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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MKL2-SNX29

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MKL2-SNX29
FusionPDB ID: 54077
FusionGDB2.0 ID: 54077
HgeneTgene
Gene symbol

MKL2

SNX29

Gene ID

57496

92017

Gene namemyocardin related transcription factor Bsorting nexin 29
SynonymsMKL2|MRTF-B|NPD001A-388D4.1|RUNDC2A
Cytomap

16p13.12

16p13.13-p13.12

Type of geneprotein-codingprotein-coding
Descriptionmyocardin-related transcription factor BCTA-276F8.1MKL and myocardin family member 2MKL/myocardin like 2MKL/myocardin-like protein 2MKL1/myocardin like 2megakaryoblastic leukemia 2sorting nexin-29RUN domain containing 2ARUN domain-containing protein 2A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000318282, ENST00000341243, 
ENST00000571589, ENST00000572567, 
ENST00000573051, ENST00000574045, 
ENST00000575537, 		ENST00000306030, 
ENST00000323433, ENST00000568359, 
ENST00000566228, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 10 X 11=209015 X 15 X 6=1350
# samples 2016
** MAII scorelog2(20/2090*10)=-3.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MKL2 [Title/Abstract] AND SNX29 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MKL2(14334341)-SNX29(12121177), # samples:1
Anticipated loss of major functional domain due to fusion event.MKL2-SNX29 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MKL2-SNX29 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MKL2-SNX29 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MKL2-SNX29 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MKL2-SNX29 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKL2

GO:0045844

positive regulation of striated muscle tissue development

14565952

HgeneMKL2

GO:0045944

positive regulation of transcription by RNA polymerase II

14565952


check buttonFusion gene breakpoints across MKL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNX29 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04T-01AMKL2chr16

14334341

+SNX29chr16

12121177

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000571589MKL2chr1614334341+ENST00000566228SNX29chr1612121177+9231125117235701132
ENST00000574045MKL2chr1614334341+ENST00000566228SNX29chr1612121177+9214123415535531132
ENST00000318282MKL2chr1614334341+ENST00000566228SNX29chr1612121177+9189120913035281132
ENST00000341243MKL2chr1614334341+ENST00000566228SNX29chr1612121177+90261046033651121
ENST00000573051MKL2chr1614334341+ENST00000566228SNX29chr1612121177+9064108415834031081

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000571589ENST00000566228MKL2chr1614334341+SNX29chr1612121177+0.0020482970.9979517
ENST00000574045ENST00000566228MKL2chr1614334341+SNX29chr1612121177+0.0020133740.9979867
ENST00000318282ENST00000566228MKL2chr1614334341+SNX29chr1612121177+0.0019364720.9980635
ENST00000341243ENST00000566228MKL2chr1614334341+SNX29chr1612121177+0.0019500550.99805
ENST00000573051ENST00000566228MKL2chr1614334341+SNX29chr1612121177+0.0023478310.99765223

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54077_54077_1_MKL2-SNX29_MKL2_chr16_14334341_ENST00000318282_SNX29_chr16_12121177_ENST00000566228_length(amino acids)=1132AA_BP=360
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLER
ARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH
TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAK
PGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK
VTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKEVLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERY
LHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREI
TASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDEEDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPF
GPNSNGSQSSNSWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDI
LFPVSGVGSYSPADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSL
RNLLDGEMEHSAALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIA
EELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKA
ANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPK

--------------------------------------------------------------

>54077_54077_2_MKL2-SNX29_MKL2_chr16_14334341_ENST00000341243_SNX29_chr16_12121177_ENST00000566228_length(amino acids)=1121AA_BP=349
MIDSSKKQQQGFPEILTAGDFEPLKEKECLEGSNQKSLKEVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKI
RSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDS
SDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHP
KNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKVTCLCAQFEAV
LQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKEVLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERYLHMLLADRCRL
STFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREITASSAVSILIK
PEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDEEDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPFGPNSNGSQSSN
SWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDILFPVSGVGSYS
PADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSLRNLLDGEMEHS
AALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIAEELASSYERKL
IEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKAANAFHVYQVYI
RIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFF

--------------------------------------------------------------

>54077_54077_3_MKL2-SNX29_MKL2_chr16_14334341_ENST00000571589_SNX29_chr16_12121177_ENST00000566228_length(amino acids)=1132AA_BP=360
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLER
ARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH
TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAK
PGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK
VTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKEVLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERY
LHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREI
TASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDEEDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPF
GPNSNGSQSSNSWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDI
LFPVSGVGSYSPADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSL
RNLLDGEMEHSAALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIA
EELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKA
ANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPK

--------------------------------------------------------------

>54077_54077_4_MKL2-SNX29_MKL2_chr16_14334341_ENST00000573051_SNX29_chr16_12121177_ENST00000566228_length(amino acids)=1081AA_BP=309
MLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDL
NEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQ
FASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQ
MDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKVTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKE
VLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERYLHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDL
NGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREITASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDE
EDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPFGPNSNGSQSSNSWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSS
GRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDILFPVSGVGSYSPADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPL
SSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSLRNLLDGEMEHSAALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLK
KYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIAEELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRG
PVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKA
IGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFFVDITPPGEPVNSRPKAASRFPKLSRGQPRETRNVEPQSGD

--------------------------------------------------------------

>54077_54077_5_MKL2-SNX29_MKL2_chr16_14334341_ENST00000574045_SNX29_chr16_12121177_ENST00000566228_length(amino acids)=1132AA_BP=360
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLER
ARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH
TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAK
PGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK
VTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKEVLNKHELQRFYSLRHIASDVGRGRAWLRCALNEHSLERY
LHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREI
TASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKKKKKVTNIISFDDEEDEQNSGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPF
GPNSNGSQSSNSWKIDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEGNTCLSQMHSWAPLKVLHNDSDI
LFPVSGVGSYSPADAPLGSLENGTGPEDHVLPDPGLRYSVEASSPGHGSPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSL
RNLLDGEMEHSAALRQEVDTLKRKVAEQEERQGMKVQALARENEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAEQKPGEIA
EELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLSQTSEDQSLSDFEISNRALINVWIPSVFLRGKA
ANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:14334341/chr16:12121177)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+916128_153359.66666666666671050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+91640_65359.66666666666671050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+91684_109359.66666666666671050.0RepeatNote=RPEL 2
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+815128_153348.66666666666671089.0RepeatNote=RPEL 3
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+81540_65348.66666666666671089.0RepeatNote=RPEL 1
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+81584_109348.66666666666671089.0RepeatNote=RPEL 2
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+89128_153308.6666666666667379.0RepeatNote=RPEL 3
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+8940_65308.6666666666667379.0RepeatNote=RPEL 1
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+8984_109308.6666666666667379.0RepeatNote=RPEL 2
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+1017128_153359.66666666666671050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+101740_65359.66666666666671050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+101784_109359.66666666666671050.0RepeatNote=RPEL 2
TgeneSNX29chr16:14334341chr16:12121177ENST00000566228221466_54540.666666666666664814.0Coiled coilOntology_term=ECO:0000255
TgeneSNX29chr16:14334341chr16:12121177ENST00000566228221656_77940.666666666666664814.0DomainPX

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+916545_601359.66666666666671050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+815545_601348.66666666666671089.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+89545_601308.6666666666667379.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+1017545_601359.66666666666671050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+916671_787359.66666666666671050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+815671_787348.66666666666671089.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+89671_787308.6666666666667379.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+1017671_787359.66666666666671050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14334341chr16:12121177ENST00000318282+916389_423359.66666666666671050.0DomainSAP
HgeneMKL2chr16:14334341chr16:12121177ENST00000341243+815389_423348.66666666666671089.0DomainSAP
HgeneMKL2chr16:14334341chr16:12121177ENST00000573051+89389_423308.6666666666667379.0DomainSAP
HgeneMKL2chr16:14334341chr16:12121177ENST00000574045+1017389_423359.66666666666671050.0DomainSAP
TgeneSNX29chr16:14334341chr16:12121177ENST0000056622822136_18040.666666666666664814.0DomainRUN


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MKL2
SNX29


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MKL2-SNX29


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MKL2-SNX29


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource