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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MEGF8-ITPKC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MEGF8-ITPKC
FusionPDB ID: 52869
FusionGDB2.0 ID: 52869
HgeneTgene
Gene symbol

MEGF8

ITPKC

Gene ID

1954

80271

Gene namemultiple EGF like domains 8inositol-trisphosphate 3-kinase C
SynonymsC19orf49|CRPT2|EGFL4|SBP1IP3-3KC|IP3KC
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmultiple epidermal growth factor-like domains protein 8EGF-like domain-containing protein 4EGF-like-domain, multiple 4HBV pre-S2-binding protein 1HBV pre-s2 binding protein 1epidermal growth factor-like protein 4hepatitis B virus pre-S2-binding protinositol-trisphosphate 3-kinase CIP3 3-kinase CIP3K CInsP 3 kinase Cinositol 1,4,5-trisphosphate 3-kinase CinsP 3-kinase C
Modification date2020031320200313
UniProtAcc

Q7Z7M0

Q96DU7

Ensembl transtripts involved in fusion geneENST idsENST00000251268, ENST00000334370, 
ENST00000378073, 		ENST00000263370, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 6=3366 X 5 X 4=120
# samples 86
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MEGF8 [Title/Abstract] AND ITPKC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MEGF8(42875634)-ITPKC(41231245), # samples:2
Anticipated loss of major functional domain due to fusion event.MEGF8-ITPKC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF8-ITPKC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF8-ITPKC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF8-ITPKC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MEGF8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITPKC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IE-A3OV-01AMEGF8chr19

42875634

-ITPKCchr19

41231245

+
ChimerDB4SARCTCGA-IE-A3OV-01AMEGF8chr19

42875634

+ITPKCchr19

41231245

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334370MEGF8chr1942875634+ENST00000263370ITPKCchr1941231245+9900770363585992654
ENST00000251268MEGF8chr1942875634+ENST00000263370ITPKCchr1941231245+94667269081652721

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334370ENST00000263370MEGF8chr1942875634+ITPKCchr1941231245+0.0162188040.9837812
ENST00000251268ENST00000263370MEGF8chr1942875634+ITPKCchr1941231245+0.0085596940.9914403

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52869_52869_1_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000251268_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=2721AA_BP=2422
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYD
GDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWESW
DLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQGPRERAF
HTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAASCLGLGRLLGDCQACLAFSSPTAPPRGPGT
LGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITLTPSAETDVSL
VYRGFIYPMLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVAHQEKETRRLQRPGSARLFPLPGRDHKYAVEIQGQLN
GSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAHCGDDGAGGSLLVLVPTLCPL
CEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCLANSSQCAWCQSTHTCFLFAAYLARYPHGGC
RGWDDSVHSEPRCRSCDGFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRL
GLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPPPTPAPGPPAPRCSRDCGCSFHSH
CRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCF
RECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLTFSPDSSTPCTLSYVLAFDGFPRF
LDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWA
GPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRFLHRLGHTMVDGPDATLWMFGGLG
LPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELPAV
AGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHC
PDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVL
GGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFGGVALGRLLALTLPPDPCRLLSSPEACNQSG
ACTWCHGACLSGDQAHRLGCGGSPCSPMPRSPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWCTNCPEGACIGRNGSCTSENDCRI
NQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPTPCHLLPNCTSC
LDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRD
GLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCRPVCAQGCVNGSCVEPDHCRCHFGFVGRNCS
TECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWV
TEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGTCQGSSPSDRRDCYKYQSKPWKKL
KTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSI
MDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQ
ALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNR

--------------------------------------------------------------

>52869_52869_2_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000334370_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=2654AA_BP=2355
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYD
GDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWESW
DLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQGPRERAF
HTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAASCLGLGRLLGDCQACLAFSSPTAPPRGPGT
LGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKEEVGRWVAHQEKETRRLQRPG
SARLFPLPGRDHKYAVEIQGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQG
GAHCGDDGAGGSLLVLVPTLCPLCEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCLANSSQCA
WCQSTHTCFLFAAYLARYPHGGCRGWDDSVHSEPRCRSCDGFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGL
GLPVALPARWAYARCPDVDECRLGLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPP
PTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHT
EGAHCQLCSPGYYGDPRAGGSCFRECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLT
FSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPV
PQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRF
LHRLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFW
VLNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLY
VFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISP
HLKEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFGGVALGRL
LALTLPPDPCRLLSSPEACNQSGACTWCHGACLSGDQAHRLGCGGSPCSPMPRSPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWC
TNCPEGACIGRNGSCTSENDCRINQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPM
PVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCG
WCAWGGQDGGGRCMEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCRPVCAQGC
VNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRK
ELQMSKGEPKKYSLDPEEIENWVTEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGT
CQGSSPSDRRDCYKYQSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGM
VLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTST
LGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42875634/chr19:41231245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEGF8

