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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:APAF1-TMPO

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: APAF1-TMPO
FusionPDB ID: 5327
FusionGDB2.0 ID: 5327
HgeneTgene
Gene symbol

APAF1

TMPO

Gene ID

317

7112

Gene nameapoptotic peptidase activating factor 1thymopoietin
SynonymsAPAF-1|CED4CMD1T|LAP2|LEMD4|PRO0868|TP
Cytomap

12q23.1

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionapoptotic protease-activating factor 1thymopoietinLEM domain containing 4lamina-associated polypeptide 2
Modification date2020031520200313
UniProtAcc

O14727

.
Ensembl transtripts involved in fusion geneENST idsENST00000333991, ENST00000339433, 
ENST00000357310, ENST00000359972, 
ENST00000547045, ENST00000549007, 
ENST00000550527, ENST00000551964, 
ENST00000552268, ENST00000547666, 
ENST00000547743, 		ENST00000261210, 
ENST00000266732, ENST00000393053, 
ENST00000548223, ENST00000343315, 
ENST00000556029, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 4=1007 X 7 X 3=147
# samples 57
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: APAF1 [Title/Abstract] AND TMPO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)APAF1(99056584)-TMPO(98931253), # samples:2
Anticipated loss of major functional domain due to fusion event.APAF1-TMPO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APAF1-TMPO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APAF1-TMPO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APAF1-TMPO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPAF1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

21827945

HgeneAPAF1

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

9267021


check buttonFusion gene breakpoints across APAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMPO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2262-01AAPAF1chr12

99056584

+TMPOchr12

98931253

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000551964APAF1chr1299056584+ENST00000556029TMPOchr1298931253+501216917362490584
ENST00000551964APAF1chr1299056584+ENST00000343315TMPOchr1298931253+334116917362370544
ENST00000339433APAF1chr1299056584+ENST00000556029TMPOchr1298931253+485315325772331584
ENST00000339433APAF1chr1299056584+ENST00000343315TMPOchr1298931253+318215325772211544
ENST00000359972APAF1chr1299056584+ENST00000556029TMPOchr1298931253+482014995772298573
ENST00000359972APAF1chr1299056584+ENST00000343315TMPOchr1298931253+314914995772178533
ENST00000333991APAF1chr1299056584+ENST00000556029TMPOchr1298931253+485315325772331584
ENST00000333991APAF1chr1299056584+ENST00000343315TMPOchr1298931253+318215325772211544
ENST00000357310APAF1chr1299056584+ENST00000556029TMPOchr1298931253+485315325772331584
ENST00000357310APAF1chr1299056584+ENST00000343315TMPOchr1298931253+318215325772211544
ENST00000552268APAF1chr1299056584+ENST00000556029TMPOchr1298931253+4320999441798584
ENST00000552268APAF1chr1299056584+ENST00000343315TMPOchr1298931253+2649999441678544
ENST00000550527APAF1chr1299056584+ENST00000556029TMPOchr1298931253+425092971728573
ENST00000550527APAF1chr1299056584+ENST00000343315TMPOchr1298931253+257992971608533
ENST00000547045APAF1chr1299056584+ENST00000556029TMPOchr1298931253+428196051759584
ENST00000547045APAF1chr1299056584+ENST00000343315TMPOchr1298931253+261096051639544
ENST00000549007APAF1chr1299056584+ENST00000556029TMPOchr1298931253+427695501754584
ENST00000549007APAF1chr1299056584+ENST00000343315TMPOchr1298931253+260595501634544

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000551964ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002256830.9997743
ENST00000551964ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003250230.99967504
ENST00000339433ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002274780.9997725
ENST00000339433ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003388260.9996612
ENST00000359972ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0003607080.9996393
ENST00000359972ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0004222030.9995778
ENST00000333991ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002274780.9997725
ENST00000333991ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003388260.9996612
ENST00000357310ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002274780.9997725
ENST00000357310ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003388260.9996612
ENST00000552268ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002139450.9997861
ENST00000552268ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003143910.99968565
ENST00000550527ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0003274140.99967265
ENST00000550527ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0003584940.99964154
ENST00000547045ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002056170.9997944
ENST00000547045ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0002968910.9997031
ENST00000549007ENST00000556029APAF1chr1299056584+TMPOchr1298931253+0.0002059460.99979407
ENST00000549007ENST00000343315APAF1chr1299056584+TMPOchr1298931253+0.0002916670.99970835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5327_5327_1_APAF1-TMPO_APAF1_chr12_99056584_ENST00000333991_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_2_APAF1-TMPO_APAF1_chr12_99056584_ENST00000333991_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_3_APAF1-TMPO_APAF1_chr12_99056584_ENST00000339433_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_4_APAF1-TMPO_APAF1_chr12_99056584_ENST00000339433_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_5_APAF1-TMPO_APAF1_chr12_99056584_ENST00000357310_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_6_APAF1-TMPO_APAF1_chr12_99056584_ENST00000357310_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_7_APAF1-TMPO_APAF1_chr12_99056584_ENST00000359972_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=533AA_BP=307
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVP
VESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRIDGPVISESTPI
AETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAA

--------------------------------------------------------------

>5327_5327_8_APAF1-TMPO_APAF1_chr12_99056584_ENST00000359972_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=573AA_BP=307
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVP
VESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGG
PLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEV
GEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFV

--------------------------------------------------------------

>5327_5327_9_APAF1-TMPO_APAF1_chr12_99056584_ENST00000547045_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_10_APAF1-TMPO_APAF1_chr12_99056584_ENST00000547045_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_11_APAF1-TMPO_APAF1_chr12_99056584_ENST00000549007_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_12_APAF1-TMPO_APAF1_chr12_99056584_ENST00000549007_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_13_APAF1-TMPO_APAF1_chr12_99056584_ENST00000550527_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=533AA_BP=307
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVP
VESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRIDGPVISESTPI
AETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAA

--------------------------------------------------------------

>5327_5327_14_APAF1-TMPO_APAF1_chr12_99056584_ENST00000550527_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=573AA_BP=307
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVP
VESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGG
PLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEV
GEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFV

--------------------------------------------------------------

>5327_5327_15_APAF1-TMPO_APAF1_chr12_99056584_ENST00000551964_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_16_APAF1-TMPO_APAF1_chr12_99056584_ENST00000551964_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

>5327_5327_17_APAF1-TMPO_APAF1_chr12_99056584_ENST00000552268_TMPO_chr12_98931253_ENST00000343315_length(amino acids)=544AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQVETSEHFRI
DGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP

--------------------------------------------------------------

>5327_5327_18_APAF1-TMPO_APAF1_chr12_99056584_ENST00000552268_TMPO_chr12_98931253_ENST00000556029_length(amino acids)=584AA_BP=318
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDG
IPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVT
DSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITE
TEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRR
APKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:99056584/chr12:98931253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APAF1

O14727

.
FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+7895_98318.3333333333333339.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+72695_98318.33333333333331206.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+72695_98307.33333333333331195.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+62595_98318.33333333333331206.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+62695_98307.33333333333331238.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+72795_98318.33333333333331249.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+6795_98318.3333333333333339.0Compositional biasNote=Poly-Ser
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781_90318.3333333333333339.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261_90318.33333333333331206.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261_90307.33333333333331195.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251_90318.33333333333331206.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261_90307.33333333333331238.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271_90318.33333333333331249.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671_90318.3333333333333339.0DomainCARD
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78154_161318.3333333333333339.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726154_161318.33333333333331206.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726154_161307.33333333333331195.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625154_161318.33333333333331206.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626154_161307.33333333333331238.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727154_161318.33333333333331249.0Nucleotide bindingATP
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67154_161318.3333333333333339.0Nucleotide bindingATP
TgeneTMPOchr12:99056584chr12:98931253ENST0000026673204558_6570695.0Coiled coilOntology_term=ECO:0000250
TgeneTMPOchr12:99056584chr12:98931253ENST0000026673204109_1530695.0DomainLEM
TgeneTMPOchr12:99056584chr12:98931253ENST00000266732045_480695.0DomainLEM-like
TgeneTMPOchr12:99056584chr12:98931253ENST0000026673204190_1960695.0MotifNuclear localization signal
TgeneTMPOchr12:99056584chr12:98931253ENST000002667320449_1080695.0RegionNote=Linker
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326299_371188.33333333333334346.0RegionNote=Binds lamins B
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326300_374188.33333333333334346.0RegionNote=NAKAP95-binding C
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929299_371188.33333333333334455.0RegionNote=Binds lamins B
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929300_374188.33333333333334455.0RegionNote=NAKAP95-binding C
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326435_454188.33333333333334346.0Topological domainLumenal
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929435_454188.33333333333334455.0Topological domainLumenal
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326411_434188.33333333333334346.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929411_434188.33333333333334455.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78104_415318.3333333333333339.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726104_415318.33333333333331206.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726104_415307.33333333333331195.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625104_415318.33333333333331206.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626104_415307.33333333333331238.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727104_415318.33333333333331249.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67104_415318.3333333333333339.0DomainNote=NB-ARC
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78910_921318.3333333333333339.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726910_921318.33333333333331206.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726910_921307.33333333333331195.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625910_921318.33333333333331206.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626910_921307.33333333333331238.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727910_921318.33333333333331249.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67910_921318.3333333333333339.0RegionInterpropeller linker
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781001_1040318.3333333333333339.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781042_1080318.3333333333333339.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781083_1122318.3333333333333339.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781125_1164318.3333333333333339.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781175_1212318.3333333333333339.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+781213_1248318.3333333333333339.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78613_652318.3333333333333339.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78655_694318.3333333333333339.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78697_738318.3333333333333339.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78741_780318.3333333333333339.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78796_836318.3333333333333339.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78838_877318.3333333333333339.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78880_910318.3333333333333339.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78922_958318.3333333333333339.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000333991+78959_998318.3333333333333339.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261001_1040318.33333333333331206.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261042_1080318.33333333333331206.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261083_1122318.33333333333331206.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261125_1164318.33333333333331206.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261175_1212318.33333333333331206.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+7261213_1248318.33333333333331206.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726613_652318.33333333333331206.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726655_694318.33333333333331206.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726697_738318.33333333333331206.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726741_780318.33333333333331206.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726796_836318.33333333333331206.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726838_877318.33333333333331206.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726880_910318.33333333333331206.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726922_958318.33333333333331206.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000357310+726959_998318.33333333333331206.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261001_1040307.33333333333331195.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261042_1080307.33333333333331195.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261083_1122307.33333333333331195.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261125_1164307.33333333333331195.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261175_1212307.33333333333331195.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+7261213_1248307.33333333333331195.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726613_652307.33333333333331195.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726655_694307.33333333333331195.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726697_738307.33333333333331195.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726741_780307.33333333333331195.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726796_836307.33333333333331195.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726838_877307.33333333333331195.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726880_910307.33333333333331195.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726922_958307.33333333333331195.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000359972+726959_998307.33333333333331195.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251001_1040318.33333333333331206.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251042_1080318.33333333333331206.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251083_1122318.33333333333331206.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251125_1164318.33333333333331206.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251175_1212318.33333333333331206.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+6251213_1248318.33333333333331206.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625613_652318.33333333333331206.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625655_694318.33333333333331206.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625697_738318.33333333333331206.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625741_780318.33333333333331206.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625796_836318.33333333333331206.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625838_877318.33333333333331206.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625880_910318.33333333333331206.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625922_958318.33333333333331206.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000547045+625959_998318.33333333333331206.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261001_1040307.33333333333331238.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261042_1080307.33333333333331238.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261083_1122307.33333333333331238.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261125_1164307.33333333333331238.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261175_1212307.33333333333331238.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+6261213_1248307.33333333333331238.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626613_652307.33333333333331238.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626655_694307.33333333333331238.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626697_738307.33333333333331238.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626741_780307.33333333333331238.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626796_836307.33333333333331238.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626838_877307.33333333333331238.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626880_910307.33333333333331238.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626922_958307.33333333333331238.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000550527+626959_998307.33333333333331238.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271001_1040318.33333333333331249.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271042_1080318.33333333333331249.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271083_1122318.33333333333331249.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271125_1164318.33333333333331249.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271175_1212318.33333333333331249.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+7271213_1248318.33333333333331249.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727613_652318.33333333333331249.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727655_694318.33333333333331249.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727697_738318.33333333333331249.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727741_780318.33333333333331249.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727796_836318.33333333333331249.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727838_877318.33333333333331249.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727880_910318.33333333333331249.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727922_958318.33333333333331249.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000551964+727959_998318.33333333333331249.0RepeatNote=WD 2-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671001_1040318.3333333333333339.0RepeatNote=WD 2-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671042_1080318.3333333333333339.0RepeatNote=WD 2-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671083_1122318.3333333333333339.0RepeatNote=WD 2-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671125_1164318.3333333333333339.0RepeatNote=WD 2-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671175_1212318.3333333333333339.0RepeatNote=WD 2-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+671213_1248318.3333333333333339.0RepeatNote=WD 2-8
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67613_652318.3333333333333339.0RepeatNote=WD 1-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67655_694318.3333333333333339.0RepeatNote=WD 1-2
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67697_738318.3333333333333339.0RepeatNote=WD 1-3
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67741_780318.3333333333333339.0RepeatNote=WD 1-4
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67796_836318.3333333333333339.0RepeatNote=WD 1-5
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67838_877318.3333333333333339.0RepeatNote=WD 1-6
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67880_910318.3333333333333339.0RepeatNote=WD 1-7
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67922_958318.3333333333333339.0RepeatNote=WD 2-1
HgeneAPAF1chr12:99056584chr12:98931253ENST00000552268+67959_998318.3333333333333339.0RepeatNote=WD 2-2
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326109_153188.33333333333334346.0DomainLEM
TgeneTMPOchr12:99056584chr12:98931253ENST00000393053265_48188.33333333333334346.0DomainLEM-like
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929109_153188.33333333333334455.0DomainLEM
TgeneTMPOchr12:99056584chr12:98931253ENST00000556029295_48188.33333333333334455.0DomainLEM-like
TgeneTMPOchr12:99056584chr12:98931253ENST0000039305326138_243188.33333333333334346.0RegionNote=NAKAP95-binding N
TgeneTMPOchr12:99056584chr12:98931253ENST00000393053261_410188.33333333333334346.0RegionNucleoplasmic
TgeneTMPOchr12:99056584chr12:98931253ENST000003930532649_108188.33333333333334346.0RegionNote=Linker
TgeneTMPOchr12:99056584chr12:98931253ENST0000055602929138_243188.33333333333334455.0RegionNote=NAKAP95-binding N
TgeneTMPOchr12:99056584chr12:98931253ENST00000556029291_410188.33333333333334455.0RegionNucleoplasmic
TgeneTMPOchr12:99056584chr12:98931253ENST000005560292949_108188.33333333333334455.0RegionNote=Linker


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
APAF1
TMPO


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to APAF1-TMPO


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to APAF1-TMPO


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource