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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MPP5-GPHN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MPP5-GPHN
FusionPDB ID: 54748
FusionGDB2.0 ID: 54748
HgeneTgene
Gene symbol

MPP5

GPHN

Gene ID

64398

10243

Gene namemembrane palmitoylated protein 5gephyrin
SynonymsPALS1GEPH|GPH|GPHRYN|HKPX1|MOCODC
Cytomap

14q23.3

14q23.3-q24.1

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardustgephyrin
Modification date2020031320200313
UniProtAcc

Q8N3R9

Q9NQX3

Ensembl transtripts involved in fusion geneENST idsENST00000554911, ENST00000261681, 
ENST00000555925, ENST00000556345, 
ENST00000305960, ENST00000315266, 
ENST00000459628, ENST00000478722, 
ENST00000543237, ENST00000544752, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 12=96042 X 51 X 15=32130
# samples 2362
** MAII scorelog2(23/960*10)=-2.06140054466414
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(62/32130*10)=-5.69550895508454
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MPP5 [Title/Abstract] AND GPHN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MPP5(67746254)-GPHN(67635650), # samples:3
GPHN(66975309)-MPP5(67736418), # samples:1
GPHN(67147903)-MPP5(67786947), # samples:1
Anticipated loss of major functional domain due to fusion event.MPP5-GPHN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-GPHN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-GPHN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-GPHN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPHN-MPP5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GPHN-MPP5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MPP5-GPHN seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MPP5-GPHN seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPHN

GO:0032324

molybdopterin cofactor biosynthetic process

26613940

TgeneGPHN

GO:0097112

gamma-aminobutyric acid receptor clustering

26613940


check buttonFusion gene breakpoints across MPP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPHN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A20W-01AMPP5chr14

67770316

-GPHNchr14

67576857

+
ChimerDB4BLCATCGA-FD-A3N6-01AMPP5chr14

67779427

-GPHNchr14

67646295

+
ChimerDB4BLCATCGA-FD-A3N6-01AMPP5chr14

67779427

+GPHNchr14

67646295

+
ChimerDB4BLCATCGA-FD-A3N6MPP5chr14

67779427

+GPHNchr14

67646294

+
ChimerDB4BRCATCGA-A2-A0YM-01AMPP5chr14

67708250

-GPHNchr14

67610079

+
ChimerDB4BRCATCGA-A2-A0YM-01AMPP5chr14

67708250

+GPHNchr14

67610079

+
ChimerDB4BRCATCGA-A2-A0YMMPP5chr14

67708250

+GPHNchr14

67610078

+
ChimerDB4COADTCGA-AU-6004-01AMPP5chr14

67708250

-GPHNchr14

67525366

+
ChimerDB4COADTCGA-AU-6004-01AMPP5chr14

67708250

+GPHNchr14

67525366

+
ChimerDB4COADTCGA-AU-6004MPP5chr14

67708250

+GPHNchr14

67525365

+
ChimerDB4ESCATCGA-R6-A6Y0-01BMPP5chr14

67784196

-GPHNchr14

67555700

+
ChimerDB4ESCATCGA-R6-A6Y0MPP5chr14

67784196

+GPHNchr14

67555699

+
ChimerDB4LUADTCGA-50-5946-01AMPP5chr14

67746254

-GPHNchr14

67635650

+
ChimerDB4LUADTCGA-50-5946-01AMPP5chr14

67746254

+GPHNchr14

67635650

+
ChimerDB4LUADTCGA-50-5946-01AMPP5chr14

67746254

+GPHNchr14

67646295

+
ChimerDB4LUADTCGA-50-5946-02AMPP5chr14

67746254

-GPHNchr14

67635650

+
ChimerDB4LUADTCGA-MP-A4SW-01AMPP5chr14

67759436

-GPHNchr14

67646295

+
ChimerDB4LUADTCGA-MP-A4SW-01AMPP5chr14

67759436

+GPHNchr14

67646295

+
ChimerDB4PRADTCGA-YJ-A8SW-01AMPP5chr14

67736500

-GPHNchr14

67147825

+
ChimerDB4READTCGA-F5-6814-01AMPP5chr14

67708250

-GPHNchr14

67346657

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261681MPP5chr1467784196+ENST00000315266GPHNchr1467555699+405720306613195844
ENST00000261681MPP5chr1467784196+ENST00000478722GPHNchr1467555699+406220306613195844
ENST00000555925MPP5chr1467784196+ENST00000315266GPHNchr1467555699+351114842172649810
ENST00000555925MPP5chr1467784196+ENST00000478722GPHNchr1467555699+351614842172649810
ENST00000261681MPP5chr1467759436+ENST00000315266GPHNchr1467646295+232912376611467268
ENST00000261681MPP5chr1467759436+ENST00000478722GPHNchr1467646295+233412376611467268
ENST00000555925MPP5chr1467759436+ENST00000315266GPHNchr1467646295+1783691217921234
ENST00000555925MPP5chr1467759436+ENST00000478722GPHNchr1467646295+1788691217921234
ENST00000261681MPP5chr1467746254+ENST00000315266GPHNchr1467635650+222410286611362233
ENST00000261681MPP5chr1467746254+ENST00000478722GPHNchr1467635650+222910286611362233
ENST00000555925MPP5chr1467746254+ENST00000315266GPHNchr1467635650+1678482217816199
ENST00000555925MPP5chr1467746254+ENST00000478722GPHNchr1467635650+1683482217816199
ENST00000261681MPP5chr1467770316-ENST00000315266GPHNchr1467576857+358017026612718685
ENST00000261681MPP5chr1467770316-ENST00000478722GPHNchr1467576857+358517026612718685
ENST00000555925MPP5chr1467770316-ENST00000315266GPHNchr1467576857+303411562172172651
ENST00000555925MPP5chr1467770316-ENST00000478722GPHNchr1467576857+303911562172172651
ENST00000261681MPP5chr1467784196-ENST00000315266GPHNchr1467555700+405720306613195844
ENST00000261681MPP5chr1467784196-ENST00000478722GPHNchr1467555700+406220306613195844
ENST00000555925MPP5chr1467784196-ENST00000315266GPHNchr1467555700+351114842172649810
ENST00000555925MPP5chr1467784196-ENST00000478722GPHNchr1467555700+351614842172649810

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261681ENST00000315266MPP5chr1467784196+GPHNchr1467555699+0.0013148010.9986852
ENST00000261681ENST00000478722MPP5chr1467784196+GPHNchr1467555699+0.0012727330.99872726
ENST00000555925ENST00000315266MPP5chr1467784196+GPHNchr1467555699+0.0012424220.9987576
ENST00000555925ENST00000478722MPP5chr1467784196+GPHNchr1467555699+0.00121530.9987847
ENST00000261681ENST00000315266MPP5chr1467759436+GPHNchr1467646295+0.0007161930.99928385
ENST00000261681ENST00000478722MPP5chr1467759436+GPHNchr1467646295+0.0006999220.9993001
ENST00000555925ENST00000315266MPP5chr1467759436+GPHNchr1467646295+0.0006323380.99936765
ENST00000555925ENST00000478722MPP5chr1467759436+GPHNchr1467646295+0.0006268730.99937314
ENST00000261681ENST00000315266MPP5chr1467746254+GPHNchr1467635650+0.0021913720.99780864
ENST00000261681ENST00000478722MPP5chr1467746254+GPHNchr1467635650+0.0021964090.9978036
ENST00000555925ENST00000315266MPP5chr1467746254+GPHNchr1467635650+0.0017235520.9982765
ENST00000555925ENST00000478722MPP5chr1467746254+GPHNchr1467635650+0.0017003490.99829966
ENST00000261681ENST00000315266MPP5chr1467770316-GPHNchr1467576857+0.0015174030.99848264
ENST00000261681ENST00000478722MPP5chr1467770316-GPHNchr1467576857+0.0014844430.99851555
ENST00000555925ENST00000315266MPP5chr1467770316-GPHNchr1467576857+0.0015019170.9984981
ENST00000555925ENST00000478722MPP5chr1467770316-GPHNchr1467576857+0.0014837290.99851626
ENST00000261681ENST00000315266MPP5chr1467784196-GPHNchr1467555700+0.0013148010.9986852
ENST00000261681ENST00000478722MPP5chr1467784196-GPHNchr1467555700+0.0012727330.99872726
ENST00000555925ENST00000315266MPP5chr1467784196-GPHNchr1467555700+0.0012424220.9987576
ENST00000555925ENST00000478722MPP5chr1467784196-GPHNchr1467555700+0.00121530.9987847

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54748_54748_1_MPP5-GPHN_MPP5_chr14_67746254_ENST00000261681_GPHN_chr14_67635650_ENST00000315266_length(amino acids)=233AA_BP=122
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQ

--------------------------------------------------------------

>54748_54748_2_MPP5-GPHN_MPP5_chr14_67746254_ENST00000261681_GPHN_chr14_67635650_ENST00000478722_length(amino acids)=233AA_BP=122
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQ

--------------------------------------------------------------

>54748_54748_3_MPP5-GPHN_MPP5_chr14_67746254_ENST00000555925_GPHN_chr14_67635650_ENST00000315266_length(amino acids)=199AA_BP=88
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILGN
PVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTE

--------------------------------------------------------------

>54748_54748_4_MPP5-GPHN_MPP5_chr14_67746254_ENST00000555925_GPHN_chr14_67635650_ENST00000478722_length(amino acids)=199AA_BP=88
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILGN
PVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTE

--------------------------------------------------------------

>54748_54748_5_MPP5-GPHN_MPP5_chr14_67759436_ENST00000261681_GPHN_chr14_67646295_ENST00000315266_length(amino acids)=268AA_BP=192
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF

--------------------------------------------------------------

>54748_54748_6_MPP5-GPHN_MPP5_chr14_67759436_ENST00000261681_GPHN_chr14_67646295_ENST00000478722_length(amino acids)=268AA_BP=192
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF

--------------------------------------------------------------

>54748_54748_7_MPP5-GPHN_MPP5_chr14_67759436_ENST00000555925_GPHN_chr14_67646295_ENST00000315266_length(amino acids)=234AA_BP=158
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQELSCDVKLDPRPEYHRCILTWHH

--------------------------------------------------------------

>54748_54748_8_MPP5-GPHN_MPP5_chr14_67759436_ENST00000555925_GPHN_chr14_67646295_ENST00000478722_length(amino acids)=234AA_BP=158
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQELSCDVKLDPRPEYHRCILTWHH

--------------------------------------------------------------

>54748_54748_9_MPP5-GPHN_MPP5_chr14_67770316_ENST00000261681_GPHN_chr14_67576857_ENST00000315266_length(amino acids)=685AA_BP=347
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVPTQTVMPGQVMRV
TTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVV
AVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLH
AQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWH

--------------------------------------------------------------

>54748_54748_10_MPP5-GPHN_MPP5_chr14_67770316_ENST00000261681_GPHN_chr14_67576857_ENST00000478722_length(amino acids)=685AA_BP=347
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVPTQTVMPGQVMRV
TTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVV
AVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLH
AQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWH

--------------------------------------------------------------

>54748_54748_11_MPP5-GPHN_MPP5_chr14_67770316_ENST00000555925_GPHN_chr14_67576857_ENST00000315266_length(amino acids)=651AA_BP=313
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEV
RILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQ
EHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALP
GNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPK

--------------------------------------------------------------

>54748_54748_12_MPP5-GPHN_MPP5_chr14_67770316_ENST00000555925_GPHN_chr14_67576857_ENST00000478722_length(amino acids)=651AA_BP=313
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEV
RILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQ
EHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALP
GNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPK

--------------------------------------------------------------

>54748_54748_13_MPP5-GPHN_MPP5_chr14_67784196_ENST00000261681_GPHN_chr14_67555699_ENST00000315266_length(amino acids)=844AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTEL
IRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKI
RDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATL
DIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMS

--------------------------------------------------------------

>54748_54748_14_MPP5-GPHN_MPP5_chr14_67784196_ENST00000261681_GPHN_chr14_67555699_ENST00000478722_length(amino acids)=844AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTEL
IRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKI
RDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATL
DIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMS

--------------------------------------------------------------

>54748_54748_15_MPP5-GPHN_MPP5_chr14_67784196_ENST00000261681_GPHN_chr14_67555700_ENST00000315266_length(amino acids)=844AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTEL
IRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKI
RDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATL
DIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMS

--------------------------------------------------------------

>54748_54748_16_MPP5-GPHN_MPP5_chr14_67784196_ENST00000261681_GPHN_chr14_67555700_ENST00000478722_length(amino acids)=844AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTEL
IRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKI
RDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATL
DIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMS

--------------------------------------------------------------

>54748_54748_17_MPP5-GPHN_MPP5_chr14_67784196_ENST00000555925_GPHN_chr14_67555699_ENST00000315266_length(amino acids)=810AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGY
AVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKR
GECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLN
ALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKM
QGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

--------------------------------------------------------------

>54748_54748_18_MPP5-GPHN_MPP5_chr14_67784196_ENST00000555925_GPHN_chr14_67555699_ENST00000478722_length(amino acids)=810AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGY
AVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKR
GECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLN
ALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKM
QGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

--------------------------------------------------------------

>54748_54748_19_MPP5-GPHN_MPP5_chr14_67784196_ENST00000555925_GPHN_chr14_67555700_ENST00000315266_length(amino acids)=810AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGY
AVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKR
GECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLN
ALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKM
QGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

--------------------------------------------------------------

>54748_54748_20_MPP5-GPHN_MPP5_chr14_67784196_ENST00000555925_GPHN_chr14_67555700_ENST00000478722_length(amino acids)=810AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDGMGRVLAQDVYAKDNLPPFPASVKDGY
AVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKR
GECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLN
ALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKM
QGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:67746254/chr14:67635650)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP5

Q8N3R9

GPHN

Q9NQX3

FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}.FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415120_177192.0676.0DomainL27 1
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815120_177347.0676.0DomainL27 1
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815179_235347.0676.0DomainL27 2
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815256_336347.0676.0DomainPDZ
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815120_177313.0642.0DomainL27 1
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815179_235313.0642.0DomainL27 2
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115120_177456.3333333333333676.0DomainL27 1
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115179_235456.3333333333333676.0DomainL27 2
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115256_336456.3333333333333676.0DomainPDZ
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115345_417456.3333333333333676.0DomainSH3
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115120_177422.3333333333333642.0DomainL27 1
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115179_235422.3333333333333642.0DomainL27 2
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115256_336422.3333333333333642.0DomainPDZ
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115345_417422.3333333333333642.0DomainSH3
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115120_177456.3333333333333676.0DomainL27 1
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115179_235456.3333333333333676.0DomainL27 2
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115256_336456.3333333333333676.0DomainPDZ
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115345_417456.3333333333333676.0DomainSH3
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115120_177422.3333333333333642.0DomainL27 1
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115179_235422.3333333333333642.0DomainL27 2
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115256_336422.3333333333333642.0DomainPDZ
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115345_417422.3333333333333642.0DomainSH3
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-8151_345347.0676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+11151_345456.3333333333333676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+11151_345422.3333333333333642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-11151_345456.3333333333333676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-11151_345422.3333333333333642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315120_177122.33333333333333676.0DomainL27 1
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315179_235122.33333333333333676.0DomainL27 2
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315256_336122.33333333333333676.0DomainPDZ
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315345_417122.33333333333333676.0DomainSH3
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315479_660122.33333333333333676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315120_17788.33333333333333642.0DomainL27 1
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315179_23588.33333333333333642.0DomainL27 2
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315256_33688.33333333333333642.0DomainPDZ
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315345_41788.33333333333333642.0DomainSH3
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315479_66088.33333333333333642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315120_177122.33333333333333676.0DomainL27 1
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315179_235122.33333333333333676.0DomainL27 2
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315256_336122.33333333333333676.0DomainPDZ
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315345_417122.33333333333333676.0DomainSH3
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315479_660122.33333333333333676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315120_17788.33333333333333642.0DomainL27 1
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315179_23588.33333333333333642.0DomainL27 2
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315256_33688.33333333333333642.0DomainPDZ
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315345_41788.33333333333333642.0DomainSH3
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315479_66088.33333333333333642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415179_235192.0676.0DomainL27 2
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415256_336192.0676.0DomainPDZ
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415345_417192.0676.0DomainSH3
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415479_660192.0676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415120_177158.0642.0DomainL27 1
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415179_235158.0642.0DomainL27 2
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415256_336158.0642.0DomainPDZ
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415345_417158.0642.0DomainSH3
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415479_660158.0642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815345_417347.0676.0DomainSH3
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815479_660347.0676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815256_336313.0642.0DomainPDZ
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815345_417313.0642.0DomainSH3
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815479_660313.0642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115479_660456.3333333333333676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115479_660422.3333333333333642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115479_660456.3333333333333676.0DomainGuanylate kinase-like
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115479_660422.3333333333333642.0DomainGuanylate kinase-like
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315486_493122.33333333333333676.0Nucleotide bindingATP
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315486_49388.33333333333333642.0Nucleotide bindingATP
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315486_493122.33333333333333676.0Nucleotide bindingATP
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315486_49388.33333333333333642.0Nucleotide bindingATP
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415486_493192.0676.0Nucleotide bindingATP
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415486_493158.0642.0Nucleotide bindingATP
HgeneMPP5chr14:67770316chr14:67576857ENST00000261681-815486_493347.0676.0Nucleotide bindingATP
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-815486_493313.0642.0Nucleotide bindingATP
HgeneMPP5chr14:67784196chr14:67555699ENST00000261681+1115486_493456.3333333333333676.0Nucleotide bindingATP
HgeneMPP5chr14:67784196chr14:67555699ENST00000555925+1115486_493422.3333333333333642.0Nucleotide bindingATP
HgeneMPP5chr14:67784196chr14:67555700ENST00000261681-1115486_493456.3333333333333676.0Nucleotide bindingATP
HgeneMPP5chr14:67784196chr14:67555700ENST00000555925-1115486_493422.3333333333333642.0Nucleotide bindingATP
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+3151_345122.33333333333333676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+3151_34588.33333333333333642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+3151_345122.33333333333333676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+3151_34588.33333333333333642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+4151_345192.0676.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+4151_345158.0642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
HgeneMPP5chr14:67770316chr14:67576857ENST00000555925-8151_345313.0642.0RegionRequired for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
TgeneGPHNchr14:67746254chr14:67635650ENST00000315266182214_166625.3333333333334737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67746254chr14:67635650ENST000003152661822326_736625.3333333333334737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67746254chr14:67635650ENST00000478722192314_166658.3333333333334770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67746254chr14:67635650ENST000004787221923326_736658.3333333333334770.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67746254chr14:67646295ENST00000315266192214_166660.0737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67746254chr14:67646295ENST000003152661922326_736660.0737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67746254chr14:67646295ENST00000478722202314_166693.0770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67746254chr14:67646295ENST000004787222023326_736693.0770.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67759436chr14:67646295ENST00000315266192214_166660.0737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67759436chr14:67646295ENST000003152661922326_736660.0737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67759436chr14:67646295ENST00000478722202314_166693.0770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67759436chr14:67646295ENST000004787222023326_736693.0770.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67770316chr14:67576857ENST00000315266112214_166398.0737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67770316chr14:67576857ENST000003152661122326_736398.0737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67770316chr14:67576857ENST00000478722122314_166431.0770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67770316chr14:67576857ENST000004787221223326_736431.0770.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67784196chr14:67555699ENST0000031526692214_166348.3333333333333737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67784196chr14:67555699ENST00000315266922326_736348.3333333333333737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67784196chr14:67555699ENST00000478722102314_166381.3333333333333770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67784196chr14:67555699ENST000004787221023326_736381.3333333333333770.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67784196chr14:67555700ENST0000031526692214_166348.3333333333333737.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67784196chr14:67555700ENST00000315266922326_736348.3333333333333737.0RegionNote=MPT adenylyltransferase
TgeneGPHNchr14:67784196chr14:67555700ENST00000478722102314_166381.3333333333333770.0RegionNote=MPT Mo-transferase
TgeneGPHNchr14:67784196chr14:67555700ENST000004787221023326_736381.3333333333333770.0RegionNote=MPT adenylyltransferase


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>361_MPP5_67746254_GPHN_67635650_ranked_0.pdbMPP56778419667746254ENST00000478722GPHNchr1467635650+
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQ
233


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
GPHN_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MPP5
GPHNall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+315181_243122.33333333333333676.0LIN7C
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+315181_24388.33333333333333642.0LIN7C
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+315181_243122.33333333333333676.0LIN7C
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+315181_24388.33333333333333642.0LIN7C
HgeneMPP5chr14:67759436chr14:67646295ENST00000261681+415181_243192.0676.0LIN7C
HgeneMPP5chr14:67759436chr14:67646295ENST00000555925+415181_243158.0642.0LIN7C
HgeneMPP5chr14:67746254chr14:67635650ENST00000261681+31521_140122.33333333333333676.0PARD6B
HgeneMPP5chr14:67746254chr14:67635650ENST00000555925+31521_14088.33333333333333642.0PARD6B
HgeneMPP5chr14:67746254chr14:67646295ENST00000261681+31521_140122.33333333333333676.0PARD6B
HgeneMPP5chr14:67746254chr14:67646295ENST00000555925+31521_14088.33333333333333642.0PARD6B
TgeneGPHNchr14:67746254chr14:67635650ENST000003152661822140_316625.3333333333334737.0GABARAP
TgeneGPHNchr14:67746254chr14:67635650ENST000004787221923140_316658.3333333333334770.0GABARAP
TgeneGPHNchr14:67746254chr14:67646295ENST000003152661922140_316660.0737.0GABARAP
TgeneGPHNchr14:67746254chr14:67646295ENST000004787222023140_316693.0770.0GABARAP
TgeneGPHNchr14:67759436chr14:67646295ENST000003152661922140_316660.0737.0GABARAP
TgeneGPHNchr14:67759436chr14:67646295ENST000004787222023140_316693.0770.0GABARAP
TgeneGPHNchr14:67770316chr14:67576857ENST000003152661122140_316398.0737.0GABARAP
TgeneGPHNchr14:67770316chr14:67576857ENST000004787221223140_316431.0770.0GABARAP
TgeneGPHNchr14:67784196chr14:67555699ENST00000315266922140_316348.3333333333333737.0GABARAP
TgeneGPHNchr14:67784196chr14:67555699ENST000004787221023140_316381.3333333333333770.0GABARAP
TgeneGPHNchr14:67784196chr14:67555700ENST00000315266922140_316348.3333333333333737.0GABARAP
TgeneGPHNchr14:67784196chr14:67555700ENST000004787221023140_316381.3333333333333770.0GABARAP


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Related Drugs to MPP5-GPHN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MPP5-GPHN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPHNC1854990Molybdenum Cofactor Deficiency, Complementation Group C5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneGPHNC0001956Alcohol Use Disorder1CTD_human
TgeneGPHNC0001973Alcoholic Intoxication, Chronic1CTD_human
TgeneGPHNC0009171Cocaine Abuse1CTD_human
TgeneGPHNC0085762Alcohol abuse1CTD_human
TgeneGPHNC0236736Cocaine-Related Disorders1CTD_human
TgeneGPHNC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneGPHNC0600427Cocaine Dependence1CTD_human