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Fusion Protein:MSI2-DHX40 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MSI2-DHX40 | FusionPDB ID: 55309 | FusionGDB2.0 ID: 55309 | Hgene | Tgene | Gene symbol | MSI2 | DHX40 | Gene ID | 124540 | 79665 |
| Gene name | musashi RNA binding protein 2 | DEAH-box helicase 40 | |
| Synonyms | MSI2H | ARG147|DDX40|PAD | |
| Cytomap | 17q22 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2 | probable ATP-dependent RNA helicase DHX40DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 40DEAH box protein 40 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q96DH6 | Q8IX18 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000284073, ENST00000322684, ENST00000416426, ENST00000442934, ENST00000579180, ENST00000579505, | ENST00000425628, ENST00000451169, ENST00000251241, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 40 X 16 X 16=10240 | 7 X 6 X 2=84 |
| # samples | 45 | 8 | |
| ** MAII score | log2(45/10240*10)=-4.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MSI2 [Title/Abstract] AND DHX40 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MSI2(55478832)-DHX40(57643988), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MSI2-DHX40 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MSI2-DHX40 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across MSI2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DHX40 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-EW-A6SD-01A | MSI2 | chr17 | 55478832 | - | DHX40 | chr17 | 57643988 | + |
| ChimerDB4 | BRCA | TCGA-EW-A6SD-01A | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57643988 | + |
| ChimerDB4 | BRCA | TCGA-EW-A6SD-01A | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000416426 | MSI2 | chr17 | 55478832 | + | ENST00000251241 | DHX40 | chr17 | 57650477 | + | 3561 | 474 | 93 | 2387 | 764 |
| ENST00000416426 | MSI2 | chr17 | 55478832 | + | ENST00000451169 | DHX40 | chr17 | 57650477 | + | 3710 | 474 | 93 | 2540 | 815 |
| ENST00000416426 | MSI2 | chr17 | 55478832 | + | ENST00000425628 | DHX40 | chr17 | 57650477 | + | 2474 | 474 | 93 | 2387 | 764 |
| ENST00000284073 | MSI2 | chr17 | 55478832 | + | ENST00000251241 | DHX40 | chr17 | 57650477 | + | 3701 | 614 | 179 | 2527 | 782 |
| ENST00000284073 | MSI2 | chr17 | 55478832 | + | ENST00000451169 | DHX40 | chr17 | 57650477 | + | 3850 | 614 | 179 | 2680 | 833 |
| ENST00000284073 | MSI2 | chr17 | 55478832 | + | ENST00000425628 | DHX40 | chr17 | 57650477 | + | 2614 | 614 | 179 | 2527 | 782 |
| ENST00000322684 | MSI2 | chr17 | 55478832 | + | ENST00000251241 | DHX40 | chr17 | 57650477 | + | 3515 | 428 | 35 | 2341 | 768 |
| ENST00000322684 | MSI2 | chr17 | 55478832 | + | ENST00000451169 | DHX40 | chr17 | 57650477 | + | 3664 | 428 | 35 | 2494 | 819 |
| ENST00000322684 | MSI2 | chr17 | 55478832 | + | ENST00000425628 | DHX40 | chr17 | 57650477 | + | 2428 | 428 | 35 | 2341 | 768 |
| ENST00000442934 | MSI2 | chr17 | 55478832 | + | ENST00000251241 | DHX40 | chr17 | 57650477 | + | 3349 | 262 | 40 | 2175 | 711 |
| ENST00000442934 | MSI2 | chr17 | 55478832 | + | ENST00000451169 | DHX40 | chr17 | 57650477 | + | 3498 | 262 | 40 | 2328 | 762 |
| ENST00000442934 | MSI2 | chr17 | 55478832 | + | ENST00000425628 | DHX40 | chr17 | 57650477 | + | 2262 | 262 | 40 | 2175 | 711 |
| ENST00000579180 | MSI2 | chr17 | 55478832 | + | ENST00000251241 | DHX40 | chr17 | 57650477 | + | 3285 | 198 | 105 | 2111 | 668 |
| ENST00000579180 | MSI2 | chr17 | 55478832 | + | ENST00000451169 | DHX40 | chr17 | 57650477 | + | 3434 | 198 | 105 | 2264 | 719 |
| ENST00000579180 | MSI2 | chr17 | 55478832 | + | ENST00000425628 | DHX40 | chr17 | 57650477 | + | 2198 | 198 | 105 | 2111 | 668 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000416426 | ENST00000251241 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001122174 | 0.9988778 |
| ENST00000416426 | ENST00000451169 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001088535 | 0.9989115 |
| ENST00000416426 | ENST00000425628 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001589659 | 0.99841034 |
| ENST00000284073 | ENST00000251241 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000785359 | 0.99921465 |
| ENST00000284073 | ENST00000451169 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000668922 | 0.9993311 |
| ENST00000284073 | ENST00000425628 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001284423 | 0.99871564 |
| ENST00000322684 | ENST00000251241 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.00051392 | 0.9994861 |
| ENST00000322684 | ENST00000451169 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000465552 | 0.9995345 |
| ENST00000322684 | ENST00000425628 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000759181 | 0.9992409 |
| ENST00000442934 | ENST00000251241 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000634481 | 0.9993655 |
| ENST00000442934 | ENST00000451169 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000771363 | 0.9992286 |
| ENST00000442934 | ENST00000425628 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.000870372 | 0.9991296 |
| ENST00000579180 | ENST00000251241 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001243723 | 0.9987563 |
| ENST00000579180 | ENST00000451169 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001154123 | 0.9988458 |
| ENST00000579180 | ENST00000425628 | MSI2 | chr17 | 55478832 | + | DHX40 | chr17 | 57650477 | + | 0.001995817 | 0.99800414 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >55309_55309_1_MSI2-DHX40_MSI2_chr17_55478832_ENST00000284073_DHX40_chr17_57650477_ENST00000251241_length(amino acids)=782AA_BP=145 MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHE RTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIH LNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGI RYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVI RFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAE QRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGY FKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVRE -------------------------------------------------------------- >55309_55309_2_MSI2-DHX40_MSI2_chr17_55478832_ENST00000284073_DHX40_chr17_57650477_ENST00000425628_length(amino acids)=782AA_BP=145 MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHE RTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIH LNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGI RYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVI RFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAE QRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGY FKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVRE -------------------------------------------------------------- >55309_55309_3_MSI2-DHX40_MSI2_chr17_55478832_ENST00000284073_DHX40_chr17_57650477_ENST00000451169_length(amino acids)=833AA_BP=145 MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHE RTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIH LNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTVSQTSLTFVTHIQIMKQISENQHSLTGLTIAGI TGVSHHARPRNMTCNEKLNQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGR AGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSM VEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKH WIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLE WIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDA -------------------------------------------------------------- >55309_55309_4_MSI2-DHX40_MSI2_chr17_55478832_ENST00000322684_DHX40_chr17_57650477_ENST00000251241_length(amino acids)=768AA_BP=131 MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKK LFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTG QFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNH NPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFN DFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFC TMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQ -------------------------------------------------------------- >55309_55309_5_MSI2-DHX40_MSI2_chr17_55478832_ENST00000322684_DHX40_chr17_57650477_ENST00000425628_length(amino acids)=768AA_BP=131 MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKK LFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTG QFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNH NPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFN DFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFC TMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQ -------------------------------------------------------------- >55309_55309_6_MSI2-DHX40_MSI2_chr17_55478832_ENST00000322684_DHX40_chr17_57650477_ENST00000451169_length(amino acids)=819AA_BP=131 MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKK LFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTG QFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTVSQTSLTFVTHIQIMKQISENQHSLTGLTIAGITGVSHHARPRNMTC NEKLNQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYS KDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVI KAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVE AQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVY ARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDARARFLERKQQRTQD -------------------------------------------------------------- >55309_55309_7_MSI2-DHX40_MSI2_chr17_55478832_ENST00000416426_DHX40_chr17_57650477_ENST00000251241_length(amino acids)=764AA_BP=127 MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQE KSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEI EKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRL GLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALK QLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFAT LAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDG RGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDG -------------------------------------------------------------- >55309_55309_8_MSI2-DHX40_MSI2_chr17_55478832_ENST00000416426_DHX40_chr17_57650477_ENST00000425628_length(amino acids)=764AA_BP=127 MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQE KSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEI EKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRL GLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALK QLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFAT LAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDG RGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDG -------------------------------------------------------------- >55309_55309_9_MSI2-DHX40_MSI2_chr17_55478832_ENST00000416426_DHX40_chr17_57650477_ENST00000451169_length(amino acids)=815AA_BP=127 MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQE KSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEI EKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTVSQTSLTFVTHIQIMKQISENQHSLTGLTIAGITGVSHHARPRNMTCNEKL NQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFW NQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAAS LDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLR ELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIV CPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDARARFLERKQQRTQDHSDT -------------------------------------------------------------- >55309_55309_10_MSI2-DHX40_MSI2_chr17_55478832_ENST00000442934_DHX40_chr17_57650477_ENST00000251241_length(amino acids)=711AA_BP=74 MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHI LGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPR DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGI RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKR TSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAML SVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPK ETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPK -------------------------------------------------------------- >55309_55309_11_MSI2-DHX40_MSI2_chr17_55478832_ENST00000442934_DHX40_chr17_57650477_ENST00000425628_length(amino acids)=711AA_BP=74 MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHI LGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPR DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGI RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKR TSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAML SVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPK ETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPK -------------------------------------------------------------- >55309_55309_12_MSI2-DHX40_MSI2_chr17_55478832_ENST00000442934_DHX40_chr17_57650477_ENST00000451169_length(amino acids)=762AA_BP=74 MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHI LGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPR DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTVSQTSLTFVTHIQI MKQISENQHSLTGLTIAGITGVSHHARPRNMTCNEKLNQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGL DILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQL YQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLA VIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRG SPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGIS -------------------------------------------------------------- >55309_55309_13_MSI2-DHX40_MSI2_chr17_55478832_ENST00000579180_DHX40_chr17_57650477_ENST00000251241_length(amino acids)=668AA_BP=31 MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRK EHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCEL LFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCD AIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFE QCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVH IHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVL -------------------------------------------------------------- >55309_55309_14_MSI2-DHX40_MSI2_chr17_55478832_ENST00000579180_DHX40_chr17_57650477_ENST00000425628_length(amino acids)=668AA_BP=31 MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRK EHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCEL LFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCD AIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFE QCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVH IHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVL -------------------------------------------------------------- >55309_55309_15_MSI2-DHX40_MSI2_chr17_55478832_ENST00000579180_DHX40_chr17_57650477_ENST00000451169_length(amino acids)=719AA_BP=31 MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRK EHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCEL LFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTVSQTSLTFVTHIQIMKQISENQHSLTGLTIAGITGVSHHARPRNMTCNEKLNQQRRI FLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPD HVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDL LLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKL KQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55478832/chr17:57643988) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSI2 | DHX40 |
| FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. | FUNCTION: Probable ATP-dependent RNA helicase. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000284073 | + | 6 | 14 | 21_111 | 135.0 | 1951.0 | Domain | RRM 1 |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000322684 | + | 5 | 10 | 21_111 | 131.0 | 252.0 | Domain | RRM 1 |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000251241 | 2 | 18 | 263_442 | 142.0 | 780.0 | Domain | Helicase C-terminal | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000425628 | 1 | 17 | 263_442 | 65.0 | 703.0 | Domain | Helicase C-terminal | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000425628 | 1 | 17 | 63_231 | 65.0 | 703.0 | Domain | Helicase ATP-binding | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000251241 | 2 | 18 | 173_176 | 142.0 | 780.0 | Motif | Note=DEAH box | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000425628 | 1 | 17 | 173_176 | 65.0 | 703.0 | Motif | Note=DEAH box | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000425628 | 1 | 17 | 76_83 | 65.0 | 703.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000284073 | + | 6 | 14 | 253_260 | 135.0 | 1951.0 | Compositional bias | Note=Poly-Ala |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000322684 | + | 5 | 10 | 253_260 | 131.0 | 252.0 | Compositional bias | Note=Poly-Ala |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000579180 | + | 2 | 7 | 253_260 | 31.0 | 152.0 | Compositional bias | Note=Poly-Ala |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000284073 | + | 6 | 14 | 110_187 | 135.0 | 1951.0 | Domain | RRM 2 |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000322684 | + | 5 | 10 | 110_187 | 131.0 | 252.0 | Domain | RRM 2 |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000579180 | + | 2 | 7 | 110_187 | 31.0 | 152.0 | Domain | RRM 2 |
| Hgene | MSI2 | chr17:55478832 | chr17:57650477 | ENST00000579180 | + | 2 | 7 | 21_111 | 31.0 | 152.0 | Domain | RRM 1 |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000251241 | 2 | 18 | 63_231 | 142.0 | 780.0 | Domain | Helicase ATP-binding | |
| Tgene | DHX40 | chr17:55478832 | chr17:57650477 | ENST00000251241 | 2 | 18 | 76_83 | 142.0 | 780.0 | Nucleotide binding | ATP |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MSI2 | |
| DHX40 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MSI2-DHX40 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MSI2-DHX40 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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