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Fusion Protein:MIB1-MYO5B |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MIB1-MYO5B | FusionPDB ID: 53493 | FusionGDB2.0 ID: 53493 | Hgene | Tgene | Gene symbol | MIB1 | MYO5B | Gene ID | 57534 | 4645 |
| Gene name | mindbomb E3 ubiquitin protein ligase 1 | myosin VB | |
| Synonyms | DIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6 | - | |
| Cytomap | 18q11.2 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2 | unconventional myosin-VbMYO5B variant proteinmyosin-Vb | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q86YT6 | Q9ULV0 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000578646, ENST00000261537, | ENST00000285039, ENST00000324581, ENST00000587895, ENST00000592688, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 11 X 12 X 7=924 | 11 X 10 X 7=770 |
| # samples | 14 | 14 | |
| ** MAII score | log2(14/924*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MIB1 [Title/Abstract] AND MYO5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MIB1(19438607)-MYO5B(47406825), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | MIB1-MYO5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MIB1-MYO5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MIB1-MYO5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MIB1-MYO5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MIB1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 23615451 |
| Fusion gene breakpoints across MIB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MYO5B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-G4-6322-01A | MIB1 | chr18 | 19438607 | - | MYO5B | chr18 | 47406825 | - |
| ChimerDB4 | COAD | TCGA-G4-6322-01A | MIB1 | chr18 | 19438607 | + | MYO5B | chr18 | 47406825 | - |
| ChimerDB4 | COAD | TCGA-G4-6322 | MIB1 | chr18 | 19438607 | + | MYO5B | chr18 | 47406825 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261537 | MIB1 | chr18 | 19438607 | + | ENST00000285039 | MYO5B | chr18 | 47406825 | - | 9304 | 3144 | 75 | 5645 | 1856 |
| ENST00000261537 | MIB1 | chr18 | 19438607 | + | ENST00000324581 | MYO5B | chr18 | 47406825 | - | 5779 | 3144 | 75 | 5567 | 1830 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261537 | ENST00000285039 | MIB1 | chr18 | 19438607 | + | MYO5B | chr18 | 47406825 | - | 0.000212547 | 0.9997875 |
| ENST00000261537 | ENST00000324581 | MIB1 | chr18 | 19438607 | + | MYO5B | chr18 | 47406825 | - | 0.00114142 | 0.9988586 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >53493_53493_1_MIB1-MYO5B_MIB1_chr18_19438607_ENST00000261537_MYO5B_chr18_47406825_ENST00000285039_length(amino acids)=1856AA_BP=1022 MGSGFGLRGDRAAAPVSYSHVPRGSLPPPPTPRVRPGPNSLTGPPAAAAAAAAAAAEPTARAPMSNSRNNRVMVEGVGARVVRGPDWKWG KQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDK HHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRV GFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQ YPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG TSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHV DILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPL HDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNA NLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGA EKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHI ATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDIS SGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVK EYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKK LQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHE ELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARL LEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMK KAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVH SLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGV LQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKD VCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVA -------------------------------------------------------------- >53493_53493_2_MIB1-MYO5B_MIB1_chr18_19438607_ENST00000261537_MYO5B_chr18_47406825_ENST00000324581_length(amino acids)=1830AA_BP=1022 MGSGFGLRGDRAAAPVSYSHVPRGSLPPPPTPRVRPGPNSLTGPPAAAAAAAAAAAEPTARAPMSNSRNNRVMVEGVGARVVRGPDWKWG KQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDK HHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRV GFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQ YPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG TSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHV DILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPL HDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNA NLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGA EKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHI ATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDIS SGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVK EYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKK LQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHE ELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSLEHEEEVEHLKAQLEAL KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVT VQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSF WLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGY RKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNL HQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMF -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:19438607/chr18:47406825) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIB1 | MYO5B |
| FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}. | FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 935_962 | 960.0 | 1007.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 143_221 | 960.0 | 1007.0 | Domain | MIB/HERC2 2 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 6_74 | 960.0 | 1007.0 | Domain | MIB/HERC2 1 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 430_460 | 960.0 | 1007.0 | Repeat | Note=ANK 1 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 463_492 | 960.0 | 1007.0 | Repeat | Note=ANK 2 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 496_525 | 960.0 | 1007.0 | Repeat | Note=ANK 3 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 529_558 | 960.0 | 1007.0 | Repeat | Note=ANK 4 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 562_591 | 960.0 | 1007.0 | Repeat | Note=ANK 5 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 595_627 | 960.0 | 1007.0 | Repeat | Note=ANK 6 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 631_661 | 960.0 | 1007.0 | Repeat | Note=ANK 7 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 665_694 | 960.0 | 1007.0 | Repeat | Note=ANK 8 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 698_729 | 960.0 | 1007.0 | Repeat | Note=ANK 9 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 79_126 | 960.0 | 1007.0 | Zinc finger | ZZ-type |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 819_854 | 960.0 | 1007.0 | Zinc finger | RING-type 1 |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 866_901 | 960.0 | 1007.0 | Zinc finger | RING-type 2 |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 1341_1471 | 1015.0 | 1849.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 1526_1803 | 1015.0 | 1849.0 | Domain | Dilute |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MIB1 | chr18:19438607 | chr18:47406825 | ENST00000261537 | + | 20 | 21 | 963_996 | 960.0 | 1007.0 | Zinc finger | RING-type 3 |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 899_1266 | 1015.0 | 1849.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 801_916 | 1015.0 | 1849.0 | Compositional bias | Note=Arg-rich | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 69_761 | 1015.0 | 1849.0 | Domain | Myosin motor | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 769_798 | 1015.0 | 1849.0 | Domain | IQ 1 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 792_821 | 1015.0 | 1849.0 | Domain | IQ 2 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 817_848 | 1015.0 | 1849.0 | Domain | IQ 3 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 840_869 | 1015.0 | 1849.0 | Domain | IQ 4 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 865_896 | 1015.0 | 1849.0 | Domain | IQ 5 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 888_917 | 1015.0 | 1849.0 | Domain | IQ 6 | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 8_60 | 1015.0 | 1849.0 | Domain | Myosin N-terminal SH3-like | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 163_170 | 1015.0 | 1849.0 | Nucleotide binding | ATP | |
| Tgene | MYO5B | chr18:19438607 | chr18:47406825 | ENST00000285039 | 21 | 40 | 640_662 | 1015.0 | 1849.0 | Region | Actin-binding |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
MIB1_pLDDT.png  |
MYO5B_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MIB1 | |
| MYO5B |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MIB1-MYO5B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MIB1-MYO5B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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