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Fusion Protein:MMP2-DYNC1LI2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MMP2-DYNC1LI2 | FusionPDB ID: 54428 | FusionGDB2.0 ID: 54428 | Hgene | Tgene | Gene symbol | MMP2 | DYNC1LI2 | Gene ID | 4313 | 1783 |
| Gene name | matrix metallopeptidase 2 | dynein cytoplasmic 1 light intermediate chain 2 | |
| Synonyms | CLG4|CLG4A|MMP-2|MMP-II|MONA|TBE-1 | DNCLI2|LIC2 | |
| Cytomap | 16q12.2 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 72 kDa type IV collagenasecollagenase type IV-Amatrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)matrix metalloproteinase-2matrix metalloproteinase-IIneutrophil gelatinase | cytoplasmic dynein 1 light intermediate chain 2LIC-2LIC53/55dynein light intermediate chain 2, cytosolicdynein, cytoplasmic, light intermediate polypeptide 2 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q9H239 | O43237 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000219070, ENST00000437642, ENST00000543485, ENST00000570308, | ENST00000440564, ENST00000570201, ENST00000258198, ENST00000379482, ENST00000443351, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 8 X 2=128 | 7 X 6 X 6=252 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MMP2 [Title/Abstract] AND DYNC1LI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MMP2(55536800)-DYNC1LI2(66770147), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MMP2-DYNC1LI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MMP2-DYNC1LI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MMP2-DYNC1LI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MMP2-DYNC1LI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MMP2 | GO:0006508 | proteolysis | 15863497 |
| Fusion gene breakpoints across MMP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DYNC1LI2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-8530 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000570308 | MMP2 | chr16 | 55536800 | + | ENST00000258198 | DYNC1LI2 | chr16 | 66770147 | - | 6115 | 2336 | 535 | 3285 | 916 |
| ENST00000570308 | MMP2 | chr16 | 55536800 | + | ENST00000379482 | DYNC1LI2 | chr16 | 66770147 | - | 2437 | 2336 | 535 | 2436 | 634 |
| ENST00000570308 | MMP2 | chr16 | 55536800 | + | ENST00000443351 | DYNC1LI2 | chr16 | 66770147 | - | 3530 | 2336 | 535 | 3285 | 916 |
| ENST00000219070 | MMP2 | chr16 | 55536800 | + | ENST00000258198 | DYNC1LI2 | chr16 | 66770147 | - | 6167 | 2388 | 509 | 3337 | 942 |
| ENST00000219070 | MMP2 | chr16 | 55536800 | + | ENST00000379482 | DYNC1LI2 | chr16 | 66770147 | - | 2489 | 2388 | 509 | 2488 | 660 |
| ENST00000219070 | MMP2 | chr16 | 55536800 | + | ENST00000443351 | DYNC1LI2 | chr16 | 66770147 | - | 3582 | 2388 | 509 | 3337 | 942 |
| ENST00000543485 | MMP2 | chr16 | 55536800 | + | ENST00000258198 | DYNC1LI2 | chr16 | 66770147 | - | 5570 | 1791 | 71 | 2740 | 889 |
| ENST00000543485 | MMP2 | chr16 | 55536800 | + | ENST00000379482 | DYNC1LI2 | chr16 | 66770147 | - | 1892 | 1791 | 71 | 1891 | 607 |
| ENST00000543485 | MMP2 | chr16 | 55536800 | + | ENST00000443351 | DYNC1LI2 | chr16 | 66770147 | - | 2985 | 1791 | 71 | 2740 | 889 |
| ENST00000437642 | MMP2 | chr16 | 55536800 | + | ENST00000258198 | DYNC1LI2 | chr16 | 66770147 | - | 5827 | 2048 | 319 | 2997 | 892 |
| ENST00000437642 | MMP2 | chr16 | 55536800 | + | ENST00000379482 | DYNC1LI2 | chr16 | 66770147 | - | 2149 | 2048 | 319 | 2148 | 610 |
| ENST00000437642 | MMP2 | chr16 | 55536800 | + | ENST00000443351 | DYNC1LI2 | chr16 | 66770147 | - | 3242 | 2048 | 319 | 2997 | 892 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000570308 | ENST00000258198 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.00018472 | 0.9998153 |
| ENST00000570308 | ENST00000379482 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.003927904 | 0.99607205 |
| ENST00000570308 | ENST00000443351 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.001173582 | 0.99882644 |
| ENST00000219070 | ENST00000258198 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.000181453 | 0.9998186 |
| ENST00000219070 | ENST00000379482 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.006051298 | 0.9939487 |
| ENST00000219070 | ENST00000443351 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.001253381 | 0.99874663 |
| ENST00000543485 | ENST00000258198 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.00023808 | 0.9997619 |
| ENST00000543485 | ENST00000379482 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.004616544 | 0.99538344 |
| ENST00000543485 | ENST00000443351 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.001692835 | 0.9983071 |
| ENST00000437642 | ENST00000258198 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.00016612 | 0.9998338 |
| ENST00000437642 | ENST00000379482 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.00379934 | 0.9962006 |
| ENST00000437642 | ENST00000443351 | MMP2 | chr16 | 55536800 | + | DYNC1LI2 | chr16 | 66770147 | - | 0.00125737 | 0.99874264 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >54428_54428_1_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000219070_DYNC1LI2_chr16_66770147_ENST00000258198_length(amino acids)=942AA_BP=626 MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLD QNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGK YGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPD IDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKD FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALI YTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAG -------------------------------------------------------------- >54428_54428_2_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000219070_DYNC1LI2_chr16_66770147_ENST00000379482_length(amino acids)=660AA_BP=626 MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLD QNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGK YGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPD IDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKD -------------------------------------------------------------- >54428_54428_3_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000219070_DYNC1LI2_chr16_66770147_ENST00000443351_length(amino acids)=942AA_BP=626 MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLD QNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGK YGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPD IDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKD FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALI YTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAG -------------------------------------------------------------- >54428_54428_4_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000437642_DYNC1LI2_chr16_66770147_ENST00000258198_length(amino acids)=892AA_BP=576 MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTT EDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPR DKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVV CTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKI AILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGT -------------------------------------------------------------- >54428_54428_5_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000437642_DYNC1LI2_chr16_66770147_ENST00000379482_length(amino acids)=610AA_BP=576 MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTT EDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPR DKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR -------------------------------------------------------------- >54428_54428_6_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000437642_DYNC1LI2_chr16_66770147_ENST00000443351_length(amino acids)=892AA_BP=576 MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTT EDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPR DKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVV CTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKI AILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGT -------------------------------------------------------------- >54428_54428_7_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000543485_DYNC1LI2_chr16_66770147_ENST00000258198_length(amino acids)=889AA_BP=573 MNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDA FARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYC KFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDY DRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEH SQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKP MGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE VKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTK CDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAIL HENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVK -------------------------------------------------------------- >54428_54428_8_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000543485_DYNC1LI2_chr16_66770147_ENST00000379482_length(amino acids)=607AA_BP=573 MNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDA FARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYC KFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDY DRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEH SQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKP MGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE -------------------------------------------------------------- >54428_54428_9_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000543485_DYNC1LI2_chr16_66770147_ENST00000443351_length(amino acids)=889AA_BP=573 MNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDA FARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYC KFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDY DRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEH SQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKP MGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE VKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTK CDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAIL HENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVK -------------------------------------------------------------- >54428_54428_10_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000570308_DYNC1LI2_chr16_66770147_ENST00000258198_length(amino acids)=916AA_BP=600 MLLLSAPHVPRARREDSCWLTVWSWQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRK PKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSH FDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFR FQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRK WGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFD GIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQ RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSD EENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHF TTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPAR GPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMT -------------------------------------------------------------- >54428_54428_11_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000570308_DYNC1LI2_chr16_66770147_ENST00000379482_length(amino acids)=634AA_BP=600 MLLLSAPHVPRARREDSCWLTVWSWQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRK PKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSH FDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFR FQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRK WGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFD GIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQ RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQEGPLSNRVEQMRPR -------------------------------------------------------------- >54428_54428_12_MMP2-DYNC1LI2_MMP2_chr16_55536800_ENST00000570308_DYNC1LI2_chr16_66770147_ENST00000443351_length(amino acids)=916AA_BP=600 MLLLSAPHVPRARREDSCWLTVWSWQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRK PKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSH FDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFR FQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRK WGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFD GIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQ RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGVVKDFQDYMEPEEGCQGSPQRRGPLTSGSD EENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHF TTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPAR GPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMT -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:55536800/chr16:66770147) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MMP2 | DYNC1LI2 |
| FUNCTION: Can degrade casein. Could play a role in tissues homeostasis and repair. | FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 228_276 | 626.3333333333334 | 661.0 | Domain | Fibronectin type-II 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 286_334 | 626.3333333333334 | 661.0 | Domain | Fibronectin type-II 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 344_392 | 626.3333333333334 | 661.0 | Domain | Fibronectin type-II 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 228_276 | 576.3333333333334 | 611.0 | Domain | Fibronectin type-II 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 286_334 | 576.3333333333334 | 611.0 | Domain | Fibronectin type-II 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 344_392 | 576.3333333333334 | 611.0 | Domain | Fibronectin type-II 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 228_276 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 286_334 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 344_392 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 228_276 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 286_334 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 344_392 | 550.3333333333334 | 585.0 | Domain | Fibronectin type-II 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 100_107 | 626.3333333333334 | 661.0 | Motif | Cysteine switch |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 100_107 | 576.3333333333334 | 611.0 | Motif | Cysteine switch |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 100_107 | 550.3333333333334 | 585.0 | Motif | Cysteine switch |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 100_107 | 550.3333333333334 | 585.0 | Motif | Cysteine switch |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 110_221 | 626.3333333333334 | 661.0 | Region | Note=Collagenase-like 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 222_396 | 626.3333333333334 | 661.0 | Region | Note=Collagen-binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 397_465 | 626.3333333333334 | 661.0 | Region | Note=Collagenase-like 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 110_221 | 576.3333333333334 | 611.0 | Region | Note=Collagenase-like 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 222_396 | 576.3333333333334 | 611.0 | Region | Note=Collagen-binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 397_465 | 576.3333333333334 | 611.0 | Region | Note=Collagenase-like 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 110_221 | 550.3333333333334 | 585.0 | Region | Note=Collagenase-like 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 222_396 | 550.3333333333334 | 585.0 | Region | Note=Collagen-binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 397_465 | 550.3333333333334 | 585.0 | Region | Note=Collagenase-like 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 110_221 | 550.3333333333334 | 585.0 | Region | Note=Collagenase-like 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 222_396 | 550.3333333333334 | 585.0 | Region | Note=Collagen-binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 397_465 | 550.3333333333334 | 585.0 | Region | Note=Collagenase-like 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 472_516 | 626.3333333333334 | 661.0 | Repeat | Note=Hemopexin 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 517_563 | 626.3333333333334 | 661.0 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 565_613 | 626.3333333333334 | 661.0 | Repeat | Note=Hemopexin 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 472_516 | 576.3333333333334 | 611.0 | Repeat | Note=Hemopexin 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 517_563 | 576.3333333333334 | 611.0 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 472_516 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 1 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 472_516 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 1 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 414_660 | 626.3333333333334 | 661.0 | Region | Required for inhibitor TIMP2 binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 414_660 | 576.3333333333334 | 611.0 | Region | Required for inhibitor TIMP2 binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 414_660 | 550.3333333333334 | 585.0 | Region | Required for inhibitor TIMP2 binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 414_660 | 550.3333333333334 | 585.0 | Region | Required for inhibitor TIMP2 binding |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000219070 | + | 12 | 13 | 614_660 | 626.3333333333334 | 661.0 | Repeat | Note=Hemopexin 4 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 565_613 | 576.3333333333334 | 611.0 | Repeat | Note=Hemopexin 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000437642 | + | 12 | 13 | 614_660 | 576.3333333333334 | 611.0 | Repeat | Note=Hemopexin 4 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 517_563 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 565_613 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000543485 | + | 12 | 13 | 614_660 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 4 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 517_563 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 565_613 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 3 |
| Hgene | MMP2 | chr16:55536800 | chr16:66770147 | ENST00000570308 | + | 13 | 14 | 614_660 | 550.3333333333334 | 585.0 | Repeat | Note=Hemopexin 4 |
| Tgene | DYNC1LI2 | chr16:55536800 | chr16:66770147 | ENST00000258198 | 3 | 13 | 61_68 | 176.33333333333334 | 493.0 | Nucleotide binding | ATP |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MMP2 | |
| DYNC1LI2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MMP2-DYNC1LI2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MMP2-DYNC1LI2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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