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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MED13L-MYBPC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MED13L-MYBPC1
FusionPDB ID: 52579
FusionGDB2.0 ID: 52579
HgeneTgene
Gene symbol

MED13L

MYBPC1

Gene ID

23389

4604

Gene namemediator complex subunit 13Lmyosin binding protein C1
SynonymsMRFACD|PROSIT240|THRAP2|TRAP240LLCCS4|MYBPCC|MYBPCS|MYOTREM|ssMyBP-C
Cytomap

12q24.21

12q23.2

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 13-likemediator complex subunit 13 likethyroid hormone receptor-associated protein 2thyroid hormone receptor-associated protein complex 240 kDa component-likemyosin-binding protein C, slow-typeC-protein, skeletal muscle slow isoformmyosin binding protein C, slow typeskeletal muscle C-proteinslow MyBP-Cslow skeletal-type muscle myosin-binding-protein C
Modification date2020032020200320
UniProtAcc

Q71F56

Q00872

Ensembl transtripts involved in fusion geneENST idsENST00000281928, ENST00000551197, 
ENST00000361466, ENST00000536007, 
ENST00000541119, ENST00000545503, 
ENST00000549145, ENST00000550270, 
ENST00000550501, ENST00000551300, 
ENST00000553190, ENST00000360610, 
ENST00000361685, ENST00000392934, 
ENST00000441232, ENST00000452455, 
ENST00000547405, ENST00000547509, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score30 X 28 X 12=1008011 X 8 X 6=528
# samples 3611
** MAII scorelog2(36/10080*10)=-4.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/528*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MED13L [Title/Abstract] AND MYBPC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MED13L(116444111)-MYBPC1(102061510), # samples:3
Anticipated loss of major functional domain due to fusion event.MED13L-MYBPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MED13L-MYBPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MED13L-MYBPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MED13L-MYBPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MED13L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYBPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5303-01AMED13Lchr12

116444111

-MYBPC1chr12

102061510

+
ChimerDB4LGGTCGA-E1-5303MED13Lchr12

116444110

-MYBPC1chr12

102061509

+
ChimerDB4LGGTCGA-E1-5303MED13Lchr12

116444111

-MYBPC1chr12

102061510

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281928MED13Lchr12116444111-ENST00000547405MYBPC1chr12102061510+3960255120737101167
ENST00000281928MED13Lchr12116444111-ENST00000452455MYBPC1chr12102061510+3975255120737371176
ENST00000281928MED13Lchr12116444111-ENST00000360610MYBPC1chr12102061510+3970255120736411144
ENST00000281928MED13Lchr12116444111-ENST00000441232MYBPC1chr12102061510+4029255120737101167
ENST00000281928MED13Lchr12116444111-ENST00000392934MYBPC1chr12102061510+3853255120737281173
ENST00000281928MED13Lchr12116444111-ENST00000547509MYBPC1chr12102061510+3961255120737101167
ENST00000281928MED13Lchr12116444111-ENST00000361685MYBPC1chr12102061510+3966255120736411144
ENST00000281928MED13Lchr12116444110-ENST00000547405MYBPC1chr12102061509+3960255120737101167
ENST00000281928MED13Lchr12116444110-ENST00000452455MYBPC1chr12102061509+3975255120737371176
ENST00000281928MED13Lchr12116444110-ENST00000360610MYBPC1chr12102061509+3970255120736411144
ENST00000281928MED13Lchr12116444110-ENST00000441232MYBPC1chr12102061509+4029255120737101167
ENST00000281928MED13Lchr12116444110-ENST00000392934MYBPC1chr12102061509+3853255120737281173
ENST00000281928MED13Lchr12116444110-ENST00000547509MYBPC1chr12102061509+3961255120737101167
ENST00000281928MED13Lchr12116444110-ENST00000361685MYBPC1chr12102061509+3966255120736411144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281928ENST00000547405MED13Lchr12116444111-MYBPC1chr12102061510+0.0006715510.9993285
ENST00000281928ENST00000452455MED13Lchr12116444111-MYBPC1chr12102061510+0.000291140.99970883
ENST00000281928ENST00000360610MED13Lchr12116444111-MYBPC1chr12102061510+0.0008074770.99919254
ENST00000281928ENST00000441232MED13Lchr12116444111-MYBPC1chr12102061510+0.0006004990.99939954
ENST00000281928ENST00000392934MED13Lchr12116444111-MYBPC1chr12102061510+0.0010711390.99892884
ENST00000281928ENST00000547509MED13Lchr12116444111-MYBPC1chr12102061510+0.000668670.99933136
ENST00000281928ENST00000361685MED13Lchr12116444111-MYBPC1chr12102061510+0.0008110030.99918896
ENST00000281928ENST00000547405MED13Lchr12116444110-MYBPC1chr12102061509+0.0006715510.9993285
ENST00000281928ENST00000452455MED13Lchr12116444110-MYBPC1chr12102061509+0.000291140.99970883
ENST00000281928ENST00000360610MED13Lchr12116444110-MYBPC1chr12102061509+0.0008074770.99919254
ENST00000281928ENST00000441232MED13Lchr12116444110-MYBPC1chr12102061509+0.0006004990.99939954
ENST00000281928ENST00000392934MED13Lchr12116444110-MYBPC1chr12102061509+0.0010711390.99892884
ENST00000281928ENST00000547509MED13Lchr12116444110-MYBPC1chr12102061509+0.000668670.99933136
ENST00000281928ENST00000361685MED13Lchr12116444110-MYBPC1chr12102061509+0.0008110030.99918896

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52579_52579_1_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000360610_length(amino acids)=1144AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_2_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000361685_length(amino acids)=1144AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_3_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000392934_length(amino acids)=1173AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK
ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKGGLSFCRLLLQGVPPNIIDSYLRDLHSSNP

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>52579_52579_4_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000441232_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_5_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000452455_length(amino acids)=1176AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK
ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIYQGVNTPGQPVFLEGQQQVGSPSADSSC

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>52579_52579_6_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000547405_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_7_MED13L-MYBPC1_MED13L_chr12_116444110_ENST00000281928_MYBPC1_chr12_102061509_ENST00000547509_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_8_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000360610_length(amino acids)=1144AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_9_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000361685_length(amino acids)=1144AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_10_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000392934_length(amino acids)=1173AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK
ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKGGLSFCRLLLQGVPPNIIDSYLRDLHSSNP

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>52579_52579_11_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000441232_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_12_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000452455_length(amino acids)=1176AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK
ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIYQGVNTPGQPVFLEGQQQVGSPSADSSC

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>52579_52579_13_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000547405_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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>52579_52579_14_MED13L-MYBPC1_MED13L_chr12_116444111_ENST00000281928_MYBPC1_chr12_102061510_ENST00000547509_length(amino acids)=1167AA_BP=781
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:116444111/chr12:102061510)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED13L

