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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MED25-MAPK15

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MED25-MAPK15
	FusionPDB ID: 52733
	FusionGDB2.0 ID: 52733
		Hgene	Tgene
	Gene symbol	MED25	MAPK15
	Gene ID	81857	225689
	Gene name	mediator complex subunit 25	mitogen-activated protein kinase 15
	Synonyms	ACID1\|ARC92\|BVSYS\|CMT2B2\|P78\|PTOV2\|TCBAP0758	ERK7\|ERK8
	Cytomap	19q13.33	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25	mitogen-activated protein kinase 15ERK-7ERK-8MAP kinase 15MAPK 15extracellular regulated kinase 8 deltaextracellular signal-regulated kinase 7extracellular signal-regulated kinase 8
	Modification date	20200328	20200313
	UniProtAcc	Q71SY5	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000312865, ENST00000538643,	ENST00000338033, ENST00000395107, ENST00000395108,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 6 X 6=360	1 X 1 X 1=1
	# samples	13	1
	** MAII score	log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: MED25 [Title/Abstract] AND MAPK15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MED25(50335672)-MAPK15(144799864), # samples:3
Anticipated loss of major functional domain due to fusion event.	MED25-MAPK15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MED25-MAPK15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MED25-MAPK15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MED25-MAPK15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED25	GO:0045944	positive regulation of transcription by RNA polymerase II	17641689
Tgene	MAPK15	GO:0006974	cellular response to DNA damage stimulus	19166846
Tgene	MAPK15	GO:0008284	positive regulation of cell proliferation	20638370
Tgene	MAPK15	GO:0010506	regulation of autophagy	22948227
Tgene	MAPK15	GO:0032212	positive regulation of telomere maintenance via telomerase	21531765
Tgene	MAPK15	GO:0046777	protein autophosphorylation	11875070
Tgene	MAPK15	GO:0051973	positive regulation of telomerase activity	21531765
Tgene	MAPK15	GO:0090494	dopamine uptake	28842414
Tgene	MAPK15	GO:1904355	positive regulation of telomere capping	21531765

Fusion gene breakpoints across MED25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAPK15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A66I-01A	MED25	chr19	50335672	-	MAPK15	chr8	144799864	+
ChimerDB4	BRCA	TCGA-OL-A66I-01A	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000312865	MED25	chr19	50335672	+	ENST00000338033	MAPK15	chr8	144799864	+	3311	1535	53	3103	1016
ENST00000312865	MED25	chr19	50335672	+	ENST00000395107	MAPK15	chr8	144799864	+	2303	1535	53	2302	750
ENST00000312865	MED25	chr19	50335672	+	ENST00000395108	MAPK15	chr8	144799864	+	2234	1535	53	2233	727
ENST00000538643	MED25	chr19	50335672	+	ENST00000338033	MAPK15	chr8	144799864	+	2619	843	0	2411	803
ENST00000538643	MED25	chr19	50335672	+	ENST00000395107	MAPK15	chr8	144799864	+	1611	843	0	1610	536
ENST00000538643	MED25	chr19	50335672	+	ENST00000395108	MAPK15	chr8	144799864	+	1542	843	0	1541	513

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000312865	ENST00000338033	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.003732594	0.9962674
ENST00000312865	ENST00000395107	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.018404275	0.9815957
ENST00000312865	ENST00000395108	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.01450966	0.9854903
ENST00000538643	ENST00000338033	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.015556435	0.98444355
ENST00000538643	ENST00000395107	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.019031163	0.98096883
ENST00000538643	ENST00000395108	MED25	chr19	50335672	+	MAPK15	chr8	144799864	+	0.010451081	0.9895489

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52733_52733_1_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000338033_length(amino acids)=1016AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL
ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG
CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSR
VYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGE
RPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALL

--------------------------------------------------------------

>52733_52733_2_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395107_length(amino acids)=750AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPS
NVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELIL

--------------------------------------------------------------

>52733_52733_3_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395108_length(amino acids)=727AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL
ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEGAQTACRS

--------------------------------------------------------------

>52733_52733_4_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000338033_length(amino acids)=803AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA
VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS
SHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLL
RRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKP
RADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAA

--------------------------------------------------------------

>52733_52733_5_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395107_length(amino acids)=536AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMGCPPSP
PPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAV

--------------------------------------------------------------

>52733_52733_6_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395108_length(amino acids)=513AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA
VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50335672/chr8:144799864)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED25 Q71SY5	.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269\|PubMed:14657022, ECO:0000269\|PubMed:14983011, ECO:0000269\|PubMed:17641689}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000312865

200_381

494.0

748.0

Compositional bias

Note=Pro-rich

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

175_177

22.0

545.0

Motif

Note=TXY

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

175_177

22.0

278.0

Motif

Note=TXY

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

175_177

22.0

255.0

Motif

Note=TXY

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

19_27

22.0

545.0

Nucleotide binding

ATP

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

19_27

22.0

278.0

Nucleotide binding

ATP

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

19_27

22.0

255.0

Nucleotide binding

ATP

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

265_285

22.0

545.0

Region

Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

265_285

22.0

278.0

Region

Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

265_285

22.0

255.0

Region

Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

371_375

22.0

545.0

Repeat

PXXXP motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

378_382

22.0

545.0

Repeat

PXXXP motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

371_375

22.0

278.0

Repeat

PXXXP motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

378_382

22.0

278.0

Repeat

PXXXP motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

371_375

22.0

255.0

Repeat

PXXXP motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

378_382

22.0

255.0

Repeat

PXXXP motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000312865

565_735

494.0

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000538643

200_381

281.0

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000538643

565_735

281.0

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000312865

646_650

494.0

748.0

Motif

Note=LXXLL motif

Hgene

MED25

chr19:50335672

chr8:144799864

ENST00000538643

646_650

281.0

535.0

Motif

Note=LXXLL motif

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000338033

13_304

22.0

545.0

Domain

Protein kinase

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395107

13_304

22.0

278.0

Domain

Protein kinase

Tgene

MAPK15

chr19:50335672

chr8:144799864

ENST00000395108

13_304

22.0

255.0

Domain

Protein kinase

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MED25
MAPK15

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000312865	+	13	18	395_545	494.0	748.0	CREBBP
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000538643	+	8	13	395_545	281.0	535.0	CREBBP
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000312865	+	13	18	564_653	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000312865	+	13	18	640_707	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000538643	+	8	13	564_653	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000538643	+	8	13	640_707	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000312865	+	13	18	389_543	494.0	748.0	VP16
Hgene	MED25	chr19:50335672	chr8:144799864	ENST00000538643	+	8	13	389_543	281.0	535.0	VP16

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Related Drugs to MED25-MAPK15

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MED25-MAPK15

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source