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Fusion Protein:MDM2-SPATS2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MDM2-SPATS2 | FusionPDB ID: 52421 | FusionGDB2.0 ID: 52421 | Hgene | Tgene | Gene symbol | MDM2 | SPATS2 | Gene ID | 4193 | 65244 |
| Gene name | MDM2 proto-oncogene | spermatogenesis associated serine rich 2 | |
| Synonyms | ACTFS|HDMX|LSKB|hdm2 | Nbla00526|P59SCR|SCR59|SPATA10 | |
| Cytomap | 12q15 | 12q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum | spermatogenesis-associated serine-rich protein 2putative protein product of Nbla00526serine-rich spermatocytes and round spermatid 59 kDa proteinserine-rich spermatocytes and round spermatid protein | |
| Modification date | 20200329 | 20200315 | |
| UniProtAcc | Q00987 | SPATS2L | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000478070, ENST00000545204, ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000462284, ENST00000517852, ENST00000540827, ENST00000544125, ENST00000544561, | ENST00000321898, ENST00000552918, ENST00000553127, ENST00000547865, ENST00000552557, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 39 X 20 X 11=8580 | 12 X 14 X 7=1176 |
| # samples | 47 | 15 | |
| ** MAII score | log2(47/8580*10)=-4.19024498582191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1176*10)=-2.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MDM2 [Title/Abstract] AND SPATS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MDM2(69233581)-SPATS2(49883248), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MDM2-SPATS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MDM2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9271120|17310983 |
| Hgene | MDM2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11278372|15314173|16173922|17310983 |
| Hgene | MDM2 | GO:0016567 | protein ubiquitination | 9450543|15878855|19656744|20153724 |
| Hgene | MDM2 | GO:0031648 | protein destabilization | 9529249|10360174|15314173 |
| Hgene | MDM2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 11278372 |
| Hgene | MDM2 | GO:0034504 | protein localization to nucleus | 10360174 |
| Hgene | MDM2 | GO:0042176 | regulation of protein catabolic process | 9153395 |
| Hgene | MDM2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 9529249|10360174 |
| Hgene | MDM2 | GO:0045184 | establishment of protein localization | 10360174 |
| Hgene | MDM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9271120 |
| Hgene | MDM2 | GO:0065003 | protein-containing complex assembly | 10608892|12915590 |
| Hgene | MDM2 | GO:0071157 | negative regulation of cell cycle arrest | 9529249 |
| Hgene | MDM2 | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Hgene | MDM2 | GO:0072717 | cellular response to actinomycin D | 15314173 |
| Hgene | MDM2 | GO:1901797 | negative regulation of signal transduction by p53 class mediator | 16173922 |
| Fusion gene breakpoints across MDM2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SPATS2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-RN-AAAQ-01A | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393412 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 3343 | 643 | 694 | 2175 | 493 |
| ENST00000393412 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 3340 | 643 | 694 | 2175 | 493 |
| ENST00000393412 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 3147 | 643 | 694 | 2175 | 493 |
| ENST00000258148 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 3533 | 833 | 884 | 2365 | 493 |
| ENST00000258148 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 3530 | 833 | 884 | 2365 | 493 |
| ENST00000258148 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 3337 | 833 | 884 | 2365 | 493 |
| ENST00000393410 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 2904 | 204 | 255 | 1736 | 493 |
| ENST00000393410 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 2901 | 204 | 255 | 1736 | 493 |
| ENST00000393410 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2708 | 204 | 255 | 1736 | 493 |
| ENST00000393413 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 2829 | 129 | 180 | 1661 | 493 |
| ENST00000393413 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 2826 | 129 | 180 | 1661 | 493 |
| ENST00000393413 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2633 | 129 | 180 | 1661 | 493 |
| ENST00000517852 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 2904 | 204 | 255 | 1736 | 493 |
| ENST00000517852 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 2901 | 204 | 255 | 1736 | 493 |
| ENST00000517852 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2708 | 204 | 255 | 1736 | 493 |
| ENST00000350057 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 3573 | 873 | 924 | 2405 | 493 |
| ENST00000350057 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 3570 | 873 | 924 | 2405 | 493 |
| ENST00000350057 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 3377 | 873 | 924 | 2405 | 493 |
| ENST00000360430 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 3063 | 363 | 414 | 1895 | 493 |
| ENST00000360430 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 3060 | 363 | 414 | 1895 | 493 |
| ENST00000360430 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2867 | 363 | 414 | 1895 | 493 |
| ENST00000299252 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 3138 | 438 | 489 | 1970 | 493 |
| ENST00000299252 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 3135 | 438 | 489 | 1970 | 493 |
| ENST00000299252 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2942 | 438 | 489 | 1970 | 493 |
| ENST00000348801 | MDM2 | chr12 | 69233581 | + | ENST00000553127 | SPATS2 | chr12 | 49883248 | + | 2970 | 270 | 321 | 1802 | 493 |
| ENST00000348801 | MDM2 | chr12 | 69233581 | + | ENST00000321898 | SPATS2 | chr12 | 49883248 | + | 2967 | 270 | 321 | 1802 | 493 |
| ENST00000348801 | MDM2 | chr12 | 69233581 | + | ENST00000552918 | SPATS2 | chr12 | 49883248 | + | 2774 | 270 | 321 | 1802 | 493 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393412 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001179344 | 0.9988206 |
| ENST00000393412 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001172023 | 0.998828 |
| ENST00000393412 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001506558 | 0.99849343 |
| ENST00000258148 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001733539 | 0.9982665 |
| ENST00000258148 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001725928 | 0.9982741 |
| ENST00000258148 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.002423209 | 0.9975768 |
| ENST00000393410 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001362739 | 0.99863726 |
| ENST00000393410 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001334545 | 0.99866545 |
| ENST00000393410 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001832063 | 0.9981679 |
| ENST00000393413 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001493895 | 0.9985061 |
| ENST00000393413 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001472066 | 0.9985279 |
| ENST00000393413 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.00203323 | 0.99796677 |
| ENST00000517852 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001362739 | 0.99863726 |
| ENST00000517852 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001334545 | 0.99866545 |
| ENST00000517852 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001832063 | 0.9981679 |
