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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MMP14-CUX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MMP14-CUX1
FusionPDB ID: 54402
FusionGDB2.0 ID: 54402
HgeneTgene
Gene symbol

MMP14

CUX1

Gene ID

4323

1523

Gene namematrix metallopeptidase 14cut like homeobox 1
SynonymsMMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRSCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

14q11.2

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionmatrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinaseprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2020032920200320
UniProtAcc

P50281

P39880

Ensembl transtripts involved in fusion geneENST idsENST00000548162, ENST00000311852, 
ENST00000292538, ENST00000437600, 
ENST00000560541, ENST00000292535, 
ENST00000360264, ENST00000393824, 
ENST00000425244, ENST00000546411, 
ENST00000547394, ENST00000549414, 
ENST00000550008, ENST00000556210, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 5=21026 X 23 X 9=5382
# samples 729
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5382*10)=-4.21401758562548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MMP14 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MMP14(23306134)-CUX1(101559394), # samples:1
Anticipated loss of major functional domain due to fusion event.MMP14-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MMP14-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MMP14-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MMP14-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP14

GO:0006508

proteolysis

15863497|24970228

HgeneMMP14

GO:0030307

positive regulation of cell growth

22065321

HgeneMMP14

GO:0030335

positive regulation of cell migration

22065321

HgeneMMP14

GO:0031638

zymogen activation

20666777


check buttonFusion gene breakpoints across MMP14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerSPNT_206MMP14chr14

23306134

+CUX1chr7

101559394

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311852MMP14chr1423306134+ENST00000437600CUX1chr7101559394+32043692402336698
ENST00000311852MMP14chr1423306134+ENST00000292538CUX1chr7101559394+32103692402342700

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54402_54402_1_MMP14-CUX1_MMP14_chr14_23306134_ENST00000311852_CUX1_chr7_101559394_ENST00000292538_length(amino acids)=700AA_BP=43
MTRWSRTMSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPERELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLL
KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIR
EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE
RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQL
EQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRI
TEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQE
LEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMG

--------------------------------------------------------------

>54402_54402_2_MMP14-CUX1_MMP14_chr14_23306134_ENST00000311852_CUX1_chr7_101559394_ENST00000437600_length(amino acids)=698AA_BP=43
MTRWSRTMSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPERELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLL
KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIR
EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE
RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQ
QLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE
AVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELE
AENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23306134/chr7:101559394)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP14

P50281

CUX1

P39880

FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140}.FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCUX1chr14:23306134chr7:101559394ENST0000029253502456_40710.01506.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST00000292538023502_55621.0679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000029253802367_45021.0679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000036026402456_40721.01517.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST00000393824022502_5560640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000039382402267_4500640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000042524402256_40721.0633.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST00000437600023502_55621.0677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000043760002367_45021.0677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000054641102456_40710.01404.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST00000547394022502_55621.0663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000054739402267_45021.0663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000054941402356_40710.01484.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000055000802256_40710.01450.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST0000055621002256_40710.01348.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr14:23306134chr7:101559394ENST000002925350241406_143810.01506.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000003602640241406_143821.01517.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000004252440221406_143821.0633.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000005464110241406_143810.01404.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000005494140231406_143810.01484.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000005500080221406_143810.01450.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000005562100221406_143810.01348.0Compositional biasNote=Ala-rich
TgeneCUX1chr14:23306134chr7:101559394ENST000002925350241117_120410.01506.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000002925350241244_130310.01506.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000292535024542_62910.01506.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000292535024934_102110.01506.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000003602640241117_120421.01517.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000003602640241244_130321.01517.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000360264024542_62921.01517.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000360264024934_102121.01517.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000004252440221117_120421.0633.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000004252440221244_130321.0633.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000425244022542_62921.0633.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000425244022934_102121.0633.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000005464110241117_120410.01404.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000005464110241244_130310.01404.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000546411024542_62910.01404.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000546411024934_102110.01404.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000005494140231117_120410.01484.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000005494140231244_130310.01484.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000549414023542_62910.01484.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000549414023934_102110.01484.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000005500080221117_120410.01450.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000005500080221244_130310.01450.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000550008022542_62910.01450.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000550008022934_102110.01450.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST000005562100221117_120410.01348.0DNA bindingCUT 3
TgeneCUX1chr14:23306134chr7:101559394ENST000005562100221244_130310.01348.0DNA bindingHomeobox
TgeneCUX1chr14:23306134chr7:101559394ENST00000556210022542_62910.01348.0DNA bindingCUT 1
TgeneCUX1chr14:23306134chr7:101559394ENST00000556210022934_102110.01348.0DNA bindingCUT 2
TgeneCUX1chr14:23306134chr7:101559394ENST00000292538023641_67821.0679.0Topological domainLumenal
TgeneCUX1chr14:23306134chr7:101559394ENST000003938240221_6190640.0Topological domainCytoplasmic
TgeneCUX1chr14:23306134chr7:101559394ENST00000393824022641_6780640.0Topological domainLumenal
TgeneCUX1chr14:23306134chr7:101559394ENST00000437600023641_67821.0677.0Topological domainLumenal
TgeneCUX1chr14:23306134chr7:101559394ENST00000547394022641_67821.0663.0Topological domainLumenal
TgeneCUX1chr14:23306134chr7:101559394ENST00000292538023620_64021.0679.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr14:23306134chr7:101559394ENST00000393824022620_6400640.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr14:23306134chr7:101559394ENST00000437600023620_64021.0677.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr14:23306134chr7:101559394ENST00000547394022620_64021.0663.0TransmembraneHelical%3B Anchor for type IV membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+11091_9836.0583.0MotifCysteine switch
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110316_36436.0583.0RepeatNote=Hemopexin 1
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110365_41036.0583.0RepeatNote=Hemopexin 2
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110412_46036.0583.0RepeatNote=Hemopexin 3
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110461_50836.0583.0RepeatNote=Hemopexin 4
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110112_54136.0583.0Topological domainExtracellular
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110563_58236.0583.0Topological domainCytoplasmic
HgeneMMP14chr14:23306134chr7:101559394ENST00000311852+110542_56236.0583.0TransmembraneHelical
TgeneCUX1chr14:23306134chr7:101559394ENST000002925380231_61921.0679.0Topological domainCytoplasmic
TgeneCUX1chr14:23306134chr7:101559394ENST000004376000231_61921.0677.0Topological domainCytoplasmic
TgeneCUX1chr14:23306134chr7:101559394ENST000005473940221_61921.0663.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MMP14
CUX1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MMP14-CUX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MMP14-CUX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource