UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MICU3-TGFBR3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MICU3-TGFBR3
FusionPDB ID: 53586
FusionGDB2.0 ID: 53586
HgeneTgene
Gene symbol

MICU3

TGFBR3

Gene ID

286097

7049

Gene namemitochondrial calcium uptake family member 3transforming growth factor beta receptor 3
SynonymsEFHA2BGCAN|betaglycan
Cytomap

8p22

1p22.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium uptake protein 3, mitochondrialEF hand domain family A2EF-hand domain family, member A2EF-hand domain-containing family member A2mitochondrial uptake family, member 3transforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III
Modification date2020031520200313
UniProtAcc

Q86XE3

.
Ensembl transtripts involved in fusion geneENST idsENST00000318063, ENST00000519866, 
ENST00000468996, ENST00000212355, 
ENST00000370399, ENST00000525962, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=810 X 9 X 9=810
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/810*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MICU3 [Title/Abstract] AND TGFBR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MICU3(16885169)-TGFBR3(92200516), # samples:2
Anticipated loss of major functional domain due to fusion event.MICU3-TGFBR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU3-TGFBR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU3-TGFBR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU3-TGFBR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTGFBR3

GO:0001837

epithelial to mesenchymal transition

18184661

TgeneTGFBR3

GO:0007179

transforming growth factor beta receptor signaling pathway

12958365

TgeneTGFBR3

GO:0030509

BMP signaling pathway

18184661

TgeneTGFBR3

GO:0032354

response to follicle-stimulating hormone

14557487

TgeneTGFBR3

GO:0034695

response to prostaglandin E

14557487

TgeneTGFBR3

GO:0034699

response to luteinizing hormone

14557487

TgeneTGFBR3

GO:0051271

negative regulation of cellular component movement

17999987

TgeneTGFBR3

GO:0060317

cardiac epithelial to mesenchymal transition

18184661


check buttonFusion gene breakpoints across MICU3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TGFBR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29L-06AMICU3chr8

16885169

+TGFBR3chr1

92200516

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000318063MICU3chr816885169+ENST00000212355TGFBR3chr192200516-5989423212594857
ENST00000318063MICU3chr816885169+ENST00000370399TGFBR3chr192200516-3905423212591856
ENST00000318063MICU3chr816885169+ENST00000525962TGFBR3chr192200516-3904423212594857

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318063ENST00000212355MICU3chr816885169+TGFBR3chr192200516-8.56E-050.9999144
ENST00000318063ENST00000370399MICU3chr816885169+TGFBR3chr192200516-0.0002904820.99970955
ENST00000318063ENST00000525962MICU3chr816885169+TGFBR3chr192200516-0.0002814430.9997185

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53586_53586_1_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000212355_length(amino acids)=857AA_BP=134
MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY
QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF
TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE
VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR
LENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEV
QGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSS
GWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVS
VTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKME
KHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGA

--------------------------------------------------------------

>53586_53586_2_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000370399_length(amino acids)=856AA_BP=134
MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY
QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF
TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE
VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR
LENNEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQ
GSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSG
WPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSV
TKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEK
HPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGAL

--------------------------------------------------------------

>53586_53586_3_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000525962_length(amino acids)=857AA_BP=134
MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY
QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF
TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE
VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR
LENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEV
QGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSS
GWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVS
VTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKME
KHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:16885169/chr1:92200516)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICU3

Q86XE3

.
FUNCTION: May play a role in mitochondrial calcium uptake. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+11559_63127.01175.6666666666667Compositional biasNote=Poly-Arg
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+11570_73127.01175.6666666666667Compositional biasNote=Poly-Ala
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+11567_83127.01175.6666666666667TransmembraneHelical
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000212355317455_730128.0852.0DomainZP
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000370399418455_730128.0851.0DomainZP
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000525962216455_730128.0852.0DomainZP
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000212355317810_851128.0852.0Topological domainCytoplasmic
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000370399418810_851128.0851.0Topological domainCytoplasmic
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000525962216810_851128.0852.0Topological domainCytoplasmic
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000212355317788_809128.0852.0TransmembraneHelical
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000370399418788_809128.0851.0TransmembraneHelical
TgeneTGFBR3chr8:16885169chr1:92200516ENST00000525962216788_809128.0852.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+115245_256127.01175.6666666666667Calcium binding1
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+115483_494127.01175.6666666666667Calcium binding2
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+115232_267127.01175.6666666666667DomainEF-hand 1
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+115401_436127.01175.6666666666667DomainEF-hand 2
HgeneMICU3chr8:16885169chr1:92200516ENST00000318063+115470_505127.01175.6666666666667DomainEF-hand 3
TgeneTGFBR3chr8:16885169chr1:92200516ENST0000021235531721_787128.0852.0Topological domainExtracellular
TgeneTGFBR3chr8:16885169chr1:92200516ENST0000037039941821_787128.0851.0Topological domainExtracellular
TgeneTGFBR3chr8:16885169chr1:92200516ENST0000052596221621_787128.0852.0Topological domainExtracellular


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MICU3
TGFBR3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to MICU3-TGFBR3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MICU3-TGFBR3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource