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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:AP3S2-CERS3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: AP3S2-CERS3
	FusionPDB ID: 5301
	FusionGDB2.0 ID: 5301
		Hgene	Tgene
	Gene symbol	AP3S2	CERS3
	Gene ID	10239	204219
	Gene name	adaptor related protein complex 3 subunit sigma 2	ceramide synthase 3
	Synonyms	AP3S3\|sigma3b	ARCI9\|LASS3
	Cytomap	15q26.1	15q26.3
	Type of gene	protein-coding	protein-coding
	Description	AP-3 complex subunit sigma-2AP-3 complex subunit sigma-3Badapter-related protein complex 3 subunit sigma-2adaptor complex sigma3Badaptor related protein complex 3 sigma 2 subunitclathrin-associated/assembly/adaptor protein, small 4, 22-kDsigma-3B-ad	ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
	Modification date	20200313	20200313
	UniProtAcc	P59780	Q8IU89
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000336418, ENST00000558011, ENST00000560940, ENST00000560771,	ENST00000560944, ENST00000284382, ENST00000394113, ENST00000538112,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 1 X 2=6	8 X 7 X 7=392
	# samples	3	11
	** MAII score	log2(3/6*10)=2.32192809488736	log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: AP3S2 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AP3S2(90414707)-CERS3(101024873), # samples:1
Anticipated loss of major functional domain due to fusion event.	AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CERS3	GO:0046513	ceramide biosynthetic process	17977534\|22038835

Fusion gene breakpoints across AP3S2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A1HI-01A	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3920	738	369	1601	410
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1804	738	369	1601	410
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1804	738	369	1601	410
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3608	426	21	1289	422
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1492	426	21	1289	422
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1492	426	21	1289	422
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3559	377	8	1240	410
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1443	377	8	1240	410
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1443	377	8	1240	410

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336418	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002685812	0.99731416
ENST00000336418	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.004644795	0.99535525
ENST00000336418	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.004644795	0.99535525
ENST00000558011	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.001874565	0.9981254
ENST00000558011	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002265393	0.99773455
ENST00000558011	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002265393	0.99773455
ENST00000560940	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.001690084	0.99830997
ENST00000560940	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002034783	0.9979652
ENST00000560940	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002034783	0.9979652

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5301_5301_1_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

>5301_5301_2_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

>5301_5301_3_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

>5301_5301_4_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------

>5301_5301_5_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------

>5301_5301_6_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------

>5301_5301_7_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

>5301_5301_8_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

>5301_5301_9_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90414707/chr15:101024873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP3S2 P59780	CERS3 Q8IU89
FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:22038835, ECO:0000269\|PubMed:23754960, ECO:0000269\|PubMed:26887952}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

346_355

96.0

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

346_355

96.0

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

346_355

96.0

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

130_331

96.0

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

130_331

96.0

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

130_331

96.0

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

319_383

96.0

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

319_383

96.0

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

319_383

96.0

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

139_159

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

174_194

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

205_225

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

264_284

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

298_318

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

139_159

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

174_194

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

205_225

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

264_284

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

298_318

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

139_159

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

174_194

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

205_225

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

264_284

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

298_318

96.0

384.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

66_127

96.0

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

66_127

96.0

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

66_127

96.0

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

32_52

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

32_52

96.0

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

32_52

96.0

384.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
AP3S2
CERS3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to AP3S2-CERS3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to AP3S2-CERS3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source