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Fusion Protein:MINK1-PELP1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MINK1-PELP1 | FusionPDB ID: 53690 | FusionGDB2.0 ID: 53690 | Hgene | Tgene | Gene symbol | MINK1 | PELP1 | Gene ID | 50488 | 27043 |
| Gene name | misshapen like kinase 1 | proline, glutamate and leucine rich protein 1 | |
| Synonyms | B55|MAP4K6|MINK|YSK2|ZC3 | MNAR|P160 | |
| Cytomap | 17p13.2 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | misshapen-like kinase 1GCK family kinase MINKMAPK/ERK kinase kinase kinase 6MEK kinase kinase 6MEKKK 6misshapen/NIK-related kinasemitogen-activated protein kinase kinase kinase kinase 6 | proline-, glutamic acid- and leucine-rich protein 1modulator of non-genomic activity of estrogen receptorproline and glutamic acid rich nuclear proteintranscription factor HMX3 | |
| Modification date | 20200320 | 20200329 | |
| UniProtAcc | Q8N4C8 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000347992, ENST00000355280, ENST00000453408, | ENST00000436683, ENST00000570823, ENST00000269230, ENST00000301396, ENST00000572293, ENST00000574876, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 8 X 5=520 | 7 X 5 X 7=245 |
| # samples | 17 | 13 | |
| ** MAII score | log2(17/520*10)=-1.61297687689075 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/245*10)=-0.914270125974116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MINK1 [Title/Abstract] AND PELP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MINK1(4736935)-PELP1(4586247), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MINK1-PELP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MINK1-PELP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MINK1-PELP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MINK1-PELP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MINK1 | GO:0046777 | protein autophosphorylation | 15469942 |
| Tgene | PELP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17505058 |
| Tgene | PELP1 | GO:0071391 | cellular response to estrogen stimulus | 17505058 |
| Fusion gene breakpoints across MINK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PELP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-HU-A4GN-01A | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000355280 | MINK1 | chr17 | 4736935 | + | ENST00000574876 | PELP1 | chr17 | 4586247 | - | 3281 | 253 | 196 | 3225 | 1009 |
| ENST00000355280 | MINK1 | chr17 | 4736935 | + | ENST00000572293 | PELP1 | chr17 | 4586247 | - | 3280 | 253 | 196 | 3225 | 1009 |
| ENST00000355280 | MINK1 | chr17 | 4736935 | + | ENST00000269230 | PELP1 | chr17 | 4586247 | - | 3010 | 253 | 196 | 2955 | 919 |
| ENST00000355280 | MINK1 | chr17 | 4736935 | + | ENST00000301396 | PELP1 | chr17 | 4586247 | - | 3712 | 253 | 196 | 3657 | 1153 |
| ENST00000347992 | MINK1 | chr17 | 4736935 | + | ENST00000574876 | PELP1 | chr17 | 4586247 | - | 3269 | 241 | 184 | 3213 | 1009 |
| ENST00000347992 | MINK1 | chr17 | 4736935 | + | ENST00000572293 | PELP1 | chr17 | 4586247 | - | 3268 | 241 | 184 | 3213 | 1009 |
| ENST00000347992 | MINK1 | chr17 | 4736935 | + | ENST00000269230 | PELP1 | chr17 | 4586247 | - | 2998 | 241 | 184 | 2943 | 919 |
| ENST00000347992 | MINK1 | chr17 | 4736935 | + | ENST00000301396 | PELP1 | chr17 | 4586247 | - | 3700 | 241 | 184 | 3645 | 1153 |
| ENST00000453408 | MINK1 | chr17 | 4736935 | + | ENST00000574876 | PELP1 | chr17 | 4586247 | - | 3085 | 57 | 0 | 3029 | 1009 |
| ENST00000453408 | MINK1 | chr17 | 4736935 | + | ENST00000572293 | PELP1 | chr17 | 4586247 | - | 3084 | 57 | 0 | 3029 | 1009 |
| ENST00000453408 | MINK1 | chr17 | 4736935 | + | ENST00000269230 | PELP1 | chr17 | 4586247 | - | 2814 | 57 | 0 | 2759 | 919 |
| ENST00000453408 | MINK1 | chr17 | 4736935 | + | ENST00000301396 | PELP1 | chr17 | 4586247 | - | 3516 | 57 | 0 | 3461 | 1153 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000355280 | ENST00000574876 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.006909051 | 0.99309087 |
| ENST00000355280 | ENST00000572293 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.006873051 | 0.993127 |
| ENST00000355280 | ENST00000269230 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.008034005 | 0.991966 |
| ENST00000355280 | ENST00000301396 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.003833615 | 0.99616647 |
| ENST00000347992 | ENST00000574876 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.006687046 | 0.9933129 |
| ENST00000347992 | ENST00000572293 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.00665159 | 0.9933484 |
| ENST00000347992 | ENST00000269230 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.007895427 | 0.99210453 |
| ENST00000347992 | ENST00000301396 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.003730489 | 0.99626946 |
| ENST00000453408 | ENST00000574876 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.006028269 | 0.99397177 |
| ENST00000453408 | ENST00000572293 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.00599973 | 0.9940003 |
| ENST00000453408 | ENST00000269230 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.008209601 | 0.9917904 |
| ENST00000453408 | ENST00000301396 | MINK1 | chr17 | 4736935 | + | PELP1 | chr17 | 4586247 | - | 0.003190179 | 0.9968098 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >53690_53690_1_MINK1-PELP1_MINK1_chr17_4736935_ENST00000347992_PELP1_chr17_4586247_ENST00000269230_length(amino acids)=919AA_BP=17 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDPCGCCCCPLSTLALDLLSALILACGSRLLR FGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPD GSLQTGKPSAPKKLKLDVGEAMAPPSHRLLPVPCKPSPSASEKIALRSPLCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPLRPHRPS GPHRSILRAPCPQWAPCPQQAPCSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_2_MINK1-PELP1_MINK1_chr17_4736935_ENST00000347992_PELP1_chr17_4586247_ENST00000301396_length(amino acids)=1153AA_BP=692 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNIVSGICHLFRALAQDTRQPGKYWGPESPQTVSSWSR PRELPTFVQITSLPMCRDTGAQCQSVANASLGEGEFGDAESLLRGPAILLTFHPGSILEDRGLILLGELRSGVGFLTYVYICKWSFPVSV SLWLSLSSSTLYLCPFFLQSLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTV RTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNA NSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSL GQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPS ARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDS VVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEED LTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGT AGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEE -------------------------------------------------------------- >53690_53690_3_MINK1-PELP1_MINK1_chr17_4736935_ENST00000347992_PELP1_chr17_4586247_ENST00000572293_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_4_MINK1-PELP1_MINK1_chr17_4736935_ENST00000347992_PELP1_chr17_4586247_ENST00000574876_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_5_MINK1-PELP1_MINK1_chr17_4736935_ENST00000355280_PELP1_chr17_4586247_ENST00000269230_length(amino acids)=919AA_BP=17 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDPCGCCCCPLSTLALDLLSALILACGSRLLR FGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPD GSLQTGKPSAPKKLKLDVGEAMAPPSHRLLPVPCKPSPSASEKIALRSPLCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPLRPHRPS GPHRSILRAPCPQWAPCPQQAPCSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_6_MINK1-PELP1_MINK1_chr17_4736935_ENST00000355280_PELP1_chr17_4586247_ENST00000301396_length(amino acids)=1153AA_BP=692 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNIVSGICHLFRALAQDTRQPGKYWGPESPQTVSSWSR PRELPTFVQITSLPMCRDTGAQCQSVANASLGEGEFGDAESLLRGPAILLTFHPGSILEDRGLILLGELRSGVGFLTYVYICKWSFPVSV SLWLSLSSSTLYLCPFFLQSLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTV RTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNA NSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSL GQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPS ARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDS VVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEED LTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGT AGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEE -------------------------------------------------------------- >53690_53690_7_MINK1-PELP1_MINK1_chr17_4736935_ENST00000355280_PELP1_chr17_4586247_ENST00000572293_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_8_MINK1-PELP1_MINK1_chr17_4736935_ENST00000355280_PELP1_chr17_4586247_ENST00000574876_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_9_MINK1-PELP1_MINK1_chr17_4736935_ENST00000453408_PELP1_chr17_4586247_ENST00000269230_length(amino acids)=919AA_BP=17 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDPCGCCCCPLSTLALDLLSALILACGSRLLR FGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPD GSLQTGKPSAPKKLKLDVGEAMAPPSHRLLPVPCKPSPSASEKIALRSPLCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPLRPHRPS GPHRSILRAPCPQWAPCPQQAPCSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_10_MINK1-PELP1_MINK1_chr17_4736935_ENST00000453408_PELP1_chr17_4586247_ENST00000301396_length(amino acids)=1153AA_BP=692 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNIVSGICHLFRALAQDTRQPGKYWGPESPQTVSSWSR PRELPTFVQITSLPMCRDTGAQCQSVANASLGEGEFGDAESLLRGPAILLTFHPGSILEDRGLILLGELRSGVGFLTYVYICKWSFPVSV SLWLSLSSSTLYLCPFFLQSLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTV RTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNA NSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSL GQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPS ARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDS VVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEED LTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGT AGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEE -------------------------------------------------------------- >53690_53690_11_MINK1-PELP1_MINK1_chr17_4736935_ENST00000453408_PELP1_chr17_4586247_ENST00000572293_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- >53690_53690_12_MINK1-PELP1_MINK1_chr17_4736935_ENST00000453408_PELP1_chr17_4586247_ENST00000574876_length(amino acids)=1009AA_BP=548 MGDPAPARSLDDIDLSALRTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACG SLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSE DGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRL LRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGS PDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYT SSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFR APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP PDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPP PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4736935/chr17:4586247) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MINK1 | . |
| FUNCTION: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 633_872 | 140.0 | 1131.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 888_1101 | 140.0 | 1131.0 | Compositional bias | Note=Glu-rich | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 977_1083 | 140.0 | 1131.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 155_159 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 4 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 177_181 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 5 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 264_268 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 6 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 271_275 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 7 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 364_368 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 8 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 459_463 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 9 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 579_583 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 10 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 584_588 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 11 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000347992 | + | 1 | 32 | 359_495 | 19.0 | 1304.0 | Compositional bias | Note=Gln-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000347992 | + | 1 | 32 | 542_729 | 19.0 | 1304.0 | Compositional bias | Note=Pro-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000355280 | + | 1 | 32 | 359_495 | 19.0 | 1333.0 | Compositional bias | Note=Gln-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000355280 | + | 1 | 32 | 542_729 | 19.0 | 1333.0 | Compositional bias | Note=Pro-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000453408 | + | 1 | 32 | 359_495 | 19.0 | 1313.0 | Compositional bias | Note=Gln-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000453408 | + | 1 | 32 | 542_729 | 19.0 | 1313.0 | Compositional bias | Note=Pro-rich |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000347992 | + | 1 | 32 | 1019_1306 | 19.0 | 1304.0 | Domain | CNH |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000347992 | + | 1 | 32 | 25_289 | 19.0 | 1304.0 | Domain | Protein kinase |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000355280 | + | 1 | 32 | 1019_1306 | 19.0 | 1333.0 | Domain | CNH |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000355280 | + | 1 | 32 | 25_289 | 19.0 | 1333.0 | Domain | Protein kinase |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000453408 | + | 1 | 32 | 1019_1306 | 19.0 | 1313.0 | Domain | CNH |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000453408 | + | 1 | 32 | 25_289 | 19.0 | 1313.0 | Domain | Protein kinase |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000347992 | + | 1 | 32 | 31_39 | 19.0 | 1304.0 | Nucleotide binding | ATP |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000355280 | + | 1 | 32 | 31_39 | 19.0 | 1333.0 | Nucleotide binding | ATP |
| Hgene | MINK1 | chr17:4736935 | chr17:4586247 | ENST00000453408 | + | 1 | 32 | 31_39 | 19.0 | 1313.0 | Nucleotide binding | ATP |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 111_115 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 3 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 33_37 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 1 | |
| Tgene | PELP1 | chr17:4736935 | chr17:4586247 | ENST00000574876 | 2 | 17 | 69_73 | 140.0 | 1131.0 | Motif | Note=LXXLL motif 2 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MINK1 | |
| PELP1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MINK1-PELP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MINK1-PELP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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