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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MECOM-LRRC34

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MECOM-LRRC34
FusionPDB ID: 52504
FusionGDB2.0 ID: 52504
HgeneTgene
Gene symbol

MECOM

LRRC34

Gene ID

2122

151827

Gene nameMDS1 and EVI1 complex locusleucine rich repeat containing 34
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2-
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein leucine-rich repeat-containing protein 34
Modification date2020031320200320
UniProtAcc

Q03112

.
Ensembl transtripts involved in fusion geneENST idsENST00000494292, ENST00000485957, 
ENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000472280, 		ENST00000522526, 
ENST00000522830, ENST00000524327, 
ENST00000316515, ENST00000446859, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 21 X 11=76232 X 3 X 3=18
# samples 435
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MECOM [Title/Abstract] AND LRRC34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MECOM(169381123)-LRRC34(169526533), # samples:4
MECOM(169381124)-LRRC34(169526533), # samples:4
Anticipated loss of major functional domain due to fusion event.MECOM-LRRC34 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-LRRC34 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-LRRC34 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MECOM-LRRC34 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MECOM-LRRC34 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0768-01AMECOMchr3

169381124

-LRRC34chr3

169526533

-
ChimerDB4OVTCGA-13-0768MECOMchr3

169381123

-LRRC34chr3

169526533

-
ChimerDB4OVTCGA-23-2078MECOMchr3

169381123

-LRRC34chr3

169526533

-
ChimerDB4OVTCGA-24-2026-01AMECOMchr3

169381124

-LRRC34chr3

169526533

-
ChimerDB4OVTCGA-24-2026MECOMchr3

169381123

-LRRC34chr3

169526533

-
ChimerDB4STADTCGA-VQ-A8DT-01AMECOMchr3

169098975

-LRRC34chr3

169521969

-
ChimerDB4STADTCGA-VQ-A8DTMECOMchr3

169098974

-LRRC34chr3

169521969

-
ChimerDB4UCECTCGA-B5-A11JMECOMchr3

169381123

-LRRC34chr3

169526533

-
ChimerDB4UCECTCGA-EO-A1Y7-01AMECOMchr3

169381124

-LRRC34chr3

169526533

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000494292MECOMchr3169098974-ENST00000446859LRRC34chr3169521969-1547473981339413
ENST00000494292MECOMchr3169098974-ENST00000316515LRRC34chr3169521969-1451473981243381
ENST00000494292MECOMchr3169098974-ENST00000522830LRRC34chr3169521969-1502473981339413
ENST00000494292MECOMchr3169098974-ENST00000522526LRRC34chr3169521969-1406473981243381
ENST00000494292MECOMchr3169098975-ENST00000446859LRRC34chr3169521969-1547473981339413
ENST00000494292MECOMchr3169098975-ENST00000316515LRRC34chr3169521969-1451473981243381
ENST00000494292MECOMchr3169098975-ENST00000522830LRRC34chr3169521969-1502473981339413
ENST00000494292MECOMchr3169098975-ENST00000522526LRRC34chr3169521969-1406473981243381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000494292ENST00000446859MECOMchr3169098974-LRRC34chr3169521969-0.000709370.9992906
ENST00000494292ENST00000316515MECOMchr3169098974-LRRC34chr3169521969-0.0009177510.9990822
ENST00000494292ENST00000522830MECOMchr3169098974-LRRC34chr3169521969-0.0008123710.99918765
ENST00000494292ENST00000522526MECOMchr3169098974-LRRC34chr3169521969-0.0010902530.9989097
ENST00000494292ENST00000446859MECOMchr3169098975-LRRC34chr3169521969-0.000709370.9992906
ENST00000494292ENST00000316515MECOMchr3169098975-LRRC34chr3169521969-0.0009177510.9990822
ENST00000494292ENST00000522830MECOMchr3169098975-LRRC34chr3169521969-0.0008123710.99918765
ENST00000494292ENST00000522526MECOMchr3169098975-LRRC34chr3169521969-0.0010902530.9989097

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52504_52504_1_MECOM-LRRC34_MECOM_chr3_169098974_ENST00000494292_LRRC34_chr3_169521969_ENST00000316515_length(amino acids)=381AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLK
ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSL
KALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTY

--------------------------------------------------------------

>52504_52504_2_MECOM-LRRC34_MECOM_chr3_169098974_ENST00000494292_LRRC34_chr3_169521969_ENST00000446859_length(amino acids)=413AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVL
TQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSN
TTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPD

--------------------------------------------------------------

>52504_52504_3_MECOM-LRRC34_MECOM_chr3_169098974_ENST00000494292_LRRC34_chr3_169521969_ENST00000522526_length(amino acids)=381AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLK
ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSL
KALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTY

--------------------------------------------------------------

>52504_52504_4_MECOM-LRRC34_MECOM_chr3_169098974_ENST00000494292_LRRC34_chr3_169521969_ENST00000522830_length(amino acids)=413AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVL
TQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSN
TTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPD

--------------------------------------------------------------

>52504_52504_5_MECOM-LRRC34_MECOM_chr3_169098975_ENST00000494292_LRRC34_chr3_169521969_ENST00000316515_length(amino acids)=381AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLK
ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSL
KALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTY

--------------------------------------------------------------

>52504_52504_6_MECOM-LRRC34_MECOM_chr3_169098975_ENST00000494292_LRRC34_chr3_169521969_ENST00000446859_length(amino acids)=413AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVL
TQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSN
TTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPD

--------------------------------------------------------------

>52504_52504_7_MECOM-LRRC34_MECOM_chr3_169098975_ENST00000494292_LRRC34_chr3_169521969_ENST00000522526_length(amino acids)=381AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLK
ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSL
KALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTY

--------------------------------------------------------------

>52504_52504_8_MECOM-LRRC34_MECOM_chr3_169098975_ENST00000494292_LRRC34_chr3_169521969_ENST00000522830_length(amino acids)=413AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVL
TQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSN
TTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169381123/chr3:169526533)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

.
FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC34chr3:169098974chr3:169521969ENST00000316515410295_315163.0420.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098974chr3:169521969ENST00000316515410323_345163.0420.0RepeatNote=LRR 2
TgeneLRRC34chr3:169098974chr3:169521969ENST00000446859411295_315176.0465.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098974chr3:169521969ENST00000446859411323_345176.0465.0RepeatNote=LRR 2
TgeneLRRC34chr3:169098974chr3:169521969ENST00000522526410295_315176.0433.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098974chr3:169521969ENST00000522526410323_345176.0433.0RepeatNote=LRR 2
TgeneLRRC34chr3:169098975chr3:169521969ENST00000316515410295_315163.0420.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098975chr3:169521969ENST00000316515410323_345163.0420.0RepeatNote=LRR 2
TgeneLRRC34chr3:169098975chr3:169521969ENST00000446859411295_315176.0465.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098975chr3:169521969ENST00000446859411323_345176.0465.0RepeatNote=LRR 2
TgeneLRRC34chr3:169098975chr3:169521969ENST00000522526410295_315176.0433.0RepeatNote=LRR 1
TgeneLRRC34chr3:169098975chr3:169521969ENST00000522526410323_345176.0433.0RepeatNote=LRR 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-1171065_111601117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-1171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-1151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-1161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-1171065_111601117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-1171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-1151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-1161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-11778_19001117.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-11678_19001052.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-11778_19001053.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-11578_19001043.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-11678_19001052.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-11678_19001053.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-11778_19001117.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-11678_19001052.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-11778_19001053.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-11578_19001043.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-11678_19001052.0DomainSET
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-11678_19001053.0DomainSET
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117609_62201117.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117741_74501117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117772_77601117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115609_62201043.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115741_74501043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115772_77601043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117609_62201117.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117741_74501117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117772_77601117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115609_62201043.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115741_74501043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115772_77601043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117209_23601117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117263_28501117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117291_31301117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117319_34201117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117348_37001117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117376_39801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117405_42701117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117912_93401117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117940_96301117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117969_99101117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115209_23601043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115263_28501043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115291_31301043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115319_34201043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115348_37001043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115376_39801043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115405_42701043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115912_93401043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115940_96301043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115969_99101043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117209_23601117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117263_28501117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117291_31301117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117319_34201117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117348_37001117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117376_39801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117405_42701117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117912_93401117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117940_96301117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117969_99101117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115209_23601043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115263_28501043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115291_31301043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115319_34201043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115348_37001043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115376_39801043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115405_42701043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115912_93401043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115940_96301043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115969_99101043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116969_99101053.0Zinc fingerC2H2-type 10


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MECOMall structure
LRRC34


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMECOMchr3:169098974chr3:169521969ENST00000264674-117189_44001117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098974chr3:169521969ENST00000392736-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098974chr3:169521969ENST00000433243-117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098974chr3:169521969ENST00000464456-115189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098974chr3:169521969ENST00000468789-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098974chr3:169521969ENST00000472280-116189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000264674-117189_44001117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000392736-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000433243-117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000464456-115189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000468789-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:169521969ENST00000472280-116189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1


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Related Drugs to MECOM-LRRC34


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MECOM-LRRC34


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 23GENOMICS_ENGLAND;UNIPROT
HgeneMECOMC0006142Malignant neoplasm of breast1CTD_human
HgeneMECOMC0007102Malignant tumor of colon1CTD_human
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneMECOMC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMECOMC0027022Myeloproliferative disease1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0030312Pancytopenia1CTD_human
HgeneMECOMC0038002Splenomegaly1CTD_human
HgeneMECOMC0238301Cancer of Nasopharynx1CTD_human
HgeneMECOMC0678222Breast Carcinoma1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1140680Malignant neoplasm of ovary1CTD_human
HgeneMECOMC1257931Mammary Neoplasms, Human1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC1854273Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia1GENOMICS_ENGLAND;ORPHANET
HgeneMECOMC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMECOMC2931456Prostate cancer, familial1CTD_human
HgeneMECOMC4704874Mammary Carcinoma, Human1CTD_human
HgeneMECOMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human