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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MECOM-FRMD5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MECOM-FRMD5
FusionPDB ID: 52496
FusionGDB2.0 ID: 52496
HgeneTgene
Gene symbol

MECOM

FRMD5

Gene ID

2122

84978

Gene nameMDS1 and EVI1 complex locusFERM domain containing 5
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2-
Cytomap

3q26.2

15q15.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein FERM domain-containing protein 5
Modification date2020031320200313
UniProtAcc

Q03112

Q7Z6J6

Ensembl transtripts involved in fusion geneENST idsENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000472280, 
ENST00000494292, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000485957, 		ENST00000402883, 
ENST00000417257, ENST00000484674, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 21 X 11=762315 X 17 X 5=1275
# samples 4318
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1275*10)=-2.82442843541655
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MECOM [Title/Abstract] AND FRMD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MECOM(168810746)-FRMD5(44180464), # samples:3
Anticipated loss of major functional domain due to fusion event.MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FRMD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-91-7771-01AMECOMchr3

168810746

-FRMD5chr15

44180464

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000464456MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-7816377411924047951
ENST00000464456MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-6917377411924047951
ENST00000464456MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-5126377411924047951
ENST00000468789MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-703029882532611078
ENST00000468789MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-613129882532611078
ENST00000468789MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-434029882532611078
ENST00000460814MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-67282686442959971
ENST00000460814MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-58292686442959971
ENST00000460814MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-40382686442959971

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000464456ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.001032730.9989673
ENST00000464456ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0008906280.9991093
ENST00000464456ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0017291570.99827087
ENST00000468789ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.000527390.9994727
ENST00000468789ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0004399620.99956006
ENST00000468789ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0012410390.9987589
ENST00000460814ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.0003571330.99964285
ENST00000460814ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0002982570.9997017
ENST00000460814ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0008220420.999178

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52496_52496_1_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

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>52496_52496_2_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

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>52496_52496_3_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

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>52496_52496_4_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

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>52496_52496_5_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

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>52496_52496_6_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

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>52496_52496_7_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

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>52496_52496_8_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

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>52496_52496_9_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:168810746/chr15:44180464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

FRMD5

Q7Z6J6

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-141778_190931.66666666666661117.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-131678_190866.66666666666661052.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-141778_190867.66666666666661053.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-121578_190857.66666666666661043.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-131678_190866.66666666666661052.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-131678_190867.66666666666661053.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417609_622931.66666666666661117.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417741_745931.66666666666661117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417772_776931.66666666666661117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316609_622866.66666666666661052.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316741_745866.66666666666661052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316772_776866.66666666666661052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417609_622867.66666666666661053.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417741_745867.66666666666661053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417772_776867.66666666666661053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215609_622857.66666666666661043.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215741_745857.66666666666661043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215772_776857.66666666666661043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316609_622866.66666666666661052.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316741_745866.66666666666661052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316772_776866.66666666666661052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316609_622867.66666666666661053.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316741_745867.66666666666661053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316772_776867.66666666666661053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417209_236931.66666666666661117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417263_285931.66666666666661117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417291_313931.66666666666661117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417319_342931.66666666666661117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417348_370931.66666666666661117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417376_398931.66666666666661117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417405_427931.66666666666661117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417912_934931.66666666666661117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316209_236866.66666666666661052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316263_285866.66666666666661052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316291_313866.66666666666661052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316319_342866.66666666666661052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316348_370866.66666666666661052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316376_398866.66666666666661052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316405_427866.66666666666661052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417209_236867.66666666666661053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417263_285867.66666666666661053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417291_313867.66666666666661053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417319_342867.66666666666661053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417348_370867.66666666666661053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417376_398867.66666666666661053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417405_427867.66666666666661053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215209_236857.66666666666661043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215263_285857.66666666666661043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215291_313857.66666666666661043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215319_342857.66666666666661043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215348_370857.66666666666661043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215376_398857.66666666666661043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215405_427857.66666666666661043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316209_236866.66666666666661052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316263_285866.66666666666661052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316291_313866.66666666666661052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316319_342866.66666666666661052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316348_370866.66666666666661052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316376_398866.66666666666661052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316405_427866.66666666666661052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316209_236867.66666666666661053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316263_285867.66666666666661053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316291_313867.66666666666661053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316319_342867.66666666666661053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316348_370867.66666666666661053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316376_398867.66666666666661053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316405_427867.66666666666661053.0Zinc fingerC2H2-type 7%3B atypical
TgeneFRMD5chr3:168810746chr15:44180464ENST00000417257814504_524264.0571.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-14171065_1116931.66666666666661117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-13161065_1116866.66666666666661052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-14171065_1116867.66666666666661053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-12151065_1116857.66666666666661043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-13161065_1116866.66666666666661052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-13161065_1116867.66666666666661053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417940_963931.66666666666661117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417969_991931.66666666666661117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316912_934866.66666666666661052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316940_963866.66666666666661052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316969_991866.66666666666661052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417912_934867.66666666666661053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417940_963867.66666666666661053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417969_991867.66666666666661053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215912_934857.66666666666661043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215940_963857.66666666666661043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215969_991857.66666666666661043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316912_934866.66666666666661052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316940_963866.66666666666661052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316969_991866.66666666666661052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316912_934867.66666666666661053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316940_963867.66666666666661053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316969_991867.66666666666661053.0Zinc fingerC2H2-type 10
TgeneFRMD5chr3:168810746chr15:44180464ENST0000041725781417_298264.0571.0DomainFERM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MECOMall structure
FRMD5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MECOM-FRMD5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MECOM-FRMD5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 23GENOMICS_ENGLAND;UNIPROT
HgeneMECOMC0006142Malignant neoplasm of breast1CTD_human
HgeneMECOMC0007102Malignant tumor of colon1CTD_human
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneMECOMC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMECOMC0027022Myeloproliferative disease1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0030312Pancytopenia1CTD_human
HgeneMECOMC0038002Splenomegaly1CTD_human
HgeneMECOMC0238301Cancer of Nasopharynx1CTD_human
HgeneMECOMC0678222Breast Carcinoma1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1140680Malignant neoplasm of ovary1CTD_human
HgeneMECOMC1257931Mammary Neoplasms, Human1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC1854273Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia1GENOMICS_ENGLAND;ORPHANET
HgeneMECOMC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMECOMC2931456Prostate cancer, familial1CTD_human
HgeneMECOMC4704874Mammary Carcinoma, Human1CTD_human
HgeneMECOMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human