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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:APOB-CLU

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: APOB-CLU
	FusionPDB ID: 5530
	FusionGDB2.0 ID: 5530
		Hgene	Tgene
	Gene symbol	APOB	CLU
	Gene ID	338	1191
	Gene name	apolipoprotein B	clusterin
	Synonyms	FCHL2\|FLDB\|LDLCQ4\|apoB-100\|apoB-48	AAG4\|APO-J\|APOJ\|CLI\|CLU1\|CLU2\|KUB1\|NA1/NA2\|SGP-2\|SGP2\|SP-40\|TRPM-2\|TRPM2
	Cytomap	2p24.1	8p21.1
	Type of gene	protein-coding	protein-coding
	Description	apolipoprotein B-100apolipoprotein B (including Ag(x) antigen)apolipoprotein B48	clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r
	Modification date	20200327	20200327
	UniProtAcc	Q8WW27	Q15846
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000233242, ENST00000399256,	ENST00000316403, ENST00000405140, ENST00000523500, ENST00000546343, ENST00000560366,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 9 X 4=252	23 X 24 X 12=6624
	# samples	9	30
	** MAII score	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/6624*10)=-4.46466826700344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: APOB [Title/Abstract] AND CLU [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	APOB(21252511)-CLU(27456152), # samples:1
Anticipated loss of major functional domain due to fusion event.	APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APOB-CLU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	APOB	GO:0010744	positive regulation of macrophage derived foam cell differentiation	17244792\|18322245\|19114110
Hgene	APOB	GO:0010884	positive regulation of lipid storage	18322245
Hgene	APOB	GO:0010886	positive regulation of cholesterol storage	19114110
Tgene	CLU	GO:0000902	cell morphogenesis	15857407
Tgene	CLU	GO:0001774	microglial cell activation	15857407
Tgene	CLU	GO:0017038	protein import	24446231
Tgene	CLU	GO:0031333	negative regulation of protein complex assembly	22179788\|23106396
Tgene	CLU	GO:0031334	positive regulation of protein complex assembly	22179788
Tgene	CLU	GO:0032760	positive regulation of tumor necrosis factor production	15857407
Tgene	CLU	GO:0045429	positive regulation of nitric oxide biosynthetic process	15857407
Tgene	CLU	GO:0050821	protein stabilization	11123922\|12176985
Tgene	CLU	GO:0051131	chaperone-mediated protein complex assembly	17412999
Tgene	CLU	GO:0051788	response to misfolded protein	19996109
Tgene	CLU	GO:0061077	chaperone-mediated protein folding	11123922
Tgene	CLU	GO:0061518	microglial cell proliferation	15857407
Tgene	CLU	GO:1900221	regulation of amyloid-beta clearance	24446231
Tgene	CLU	GO:1901214	regulation of neuron death	17412999
Tgene	CLU	GO:1901216	positive regulation of neuron death	15857407
Tgene	CLU	GO:1902430	negative regulation of amyloid-beta formation	12047389\|17412999
Tgene	CLU	GO:1905907	negative regulation of amyloid fibril formation	22179788

Fusion gene breakpoints across APOB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A1EH-01A	APOB	chr2	21252511	-	CLU	chr8	27456152	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000233242	APOB	chr2	21252511	-	ENST00000316403	CLU	chr8	27456152	-	3255	1745	122	1930	602
ENST00000233242	APOB	chr2	21252511	-	ENST00000546343	CLU	chr8	27456152	-	3237	1745	122	1930	602
ENST00000233242	APOB	chr2	21252511	-	ENST00000560366	CLU	chr8	27456152	-	3237	1745	122	1930	602
ENST00000233242	APOB	chr2	21252511	-	ENST00000405140	CLU	chr8	27456152	-	2364	1745	122	1930	602
ENST00000233242	APOB	chr2	21252511	-	ENST00000523500	CLU	chr8	27456152	-	2176	1745	122	1930	602
ENST00000399256	APOB	chr2	21252511	-	ENST00000316403	CLU	chr8	27456152	-	3144	1634	11	1819	602
ENST00000399256	APOB	chr2	21252511	-	ENST00000546343	CLU	chr8	27456152	-	3126	1634	11	1819	602
ENST00000399256	APOB	chr2	21252511	-	ENST00000560366	CLU	chr8	27456152	-	3126	1634	11	1819	602
ENST00000399256	APOB	chr2	21252511	-	ENST00000405140	CLU	chr8	27456152	-	2253	1634	11	1819	602
ENST00000399256	APOB	chr2	21252511	-	ENST00000523500	CLU	chr8	27456152	-	2065	1634	11	1819	602

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000233242	ENST00000316403	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.001952505	0.9980475
ENST00000233242	ENST00000546343	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.00206495	0.99793506
ENST00000233242	ENST00000560366	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.00206495	0.99793506
ENST00000233242	ENST00000405140	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.006448698	0.99355125
ENST00000233242	ENST00000523500	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.009076417	0.9909236
ENST00000399256	ENST00000316403	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.001746974	0.99825305
ENST00000399256	ENST00000546343	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.001845457	0.9981546
ENST00000399256	ENST00000560366	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.001845457	0.9981546
ENST00000399256	ENST00000405140	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.005979851	0.9940202
ENST00000399256	ENST00000523500	APOB	chr2	21252511	-	CLU	chr8	27456152	-	0.008274778	0.9917252

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5530_5530_1_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000316403_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_2_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000405140_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_3_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000523500_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_4_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000546343_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_5_APOB-CLU_APOB_chr2_21252511_ENST00000233242_CLU_chr8_27456152_ENST00000560366_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_6_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000316403_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_7_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000405140_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_8_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000523500_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_9_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000546343_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

>5530_5530_10_APOB-CLU_APOB_chr2_21252511_ENST00000399256_CLU_chr8_27456152_ENST00000560366_length(amino acids)=602AA_BP=541
MAMDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLC
SFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLF
LDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFL
PFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGL
SDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHA
VNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:21252511/chr8:27456152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
APOB Q8WW27	CLU Q15846
FUNCTION: Putative C to U editing enzyme whose physiological substrate is not yet known. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

232_306

539.0

4564.0

Region

Note=Heparin-binding

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

32_126

539.0

4564.0

Region

Note=Heparin-binding

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000316403

443_447

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000405140

443_447

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000523500

443_447

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000546343

443_447

399.0

461.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000560366

443_447

440.0

502.0

Motif

Nuclear localization signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

46_672

539.0

4564.0

Domain

Vitellogenin

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

2043_2178

539.0

4564.0

Region

Note=Heparin-binding

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

3161_3236

539.0

4564.0

Region

Note=Heparin-binding

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

3174_3184

539.0

4564.0

Region

Note=Basic (possible receptor binding region)

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

3373_3393

539.0

4564.0

Region

Note=LDL receptor binding

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

3383_3516

539.0

4564.0

Region

Note=Heparin-binding

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

3386_3394

539.0

4564.0

Region

Note=Basic (possible receptor binding region)

Hgene

APOB

chr2:21252511

chr8:27456152

ENST00000233242

902_959

539.0

4564.0

Region

Note=Heparin-binding

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000316403

78_81

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000405140

78_81

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000523500

78_81

388.0

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000546343

78_81

399.0

461.0

Motif

Nuclear localization signal

Tgene

CLU

chr2:21252511

chr8:27456152

ENST00000560366

78_81

440.0

502.0

Motif

Nuclear localization signal

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
APOB
CLU

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to APOB-CLU

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to APOB-CLU

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CLU	C0022660	Kidney Failure, Acute	6	CTD_human
Tgene	CLU	C1565662	Acute Kidney Insufficiency	6	CTD_human
Tgene	CLU	C2609414	Acute kidney injury	6	CTD_human
Tgene	CLU	C0002395	Alzheimer's Disease	3	CTD_human
Tgene	CLU	C0011265	Presenile dementia	3	CTD_human
Tgene	CLU	C0022658	Kidney Diseases	3	CTD_human
Tgene	CLU	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Tgene	CLU	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Tgene	CLU	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Tgene	CLU	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Tgene	CLU	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Tgene	CLU	C0013221	Drug toxicity	2	CTD_human
Tgene	CLU	C0029408	Degenerative polyarthritis	2	CTD_human
Tgene	CLU	C0041755	Adverse reaction to drug	2	CTD_human
Tgene	CLU	C0086743	Osteoarthrosis Deformans	2	CTD_human
Tgene	CLU	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	CLU	C0022333	Jacksonian Seizure	1	CTD_human
Tgene	CLU	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
Tgene	CLU	C0025202	melanoma	1	CTD_human
Tgene	CLU	C0027686	Pathologic Neovascularization	1	CTD_human
Tgene	CLU	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	CLU	C0036341	Schizophrenia	1	PSYGENET
Tgene	CLU	C0036572	Seizures	1	CTD_human
Tgene	CLU	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	CLU	C0149958	Complex partial seizures	1	CTD_human
Tgene	CLU	C0234533	Generalized seizures	1	CTD_human
Tgene	CLU	C0234535	Clonic Seizures	1	CTD_human
Tgene	CLU	C0234985	Mental deterioration	1	CTD_human
Tgene	CLU	C0242380	Libman-Sacks Disease	1	CTD_human
Tgene	CLU	C0270824	Visual seizure	1	CTD_human
Tgene	CLU	C0270844	Tonic Seizures	1	CTD_human
Tgene	CLU	C0270846	Epileptic drop attack	1	CTD_human
Tgene	CLU	C0333641	Atrophic	1	CTD_human
Tgene	CLU	C0338656	Impaired cognition	1	CTD_human
Tgene	CLU	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	CLU	C0422850	Seizures, Somatosensory	1	CTD_human
Tgene	CLU	C0422852	Seizures, Auditory	1	CTD_human
Tgene	CLU	C0422853	Olfactory seizure	1	CTD_human
Tgene	CLU	C0422854	Gustatory seizure	1	CTD_human
Tgene	CLU	C0422855	Vertiginous seizure	1	CTD_human
Tgene	CLU	C0494475	Tonic - clonic seizures	1	CTD_human
Tgene	CLU	C0751056	Non-epileptic convulsion	1	CTD_human
Tgene	CLU	C0751110	Single Seizure	1	CTD_human
Tgene	CLU	C0751123	Atonic Absence Seizures	1	CTD_human
Tgene	CLU	C0751494	Convulsive Seizures	1	CTD_human
Tgene	CLU	C0751495	Seizures, Focal	1	CTD_human
Tgene	CLU	C0751496	Seizures, Sensory	1	CTD_human
Tgene	CLU	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	CLU	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	CLU	C1270972	Mild cognitive disorder	1	CTD_human
Tgene	CLU	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Tgene	CLU	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Tgene	CLU	C3495559	Juvenile arthritis	1	CTD_human
Tgene	CLU	C3495874	Nonepileptic Seizures	1	CTD_human
Tgene	CLU	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	CLU	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	CLU	C4048158	Convulsions	1	CTD_human
Tgene	CLU	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	CLU	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene	CLU	C4316903	Absence Seizures	1	CTD_human
Tgene	CLU	C4317109	Epileptic Seizures	1	CTD_human
Tgene	CLU	C4317123	Myoclonic Seizures	1	CTD_human
Tgene	CLU	C4505436	Generalized Absence Seizures	1	CTD_human
Tgene	CLU	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human
Tgene	CLU	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	CLU	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human