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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MROH1-XRCC5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MROH1-XRCC5
	FusionPDB ID: 54887
	FusionGDB2.0 ID: 54887
		Hgene	Tgene
	Gene symbol	MROH1	XRCC5
	Gene ID	727957	7520
	Gene name	maestro heat like repeat family member 1	X-ray repair cross complementing 5
	Synonyms	HEATR7A	KARP-1\|KARP1\|KU80\|KUB2\|Ku86\|NFIV
	Cytomap	8q24.3	2q35
	Type of gene	protein-coding	protein-coding
	Description	maestro heat-like repeat-containing protein family member 1HEAT repeat containing 7AHEAT repeat-containing protein 7A	X-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKu
	Modification date	20200320	20200313
	UniProtAcc	Q8NDA8	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000527071, ENST00000326134, ENST00000398656, ENST00000423230, ENST00000528919, ENST00000534366, ENST00000544576,	ENST00000392132, ENST00000392133, ENST00000471649,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 8 X 8=1152	9 X 6 X 5=270
	# samples	19	10
	** MAII score	log2(19/1152*10)=-2.60006939311136 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MROH1 [Title/Abstract] AND XRCC5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MROH1(145255444)-XRCC5(217054948), # samples:2
Anticipated loss of major functional domain due to fusion event.	MROH1-XRCC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MROH1-XRCC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MROH1-XRCC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MROH1-XRCC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	XRCC5	GO:0002218	activation of innate immune response	28712728
Tgene	XRCC5	GO:0006303	double-strand break repair via nonhomologous end joining	26359349
Tgene	XRCC5	GO:0045860	positive regulation of protein kinase activity	22504299
Tgene	XRCC5	GO:0071480	cellular response to gamma radiation	26359349

Fusion gene breakpoints across MROH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across XRCC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1030-01A	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000423230	MROH1	chr8	145255444	+	ENST00000392133	XRCC5	chr2	217054948	+	2704	1238	97	1602	501
ENST00000423230	MROH1	chr8	145255444	+	ENST00000392132	XRCC5	chr2	217054948	+	2692	1238	97	1602	501
ENST00000398656	MROH1	chr8	145255444	+	ENST00000392133	XRCC5	chr2	217054948	+	2704	1238	97	1602	501
ENST00000398656	MROH1	chr8	145255444	+	ENST00000392132	XRCC5	chr2	217054948	+	2692	1238	97	1602	501
ENST00000534366	MROH1	chr8	145255444	+	ENST00000392133	XRCC5	chr2	217054948	+	2731	1265	124	1629	501
ENST00000534366	MROH1	chr8	145255444	+	ENST00000392132	XRCC5	chr2	217054948	+	2719	1265	124	1629	501
ENST00000528919	MROH1	chr8	145255444	+	ENST00000392133	XRCC5	chr2	217054948	+	2728	1262	37	1626	529
ENST00000528919	MROH1	chr8	145255444	+	ENST00000392132	XRCC5	chr2	217054948	+	2716	1262	37	1626	529
ENST00000326134	MROH1	chr8	145255444	+	ENST00000392133	XRCC5	chr2	217054948	+	2664	1198	57	1562	501
ENST00000326134	MROH1	chr8	145255444	+	ENST00000392132	XRCC5	chr2	217054948	+	2652	1198	57	1562	501

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000423230	ENST00000392133	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001831571	0.99816835
ENST00000423230	ENST00000392132	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001799314	0.99820065
ENST00000398656	ENST00000392133	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001831571	0.99816835
ENST00000398656	ENST00000392132	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001799314	0.99820065
ENST00000534366	ENST00000392133	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001872131	0.9981279
ENST00000534366	ENST00000392132	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001833401	0.99816656
ENST00000528919	ENST00000392133	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001857764	0.99814224
ENST00000528919	ENST00000392132	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.0018373	0.9981627
ENST00000326134	ENST00000392133	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.00168827	0.99831176
ENST00000326134	ENST00000392132	MROH1	chr8	145255444	+	XRCC5	chr2	217054948	+	0.001650349	0.99834967

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54887_54887_1_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000326134_XRCC5_chr2_217054948_ENST00000392132_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_2_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000326134_XRCC5_chr2_217054948_ENST00000392133_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_3_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000398656_XRCC5_chr2_217054948_ENST00000392132_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_4_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000398656_XRCC5_chr2_217054948_ENST00000392133_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_5_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000423230_XRCC5_chr2_217054948_ENST00000392132_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_6_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000423230_XRCC5_chr2_217054948_ENST00000392133_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_7_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000528919_XRCC5_chr2_217054948_ENST00000392132_length(amino acids)=529AA_BP=408
MHPPSQQLWDGRRSCPCSHWVKEAETTDMTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYR
AAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSV
ANAFGVVPFLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLA
VVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQ
KEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQ

--------------------------------------------------------------

>54887_54887_8_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000528919_XRCC5_chr2_217054948_ENST00000392133_length(amino acids)=529AA_BP=408
MHPPSQQLWDGRRSCPCSHWVKEAETTDMTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYR
AAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSV
ANAFGVVPFLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLA
VVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQ
KEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQ

--------------------------------------------------------------

>54887_54887_9_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000534366_XRCC5_chr2_217054948_ENST00000392132_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

>54887_54887_10_MROH1-XRCC5_MROH1_chr8_145255444_ENST00000534366_XRCC5_chr2_217054948_ENST00000392133_length(amino acids)=501AA_BP=380
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145255444/chr2:217054948)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MROH1 Q8NDA8	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

159_198

380.3333333333333

1642.0

Repeat

Note=HEAT 2

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

344_382

380.3333333333333

1642.0

Repeat

Note=HEAT 3

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

3_41

380.3333333333333

1642.0

Repeat

Note=HEAT 1

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

159_198

380.3333333333333

1642.0

Repeat

Note=HEAT 2

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

344_382

380.3333333333333

1642.0

Repeat

Note=HEAT 3

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

3_41

380.3333333333333

1642.0

Repeat

Note=HEAT 1

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

159_198

380.3333333333333

423.0

Repeat

Note=HEAT 2

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

344_382

380.3333333333333

423.0

Repeat

Note=HEAT 3

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

3_41

380.3333333333333

423.0

Repeat

Note=HEAT 1

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

159_198

380.3333333333333

1642.0

Repeat

Note=HEAT 2

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

344_382

380.3333333333333

1642.0

Repeat

Note=HEAT 3

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

3_41

380.3333333333333

1642.0

Repeat

Note=HEAT 1

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392132

720_728

611.3333333333334

733.0

Motif

Note=EEXXXDL motif

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392133

720_728

611.3333333333334

733.0

Motif

Note=EEXXXDL motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

1048_1086

380.3333333333333

1642.0

Repeat

Note=HEAT 5

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

1358_1396

380.3333333333333

1642.0

Repeat

Note=HEAT 6

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

1605_1641

380.3333333333333

1642.0

Repeat

Note=HEAT 7

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000326134

385_423

380.3333333333333

1642.0

Repeat

Note=HEAT 4

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

1048_1086

380.3333333333333

1642.0

Repeat

Note=HEAT 5

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

1358_1396

380.3333333333333

1642.0

Repeat

Note=HEAT 6

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

1605_1641

380.3333333333333

1642.0

Repeat

Note=HEAT 7

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000398656

385_423

380.3333333333333

1642.0

Repeat

Note=HEAT 4

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

1048_1086

380.3333333333333

423.0

Repeat

Note=HEAT 5

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

1358_1396

380.3333333333333

423.0

Repeat

Note=HEAT 6

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

1605_1641

380.3333333333333

423.0

Repeat

Note=HEAT 7

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000423230

385_423

380.3333333333333

423.0

Repeat

Note=HEAT 4

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

1048_1086

380.3333333333333

1642.0

Repeat

Note=HEAT 5

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

1358_1396

380.3333333333333

1642.0

Repeat

Note=HEAT 6

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

1605_1641

380.3333333333333

1642.0

Repeat

Note=HEAT 7

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000528919

385_423

380.3333333333333

1642.0

Repeat

Note=HEAT 4

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

1048_1086

616.0

Repeat

Note=HEAT 5

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

1358_1396

616.0

Repeat

Note=HEAT 6

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

159_198

616.0

Repeat

Note=HEAT 2

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

1605_1641

616.0

Repeat

Note=HEAT 7

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

344_382

616.0

Repeat

Note=HEAT 3

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

385_423

616.0

Repeat

Note=HEAT 4

Hgene

MROH1

chr8:145255444

chr2:217054948

ENST00000544576

3_41

616.0

Repeat

Note=HEAT 1

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392132

478_519

611.3333333333334

733.0

Compositional bias

Note=Pro-rich

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392133

478_519

611.3333333333334

733.0

Compositional bias

Note=Pro-rich

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392132

251_460

611.3333333333334

733.0

Domain

Note=Ku

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392133

251_460

611.3333333333334

733.0

Domain

Note=Ku

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392132

138_165

611.3333333333334

733.0

Region

Note=Leucine-zipper

Tgene

XRCC5

chr8:145255444

chr2:217054948

ENST00000392133

138_165

611.3333333333334

733.0

Region

Note=Leucine-zipper

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MROH1
XRCC5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MROH1-XRCC5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MROH1-XRCC5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source