM2	chr12:69230529	chr12:106820975	ENST00000540827	+	4	5	223_232	105.0	297.0	USP7

Top

Related Drugs to MDM2-POLR3B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MDM2-POLR3B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source