| ENST00000350057 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.00180334 | 0.99819666 |
| ENST00000350057 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001783174 | 0.9982168 |
| ENST00000350057 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.00256574 | 0.9974343 |
| ENST00000360430 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001912916 | 0.99808717 |
| ENST00000360430 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001901651 | 0.9980983 |
| ENST00000360430 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.002936457 | 0.9970636 |
| ENST00000299252 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001758367 | 0.99824166 |
| ENST00000299252 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001749582 | 0.9982504 |
| ENST00000299252 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.002544133 | 0.9974559 |
| ENST00000348801 | ENST00000553127 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001923911 | 0.9980761 |
| ENST00000348801 | ENST00000321898 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.001902462 | 0.9980976 |
| ENST00000348801 | ENST00000552918 | MDM2 | chr12 | 69233581 | + | SPATS2 | chr12 | 49883248 | + | 0.002948941 | 0.997051 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >52421_52421_1_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_2_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_3_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_4_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_5_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_6_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_7_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_8_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_9_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_10_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_11_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_12_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_13_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_14_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_15_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_16_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_17_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_18_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_19_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_20_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_21_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_22_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_23_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_24_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_25_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_26_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- >52421_52421_27_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP= MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69233581/chr12:49883248) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MDM2 | SPATS2 |
| FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}. | 558 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000321898 | 2 | 13 | 364_414 | 35.0 | 546.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000321898 | 2 | 13 | 86_97 | 35.0 | 546.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000552918 | 3 | 14 | 364_414 | 35.0 | 546.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000552918 | 3 | 14 | 86_97 | 35.0 | 546.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000553127 | 4 | 15 | 364_414 | 35.0 | 546.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SPATS2 | chr12:69233581 | chr12:49883248 | ENST00000553127 | 4 | 15 | 86_97 | 35.0 | 546.0 | Compositional bias | Note=Poly-Lys |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 210_215 | 0 | 437.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 243_301 | 0 | 437.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 210_215 | 0.0 | 322.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 243_301 | 0.0 | 322.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 210_215 | 0.0 | 266.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 243_301 | 0.0 | 266.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 210_215 | 0 | 322.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 243_301 | 0 | 322.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 210_215 | 0.0 | 297.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 243_301 | 0.0 | 297.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 210_215 | 0 | 219.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 243_301 | 0 | 219.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 210_215 | 0.0 | 219.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 243_301 | 0.0 | 219.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 210_215 | 0 | 271.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 243_301 | 0 | 271.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 210_215 | 0 | 498.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 243_301 | 0 | 498.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 210_215 | 0 | 297.0 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 243_301 | 0 | 297.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 26_109 | 0 | 437.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 26_109 | 0.0 | 322.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 26_109 | 0.0 | 266.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 26_109 | 0 | 322.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 26_109 | 0.0 | 297.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 26_109 | 0 | 219.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 26_109 | 0.0 | 219.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 26_109 | 0 | 271.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 26_109 | 0 | 498.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 26_109 | 0 | 297.0 | Domain | SWIB/MDM2 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 179_185 | 0 | 437.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 190_202 | 0 | 437.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 466_473 | 0 | 437.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 179_185 | 0.0 | 322.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 190_202 | 0.0 | 322.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 466_473 | 0.0 | 322.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 179_185 | 0.0 | 266.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 190_202 | 0.0 | 266.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 466_473 | 0.0 | 266.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 179_185 | 0 | 322.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 190_202 | 0 | 322.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 466_473 | 0 | 322.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 179_185 | 0.0 | 297.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 190_202 | 0.0 | 297.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 466_473 | 0.0 | 297.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 179_185 | 0 | 219.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 190_202 | 0 | 219.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 466_473 | 0 | 219.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 179_185 | 0.0 | 219.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 190_202 | 0.0 | 219.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 466_473 | 0.0 | 219.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 179_185 | 0 | 271.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 190_202 | 0 | 271.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 466_473 | 0 | 271.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 179_185 | 0 | 498.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 190_202 | 0 | 498.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 466_473 | 0 | 498.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 179_185 | 0 | 297.0 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 190_202 | 0 | 297.0 | Motif | Note=Nuclear export signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 466_473 | 0 | 297.0 | Motif | Nucleolar localization signal |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 1_101 | 0 | 437.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 210_304 | 0 | 437.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 242_331 | 0 | 437.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 1_101 | 0.0 | 322.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 210_304 | 0.0 | 322.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 242_331 | 0.0 | 322.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 1_101 | 0.0 | 266.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 210_304 | 0.0 | 266.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 242_331 | 0.0 | 266.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 1_101 | 0 | 322.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 210_304 | 0 | 322.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 242_331 | 0 | 322.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 1_101 | 0.0 | 297.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 210_304 | 0.0 | 297.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 242_331 | 0.0 | 297.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 1_101 | 0 | 219.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 210_304 | 0 | 219.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 242_331 | 0 | 219.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 1_101 | 0.0 | 219.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 210_304 | 0.0 | 219.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 242_331 | 0.0 | 219.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 1_101 | 0 | 271.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 210_304 | 0 | 271.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 242_331 | 0 | 271.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 1_101 | 0 | 498.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 210_304 | 0 | 498.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 242_331 | 0 | 498.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 1_101 | 0 | 297.0 | Region | Sufficient to promote the mitochondrial pathway of apoptosis |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 210_304 | 0 | 297.0 | Region | Note=ARF-binding |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 242_331 | 0 | 297.0 | Region | Note=Region II |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 299_328 | 0 | 437.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 438_479 | 0 | 437.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 299_328 | 0.0 | 322.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 438_479 | 0.0 | 322.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 299_328 | 0.0 | 266.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 438_479 | 0.0 | 266.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 299_328 | 0 | 322.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 438_479 | 0 | 322.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 299_328 | 0.0 | 297.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 438_479 | 0.0 | 297.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 299_328 | 0 | 219.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 438_479 | 0 | 219.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 299_328 | 0.0 | 219.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 438_479 | 0.0 | 219.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 299_328 | 0 | 271.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 438_479 | 0 | 271.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 299_328 | 0 | 498.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 438_479 | 0 | 498.0 | Zinc finger | RING-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 299_328 | 0 | 297.0 | Zinc finger | RanBP2-type |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 438_479 | 0 | 297.0 | Zinc finger | RING-type |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MDM2 | |
| SPATS2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 170_306 | 0 | 437.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 170_306 | 0.0 | 322.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 170_306 | 0.0 | 266.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 170_306 | 0 | 322.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 170_306 | 0.0 | 297.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 170_306 | 0 | 219.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 170_306 | 0.0 | 219.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 170_306 | 0 | 271.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 170_306 | 0 | 498.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 170_306 | 0 | 297.0 | MTBP |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 150_230 | 0 | 437.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 150_230 | 0.0 | 322.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 150_230 | 0.0 | 266.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 150_230 | 0 | 322.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 150_230 | 0.0 | 297.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 150_230 | 0 | 219.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 150_230 | 0.0 | 219.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 150_230 | 0 | 271.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 150_230 | 0 | 498.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 150_230 | 0 | 297.0 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000258149 | + | 1 | 9 | 223_232 | 0 | 437.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000299252 | + | 1 | 5 | 223_232 | 0.0 | 322.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000348801 | + | 1 | 3 | 223_232 | 0.0 | 266.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000356290 | + | 1 | 6 | 223_232 | 0 | 322.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000360430 | + | 1 | 4 | 223_232 | 0.0 | 297.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393412 | + | 1 | 3 | 223_232 | 0 | 219.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000393413 | + | 1 | 2 | 223_232 | 0.0 | 219.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000428863 | + | 1 | 4 | 223_232 | 0 | 271.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000462284 | + | 1 | 11 | 223_232 | 0 | 498.0 | USP7 |
| Hgene | MDM2 | chr12:69233581 | chr12:49883248 | ENST00000540827 | + | 1 | 5 | 223_232 | 0 | 297.0 | USP7 |
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Related Drugs to MDM2-SPATS2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to MDM2-SPATS2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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