UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MPP5-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MPP5-RAD51B
	FusionPDB ID: 54749
	FusionGDB2.0 ID: 54749
		Hgene	Tgene
	Gene symbol	MPP5	RAD51B
	Gene ID	64398	5890
	Gene name	membrane palmitoylated protein 5	RAD51 paralog B
	Synonyms	PALS1	R51H2\|RAD51L1\|REC2
	Cytomap	14q23.3	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	MAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardust	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200313	20200313
	UniProtAcc	Q8N3R9	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000261681, ENST00000555925, ENST00000554911, ENST00000556345,	ENST00000469165, ENST00000488612, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 10 X 12=960	41 X 23 X 12=11316
	# samples	23	56
	** MAII score	log2(23/960*10)=-2.06140054466414 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MPP5 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MPP5(67779427)-RAD51B(69196525), # samples:2 RAD51B(68353921)-MPP5(67770238), # samples:2
Anticipated loss of major functional domain due to fusion event.	MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-MPP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-MPP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MPP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0ES-01A	MPP5	chr14	67779427	-	RAD51B	chr14	69196525	+
ChimerDB4	BRCA	TCGA-A2-A0ES-01A	MPP5	chr14	67779427	+	RAD51B	chr14	69196525	+
ChimerDB4	UCEC	TCGA-D1-A1O0-01A	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+
ChimerDB4	UCEC	TCGA-D1-A1O0	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261681	MPP5	chr14	67784196	+	ENST00000487861	RAD51B	chr14	68878140	+	2773	2030	661	2454	597
ENST00000261681	MPP5	chr14	67784196	+	ENST00000471583	RAD51B	chr14	68878140	+	2665	2030	661	2229	522
ENST00000261681	MPP5	chr14	67784196	+	ENST00000487270	RAD51B	chr14	68878140	+	3725	2030	661	2331	556
ENST00000261681	MPP5	chr14	67784196	+	ENST00000488612	RAD51B	chr14	68878140	+	2700	2030	661	2277	538
ENST00000261681	MPP5	chr14	67784196	+	ENST00000390683	RAD51B	chr14	68878140	+	2278	2030	661	2277	539
ENST00000555925	MPP5	chr14	67784196	+	ENST00000487861	RAD51B	chr14	68878140	+	2227	1484	217	1908	563
ENST00000555925	MPP5	chr14	67784196	+	ENST00000471583	RAD51B	chr14	68878140	+	2119	1484	217	1683	488
ENST00000555925	MPP5	chr14	67784196	+	ENST00000487270	RAD51B	chr14	68878140	+	3179	1484	217	1785	522
ENST00000555925	MPP5	chr14	67784196	+	ENST00000488612	RAD51B	chr14	68878140	+	2154	1484	217	1731	504
ENST00000555925	MPP5	chr14	67784196	+	ENST00000390683	RAD51B	chr14	68878140	+	1732	1484	217	1731	505
ENST00000261681	MPP5	chr14	67784196	+	ENST00000487861	RAD51B	chr14	68878141	+	2773	2030	661	2454	597
ENST00000261681	MPP5	chr14	67784196	+	ENST00000471583	RAD51B	chr14	68878141	+	2665	2030	661	2229	522
ENST00000261681	MPP5	chr14	67784196	+	ENST00000487270	RAD51B	chr14	68878141	+	3725	2030	661	2331	556
ENST00000261681	MPP5	chr14	67784196	+	ENST00000488612	RAD51B	chr14	68878141	+	2700	2030	661	2277	538
ENST00000261681	MPP5	chr14	67784196	+	ENST00000390683	RAD51B	chr14	68878141	+	2278	2030	661	2277	539
ENST00000555925	MPP5	chr14	67784196	+	ENST00000487861	RAD51B	chr14	68878141	+	2227	1484	217	1908	563
ENST00000555925	MPP5	chr14	67784196	+	ENST00000471583	RAD51B	chr14	68878141	+	2119	1484	217	1683	488
ENST00000555925	MPP5	chr14	67784196	+	ENST00000487270	RAD51B	chr14	68878141	+	3179	1484	217	1785	522
ENST00000555925	MPP5	chr14	67784196	+	ENST00000488612	RAD51B	chr14	68878141	+	2154	1484	217	1731	504
ENST00000555925	MPP5	chr14	67784196	+	ENST00000390683	RAD51B	chr14	68878141	+	1732	1484	217	1731	505

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261681	ENST00000487861	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.00128916	0.9987109
ENST00000261681	ENST00000471583	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000685464	0.99931455
ENST00000261681	ENST00000487270	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000653779	0.9993462
ENST00000261681	ENST00000488612	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000905998	0.999094
ENST00000261681	ENST00000390683	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000843277	0.9991567
ENST00000555925	ENST00000487861	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.001287343	0.99871266
ENST00000555925	ENST00000471583	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000444005	0.999556
ENST00000555925	ENST00000487270	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000459172	0.9995408
ENST00000555925	ENST00000488612	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000623846	0.99937624
ENST00000555925	ENST00000390683	MPP5	chr14	67784196	+	RAD51B	chr14	68878140	+	0.000595926	0.9994041
ENST00000261681	ENST00000487861	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.00128916	0.9987109
ENST00000261681	ENST00000471583	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000685464	0.99931455
ENST00000261681	ENST00000487270	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000653779	0.9993462
ENST00000261681	ENST00000488612	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000905998	0.999094
ENST00000261681	ENST00000390683	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000843277	0.9991567
ENST00000555925	ENST00000487861	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.001287343	0.99871266
ENST00000555925	ENST00000471583	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000444005	0.999556
ENST00000555925	ENST00000487270	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000459172	0.9995408
ENST00000555925	ENST00000488612	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000623846	0.99937624
ENST00000555925	ENST00000390683	MPP5	chr14	67784196	+	RAD51B	chr14	68878141	+	0.000595926	0.9994041

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54749_54749_1_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878140_ENST00000390683_length(amino acids)=539AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_2_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878140_ENST00000471583_length(amino acids)=522AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_3_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878140_ENST00000487270_length(amino acids)=556AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQP

--------------------------------------------------------------

>54749_54749_4_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878140_ENST00000487861_length(amino acids)=597AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPS

--------------------------------------------------------------

>54749_54749_5_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878140_ENST00000488612_length(amino acids)=538AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_6_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878141_ENST00000390683_length(amino acids)=539AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_7_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878141_ENST00000471583_length(amino acids)=522AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_8_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878141_ENST00000487270_length(amino acids)=556AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQP

--------------------------------------------------------------

>54749_54749_9_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878141_ENST00000487861_length(amino acids)=597AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPS

--------------------------------------------------------------

>54749_54749_10_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000261681_RAD51B_chr14_68878141_ENST00000488612_length(amino acids)=538AA_BP=456
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKL
AQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGAT
VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY

--------------------------------------------------------------

>54749_54749_11_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878140_ENST00000390683_length(amino acids)=505AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_12_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878140_ENST00000471583_length(amino acids)=488AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_13_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878140_ENST00000487270_length(amino acids)=522AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_14_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878140_ENST00000487861_length(amino acids)=563AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY
LDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVL

--------------------------------------------------------------

>54749_54749_15_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878140_ENST00000488612_length(amino acids)=504AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_16_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878141_ENST00000390683_length(amino acids)=505AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_17_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878141_ENST00000471583_length(amino acids)=488AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_18_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878141_ENST00000487270_length(amino acids)=522AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

>54749_54749_19_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878141_ENST00000487861_length(amino acids)=563AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY
LDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVL

--------------------------------------------------------------

>54749_54749_20_MPP5-RAD51B_MPP5_chr14_67784196_ENST00000555925_RAD51B_chr14_68878141_ENST00000488612_length(amino acids)=504AA_BP=422
MAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEI
EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNT
PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEI
NGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYR
EGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDGTSGSSCVIAALGNTWSHSVNTRLILQY

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:67779427/chr14:69196525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MPP5 Q8N3R9	RAD51B O15315
FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250\|UniProtKB:B4F7E7, ECO:0000250\|UniProtKB:Q9JLB2, ECO:0000269\|PubMed:16678097, ECO:0000269\|PubMed:21479189, ECO:0000269\|PubMed:25385611, ECO:0000269\|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269\|PubMed:20861307, ECO:0000303\|PubMed:32891874}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

120_177

456.3333333333333

676.0

Domain

L27 1

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

179_235

456.3333333333333

676.0

Domain

L27 2

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

256_336

456.3333333333333

676.0

Domain

PDZ

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

345_417

456.3333333333333

676.0

Domain

SH3

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

120_177

422.3333333333333

642.0

Domain

L27 1

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

179_235

422.3333333333333

642.0

Domain

L27 2

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

256_336

422.3333333333333

642.0

Domain

PDZ

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

345_417

422.3333333333333

642.0

Domain

SH3

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

120_177

456.3333333333333

676.0

Domain

L27 1

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

179_235

456.3333333333333

676.0

Domain

L27 2

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

256_336

456.3333333333333

676.0

Domain

PDZ

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

345_417

456.3333333333333

676.0

Domain

SH3

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

120_177

422.3333333333333

642.0

Domain

L27 1

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

179_235

422.3333333333333

642.0

Domain

L27 2

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

256_336

422.3333333333333

642.0

Domain

PDZ

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

345_417

422.3333333333333

642.0

Domain

SH3

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

1_345

456.3333333333333

676.0

Region

Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

1_345

422.3333333333333

642.0

Region

Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

1_345

456.3333333333333

676.0

Region

Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

1_345

422.3333333333333

642.0

Region

Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

479_660

456.3333333333333

676.0

Domain

Guanylate kinase-like

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

479_660

422.3333333333333

642.0

Domain

Guanylate kinase-like

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

479_660

456.3333333333333

676.0

Domain

Guanylate kinase-like

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

479_660

422.3333333333333

642.0

Domain

Guanylate kinase-like

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000261681

486_493

456.3333333333333

676.0

Nucleotide binding

ATP

Hgene

MPP5

chr14:67784196

chr14:68878140

ENST00000555925

486_493

422.3333333333333

642.0

Nucleotide binding

ATP

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000261681

486_493

456.3333333333333

676.0

Nucleotide binding

ATP

Hgene

MPP5

chr14:67784196

chr14:68878141

ENST00000555925

486_493

422.3333333333333

642.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878140

ENST00000390683

108_115

284.3333333333333

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878140

ENST00000471583

108_115

284.3333333333333

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878140

ENST00000487270

108_115

284.3333333333333

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878140

ENST00000488612

108_115

284.3333333333333

495.6666666666667

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878141

ENST00000390683

108_115

284.3333333333333

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878141

ENST00000471583

108_115

284.3333333333333

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878141

ENST00000487270

108_115

284.3333333333333

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67784196

chr14:68878141

ENST00000488612

108_115

284.3333333333333

495.6666666666667

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MPP5
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RAD51B	chr14:67784196	chr14:68878140	ENST00000390683		6	10	1_75	284.3333333333333	367.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878140	ENST00000471583		7	11	1_75	284.3333333333333	351.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878140	ENST00000487270		7	11	1_75	284.3333333333333	385.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878140	ENST00000488612		7	12	1_75	284.3333333333333	495.6666666666667	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878141	ENST00000390683		6	10	1_75	284.3333333333333	367.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878141	ENST00000471583		7	11	1_75	284.3333333333333	351.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878141	ENST00000487270		7	11	1_75	284.3333333333333	385.0	RAD51C
Tgene	RAD51B	chr14:67784196	chr14:68878141	ENST00000488612		7	12	1_75	284.3333333333333	495.6666666666667	RAD51C

Top

Related Drugs to MPP5-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MPP5-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human