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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MEMO1-IMMT

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MEMO1-IMMT
	FusionPDB ID: 52977
	FusionGDB2.0 ID: 52977
		Hgene	Tgene
	Gene symbol	MEMO1	IMMT
	Gene ID	51072	10989
	Gene name	mediator of cell motility 1	inner membrane mitochondrial protein
	Synonyms	C2orf4\|CGI-27\|MEMO\|NS5ATP7	HMP\|MICOS60\|MINOS2\|Mic60\|P87\|P87/89\|P89\|PIG4\|PIG52
	Cytomap	2p22.3	2p11.2\|2
	Type of gene	protein-coding	protein-coding
	Description	protein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1	MICOS complex subunit MIC60cell proliferation-inducing gene 4/52 proteincell proliferation-inducing protein 52heart muscle proteinmitochondrial contact site and cristae organizing system subunit 60mitochondrial inner membrane organizing system 2mito
	Modification date	20200329	20200327
	UniProtAcc	Q9Y316	Q16891
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000295065, ENST00000379383, ENST00000404530, ENST00000426310, ENST00000407893, ENST00000490459,	ENST00000490238, ENST00000254636, ENST00000409051, ENST00000410111, ENST00000442664, ENST00000449247,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	14 X 12 X 7=1176
	# samples	6	16
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1176*10)=-2.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MEMO1 [Title/Abstract] AND IMMT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MEMO1(32108455)-IMMT(86389202), # samples:2
Anticipated loss of major functional domain due to fusion event.	MEMO1-IMMT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MEMO1-IMMT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MEMO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IMMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-G7-6792-01A	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-
ChimerDB4	KIRP	TCGA-G7-6792	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295065	MEMO1	chr2	32108455	-	ENST00000254636	IMMT	chr2	86389202	-	2788	967	133	2451	772
ENST00000295065	MEMO1	chr2	32108455	-	ENST00000449247	IMMT	chr2	86389202	-	2788	967	133	2451	772
ENST00000295065	MEMO1	chr2	32108455	-	ENST00000410111	IMMT	chr2	86389202	-	2788	967	133	2451	772
ENST00000295065	MEMO1	chr2	32108455	-	ENST00000442664	IMMT	chr2	86389202	-	2784	967	133	2451	772
ENST00000295065	MEMO1	chr2	32108455	-	ENST00000409051	IMMT	chr2	86389202	-	2780	967	133	2451	772
ENST00000379383	MEMO1	chr2	32108455	-	ENST00000254636	IMMT	chr2	86389202	-	2544	723	57	2207	716
ENST00000379383	MEMO1	chr2	32108455	-	ENST00000449247	IMMT	chr2	86389202	-	2544	723	57	2207	716
ENST00000379383	MEMO1	chr2	32108455	-	ENST00000410111	IMMT	chr2	86389202	-	2544	723	57	2207	716
ENST00000379383	MEMO1	chr2	32108455	-	ENST00000442664	IMMT	chr2	86389202	-	2540	723	57	2207	716
ENST00000379383	MEMO1	chr2	32108455	-	ENST00000409051	IMMT	chr2	86389202	-	2536	723	57	2207	716
ENST00000426310	MEMO1	chr2	32108455	-	ENST00000254636	IMMT	chr2	86389202	-	2537	716	65	2200	711
ENST00000426310	MEMO1	chr2	32108455	-	ENST00000449247	IMMT	chr2	86389202	-	2537	716	65	2200	711
ENST00000426310	MEMO1	chr2	32108455	-	ENST00000410111	IMMT	chr2	86389202	-	2537	716	65	2200	711
ENST00000426310	MEMO1	chr2	32108455	-	ENST00000442664	IMMT	chr2	86389202	-	2533	716	65	2200	711
ENST00000426310	MEMO1	chr2	32108455	-	ENST00000409051	IMMT	chr2	86389202	-	2529	716	65	2200	711

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295065	ENST00000254636	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.00339134	0.99660873
ENST00000295065	ENST00000449247	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.00339134	0.99660873
ENST00000295065	ENST00000410111	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.00339134	0.99660873
ENST00000295065	ENST00000442664	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.003380697	0.9966192
ENST00000295065	ENST00000409051	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.003382777	0.99661726
ENST00000379383	ENST00000254636	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.006817379	0.9931826
ENST00000379383	ENST00000449247	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.006817379	0.9931826
ENST00000379383	ENST00000410111	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.006817379	0.9931826
ENST00000379383	ENST00000442664	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.006802497	0.99319756
ENST00000379383	ENST00000409051	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.006852757	0.9931472
ENST00000426310	ENST00000254636	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.007010819	0.9929892
ENST00000426310	ENST00000449247	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.007010819	0.9929892
ENST00000426310	ENST00000410111	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.007010819	0.9929892
ENST00000426310	ENST00000442664	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.00703659	0.9929635
ENST00000426310	ENST00000409051	MEMO1	chr2	32108455	-	IMMT	chr2	86389202	-	0.007039912	0.99296004

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52977_52977_1_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000295065_IMMT_chr2_86389202_ENST00000254636_length(amino acids)=772AA_BP=278
MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW
LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER
MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR
SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ
AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK
QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR
LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI
PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA

--------------------------------------------------------------

>52977_52977_2_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000295065_IMMT_chr2_86389202_ENST00000409051_length(amino acids)=772AA_BP=278
MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW
LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER
MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR
SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ
AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK
QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR
LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI
PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA

--------------------------------------------------------------

>52977_52977_3_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000295065_IMMT_chr2_86389202_ENST00000410111_length(amino acids)=772AA_BP=278
MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW
LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER
MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR
SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ
AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK
QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR
LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI
PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA

--------------------------------------------------------------

>52977_52977_4_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000295065_IMMT_chr2_86389202_ENST00000442664_length(amino acids)=772AA_BP=278
MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW
LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER
MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR
SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ
AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK
QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR
LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI
PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA

--------------------------------------------------------------

>52977_52977_5_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000295065_IMMT_chr2_86389202_ENST00000449247_length(amino acids)=772AA_BP=278
MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW
LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER
MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR
SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ
AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK
QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR
LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI
PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA

--------------------------------------------------------------

>52977_52977_6_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000379383_IMMT_chr2_86389202_ENST00000254636_length(amino acids)=716AA_BP=222
MPLWRADKCQDVQSASWRPRRADGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSR
CALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYL
ADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENA
KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN
SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTD
HLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKT
SSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQ

--------------------------------------------------------------

>52977_52977_7_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000379383_IMMT_chr2_86389202_ENST00000409051_length(amino acids)=716AA_BP=222
MPLWRADKCQDVQSASWRPRRADGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSR
CALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYL
ADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENA
KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN
SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTD
HLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKT
SSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQ

--------------------------------------------------------------

>52977_52977_8_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000379383_IMMT_chr2_86389202_ENST00000410111_length(amino acids)=716AA_BP=222
MPLWRADKCQDVQSASWRPRRADGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSR
CALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYL
ADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENA
KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN
SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTD
HLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKT
SSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQ

--------------------------------------------------------------

>52977_52977_9_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000379383_IMMT_chr2_86389202_ENST00000442664_length(amino acids)=716AA_BP=222
MPLWRADKCQDVQSASWRPRRADGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSR
CALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYL
ADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENA
KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN
SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTD
HLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKT
SSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQ

--------------------------------------------------------------

>52977_52977_10_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000379383_IMMT_chr2_86389202_ENST00000449247_length(amino acids)=716AA_BP=222
MPLWRADKCQDVQSASWRPRRADGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSR
CALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYL
ADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENA
KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN
SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTD
HLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKT
SSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQ

--------------------------------------------------------------

>52977_52977_11_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000426310_IMMT_chr2_86389202_ENST00000254636_length(amino acids)=711AA_BP=217
MPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSS
VDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSN
LFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV
AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH
AHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV
LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAET
PTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPP

--------------------------------------------------------------

>52977_52977_12_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000426310_IMMT_chr2_86389202_ENST00000409051_length(amino acids)=711AA_BP=217
MPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSS
VDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSN
LFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV
AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH
AHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV
LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAET
PTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPP

--------------------------------------------------------------

>52977_52977_13_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000426310_IMMT_chr2_86389202_ENST00000410111_length(amino acids)=711AA_BP=217
MPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSS
VDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSN
LFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV
AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH
AHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV
LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAET
PTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPP

--------------------------------------------------------------

>52977_52977_14_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000426310_IMMT_chr2_86389202_ENST00000442664_length(amino acids)=711AA_BP=217
MPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSS
VDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSN
LFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV
AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH
AHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV
LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAET
PTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPP

--------------------------------------------------------------

>52977_52977_15_MEMO1-IMMT_MEMO1_chr2_32108455_ENST00000426310_IMMT_chr2_86389202_ENST00000449247_length(amino acids)=711AA_BP=217
MPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSS
VDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSN
LFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV
AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH
AHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV
LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAET
PTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:32108455/chr2:86389202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MEMO1 Q9Y316	IMMT Q16891
FUNCTION: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269\|PubMed:15156151, ECO:0000269\|PubMed:20937854}.	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180). {ECO:0000269\|PubMed:22114354, ECO:0000269\|PubMed:25781180}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000410111

34_45

264.0

759.0

Topological domain

Mitochondrial matrix

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000410111

65_758

264.0

759.0

Topological domain

Mitochondrial intermembrane

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000442664

34_45

263.0

758.0

Topological domain

Mitochondrial matrix

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000442664

65_758

263.0

758.0

Topological domain

Mitochondrial intermembrane

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000449247

34_45

253.0

748.0

Topological domain

Mitochondrial matrix

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000449247

65_758

253.0

748.0

Topological domain

Mitochondrial intermembrane

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000410111

46_64

264.0

759.0

Transmembrane

Helical

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000442664

46_64

263.0

758.0

Transmembrane

Helical

Tgene

IMMT

chr2:32108455

chr2:86389202

ENST00000449247

46_64

253.0

748.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1548_MEMO1_32108455_IMMT_86389202_ranked_0.pdb	MEMO1	32108455	32108455	ENST00000409051	IMMT	chr2	86389202	-	MGRRLLLFLLLLGRADPLPAAASSWAGPAVSRPLAEPLLPPPPPPPHSSSCTIGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGW LSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFER MSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYR SIEHLDKMIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQ AAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRR LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAI PPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELA	772

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MEMO1_pLDDT.png

IMMT_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MEMO1
IMMT

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MEMO1-IMMT

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MEMO1-IMMT

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source