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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MGST3-SPOP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MGST3-SPOP
	FusionPDB ID: 53454
	FusionGDB2.0 ID: 53454
		Hgene	Tgene
	Gene symbol	MGST3	SPOP
	Gene ID	4259	8405
	Gene name	microsomal glutathione S-transferase 3	speckle type BTB/POZ protein
	Synonyms	GST-III	BTBD32\|TEF2
	Cytomap	1q24.1	17q21.33
	Type of gene	protein-coding	protein-coding
	Description	microsomal glutathione S-transferase 3LTC4 synthase MGST3glutathione peroxidase MGST3microsomal GST-3microsomal GST-IIImicrosomal glutathione S-transferase III	speckle-type POZ proteinHIB homolog 1roadkill homolog 1
	Modification date	20200313	20200329
	UniProtAcc	O14880	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367883, ENST00000367884, ENST00000367885, ENST00000367886, ENST00000367888, ENST00000367889, ENST00000461759,	ENST00000513080, ENST00000347630, ENST00000393328, ENST00000393331, ENST00000503676, ENST00000504102,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 4=120	18 X 13 X 6=1404
	# samples	6	18
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1404*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MGST3 [Title/Abstract] AND SPOP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MGST3(165621237)-SPOP(47679312), # samples:1
Anticipated loss of major functional domain due to fusion event.	MGST3-SPOP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGST3-SPOP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MGST3	GO:0006629	lipid metabolic process	9278457
Hgene	MGST3	GO:0019370	leukotriene biosynthetic process	9278457

Fusion gene breakpoints across MGST3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPOP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DW407758	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367889	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	2391	666	440	799	119
ENST00000367889	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	2389	666	440	799	119
ENST00000367889	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	2389	666	440	799	119
ENST00000367889	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	1269	666	1198	836	120
ENST00000367889	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	1072	666	440	799	119
ENST00000367888	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	2039	314	88	447	119
ENST00000367888	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	2037	314	88	447	119
ENST00000367888	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	2037	314	88	447	119
ENST00000367888	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	917	314	846	484	120
ENST00000367888	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	720	314	88	447	119
ENST00000367885	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	2056	331	21	464	147
ENST00000367885	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	2054	331	21	464	147
ENST00000367885	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	2054	331	21	464	147
ENST00000367885	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	934	331	21	464	147
ENST00000367885	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	737	331	21	464	147
ENST00000367884	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	2092	367	141	500	119
ENST00000367884	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	2090	367	141	500	119
ENST00000367884	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	2090	367	141	500	119
ENST00000367884	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	970	367	899	537	120
ENST00000367884	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	773	367	141	500	119
ENST00000367883	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	2082	357	89	490	133
ENST00000367883	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	2080	357	89	490	133
ENST00000367883	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	2080	357	89	490	133
ENST00000367883	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	960	357	89	490	133
ENST00000367883	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	763	357	89	490	133
ENST00000367886	MGST3	chr1	165621237	+	ENST00000393328	SPOP	chr17	47679312	-	1993	268	0	401	133
ENST00000367886	MGST3	chr1	165621237	+	ENST00000393331	SPOP	chr17	47679312	-	1991	268	0	401	133
ENST00000367886	MGST3	chr1	165621237	+	ENST00000347630	SPOP	chr17	47679312	-	1991	268	0	401	133
ENST00000367886	MGST3	chr1	165621237	+	ENST00000504102	SPOP	chr17	47679312	-	871	268	0	401	133
ENST00000367886	MGST3	chr1	165621237	+	ENST00000503676	SPOP	chr17	47679312	-	674	268	0	401	133

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367889	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.88649005	0.11350995
ENST00000367889	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.8788309	0.12116913
ENST00000367889	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.8788309	0.12116913
ENST00000367889	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.7528652	0.2471348
ENST00000367889	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.72664046	0.27335948
ENST00000367888	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.91481423	0.08518577
ENST00000367888	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.90990216	0.09009782
ENST00000367888	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.90990216	0.09009782
ENST00000367888	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.74882334	0.25117663
ENST00000367888	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.54561067	0.45438936
ENST00000367885	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.6722559	0.32774407
ENST00000367885	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.6655622	0.33443776
ENST00000367885	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.6655622	0.33443776
ENST00000367885	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.59800065	0.4019994
ENST00000367885	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.43386465	0.5661353
ENST00000367884	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.776663	0.22333704
ENST00000367884	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.7702938	0.22970618
ENST00000367884	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.7702938	0.22970618
ENST00000367884	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.41959316	0.5804069
ENST00000367884	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.20237333	0.7976267
ENST00000367883	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.7285806	0.2714194
ENST00000367883	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.72564507	0.2743549
ENST00000367883	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.72564507	0.2743549
ENST00000367883	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.62727904	0.37272093
ENST00000367883	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.44974256	0.55025744
ENST00000367886	ENST00000393328	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.7570995	0.24290048
ENST00000367886	ENST00000393331	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.75662327	0.24337678
ENST00000367886	ENST00000347630	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.75662327	0.24337678
ENST00000367886	ENST00000504102	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.4658479	0.5341521
ENST00000367886	ENST00000503676	MGST3	chr1	165621237	+	SPOP	chr17	47679312	-	0.30667257	0.6933274

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53454_53454_1_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367883_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_2_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367883_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_3_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367883_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_4_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367883_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_5_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367883_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_6_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367884_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_7_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367884_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_8_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367884_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_9_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367884_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_10_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367884_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=120AA_BP=
MQRSPLFFFSFLLQAPDDLFCSVRCRQVSPKYHRWDILGPAPKLNPHSIKLSQAKGNTVTQQQGFHFIFPPPVSPKLFSAVLKVWGHNAV

--------------------------------------------------------------

>53454_53454_11_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367885_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=147AA_BP=
MFCSSCSKVIQGQEMPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQ

--------------------------------------------------------------

>53454_53454_12_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367885_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=147AA_BP=
MFCSSCSKVIQGQEMPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQ

--------------------------------------------------------------

>53454_53454_13_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367885_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=147AA_BP=
MFCSSCSKVIQGQEMPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQ

--------------------------------------------------------------

>53454_53454_14_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367885_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=147AA_BP=
MFCSSCSKVIQGQEMPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQ

--------------------------------------------------------------

>53454_53454_15_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367885_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=147AA_BP=
MFCSSCSKVIQGQEMPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQ

--------------------------------------------------------------

>53454_53454_16_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367886_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_17_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367886_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_18_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367886_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_19_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367886_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_20_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367886_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=133AA_BP=
MPWRGRRFRLCRRKMAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPV

--------------------------------------------------------------

>53454_53454_21_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367888_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_22_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367888_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_23_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367888_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_24_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367888_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_25_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367888_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=120AA_BP=
MQRSPLFFFSFLLQAPDDLFCSVRCRQVSPKYHRWDILGPAPKLNPHSIKLSQAKGNTVTQQQGFHFIFPPPVSPKLFSAVLKVWGHNAV

--------------------------------------------------------------

>53454_53454_26_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367889_SPOP_chr17_47679312_ENST00000347630_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_27_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367889_SPOP_chr17_47679312_ENST00000393328_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_28_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367889_SPOP_chr17_47679312_ENST00000393331_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_29_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367889_SPOP_chr17_47679312_ENST00000503676_length(amino acids)=119AA_BP=
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTIFSSCWRCLPPVMLRMSWRPLGGSQW

--------------------------------------------------------------

>53454_53454_30_MGST3-SPOP_MGST3_chr1_165621237_ENST00000367889_SPOP_chr17_47679312_ENST00000504102_length(amino acids)=120AA_BP=
MQRSPLFFFSFLLQAPDDLFCSVRCRQVSPKYHRWDILGPAPKLNPHSIKLSQAKGNTVTQQQGFHFIFPPPVSPKLFSAVLKVWGHNAV

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165621237/chr17:47679312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MGST3 O14880	.
FUNCTION: Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate in the lipid metabolism (PubMed:9278457). {ECO:0000269\|PubMed:9278457, ECO:0000303\|PubMed:9278457}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

173_297

375.0

Domain

BTB

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

31_161

375.0

Domain

MATH

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

173_297

375.0

Domain

BTB

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

31_161

375.0

Domain

MATH

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

173_297

375.0

Domain

BTB

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

31_161

375.0

Domain

MATH

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

173_297

375.0

Domain

BTB

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

31_161

375.0

Domain

MATH

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

173_297

375.0

Domain

BTB

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

31_161

375.0

Domain

MATH

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

123_133

375.0

Region

Note=Important for binding substrate proteins

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

186_217

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

297_355

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000347630

71_191

375.0

Region

Note=Required for nuclear localization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

123_133

375.0

Region

Note=Important for binding substrate proteins

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

186_217

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

297_355

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393328

71_191

375.0

Region

Note=Required for nuclear localization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

123_133

375.0

Region

Note=Important for binding substrate proteins

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

186_217

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

297_355

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000393331

71_191

375.0

Region

Note=Required for nuclear localization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

123_133

375.0

Region

Note=Important for binding substrate proteins

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

186_217

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

297_355

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000503676

71_191

375.0

Region

Note=Required for nuclear localization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

123_133

375.0

Region

Note=Important for binding substrate proteins

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

186_217

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

297_355

375.0

Region

Note=Important for homodimerization

Tgene

SPOP

chr1:165621237

chr17:47679312

ENST00000504102

71_191

375.0

Region

Note=Required for nuclear localization

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367884

120_140

153.0

Transmembrane

Helical

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367884

71_91

153.0

Transmembrane

Helical

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367884

9_29

153.0

Transmembrane

Helical

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367889

120_140

153.0

Transmembrane

Helical

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367889

71_91

153.0

Transmembrane

Helical

Hgene

MGST3

chr1:165621237

chr17:47679312

ENST00000367889

9_29

153.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MGST3
SPOP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MGST3-SPOP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MGST3-SPOP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source