Q71F56

MYBPC1

Q00872

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.FUNCTION: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31264822, PubMed:31025394). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED13Lchr12:116444110chr12:102061509ENST00000281928-1231669_673781.33333333333342211.0MotifNote=LXXLL motif 1
HgeneMED13Lchr12:116444111chr12:102061510ENST00000281928-1231669_673781.33333333333342211.0MotifNote=LXXLL motif 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000036061020301047_1141778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030837_931778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030934_1029778.33333333333341199.3333333333333DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000036146621321047_1141785.33333333333341235.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132837_931785.33333333333341235.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132934_1029785.33333333333341235.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000036168521311047_1141785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131837_931785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131934_1029785.33333333333341205.6666666666667DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000039293418271047_1141747.33333333333341140.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827837_931747.33333333333341140.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827934_1029747.33333333333341140.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000045245520301047_1141778.33333333333341174.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030837_931778.33333333333341174.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030934_1029778.33333333333341174.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000053600718291047_1141741.33333333333341106.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829837_931741.33333333333341106.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829934_1029741.33333333333341106.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000054111918291047_1141748.33333333333341113.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829837_931748.33333333333341113.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829934_1029748.33333333333341113.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000054550319301047_1141760.33333333333341125.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930837_931760.33333333333341125.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930934_1029760.33333333333341125.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000054740517281047_1141734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728837_931734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728934_1029734.33333333333341115.3333333333333DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000055027020291047_1141778.33333333333341142.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029837_931778.33333333333341142.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029934_1029778.33333333333341142.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST0000055319019291047_1141760.33333333333341183.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929837_931760.33333333333341183.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929934_1029760.33333333333341183.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000036061020301047_1141778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030837_931778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030934_1029778.33333333333341199.3333333333333DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000036146621321047_1141785.33333333333341235.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132837_931785.33333333333341235.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132934_1029785.33333333333341235.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000036168521311047_1141785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131837_931785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131934_1029785.33333333333341205.6666666666667DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000039293418271047_1141747.33333333333341140.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827837_931747.33333333333341140.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827934_1029747.33333333333341140.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000045245520301047_1141778.33333333333341174.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030837_931778.33333333333341174.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030934_1029778.33333333333341174.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000053600718291047_1141741.33333333333341106.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829837_931741.33333333333341106.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829934_1029741.33333333333341106.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000054111918291047_1141748.33333333333341113.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829837_931748.33333333333341113.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829934_1029748.33333333333341113.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000054550319301047_1141760.33333333333341125.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930837_931760.33333333333341125.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930934_1029760.33333333333341125.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000054740517281047_1141734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728837_931734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728934_1029734.33333333333341115.3333333333333DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000055027020291047_1141778.33333333333341142.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029837_931778.33333333333341142.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029934_1029778.33333333333341142.0DomainFibronectin type-III 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST0000055319019291047_1141760.33333333333341183.0DomainNote=Ig-like C2-type 7
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929837_931760.33333333333341183.0DomainNote=Ig-like C2-type 6
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929934_1029760.33333333333341183.0DomainFibronectin type-III 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED13Lchr12:116444110chr12:102061509ENST00000281928-12311566_1610781.33333333333342211.0Compositional biasNote=Ser-rich
HgeneMED13Lchr12:116444111chr12:102061510ENST00000281928-12311566_1610781.33333333333342211.0Compositional biasNote=Ser-rich
HgeneMED13Lchr12:116444110chr12:102061509ENST00000281928-12311225_1229781.33333333333342211.0MotifNote=LXXLL motif 2
HgeneMED13Lchr12:116444111chr12:102061510ENST00000281928-12311225_1229781.33333333333342211.0MotifNote=LXXLL motif 2
HgeneMED13Lchr12:116444110chr12:102061509ENST00000281928-12311380_1401781.33333333333342211.0RegionNote=Leucine-zipper
HgeneMED13Lchr12:116444111chr12:102061510ENST00000281928-12311380_1401781.33333333333342211.0RegionNote=Leucine-zipper
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030251_340778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030341_431778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030432_520778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030522_619778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030622_721778.33333333333341199.3333333333333DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003606102030722_833778.33333333333341199.3333333333333DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000360610203072_144778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132251_340785.33333333333341235.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132341_431785.33333333333341235.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132432_520785.33333333333341235.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132522_619785.33333333333341235.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132622_721785.33333333333341235.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003614662132722_833785.33333333333341235.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000361466213272_144785.33333333333341235.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131251_340785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131341_431785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131432_520785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131522_619785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131622_721785.33333333333341205.6666666666667DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003616852131722_833785.33333333333341205.6666666666667DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000361685213172_144785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827251_340747.33333333333341140.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827341_431747.33333333333341140.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827432_520747.33333333333341140.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827522_619747.33333333333341140.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827622_721747.33333333333341140.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000003929341827722_833747.33333333333341140.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000392934182772_144747.33333333333341140.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030251_340778.33333333333341174.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030341_431778.33333333333341174.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030432_520778.33333333333341174.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030522_619778.33333333333341174.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030622_721778.33333333333341174.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000004524552030722_833778.33333333333341174.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000452455203072_144778.33333333333341174.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829251_340741.33333333333341106.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829341_431741.33333333333341106.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829432_520741.33333333333341106.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829522_619741.33333333333341106.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829622_721741.33333333333341106.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005360071829722_833741.33333333333341106.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000536007182972_144741.33333333333341106.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829251_340748.33333333333341113.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829341_431748.33333333333341113.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829432_520748.33333333333341113.