Q7Z7M0

ITPKC

Q96DU7

FUNCTION: Acts as a negative regulator of hedgehog signaling. {ECO:0000250|UniProtKB:P60882}.FUNCTION: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421074_11152423.02846.0DomainEGF-like 3%3B calcium-binding
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421163_12102423.02846.0DomainLaminin EGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421211_12612423.02846.0DomainLaminin EGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421263_14052423.02846.0DomainCUB 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142138_1682423.02846.0DomainEGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421403_14452423.02846.0DomainEGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142170_2032423.02846.0DomainEGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421876_19162423.02846.0DomainNote=PSI 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421924_19792423.02846.0DomainNote=PSI 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422060_21182423.02846.0DomainNote=PSI 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422120_21772423.02846.0DomainNote=PSI 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422178_22162423.02846.0DomainEGF-like 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422253_23012423.02846.0DomainLaminin EGF-like 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+414230_1402423.02846.0DomainCUB 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142561_6132423.02846.0DomainNote=PSI 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142847_8992423.02846.0DomainNote=PSI 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142900_9472423.02846.0DomainNote=PSI 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411074_11152356.02779.0DomainEGF-like 3%3B calcium-binding
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411163_12102356.02779.0DomainLaminin EGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411211_12612356.02779.0DomainLaminin EGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411263_14052356.02779.0DomainCUB 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041138_1682356.02779.0DomainEGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411403_14452356.02779.0DomainEGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041170_2032356.02779.0DomainEGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411876_19162356.02779.0DomainNote=PSI 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411924_19792356.02779.0DomainNote=PSI 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412060_21182356.02779.0DomainNote=PSI 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412120_21772356.02779.0DomainNote=PSI 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412178_22162356.02779.0DomainEGF-like 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412253_23012356.02779.0DomainLaminin EGF-like 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+404130_1402356.02779.0DomainCUB 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041561_6132356.02779.0DomainNote=PSI 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041847_8992356.02779.0DomainNote=PSI 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041900_9472356.02779.0DomainNote=PSI 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421522_15702423.02846.0RepeatNote=Kelch 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421580_16262423.02846.0RepeatNote=Kelch 8
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421632_16792423.02846.0RepeatNote=Kelch 9
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421685_17352423.02846.0RepeatNote=Kelch 10
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421796_18432423.02846.0RepeatNote=Kelch 11
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421852_18982423.02846.0RepeatNote=Kelch 12
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142241_2872423.02846.0RepeatNote=Kelch 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142290_3382423.02846.0RepeatNote=Kelch 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142346_3992423.02846.0RepeatNote=Kelch 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142402_4532423.02846.0RepeatNote=Kelch 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142459_5112423.02846.0RepeatNote=Kelch 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142525_5752423.02846.0RepeatNote=Kelch 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411522_15702356.02779.0RepeatNote=Kelch 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411580_16262356.02779.0RepeatNote=Kelch 8
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411632_16792356.02779.0RepeatNote=Kelch 9
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411685_17352356.02779.0RepeatNote=Kelch 10
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411796_18432356.02779.0RepeatNote=Kelch 11
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411852_18982356.02779.0RepeatNote=Kelch 12
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041241_2872356.02779.0RepeatNote=Kelch 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041290_3382356.02779.0RepeatNote=Kelch 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041346_3992356.02779.0RepeatNote=Kelch 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041402_4532356.02779.0RepeatNote=Kelch 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041459_5112356.02779.0RepeatNote=Kelch 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041525_5752356.02779.0RepeatNote=Kelch 6
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007471_473385.0684.0Nucleotide bindingATP
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007507_513385.0684.0RegionNote=Substrate binding
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007509_517385.0684.0RegionCalmodulin-binding
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007534_541385.0684.0RegionNote=Substrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422528_25642423.02846.0Compositional biasNote=Pro-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422739_28332423.02846.0Compositional biasNote=Gly-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412528_25642356.02779.0Compositional biasNote=Pro-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412739_28332356.02779.0Compositional biasNote=Gly-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422380_24432423.02846.0DomainLaminin EGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412380_24432356.02779.0DomainLaminin EGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422669_28452423.02846.0Topological domainCytoplasmic
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+414228_26472423.02846.0Topological domainExtracellular
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412669_28452356.02779.0Topological domainCytoplasmic
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+404128_26472356.02779.0Topological domainExtracellular
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422648_26682423.02846.0TransmembraneHelical
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412648_26682356.02779.0TransmembraneHelical
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007324_332385.0684.0MotifNuclear export signal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MEGF8
ITPKC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MEGF8-ITPKC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MEGF8-ITPKC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource