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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MLLT3-KMT2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MLLT3-KMT2A
FusionPDB ID: 54292
FusionGDB2.0 ID: 54292
HgeneTgene
Gene symbol

MLLT3

KMT2A

Gene ID

4300

4297

Gene nameMLLT3 super elongation complex subunitlysine methyltransferase 2A
SynonymsAF9|YEATS3ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS
Cytomap

9p21.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-9ALL1-fused gene from chromosome 9 proteinKMT2A/MLLT3 fusionKMT2A/MLLT3 fusion proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leuhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
Modification date2020032720200319
UniProtAcc

P42568

Q03164

Ensembl transtripts involved in fusion geneENST idsENST00000380338, ENST00000429426, 
ENST00000355930, ENST00000475957, 
ENST00000380321, 
ENST00000354520, 
ENST00000420751, ENST00000389506, 
ENST00000534358, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 14 X 11=277231 X 72 X 3=6696
# samples 2579
** MAII scorelog2(25/2772*10)=-3.47092725747513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(79/6696*10)=-3.08337496948588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MLLT3 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2A(118353210)-MLLT3(20365742), # samples:2
MLLT3(20360029)-KMT2A(118353560), # samples:2
Anticipated loss of major functional domain due to fusion event.KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT3-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KMT2A-MLLT3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

HgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803

TgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

TgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

TgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

TgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

TgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

TgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722


check buttonFusion gene breakpoints across MLLT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..MLLT3chr9

20413718

-KMT2Achr11

118355576

ChimerKB3..MLLT3chr9

20413718

-KMT2Achr11

118359328

ChiTaRS5.0N/AAY282402MLLT3chr9

20410548

-KMT2Achr11

118359129

+
ChiTaRS5.0N/AAY282403MLLT3chr9

20358126

-KMT2Achr11

118354734

+
ChiTaRS5.0N/AAY282404MLLT3chr9

20373293

-KMT2Achr11

118359137

+
ChiTaRS5.0N/AAY282405MLLT3chr9

20372883

-KMT2Achr11

118359141

+
ChiTaRS5.0N/AAY387662MLLT3chr9

20413320

-KMT2Achr11

118359129

+
ChiTaRS5.0N/AAY840547MLLT3chr9

20360029

+KMT2Achr11

118353560

-
ChiTaRS5.0N/AAY840550MLLT3chr9

20360029

+KMT2Achr11

118353560

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000380338MLLT3chr920413718-ENST00000534358KMT2Achr1111835557613765141228791122941
ENST00000380338MLLT3chr920413718-ENST00000389506KMT2Achr1111835557610849141228791032938
ENST00000429426MLLT3chr920413718-ENST00000534358KMT2Achr111183555761356712149889142938
ENST00000429426MLLT3chr920413718-ENST00000389506KMT2Achr111183555761065112149889052935
ENST00000380338MLLT3chr920413718-ENST00000534358KMT2Achr1111835932813651141228789982903
ENST00000380338MLLT3chr920413718-ENST00000389506KMT2Achr1111835932810735141228789892900
ENST00000380338MLLT3chr920413718-ENST00000354520KMT2Achr1111835932811514141228789892900
ENST00000429426MLLT3chr920413718-ENST00000534358KMT2Achr111183593281345312149888002900
ENST00000429426MLLT3chr920413718-ENST00000389506KMT2Achr111183593281053712149887912897
ENST00000429426MLLT3chr920413718-ENST00000354520KMT2Achr111183593281131612149887912897

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54292_54292_1_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000380338_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2938AA_BP=375
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLL
TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKF
CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPL
CDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLL
RYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKAN
SMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPL
HPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQL
RCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHM
MIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQ
NTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLS
PQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQS
SASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQ
HTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTP
EYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISA
SENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSS
TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIP
KRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKS
DSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQF
ELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGS
VEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQK
IQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPP
PDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRT
VPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLG
TPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLAS
KTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGN
GKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESN
FSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLI
EQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFR
HLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEP

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>54292_54292_2_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000380338_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2941AA_BP=375
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLL
TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKF
CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPL
CDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTS
HLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIK
KANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSP
TPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG
KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPEN
IHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSK
ESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTS
SLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEM
KQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND
RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV
LTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEP
ISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY
SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSS
QIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL
LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAE
EQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPP
CGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGV
TQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGV
QPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS
HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPR
LLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQL
LASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLD
KGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEE
ESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV
FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPM
RFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHS

--------------------------------------------------------------

>54292_54292_3_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000380338_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=2900AA_BP=375
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLL
TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPT
KKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEI
LSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSK
QDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML
PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTY
GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTT
DARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPS
YSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS
AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIP
KLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSA
KELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLM
LPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI
SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPK
MDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKR
VTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPN
STDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL
PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR
KNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQL
GTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNK
ALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE
QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGF
QICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYA
GNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE

--------------------------------------------------------------

>54292_54292_4_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000380338_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=2900AA_BP=375
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLL
TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPT
KKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEI
LSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSK
QDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML
PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTY
GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTT
DARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPS
YSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS
AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIP
KLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSA
KELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLM
LPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI
SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPK
MDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKR
VTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPN
STDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL
PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR
KNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQL
GTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNK
ALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE
QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGF
QICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYA
GNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE

--------------------------------------------------------------

>54292_54292_5_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000380338_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=2903AA_BP=375
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLL
TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPT
KKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEM
YEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTE
VSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNS
GMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALC
LTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF
LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYW
STTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIR
TPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDL
ESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP
GIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE
HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVE
GSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDR
NLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTR
TVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKN
EPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES
PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSG
EKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKY
VPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLN
PSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRL
QTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT
STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMF
PQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLE
QNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGA
EAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSD
DGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVI
EYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKF

--------------------------------------------------------------

>54292_54292_6_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000429426_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2935AA_BP=372
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKE
EPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTIT
SGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPND
SDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHV
CGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDK
CYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYR
QAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMV
KSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPP
TPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCE
FCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIG
SMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTA
EIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQR
SKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSAS
DLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTD
STQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYM
GQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASEN
PGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGK
KRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRN
GKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSD
NNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELP
LELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQ
GHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQL
TSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDP
QLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPN
IIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPD
IGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTG
IHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKK
HKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSS
PLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQL
SGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLK
KTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCY

--------------------------------------------------------------

>54292_54292_7_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000429426_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2938AA_BP=372
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKE
EPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTIT
SGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPND
SDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHV
CGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDK
CYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLL
RYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKAN
SMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPL
HPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQL
RCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHM
MIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQ
NTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLS
PQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQS
SASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQ
HTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTP
EYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISA
SENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSS
TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIP
KRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKS
DSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQF
ELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGS
VEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQK
IQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPP
PDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRT
VPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLG
TPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLAS
KTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGN
GKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESN
FSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLI
EQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFR
HLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEP

--------------------------------------------------------------

>54292_54292_8_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000429426_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=2897AA_BP=372
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKE
EPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTIT
SGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPND
SDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSN
LPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDD
QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNA
VLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDD
SANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKV
YCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDAR
KRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSP
TQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKV
VDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLA
PQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSS
RDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKEL
QAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPD
GPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSG
GEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDN
CHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSS
ELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTI
TEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTD
SPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTS
QSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNK
KLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQD
TSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTS
QTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALS
SAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQD
TASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQIC
AESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRK
SAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNV
IRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDAS

--------------------------------------------------------------

>54292_54292_9_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000429426_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=2897AA_BP=372
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKE
EPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTIT
SGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPND
SDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSN
LPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDD
QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNA
VLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDD
SANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKV
YCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDAR
KRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSP
TQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKV
VDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLA
PQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSS
RDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKEL
QAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPD
GPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSG
GEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDN
CHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSS
ELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTI
TEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTD
SPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTS
QSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNK
KLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQD
TSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTS
QTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALS
SAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQD
TASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQIC
AESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRK
SAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNV
IRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDAS

--------------------------------------------------------------

>54292_54292_10_MLLT3-KMT2A_MLLT3_chr9_20413718_ENST00000429426_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=2900AA_BP=372
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKE
EPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTIT
SGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPND
SDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEI
LSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSK
QDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML
PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTY
GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTT
DARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPS
YSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS
AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIP
KLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSA
KELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLM
LPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI
SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPK
MDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKR
VTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPN
STDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL
PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR
KNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQL
GTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNK
ALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE
QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGF
QICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYA
GNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:118353210/chr11:20365742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT3

P42568

KMT2A

Q03164

FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511143_195375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511196_262375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511282_304375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511323_354375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511143_195375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511196_262375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511282_304375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511323_354375.0569.0Compositional biasBasic and acidic residues
HgeneMLLT3chr9:20413718chr11:118355576ENST000003803385111_138375.0569.0DomainYEATS
HgeneMLLT3chr9:20413718chr11:118359328ENST000003803385111_138375.0569.0DomainYEATS
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511295_300375.0569.0MotifNuclear localization signal
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511295_300375.0569.0MotifNuclear localization signal
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511106_108375.0569.0RegionHistone H3K9cr binding
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511106_109375.0569.0RegionXL-07i binding%3B inhibitor
HgeneMLLT3chr9:20413718chr11:118355576ENST0000038033851156_58375.0569.0RegionXL-07i binding%3B inhibitor
HgeneMLLT3chr9:20413718chr11:118355576ENST0000038033851178_80375.0569.0RegionHistone H3K9cr binding
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511106_108375.0569.0RegionHistone H3K9cr binding
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511106_109375.0569.0RegionXL-07i binding%3B inhibitor
HgeneMLLT3chr9:20413718chr11:118359328ENST0000038033851156_58375.0569.0RegionXL-07i binding%3B inhibitor
HgeneMLLT3chr9:20413718chr11:118359328ENST0000038033851178_80375.0569.0RegionHistone H3K9cr binding
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351046_10610.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351249_12720.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351278_13020.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351303_13170.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351822_18470.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035184_2030.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035204_2260.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352096_21180.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352146_21740.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352189_22320.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352275_23200.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035236_2530.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352402_24180.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352419_24450.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352526_25940.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352721_27460.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352747_27840.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352785_28210.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353011_30640.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353166_31830.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353195_32220.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353230_32440.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035325_3510.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353464_35300.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353563_36060.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000035452003537_580.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035445_4950.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035535_5560.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035557_5760.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035713_7310.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035747_7800.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035798_8450.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000035452003581_1030.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035846_8980.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361822_18471406.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362096_21181406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362146_21741406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362189_22321406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362275_23201406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362402_24181406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362419_24451406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362526_25941406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362721_27461406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362747_27841406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362785_28211406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363011_30641406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363166_31831406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363195_32221406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363230_32441406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363464_35301406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363563_36061406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361822_18471406.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362096_21181406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362146_21741406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362189_22321406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362275_23201406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362402_24181406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362419_24451406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362526_25941406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362721_27461406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362747_27841406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362785_28211406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363011_30641406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363166_31831406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363195_32221406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363230_32441406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363464_35301406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363563_36061406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351822_18471406.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352096_21181406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352146_21741406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352189_22321406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352275_23201406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352402_24181406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352419_24451406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352526_25941406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352721_27461406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352747_27841406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352785_28211406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353011_30641406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353166_31831406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353195_32221406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353230_32441406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353464_35301406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353563_36061406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361822_18471444.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362096_21181444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362146_21741444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362189_22321444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362275_23201444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362402_24181444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362419_24451444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362526_25941444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362721_27461444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362747_27841444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362785_28211444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363011_30641444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363166_31831444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363195_32221444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363230_32441444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363464_35301444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363563_36061444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361822_18471444.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362096_21181444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362146_21741444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362189_22321444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362275_23201444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362402_24181444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362419_24451444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362526_25941444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362721_27461444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362747_27841444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362785_28211444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363011_30641444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363166_31831444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363195_32221444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363230_32441444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363464_35301444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363563_36061444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035169_1800.03932.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035217_2270.03932.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035301_3090.03932.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351703_17480.03932.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352018_20740.03932.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353666_37470.03932.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353829_39450.03932.0DomainSET
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353953_39690.03932.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361703_17481406.03970.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362018_20741406.03970.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363666_37471406.03970.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363829_39451406.03970.0DomainSET
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363953_39691406.03970.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361703_17481406.03973.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362018_20741406.03973.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363666_37471406.03973.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363829_39451406.03973.0DomainSET
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363953_39691406.03973.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351703_17481406.03932.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352018_20741406.03932.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353666_37471406.03932.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353829_39451406.03932.0DomainSET
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353953_39691406.03932.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361703_17481444.03970.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362018_20741444.03970.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363666_37471444.03970.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363829_39451444.03970.0DomainSET
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363953_39691444.03970.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361703_17481444.03973.0DomainBromo%3B divergent
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362018_20741444.03973.0DomainFYR N-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363666_37471444.03973.0DomainFYR C-terminal
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363829_39451444.03973.0DomainSET
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363953_39691444.03973.0DomainPost-SET
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035123_1340.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035147_1520.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200356_250.03932.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351038_10660.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351106_11660.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351200_13750.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035132_2530.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351663_17130.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351806_18690.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351_1080.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352081_21330.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352145_22320.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352275_23330.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352373_24600.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352475_26180.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352647_26750.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352713_28210.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200352961_30640.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035301_3520.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353166_32440.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353464_36080.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353620_36430.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353785_38080.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200353906_39070.03932.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035445_5850.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035713_7800.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000354520035798_9490.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361663_17131406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361806_18691406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362081_21331406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362145_22321406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362275_23331406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362373_24601406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362475_26181406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362647_26751406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362713_28211406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068362961_30641406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363166_32441406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363464_36081406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363620_36431406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363785_38081406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068363906_39071406.03970.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361663_17131406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361806_18691406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362081_21331406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362145_22321406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362275_23331406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362373_24601406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362475_26181406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362647_26751406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362713_28211406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588362961_30641406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363166_32441406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363464_36081406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363620_36431406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363785_38081406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588363906_39071406.03973.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351663_17131406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351806_18691406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352081_21331406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352145_22321406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352275_23331406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352373_24601406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352475_26181406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352647_26751406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352713_28211406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208352961_30641406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353166_32441406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353464_36081406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353620_36431406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353785_38081406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208353906_39071406.03932.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361663_17131444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361806_18691444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362081_21331444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362145_22321444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362275_23331444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362373_24601444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362475_26181444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362647_26751444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362713_28211444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069362961_30641444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363166_32441444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363464_36081444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363620_36431444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363785_38081444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069363906_39071444.03970.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361663_17131444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361806_18691444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362081_21331444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362145_22321444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362275_23331444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362373_24601444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362475_26181444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362647_26751444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362713_28211444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589362961_30641444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363166_32441444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363464_36081444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363620_36431444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363785_38081444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589363906_39071444.03973.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351147_11950.03932.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351431_14820.03932.0Zinc fingerPHD-type 1
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351479_15330.03932.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351566_16270.03932.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351870_19100.03932.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118355576ENST000003545200351931_19780.03932.0Zinc fingerPHD-type 4
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361431_14821406.03970.0Zinc fingerPHD-type 1
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361479_15331406.03970.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361566_16271406.03970.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361870_19101406.03970.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361931_19781406.03970.0Zinc fingerPHD-type 4
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361431_14821406.03973.0Zinc fingerPHD-type 1
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361479_15331406.03973.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361566_16271406.03973.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361870_19101406.03973.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361931_19781406.03973.0Zinc fingerPHD-type 4
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351431_14821406.03932.0Zinc fingerPHD-type 1
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351479_15331406.03932.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351566_16271406.03932.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351870_19101406.03932.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351931_19781406.03932.0Zinc fingerPHD-type 4
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361479_15331444.03970.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361566_16271444.03970.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361870_19101444.03970.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361931_19781444.03970.0Zinc fingerPHD-type 4
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361479_15331444.03973.0Zinc fingerPHD-type 2
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361566_16271444.03973.0Zinc fingerPHD-type 3
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361870_19101444.03973.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361931_19781444.03973.0Zinc fingerPHD-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511373_403375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511414_428375.0569.0Compositional biasAcidic residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511441_461375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511373_403375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511414_428375.0569.0Compositional biasAcidic residues
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511441_461375.0569.0Compositional biasPolar residues
HgeneMLLT3chr9:20413718chr11:118355576ENST00000380338511137_475375.0569.0RegionDisordered
HgeneMLLT3chr9:20413718chr11:118359328ENST00000380338511137_475375.0569.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361046_10611406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361249_12721406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361278_13021406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361303_13171406.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836184_2031406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836204_2261406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836236_2531406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836325_3511406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000038950683637_581406.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836445_4951406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836535_5561406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836557_5761406.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836713_7311406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836747_7801406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836798_8451406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000038950683681_1031406.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836846_8981406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361046_10611406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361249_12721406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361278_13021406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361303_13171406.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836184_2031406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836204_2261406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836236_2531406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836325_3511406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000053435883637_581406.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836445_4951406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836535_5561406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836557_5761406.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836713_7311406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836747_7801406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836798_8451406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST0000053435883681_1031406.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836846_8981406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351046_10611406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351249_12721406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351278_13021406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351303_13171406.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835184_2031406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835204_2261406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835236_2531406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835325_3511406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000035452083537_581406.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835445_4951406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835535_5561406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835557_5761406.03932.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835713_7311406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835747_7801406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835798_8451406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000035452083581_1031406.03932.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835846_8981406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361046_10611444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361249_12721444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361278_13021444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361303_13171444.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936184_2031444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936204_2261444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936236_2531444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936325_3511444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000038950693637_581444.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936445_4951444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936535_5561444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936557_5761444.03970.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936713_7311444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936747_7801444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936798_8451444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000038950693681_1031444.03970.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936846_8981444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361046_10611444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361249_12721444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361278_13021444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361303_13171444.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936184_2031444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936204_2261444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936236_2531444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936325_3511444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000053435893637_581444.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936445_4951444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936535_5561444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936557_5761444.03973.0Compositional biasPro residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936713_7311444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936747_7801444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936798_8451444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST0000053435893681_1031444.03973.0Compositional biasPolar residues
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936846_8981444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836169_1801406.03970.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836217_2271406.03970.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836301_3091406.03970.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836169_1801406.03973.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836217_2271406.03973.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836301_3091406.03973.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835169_1801406.03932.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835217_2271406.03932.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835301_3091406.03932.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936169_1801444.03970.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936217_2271444.03970.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936301_3091444.03970.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936169_1801444.03973.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936217_2271444.03973.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936301_3091444.03973.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836123_1341406.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836147_1521406.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068366_251406.03970.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836123_1341406.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836147_1521406.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588366_251406.03973.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835123_1341406.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835147_1521406.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208356_251406.03932.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936123_1341444.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936147_1521444.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069366_251444.03970.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936123_1341444.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936147_1521444.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589366_251444.03973.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361038_10661406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361106_11661406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361200_13751406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836132_2531406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361_1081406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836301_3521406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836445_5851406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836713_7801406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000389506836798_9491406.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361038_10661406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361106_11661406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361200_13751406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836132_2531406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361_1081406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836301_3521406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836445_5851406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836713_7801406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST00000534358836798_9491406.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351038_10661406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351106_11661406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351200_13751406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835132_2531406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351_1081406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835301_3521406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835445_5851406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835713_7801406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000354520835798_9491406.03932.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361038_10661444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361106_11661444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361200_13751444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936132_2531444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361_1081444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936301_3521444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936445_5851444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936713_7801444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000389506936798_9491444.03970.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361038_10661444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361106_11661444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361200_13751444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936132_2531444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361_1081444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936301_3521444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936445_5851444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936713_7801444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118359328ENST00000534358936798_9491444.03973.0RegionDisordered
TgeneKMT2Achr9:20413718chr11:118355576ENST000003895068361147_11951406.03970.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118355576ENST000005343588361147_11951406.03973.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000003545208351147_11951406.03932.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361147_11951444.03970.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000003895069361431_14821444.03970.0Zinc fingerPHD-type 1
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361147_11951444.03973.0Zinc fingerCXXC-type
TgeneKMT2Achr9:20413718chr11:118359328ENST000005343589361431_14821444.03973.0Zinc fingerPHD-type 1


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1220) >>>1220.pdbFusion protein BP residue: 372
CIF file (1220) >>>1220.cif
MLLT3chr920413718-KMT2Achr11118359328
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVF
HLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYD
LFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH
KEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAF
KEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSS
EALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLP
PFDDIVDPNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLC
DKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCV
NCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDL
NPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTS
VLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVK
KSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKK
IIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQ
CALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVH
MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKV
YCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMM
IGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIV
ECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSP
DRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTT
HEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRN
NVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVT
VGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHN
VAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHL
RGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSS
RDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPE
YMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKV
TLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQ
PSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSAR
ARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLS
TSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDD
GTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSV
GHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLD
TYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSS
ELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFE
LPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSES
DPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDL
TRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLK
PATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVL
GPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSS
FPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRP
ISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLG
SLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQD
TSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGT
PDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITA
ASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDL
DSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSG
QRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQ
ETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQN
PANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFE
ISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGI
LHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRK
SAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRH
LKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKRE
KYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDG
2897
3D view using mol* of 1220 (AA BP:372)
PDB file (1221)MLLT3chr920413718-KMT2Achr11118359328
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEK
VVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRF
DYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLM
KEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPK
MAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKS
TLPPFDDIVDPNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLED
QLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPT
KKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFC
PLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAY
TCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKP
PDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGN
YTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWF
SVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPL
MKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIED
NRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLK
NVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENI
HMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTC
KIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISP
PSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPT
PTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTY
SRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRT
VVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGS
AHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPH
LHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVL
TPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRT
VKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGP
VAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRR
SARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGAD
DLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDG
VDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTK
SSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKN
LLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEE
QFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVAS
SESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNN
QDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPP
HLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNT
SVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAAT
QSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLK
KRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLL
DLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRL
LGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAA
ITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQ
RDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSP
SSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHI
PDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQV
TQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGL
VFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRM
LGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR
FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTD
KREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVIN
IDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN
2900
PDB file (1222)MLLT3chr920413718-KMT2Achr11118359328
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVF
HLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYD
LFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH
KEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAF
KEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSS
EALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLP
PFDDIVDPNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLC
DKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAY
TCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKP
PDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGN
YTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWF
SVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPL
MKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIED
NRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLK
NVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENI
HMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTC
KIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISP
PSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPT
PTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTY
SRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRT
VVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGS
AHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPH
LHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVL
TPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRT
VKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGP
VAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRR
SARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGAD
DLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDG
VDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTK
SSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKN
LLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEE
QFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVAS
SESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNN
QDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPP
HLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNT
SVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAAT
QSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLK
KRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLL
DLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRL
LGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAA
ITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQ
RDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSP
SSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHI
PDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQV
TQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGL
VFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRM
LGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR
FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTD
KREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVIN
IDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN
2900
PDB file (1225) >>>1225.pdbFusion protein BP residue: 375
CIF file (1225) >>>1225.cif
MLLT3chr920413718-KMT2Achr11118359328
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEK
VVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRF
DYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLM
KEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPK
MAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKS
TLPPFDDIVDPNDSDVEENISSKSDFVYCQVCCEPFHKFCLEENERPLED
QLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPT
KKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFC
PLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPES
VAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQA
AKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMD
QGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVF
PWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQ
PPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPG
IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDG
SLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF
LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEP
ENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCV
YTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEI
ISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAG
SPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTG
NTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNL
QRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSS
EGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALS
FPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE
HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMD
EVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPR
KRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPG
DGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRY
PRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVD
GADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQ
LDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEH
VTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPS
DKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES
PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSIS
AEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKS
VASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGH
GNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQT
TPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVME
TNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFP
AATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSS
GLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHP
SLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT
STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTN
PRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPS
TAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIH
SSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSP
SSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSE
AHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPE
VQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPK
KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNG
LRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPM
PMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSI
QTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSR
VINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRK
2903
3D view using mol* of 1225 (AA BP:375)
PDB file (1230) >>>1230.pdbFusion protein BP residue: 372
CIF file (1230) >>>1230.cif
MLLT3chr920413718-KMT2Achr11118355576
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVF
HLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYD
LFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH
KEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAF
KEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSS
EALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLP
PFDDIVDPNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVC
FLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHV
CGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCK
SCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESK
MMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRL
ALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRS
SPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKII
QAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSS
NSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGE
PDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSA
NDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCE
FCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGE
VVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGIL
NDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDIN
STVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSC
YYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLS
SGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTAT
DLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSS
SSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQ
VHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTD
STQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCK
ETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSS
DKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQ
SKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQ
SNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPL
YGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNF
TRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATT
RKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCH
SVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSD
NNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLD
SNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVL
TTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPT
PEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVP
VSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQN
MQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTG
LNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGL
LIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKL
APSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPN
IIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGL
ASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIK
ASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQT
TGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFT
QTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPT
KPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTP
GAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKT
VEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAE
SIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQL
SGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASK
HRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVY
RSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYM
FRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKI
2935
3D view using mol* of 1230 (AA BP:372)
PDB file (1231)MLLT3chr920413718-KMT2Achr11118355576
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEK
VVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRF
DYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLM
KEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPK
MAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKS
TLPPFDDIVDPNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPR
VVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKF
CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCV
RCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDY
ESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAE
WRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIP
SRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIV
KIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNK
VSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKG
PGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGD
DSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQL
RCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLI
KGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCL
GILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEP
DINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTS
GSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDP
LLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTG
TATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLD
GSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKL
APQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQ
HTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKK
SCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNN
VSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMEN
ESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQ
DSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGL
TPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYY
YNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVT
ATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMD
NCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKS
DSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGL
GLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDL
SVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGV
DPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGL
QVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVV
NQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTL
TTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP
SGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKN
KKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRT
VPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSV
SGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNL
LIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPS
TQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVS
NFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVP
GPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGT
GTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAE
PKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQI
CAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLI
EQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFL
ASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAV
GVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG
CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM
2938
PDB file (1232)MLLT3chr920413718-KMT2Achr11118355576
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVF
HLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYD
LFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH
KEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAF
KEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSS
EALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLP
PFDDIVDPNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPRVVC
FLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHV
CGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCK
SCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESK
MMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAE
WRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIP
SRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIV
KIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNK
VSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKG
PGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGD
DSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQL
RCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLI
KGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCL
GILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEP
DINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTS
GSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDP
LLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTG
TATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLD
GSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKL
APQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQ
HTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKK
SCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNN
VSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMEN
ESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQ
DSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGL
TPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYY
YNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVT
ATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMD
NCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKS
DSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGL
GLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDL
SVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGV
DPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGL
QVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVV
NQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTL
TTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP
SGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKN
KKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRT
VPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSV
SGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNL
LIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPS
TQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVS
NFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVP
GPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGT
GTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAE
PKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQI
CAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLI
EQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFL
ASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAV
GVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG
CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM
2938
PDB file (1235)MLLT3chr920413718-KMT2Achr11118355576
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEK
VVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRF
DYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLM
KEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPK
MAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKS
TLPPFDDIVDPNDSDVEENISSKSDEDCEAENVWEMGGLGILTSVPITPR
VVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKF
CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCV
RCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDY
ESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERH
PAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEE
SIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSD
DIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWE
PNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPK
PKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLT
YGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG
KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHR
DLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTI
DCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPV
VEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHS
QTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTV
GDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVS
TTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNS
HLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGI
PKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND
RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQK
GKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRP
CNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLK
MENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNT
SCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMF
FGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDD
LYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDT
SVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP
KMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL
LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLG
EGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELP
SDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLS
PGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSST
PGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKL
IVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGG
LTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNIS
NPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQT
RKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS
HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS
GSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSI
SNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICV
LPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGP
QVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASP
SVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLT
SGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQE
SAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDG
FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV
FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMF
NFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSK
EAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSK
GIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVI
2941


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MLLT3_pLDDT.png
all structure
all structure
KMT2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MLLT3_KMT2A_1220_pLDDT.png (AA BP:372)
all structure
MLLT3_KMT2A_1220_pLDDT_and_active_sites.png (AA BP:372)
all structure
MLLT3_KMT2A_1220_violinplot.png (AA BP:372)
all structure
MLLT3_KMT2A_1222_pLDDT_and_active_sites.png (AA BP:)
all structure
MLLT3_KMT2A_1222_violinplot.png (AA BP:)
all structure
MLLT3_KMT2A_1225_pLDDT.png (AA BP:375)
all structure
MLLT3_KMT2A_1225_pLDDT_and_active_sites.png (AA BP:375)
all structure
MLLT3_KMT2A_1225_violinplot.png (AA BP:375)
all structure
MLLT3_KMT2A_1230_pLDDT.png (AA BP:372)
all structure
MLLT3_KMT2A_1230_pLDDT_and_active_sites.png (AA BP:372)
all structure
MLLT3_KMT2A_1230_violinplot.png (AA BP:372)
all structure
MLLT3_KMT2A_1231_pLDDT_and_active_sites.png (AA BP:)
all structure
MLLT3_KMT2A_1231_violinplot.png (AA BP:)
all structure
MLLT3_KMT2A_1232_pLDDT_and_active_sites.png (AA BP:)
all structure
MLLT3_KMT2A_1232_violinplot.png (AA BP:)
all structure
MLLT3_KMT2A_1235_pLDDT_and_active_sites.png (AA BP:)
all structure
MLLT3_KMT2A_1235_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
MLLT3_KMT2A_1220.png
all structure
MLLT3_KMT2A_1225.png
all structure
MLLT3_KMT2A_1230.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
12201.0133441.0441249.2060.650.6940.8660.5260.9590.5480.833Chain A: 9,11,12,13,30,32,33,34,35,38,39,40,41,42,
66,67,68,69,79,98,100,102,112,113,114,115,116,377,
391,392,393,394,395,398,400,401,402,403,404,405,40
7,408,409,411,417,422,423,424,425,427,428,429,430,
431,432,446,451,452,453,457,458,459,460,461,462,46
3,465,467,481,482,500,501,502
12221.0111491.044432.180.5780.6860.8520.4080.9430.4330.89Chain A: 141,143,389,391,392,393,394,395,396,397,3
98,401,402,403,404,405,407,408,409,411,417,422,423
,425,430,431,432
12250.98762011.0139691.1450.64420.66860.87140.35591.00370.35460.8871Chain A: 2705,2706,2707,2708,2709,2710,2711,2712,2
772,2773,2774,2775,2792,2802,2806,2813,2814,2816,2
817,2818,2819,2820,2821,2831,2837,2838,2839,2840,2
841,2845,2847,2848,2849,2850,2851,2860,2876,2877,2
878,2879,2880,2890,2891,2892,2893,2902
12250.868610.892230.4960.6160.6420.8290.8340.6971.1971.224Chain A: 9,10,11,12,13,14,15,1736,1739,1740,1743,1
747,1759
12301.0461810.92453.1030.5520.7661.0430.1581.4720.1080.57Chain A: 381,382,383,384,401,416,417,419,443,444,4
45,446,447,454,455,989,992,1007,1008,1009,1010,101
9,1606,1607,1608,1609,2679,2680,2681,2684,2685,268
7,2688,2689,2690,2691,2694,2697,2708,2709,2710,271
2
12311.0292661.053564.2350.5050.7270.920.5810.990.5860.635Chain A: 432,433,434,435,436,438,439,442,443,444,4
45,446,448,449,450,452,458,463,464,465,466,468,470
,471,472,473,487,492,493,494,2676,2677,2678,2679
12321.0583031.05615.6850.4760.7841.0030.5831.1060.5270.789Chain A: 102,105,108,110,112,113,189,190,191,192,3
70,371,372,373,374,375,376,379,380,383,385,386,387
,389,861,863,864,882,884,886,888,967,969,970,971,9
72,973,974,975,976,979,992,2693,2695,2698,2716,271
7,2718
12351.034771.0291166.20.4730.7420.9720.6081.0930.5560.992Chain A: 366,368,369,370,371,372,373,374,375,376,3
77,378,379,383,386,388,389,390,392,406,407,863,864
,866,867,887,889,891,970,971,972,973,974,975,976,9
77,978,979,982,983,985,986,988,991,993,1003,2193,2
194,2195,2196,2197,2198,2696,2697,2698,2701,2702,2
705,2706,2717,2718,2719,2720,2721

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
1231ZINC000085537017DB06441Cangrelor-7.21673-9.44303
1231ZINC000013585233DB00360Sapropterin-6.7936-8.8205
1231ZINC000001550477DB01259Lapatinib-8.66897-8.75777
1231ZINC000004097344DB01167Itraconazole-8.51832-8.53992
1231ZINC000004214955DB06769Bendamustine-8.03484-8.47874
1231ZINC000008577218DB00158Folic acid-7.11012-8.45482
1231ZINC000002008866DB00601Linezolid-8.37085-8.37085
1231ZINC000000121541DB00643Mebendazole-7.59114-8.24934
1231ZINC000003830500DB00567Cephalexin-7.61036-8.24816
1231ZINC000004474443DB01150Cefprozil-7.42595-8.15665
1231ZINC000000403010DB00598Labetalol-6.15845-8.09625
1231NetarsudilDB00598-8.01802-8.02912
1231ZINC000000897408DB01128Bicalutamide-8.01096-8.01096
1231ZINC000001997125DB08910Pomalidomide-8.0098-8.0098
1231ZINC000008383240DB08933Luliconazole-7.95747-7.95747
1231ZINC000003830391DB01140Cefadroxil-7.22371-7.94771
1231ZINC000043206370DB11793Niraparib-7.87384-7.87384
1231ZINC000001996784DB08893Mirabegron-7.69985-7.86785
1231ZINC000003922770DB06211Doripenem-7.41698-7.83858
1231ZINC000000403566DB01058Praziquantel-7.82178-7.82178

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000085537017DB06441CangrelorSmall moleculeCSCCNC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC(F)(F)F)=N1Approved
ZINC000001550477DB01259LapatinibSmall moleculeCS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1Approved|Investigational
ZINC000004097344DB01167ItraconazoleSmall moleculeCCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1Approved|Investigational
ZINC000004214955DB06769BendamustineSmall moleculeCN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCClApproved|Investigational
ZINC000008577218DB00158Folic acidSmall moleculeNC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1Approved|Nutraceutical|Vet_approved
ZINC000002008866DB00601LinezolidSmall moleculeCC(=O)NC[C@H]1CN(C(=O)O1)C1=CC(F)=C(C=C1)N1CCOCC1Approved|Investigational
ZINC000000121541DB00643MebendazoleSmall moleculeCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1Approved|Vet_approved
ZINC000003830500DB00567CephalexinSmall molecule[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=OApproved|Investigational|Vet_approved
ZINC000000897408DB01128BicalutamideSmall moleculeCC(O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)FApproved
ZINC000008383240DB08933LuliconazoleSmall moleculeClC1=CC(Cl)=C(C=C1)[C@@H]1CSC(S1)=C(C#N)N1C=CN=C1Approved
ZINC000003830391DB01140CefadroxilSmall molecule[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=OApproved|Vet_approved|Withdrawn
ZINC000043206370DB11793NiraparibSmall moleculeNC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1Approved|Investigational
ZINC000001996784DB08893MirabegronSmall moleculeNC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1Approved
ZINC000003922770DB06211DoripenemSmall molecule[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=OApproved|Investigational
ZINC000000403566DB01058PraziquantelSmall moleculeO=C(C1CCCCC1)N1CC2N(CCC3=CC=CC=C23)C(=O)C1Approved|Investigational|Vet_approved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000085537017776.3537.43927.054287.655393.58554.42191.3941783.369320.68.4621031
ZINC000085537017776.3535.036918.307262.294312.53251.82291.6611775.566320.68.6031031
ZINC000013585233241.2497.548455.149158.349273.98222.8190749.38778.97.637228.32310
ZINC000013585233241.24911.056455.167158.05274.48622.6310750.26378.97.777228.24910
ZINC000001550477581.068.763984.429219.392136.563520.447108.0271738.43918.258.353175.11221
ZINC000001550477581.068.228914.704239.85389.107476.75108.9941676.88418.258.025182.62721
ZINC000004097344705.6427.2011108.356441.22893.993451.204121.9312059.909010.258.234176.93131
ZINC000004097344705.6429.2311077.094456.70894.986424.927100.4732039.22010.258.496177.44131
ZINC000004214955358.2673.446660.401298.857122.7892.485146.2791135.21914.58.979395.31601
ZINC000004214955358.2675.922650.52300.031115.16497.2138.1251124.97914.58.29396.40301
ZINC000008577218441.40213.51755.446101.238451.657202.55101308.0746.2512.758.351021
ZINC000008577218441.40214.14754.923100.926451.592202.40501306.4516.2512.758.3021021
ZINC000008577218441.40214.323755.349100.67452.288202.39101307.5776.2512.758.3991021
ZINC000002008866337.3511.384587.905370.55399.01286.52531.8151034.05818.78.411380.73200
ZINC000000121541295.2976.562576.16198.468169.387308.3060957.18158.911383.64100
ZINC000000121541295.2972.873577.03396.773172.83307.430959.022038.668388.18700
ZINC000000121541295.29710.919575.19998.469170.072306.6580956.419158.861383.46100
ZINC000003830500347.3883.532589.473171.873223.424174.5419.6371035.6753.257.259.332126.95101
ZINC000003830500347.3887.582608.334170.735219.483186.49331.6231064.693.257.259.268229.46201
ZINC000004474443389.4255.794646.882196.806278.227152.33819.5111147.6474.2589.006117.18101
ZINC000004474443389.4258.143664.86196.035273.731163.8431.2551174.6394.2588.985119.44301
ZINC000000403010328.415.633665.048169.772199.786295.4901141.27145.459.068270.57200
ZINC000000403010328.418.153662.671168.348200.011294.31201140.63345.459.267270.52100
ZINC000000897408430.37312.424661.08897.712165.71242.801154.8651170.18817.759.392388.51101
ZINC000001997125273.2486.886463.2689.305237.368136.5870796.928268.695259.94500
ZINC000008383240354.2718.408573.52446.92694.828243.441188.329977.448039.355110001
ZINC000003830391363.3874.293599.921172.876276.489135.41415.1421057.3254.2588.995114.68201
ZINC000003830391363.3877.919618.792171.183273.319143.05431.2361086.8094.2589.217116.58101
ZINC000043206370320.3933.754607.688185.794143.417278.47601055.805358.546376.7200
ZINC000001996784396.5065.759766.121167.737163.909381.05653.421313.34757.78.494375.07100
ZINC000001996784396.5065.465768.333168.285165.496381.31553.2371317.85557.78.411374.8900
ZINC000003922770420.4989.875638.137304.768322.1220.93510.3131181.25859.79.2621011
ZINC000003922770420.49810.112669.605312.199335.5840.82221.0011208.70159.79.2091011
ZINC000000403566312.4118.136587.262357.48379.355150.42401050.632069.514385.52600


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000085537017CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)(O)O[P@](=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O0.0178895410.259362736
ZINC000013585233C[C@H](O)[C@H](O)[C@H]1CNc2nc(N)[nH]c(=O)c2N10.0314105690.318425003
ZINC000001550477CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o10.187595690.281219747
ZINC000004097344CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O0.0443632860.444547752
ZINC000004214955Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc210.207953310.394281261
ZINC000008577218Nc1nc(O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n10.1276881860.392534973
ZINC000002008866CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O10.1721880250.409724838
ZINC000000121541COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]10.2096963420.592445172
ZINC000003830500CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC10.0939986080.215846284
ZINC000004474443C/C=CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC10.0675634840.161076886
ZINC000000403010C[C@@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000000897408C[C@@](O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c10.1418939280.460514639
ZINC000001997125Nc1cccc2c1C(=O)N([C@@H]1CCC(=O)NC1=O)C2=O0.1491246130.442164593
ZINC000008383240N#C/C(=C1/SC[C@H](c2ccc(Cl)cc2Cl)S1)n1ccnc10.0607268710.27621319
ZINC000003830391CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC10.08228260.17802178
ZINC000043206370NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc120.158103060.243905197
ZINC000001996784Nc1nc(CC(=O)Nc2ccc(CCNC[C@H](O)c3ccccc3)cc2)cs10.205681060.138337618
ZINC000003922770C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]120.0292263440.310060248
ZINC000000403566O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3[C@H]2C10.1809979670.220112088


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KMT2APPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,
MLLT3APPBP2, MCM6, BCOR, RBM48, EEF1A1, PTN, LRIF1, DOT1L, SGK1, AFF4, AFF1, CDK9, AFF3, ACACA, SIRT1, CCNT1, NIPBL, EAF1, ELL3, PCGF1, MLLT1, EEF2, ELL, MLLT10, CCNT2, RNF2, KMT2A, CHD4, ELL2, PAF1, Cbx8, APP, CDK6, MED26, HSP90B1, EXOSC3, FAM9A, EDA, DENND2D, EPB41L3, XPO1, Aff1, Mllt1, H3F3A, PIP4K2A, EPB41L2, CAMKV, MLLT6, SNX24, BPIFB1, MDK, PES1, EPB41L5, ARRB2, ORF35, ALKBH4, LRRK2, HIST1H3A, KIAA1429, HHT1, DYRK1A, MIIP, VAX1, ZNF572, CCAR2, STH1, TULP3, COIL, FGF11, CT45A5, FGF12, RASA2, NDUFAF4, CREB3L3, SMOC1, SYT2, RNF151, PLCD4, CEP89, DAXX, EPB41L1, PLCD3, KCNE3, SULF2, SKP1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MLLT3all structure
KMT2Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MLLT3-KMT2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
MLLT3KMT2ADot1l InhibitorPubMed31701557

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Related Diseases to MLLT3-KMT2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
MLLT3KMT2AAcute Monocytic LeukemiaPubMed31701557
MLLT3KMT2AAcute Myeloid LeukemiaMyCancerGenome
MLLT3KMT2ALung AdenocarcinomaMyCancerGenome
MLLT3KMT2ABladder Urothelial CarcinomaMyCancerGenome
MLLT3KMT2ABreast Invasive Ductal CarcinomaMyCancerGenome
MLLT3KMT2AColon AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT3C0005586Bipolar Disorder1PSYGENET
TgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
TgeneKMT2AC0023418leukemia2CTD_human
TgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
TgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneKMT2AC0023470Myeloid Leukemia2CTD_human
TgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
TgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
TgeneKMT2AC0001418Adenocarcinoma1CTD_human
TgeneKMT2AC0004403Autosome Abnormalities1CTD_human
TgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneKMT2AC0005695Bladder Neoplasm1CTD_human
TgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
TgeneKMT2AC0008625Chromosome Aberrations1CTD_human
TgeneKMT2AC0023448Lymphoid leukemia1CTD_human
TgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
TgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
TgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
TgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
TgeneKMT2AC0036341Schizophrenia1PSYGENET
TgeneKMT2AC0038356Stomach Neoplasms1CTD_human
TgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
TgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
TgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
TgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
TgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
TgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
TgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
TgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
TgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
TgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneKMT2AC2239176Liver carcinoma1CTD_human
TgeneKMT2AC2930974Acute erythroleukemia1CTD_human
TgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human