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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MDM2-SYK

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MDM2-SYK
	FusionPDB ID: 52422
	FusionGDB2.0 ID: 52422
		Hgene	Tgene
	Gene symbol	MDM2	SYK
	Gene ID	4193	6850
	Gene name	MDM2 proto-oncogene	spleen associated tyrosine kinase
	Synonyms	ACTFS\|HDMX\|LSKB\|hdm2	p72-Syk
	Cytomap	12q15	9q22.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum	tyrosine-protein kinase SYKspleen tyrosine kinase
	Modification date	20200329	20200329
	UniProtAcc	Q00987	P43405
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000462284, ENST00000478070, ENST00000517852, ENST00000540827, ENST00000544561, ENST00000545204, ENST00000544125,	ENST00000375746, ENST00000476708, ENST00000375747, ENST00000375751, ENST00000375754,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	39 X 20 X 11=8580	9 X 9 X 6=486
	# samples	47	9
	** MAII score	log2(47/8580*10)=-4.19024498582191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MDM2 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MDM2(69203072)-SYK(93657810), # samples:2
Anticipated loss of major functional domain due to fusion event.	MDM2-SYK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MDM2-SYK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Hgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Hgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Hgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Hgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Hgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Hgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Hgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Hgene	MDM2	GO:0045184	establishment of protein localization	10360174
Hgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Hgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Hgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Hgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Hgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Hgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922
Tgene	SYK	GO:0006468	protein phosphorylation	17681949
Tgene	SYK	GO:0007159	leukocyte cell-cell adhesion	12885943
Tgene	SYK	GO:0030593	neutrophil chemotaxis	12885943

Fusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SYK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A3M1-01A	MDM2	chr12	69203072	+	SYK	chr9	93657810	+
ChimerDB4	SARC	TCGA-DX-A3M1	MDM2	chr12	69203072	+	SYK	chr9	93657809	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3423	401	2429	1989	146
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3423	401	2429	1989	146
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3423	401	2429	1989	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3408	386	2414	1974	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3377	355	2383	1943	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3377	355	2383	1943	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3377	355	2383	1943	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3135	113	2141	1701	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3135	113	2141	1701	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3135	113	2141	1701	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3109	87	2115	1675	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3109	87	2115	1675	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3109	87	2115	1675	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3103	81	2109	1669	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657810	+	3088	66	2094	1654	146
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3423	401	2429	1989	146
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3423	401	2429	1989	146
ENST00000462284	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3423	401	2429	1989	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000356290	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000540827	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000258149	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000428863	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3408	386	2414	1974	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3377	355	2383	1943	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3377	355	2383	1943	146
ENST00000393412	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3377	355	2383	1943	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3135	113	2141	1701	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3135	113	2141	1701	146
ENST00000258148	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3135	113	2141	1701	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000544561	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393410	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000393413	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000517852	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3109	87	2115	1675	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3109	87	2115	1675	146
ENST00000545204	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3109	87	2115	1675	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000350057	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000360430	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000299252	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3103	81	2109	1669	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3088	66	2094	1654	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3088	66	2094	1654	146
ENST00000348801	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375751	SYK	chr9	93657809	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375754	SYK	chr9	93657809	+	3088	66	2094	1654	146
ENST00000478070	MDM2	chr12	69203072	+	ENST00000375747	SYK	chr9	93657809	+	3088	66	2094	1654	146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000462284	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.63334846	0.36665154
ENST00000462284	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.63334846	0.36665154
ENST00000462284	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.63334846	0.36665154
ENST00000356290	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000356290	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000356290	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000540827	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000540827	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000540827	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000258149	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000258149	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000258149	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000428863	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000428863	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000428863	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6249385	0.3750615
ENST00000393412	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6132836	0.38671643
ENST00000393412	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6132836	0.38671643
ENST00000393412	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.6132836	0.38671643
ENST00000258148	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5402276	0.4597724
ENST00000258148	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5402276	0.4597724
ENST00000258148	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5402276	0.4597724
ENST00000544561	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000544561	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000544561	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393410	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393410	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393410	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393413	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393413	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000393413	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000517852	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000517852	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000517852	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000545204	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5309887	0.46901137
ENST00000545204	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5309887	0.46901137
ENST00000545204	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5309887	0.46901137
ENST00000350057	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000350057	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000350057	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000360430	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000360430	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000360430	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000299252	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000299252	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000299252	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.5435976	0.45640236
ENST00000348801	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000348801	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000348801	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000478070	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000478070	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000478070	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657810	+	0.549285	0.450715
ENST00000462284	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.63334846	0.36665154
ENST00000462284	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.63334846	0.36665154
ENST00000462284	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.63334846	0.36665154
ENST00000356290	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000356290	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000356290	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000540827	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000540827	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000540827	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000258149	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000258149	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000258149	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000428863	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000428863	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000428863	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6249385	0.3750615
ENST00000393412	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6132836	0.38671643
ENST00000393412	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6132836	0.38671643
ENST00000393412	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.6132836	0.38671643
ENST00000258148	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5402276	0.4597724
ENST00000258148	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5402276	0.4597724
ENST00000258148	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5402276	0.4597724
ENST00000544561	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000544561	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000544561	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393410	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393410	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393410	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393413	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393413	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000393413	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000517852	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000517852	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000517852	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000545204	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5309887	0.46901137
ENST00000545204	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5309887	0.46901137
ENST00000545204	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5309887	0.46901137
ENST00000350057	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000350057	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000350057	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000360430	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000360430	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000360430	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000299252	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000299252	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000299252	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.5435976	0.45640236
ENST00000348801	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715
ENST00000348801	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715
ENST00000348801	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715
ENST00000478070	ENST00000375751	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715
ENST00000478070	ENST00000375754	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715
ENST00000478070	ENST00000375747	MDM2	chr12	69203072	+	SYK	chr9	93657809	+	0.549285	0.450715

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52422_52422_1_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_2_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_3_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_4_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_5_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_6_MDM2-SYK_MDM2_chr12_69203072_ENST00000258148_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_7_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_8_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_9_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_10_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_11_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_12_MDM2-SYK_MDM2_chr12_69203072_ENST00000258149_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_13_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_14_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_15_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_16_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_17_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_18_MDM2-SYK_MDM2_chr12_69203072_ENST00000299252_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_19_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_20_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_21_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_22_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_23_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_24_MDM2-SYK_MDM2_chr12_69203072_ENST00000348801_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_25_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_26_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_27_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_28_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_29_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_30_MDM2-SYK_MDM2_chr12_69203072_ENST00000350057_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_31_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_32_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_33_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_34_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_35_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_36_MDM2-SYK_MDM2_chr12_69203072_ENST00000356290_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_37_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_38_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_39_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_40_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_41_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_42_MDM2-SYK_MDM2_chr12_69203072_ENST00000360430_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_43_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_44_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_45_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_46_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_47_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_48_MDM2-SYK_MDM2_chr12_69203072_ENST00000393410_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_49_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_50_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_51_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_52_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_53_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_54_MDM2-SYK_MDM2_chr12_69203072_ENST00000393412_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_55_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_56_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_57_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_58_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_59_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_60_MDM2-SYK_MDM2_chr12_69203072_ENST00000393413_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_61_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_62_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_63_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_64_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_65_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_66_MDM2-SYK_MDM2_chr12_69203072_ENST00000428863_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_67_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_68_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_69_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_70_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_71_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_72_MDM2-SYK_MDM2_chr12_69203072_ENST00000462284_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_73_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_74_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_75_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_76_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_77_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_78_MDM2-SYK_MDM2_chr12_69203072_ENST00000478070_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_79_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_80_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_81_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_82_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_83_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_84_MDM2-SYK_MDM2_chr12_69203072_ENST00000517852_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_85_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_86_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_87_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_88_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_89_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_90_MDM2-SYK_MDM2_chr12_69203072_ENST00000540827_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_91_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_92_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_93_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_94_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_95_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_96_MDM2-SYK_MDM2_chr12_69203072_ENST00000544561_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_97_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657809_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_98_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657809_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_99_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657809_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_100_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657810_ENST00000375747_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_101_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657810_ENST00000375751_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

>52422_52422_102_MDM2-SYK_MDM2_chr12_69203072_ENST00000545204_SYK_chr9_93657810_ENST00000375754_length(amino acids)=146AA_BP=
MKTPSGSYRRKPPRVQPHSLFLRCSHHFTKLGTSNHSFHNFTPVCGLADRYFVIDLSNFRDSKCVLRICSALRDSVFKNMIKPPDSVISE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69203072/chr9:93657810)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDM2 Q00987	SYK P43405
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:30879903}.	FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250\|UniProtKB:P48025, ECO:0000269\|PubMed:12387735, ECO:0000269\|PubMed:12456653, ECO:0000269\|PubMed:15123770, ECO:0000269\|PubMed:15388330, ECO:0000269\|PubMed:19909739, ECO:0000269\|PubMed:8657103, ECO:0000269\|PubMed:9535867}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

210_215

27.0

437.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

243_301

27.0

437.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

210_215

27.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

243_301

27.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

210_215

22.0

266.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

243_301

22.0

266.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

210_215

27.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

243_301

27.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

210_215

27.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

243_301

27.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

210_215

27.0

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

243_301

27.0

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

210_215

27.0

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

243_301

27.0

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

210_215

27.0

271.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

243_301

27.0

271.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

210_215

33.0

498.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

243_301

33.0

498.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

210_215

27.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

243_301

27.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

210_215

27.0

437.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

243_301

27.0

437.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

210_215

27.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

243_301

27.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

210_215

22.0

266.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

243_301

22.0

266.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

210_215

27.0

322.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

243_301

27.0

322.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

210_215

27.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

243_301

27.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

210_215

27.0

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

243_301

27.0

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

210_215

27.0

219.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

243_301

27.0

219.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

210_215

27.0

271.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

243_301

27.0

271.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

210_215

33.0

498.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

243_301

33.0

498.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

210_215

27.0

297.0

Compositional bias

Note=Poly-Ser

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

243_301

27.0

297.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

26_109

27.0

437.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

26_109

27.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

26_109

22.0

266.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

26_109

27.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

26_109

27.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

26_109

27.0

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

26_109

27.0

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

26_109

27.0

271.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

26_109

33.0

498.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

26_109

27.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

26_109

27.0

437.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

26_109

27.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

26_109

22.0

266.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

26_109

27.0

322.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

26_109

27.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

26_109

27.0

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

26_109

27.0

219.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

26_109

27.0

271.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

26_109

33.0

498.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

26_109

27.0

297.0

Domain

SWIB/MDM2

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

179_185

27.0

437.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

190_202

27.0

437.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

466_473

27.0

437.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

179_185

27.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

190_202

27.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

466_473

27.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

179_185

22.0

266.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

190_202

22.0

266.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

466_473

22.0

266.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

179_185

27.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

190_202

27.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

466_473

27.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

179_185

27.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

190_202

27.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

466_473

27.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

179_185

27.0

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

190_202

27.0

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

466_473

27.0

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

179_185

27.0

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

190_202

27.0

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

466_473

27.0

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

179_185

27.0

271.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

190_202

27.0

271.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

466_473

27.0

271.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

179_185

33.0

498.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

190_202

33.0

498.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

466_473

33.0

498.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

179_185

27.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

190_202

27.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

466_473

27.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

179_185

27.0

437.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

190_202

27.0

437.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

466_473

27.0

437.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

179_185

27.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

190_202

27.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

466_473

27.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

179_185

22.0

266.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

190_202

22.0

266.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

466_473

22.0

266.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

179_185

27.0

322.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

190_202

27.0

322.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

466_473

27.0

322.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

179_185

27.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

190_202

27.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

466_473

27.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

179_185

27.0

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

190_202

27.0

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

466_473

27.0

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

179_185

27.0

219.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

190_202

27.0

219.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

466_473

27.0

219.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

179_185

27.0

271.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

190_202

27.0

271.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

466_473

27.0

271.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

179_185

33.0

498.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

190_202

33.0

498.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

466_473

33.0

498.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

179_185

27.0

297.0

Motif

Nuclear localization signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

190_202

27.0

297.0

Motif

Note=Nuclear export signal

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

466_473

27.0

297.0

Motif

Nucleolar localization signal

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

1_101

27.0

437.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

210_304

27.0

437.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

242_331

27.0

437.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

1_101

27.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

210_304

27.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

242_331

27.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

1_101

22.0

266.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

210_304

22.0

266.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

242_331

22.0

266.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

1_101

27.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

210_304

27.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

242_331

27.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

1_101

27.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

210_304

27.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

242_331

27.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

1_101

27.0

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

210_304

27.0

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

242_331

27.0

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

1_101

27.0

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

210_304

27.0

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

242_331

27.0

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

1_101

27.0

271.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

210_304

27.0

271.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

242_331

27.0

271.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

1_101

33.0

498.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

210_304

33.0

498.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

242_331

33.0

498.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

1_101

27.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

210_304

27.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

242_331

27.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

1_101

27.0

437.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

210_304

27.0

437.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

242_331

27.0

437.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

1_101

27.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

210_304

27.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

242_331

27.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

1_101

22.0

266.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

210_304

22.0

266.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

242_331

22.0

266.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

1_101

27.0

322.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

210_304

27.0

322.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

242_331

27.0

322.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

1_101

27.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

210_304

27.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

242_331

27.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

1_101

27.0

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

210_304

27.0

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

242_331

27.0

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

1_101

27.0

219.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

210_304

27.0

219.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

242_331

27.0

219.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

1_101

27.0

271.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

210_304

27.0

271.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

242_331

27.0

271.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

1_101

33.0

498.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

210_304

33.0

498.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

242_331

33.0

498.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

1_101

27.0

297.0

Region

Sufficient to promote the mitochondrial pathway of apoptosis

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

210_304

27.0

297.0

Region

Note=ARF-binding

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

242_331

27.0

297.0

Region

Note=Region II

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

299_328

27.0

437.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000258149

438_479

27.0

437.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

299_328

27.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000299252

438_479

27.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

299_328

22.0

266.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000348801

438_479

22.0

266.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

299_328

27.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000356290

438_479

27.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

299_328

27.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000360430

438_479

27.0

297.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

299_328

27.0

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393412

438_479

27.0

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

299_328

27.0

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000393413

438_479

27.0

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

299_328

27.0

271.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000428863

438_479

27.0

271.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

299_328

33.0

498.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000462284

438_479

33.0

498.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

299_328

27.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657809

ENST00000540827

438_479

27.0

297.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

299_328

27.0

437.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000258149

438_479

27.0

437.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

299_328

27.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000299252

438_479

27.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

299_328

22.0

266.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000348801

438_479

22.0

266.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

299_328

27.0

322.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000356290

438_479

27.0

322.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

299_328

27.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000360430

438_479

27.0

297.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

299_328

27.0

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393412

438_479

27.0

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

299_328

27.0

219.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000393413

438_479

27.0

219.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

299_328

27.0

271.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000428863

438_479

27.0

271.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

299_328

33.0

498.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000462284

438_479

33.0

498.0

Zinc finger

RING-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

299_328

27.0

297.0

Zinc finger

RanBP2-type

Hgene

MDM2

chr12:69203072

chr9:93657810

ENST00000540827

438_479

27.0

297.0

Zinc finger

RING-type

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

15_107

611.6666666666666

636.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

168_259

611.6666666666666

636.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

371_631

611.6666666666666

636.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

15_107

588.6666666666666

613.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

168_259

588.6666666666666

613.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

371_631

588.6666666666666

613.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

15_107

588.6666666666666

613.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

168_259

588.6666666666666

613.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

371_631

588.6666666666666

613.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

15_107

611.6666666666666

636.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

168_259

611.6666666666666

636.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

371_631

611.6666666666666

636.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

15_107

611.6666666666666

636.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

168_259

611.6666666666666

636.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

371_631

611.6666666666666

636.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

15_107

588.6666666666666

613.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

168_259

588.6666666666666

613.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

371_631

588.6666666666666

613.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

15_107

588.6666666666666

613.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

168_259

588.6666666666666

613.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

371_631

588.6666666666666

613.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

15_107

611.6666666666666

636.0

Domain

SH2 1

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

168_259

611.6666666666666

636.0

Domain

SH2 2

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

371_631

611.6666666666666

636.0

Domain

Protein kinase

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

377_385

611.6666666666666

636.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

377_385

588.6666666666666

613.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

377_385

588.6666666666666

613.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

377_385

611.6666666666666

636.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

377_385

611.6666666666666

636.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

377_385

588.6666666666666

613.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

377_385

588.6666666666666

613.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

377_385

611.6666666666666

636.0

Nucleotide binding

ATP

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

108_167

611.6666666666666

636.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375746

260_370

611.6666666666666

636.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

108_167

588.6666666666666

613.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375747

260_370

588.6666666666666

613.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

108_167

588.6666666666666

613.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375751

260_370

588.6666666666666

613.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

108_167

611.6666666666666

636.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657809

ENST00000375754

260_370

611.6666666666666

636.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

108_167

611.6666666666666

636.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375746

260_370

611.6666666666666

636.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

108_167

588.6666666666666

613.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375747

260_370

588.6666666666666

613.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

108_167

588.6666666666666

613.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375751

260_370

588.6666666666666

613.0

Region

Note=Interdomain B

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

108_167

611.6666666666666

636.0

Region

Note=Interdomain A

Tgene

SYK

chr12:69203072

chr9:93657810

ENST00000375754

260_370

611.6666666666666

636.0

Region

Note=Interdomain B

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MDM2
SYK

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000258149	+	2	9	170_306	27.0	437.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000299252	+	1	5	170_306	27.0	322.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000348801	+	1	3	170_306	22.0	266.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000356290	+	2	6	170_306	27.0	322.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000360430	+	1	4	170_306	27.0	297.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393412	+	2	3	170_306	27.0	219.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393413	+	1	2	170_306	27.0	219.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000428863	+	2	4	170_306	27.0	271.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000462284	+	2	11	170_306	33.0	498.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000540827	+	2	5	170_306	27.0	297.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000258149	+	2	9	170_306	27.0	437.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000299252	+	1	5	170_306	27.0	322.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000348801	+	1	3	170_306	22.0	266.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000356290	+	2	6	170_306	27.0	322.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000360430	+	1	4	170_306	27.0	297.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393412	+	2	3	170_306	27.0	219.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393413	+	1	2	170_306	27.0	219.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000428863	+	2	4	170_306	27.0	271.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000462284	+	2	11	170_306	33.0	498.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000540827	+	2	5	170_306	27.0	297.0	MTBP
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000258149	+	2	9	150_230	27.0	437.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000299252	+	1	5	150_230	27.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000348801	+	1	3	150_230	22.0	266.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000356290	+	2	6	150_230	27.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000360430	+	1	4	150_230	27.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393412	+	2	3	150_230	27.0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393413	+	1	2	150_230	27.0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000428863	+	2	4	150_230	27.0	271.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000462284	+	2	11	150_230	33.0	498.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000540827	+	2	5	150_230	27.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000258149	+	2	9	150_230	27.0	437.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000299252	+	1	5	150_230	27.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000348801	+	1	3	150_230	22.0	266.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000356290	+	2	6	150_230	27.0	322.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000360430	+	1	4	150_230	27.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393412	+	2	3	150_230	27.0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393413	+	1	2	150_230	27.0	219.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000428863	+	2	4	150_230	27.0	271.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000462284	+	2	11	150_230	33.0	498.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000540827	+	2	5	150_230	27.0	297.0	PYHIN1 and necessary for interaction with RFFL and RNF34
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000258149	+	2	9	223_232	27.0	437.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000299252	+	1	5	223_232	27.0	322.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000348801	+	1	3	223_232	22.0	266.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000356290	+	2	6	223_232	27.0	322.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000360430	+	1	4	223_232	27.0	297.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393412	+	2	3	223_232	27.0	219.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000393413	+	1	2	223_232	27.0	219.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000428863	+	2	4	223_232	27.0	271.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000462284	+	2	11	223_232	33.0	498.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657809	ENST00000540827	+	2	5	223_232	27.0	297.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000258149	+	2	9	223_232	27.0	437.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000299252	+	1	5	223_232	27.0	322.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000348801	+	1	3	223_232	22.0	266.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000356290	+	2	6	223_232	27.0	322.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000360430	+	1	4	223_232	27.0	297.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393412	+	2	3	223_232	27.0	219.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000393413	+	1	2	223_232	27.0	219.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000428863	+	2	4	223_232	27.0	271.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000462284	+	2	11	223_232	33.0	498.0	USP7
Hgene	MDM2	chr12:69203072	chr9:93657810	ENST00000540827	+	2	5	223_232	27.0	297.0	USP7

Top

Related Drugs to MDM2-SYK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MDM2-SYK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SYK	C0025202	melanoma	1	CTD_human
Tgene	SYK	C0025500	Mesothelioma	1	CTD_human