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829522_619748.33333333333341113.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829622_721748.33333333333341113.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005411191829722_833748.33333333333341113.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000541119182972_144748.33333333333341113.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930251_340760.33333333333341125.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930341_431760.33333333333341125.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930432_520760.33333333333341125.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930522_619760.33333333333341125.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930622_721760.33333333333341125.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005455031930722_833760.33333333333341125.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000545503193072_144760.33333333333341125.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728251_340734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728341_431734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728432_520734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728522_619734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728622_721734.33333333333341115.3333333333333DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005474051728722_833734.33333333333341115.3333333333333DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000547405172872_144734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029251_340778.33333333333341142.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029341_431778.33333333333341142.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029432_520778.33333333333341142.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029522_619778.33333333333341142.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029622_721778.33333333333341142.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005502702029722_833778.33333333333341142.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000550270202972_144778.33333333333341142.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929251_340760.33333333333341183.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929341_431760.33333333333341183.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929432_520760.33333333333341183.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929522_619760.33333333333341183.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929622_721760.33333333333341183.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444110chr12:102061509ENST000005531901929722_833760.33333333333341183.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444110chr12:102061509ENST00000553190192972_144760.33333333333341183.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030251_340778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030341_431778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030432_520778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030522_619778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030622_721778.33333333333341199.3333333333333DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003606102030722_833778.33333333333341199.3333333333333DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000360610203072_144778.33333333333341199.3333333333333DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132251_340785.33333333333341235.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132341_431785.33333333333341235.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132432_520785.33333333333341235.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132522_619785.33333333333341235.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132622_721785.33333333333341235.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003614662132722_833785.33333333333341235.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000361466213272_144785.33333333333341235.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131251_340785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131341_431785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131432_520785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131522_619785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131622_721785.33333333333341205.6666666666667DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003616852131722_833785.33333333333341205.6666666666667DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000361685213172_144785.33333333333341205.6666666666667DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827251_340747.33333333333341140.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827341_431747.33333333333341140.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827432_520747.33333333333341140.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827522_619747.33333333333341140.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827622_721747.33333333333341140.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000003929341827722_833747.33333333333341140.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000392934182772_144747.33333333333341140.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030251_340778.33333333333341174.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030341_431778.33333333333341174.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030432_520778.33333333333341174.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030522_619778.33333333333341174.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030622_721778.33333333333341174.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000004524552030722_833778.33333333333341174.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000452455203072_144778.33333333333341174.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829251_340741.33333333333341106.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829341_431741.33333333333341106.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829432_520741.33333333333341106.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829522_619741.33333333333341106.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829622_721741.33333333333341106.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005360071829722_833741.33333333333341106.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000536007182972_144741.33333333333341106.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829251_340748.33333333333341113.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829341_431748.33333333333341113.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829432_520748.33333333333341113.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829522_619748.33333333333341113.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829622_721748.33333333333341113.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005411191829722_833748.33333333333341113.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000541119182972_144748.33333333333341113.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930251_340760.33333333333341125.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930341_431760.33333333333341125.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930432_520760.33333333333341125.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930522_619760.33333333333341125.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930622_721760.33333333333341125.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005455031930722_833760.33333333333341125.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000545503193072_144760.33333333333341125.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728251_340734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728341_431734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728432_520734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728522_619734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728622_721734.33333333333341115.3333333333333DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005474051728722_833734.33333333333341115.3333333333333DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000547405172872_144734.33333333333341115.3333333333333DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029251_340778.33333333333341142.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029341_431778.33333333333341142.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029432_520778.33333333333341142.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029522_619778.33333333333341142.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029622_721778.33333333333341142.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005502702029722_833778.33333333333341142.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000550270202972_144778.33333333333341142.0DomainNote=Ig-like C2-type 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929251_340760.33333333333341183.0DomainNote=Ig-like C2-type 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929341_431760.33333333333341183.0DomainNote=Ig-like C2-type 3
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929432_520760.33333333333341183.0DomainNote=Ig-like C2-type 4
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929522_619760.33333333333341183.0DomainNote=Ig-like C2-type 5
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929622_721760.33333333333341183.0DomainFibronectin type-III 1
TgeneMYBPC1chr12:116444111chr12:102061510ENST000005531901929722_833760.33333333333341183.0DomainFibronectin type-III 2
TgeneMYBPC1chr12:116444111chr12:102061510ENST00000553190192972_144760.33333333333341183.0DomainNote=Ig-like C2-type 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1914_MED13L_116444111_MYBPC1_102061510_ranked_0.pdbMED13L116444110116444111ENST00000361685MYBPC1chr12102061510+
MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGD
EPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTS
VEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVE
VIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMH
SPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQM
NLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSE
KWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFED
GDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTAEDWIVANKDLIDKTKFTITGLPTDAKIF
VRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIF
IRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHR
TSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPK
ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIYQGVNTPGQPVFLEGQQQVGSPSADSSC
1176


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MED13L_pLDDT.png
all structure
all structure
MYBPC1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MED13L
MYBPC1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MED13L-MYBPC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MED13L-MYBPC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource