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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MSI2-ICAM2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MSI2-ICAM2
	FusionPDB ID: 55319
	FusionGDB2.0 ID: 55319
		Hgene	Tgene
	Gene symbol	MSI2	ICAM2
	Gene ID	124540	3384
	Gene name	musashi RNA binding protein 2	intercellular adhesion molecule 2
	Synonyms	MSI2H	CD102
	Cytomap	17q22	17q23.3
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2	intercellular adhesion molecule 2ICAM-2
	Modification date	20200313	20200313
	UniProtAcc	Q96DH6	P13598
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000579505, ENST00000284073, ENST00000322684, ENST00000416426, ENST00000442934, ENST00000579180,	ENST00000412356, ENST00000418105, ENST00000449662, ENST00000578379, ENST00000578892, ENST00000579788, ENST00000579687, ENST00000581417,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	40 X 16 X 16=10240	2 X 2 X 2=8
	# samples	45	2
	** MAII score	log2(45/10240*10)=-4.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: MSI2 [Title/Abstract] AND ICAM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MSI2(55704664)-ICAM2(62081324), # samples:3
Anticipated loss of major functional domain due to fusion event.	MSI2-ICAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-ICAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-ICAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MSI2-ICAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MSI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ICAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-66-2783-01A	MSI2	chr17	55704664	-	ICAM2	chr17	62081324	-
ChimerDB4	LUSC	TCGA-66-2783-01A	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-
ChimerDB4	LUSC	TCGA-66-2783	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000416426	MSI2	chr17	55704664	+	ENST00000578892	ICAM2	chr17	62081324	-	1449	796	93	1295	400
ENST00000416426	MSI2	chr17	55704664	+	ENST00000578379	ICAM2	chr17	62081324	-	1449	796	93	1295	400
ENST00000416426	MSI2	chr17	55704664	+	ENST00000449662	ICAM2	chr17	62081324	-	1448	796	93	1295	400
ENST00000416426	MSI2	chr17	55704664	+	ENST00000579788	ICAM2	chr17	62081324	-	1447	796	93	1295	400
ENST00000416426	MSI2	chr17	55704664	+	ENST00000418105	ICAM2	chr17	62081324	-	1447	796	93	1295	400
ENST00000416426	MSI2	chr17	55704664	+	ENST00000412356	ICAM2	chr17	62081324	-	1447	796	93	1295	400
ENST00000284073	MSI2	chr17	55704664	+	ENST00000578892	ICAM2	chr17	62081324	-	1589	936	179	1435	418
ENST00000284073	MSI2	chr17	55704664	+	ENST00000578379	ICAM2	chr17	62081324	-	1589	936	179	1435	418
ENST00000284073	MSI2	chr17	55704664	+	ENST00000449662	ICAM2	chr17	62081324	-	1588	936	179	1435	418
ENST00000284073	MSI2	chr17	55704664	+	ENST00000579788	ICAM2	chr17	62081324	-	1587	936	179	1435	418
ENST00000284073	MSI2	chr17	55704664	+	ENST00000418105	ICAM2	chr17	62081324	-	1587	936	179	1435	418
ENST00000284073	MSI2	chr17	55704664	+	ENST00000412356	ICAM2	chr17	62081324	-	1587	936	179	1435	418
ENST00000322684	MSI2	chr17	55704664	+	ENST00000578892	ICAM2	chr17	62081324	-	1403	750	35	1249	404
ENST00000322684	MSI2	chr17	55704664	+	ENST00000578379	ICAM2	chr17	62081324	-	1403	750	35	1249	404
ENST00000322684	MSI2	chr17	55704664	+	ENST00000449662	ICAM2	chr17	62081324	-	1402	750	35	1249	404
ENST00000322684	MSI2	chr17	55704664	+	ENST00000579788	ICAM2	chr17	62081324	-	1401	750	35	1249	404
ENST00000322684	MSI2	chr17	55704664	+	ENST00000418105	ICAM2	chr17	62081324	-	1401	750	35	1249	404
ENST00000322684	MSI2	chr17	55704664	+	ENST00000412356	ICAM2	chr17	62081324	-	1401	750	35	1249	404
ENST00000442934	MSI2	chr17	55704664	+	ENST00000578892	ICAM2	chr17	62081324	-	1237	584	40	1083	347
ENST00000442934	MSI2	chr17	55704664	+	ENST00000578379	ICAM2	chr17	62081324	-	1237	584	40	1083	347
ENST00000442934	MSI2	chr17	55704664	+	ENST00000449662	ICAM2	chr17	62081324	-	1236	584	40	1083	347
ENST00000442934	MSI2	chr17	55704664	+	ENST00000579788	ICAM2	chr17	62081324	-	1235	584	40	1083	347
ENST00000442934	MSI2	chr17	55704664	+	ENST00000418105	ICAM2	chr17	62081324	-	1235	584	40	1083	347
ENST00000442934	MSI2	chr17	55704664	+	ENST00000412356	ICAM2	chr17	62081324	-	1235	584	40	1083	347
ENST00000579180	MSI2	chr17	55704664	+	ENST00000578892	ICAM2	chr17	62081324	-	1173	520	105	1019	304
ENST00000579180	MSI2	chr17	55704664	+	ENST00000578379	ICAM2	chr17	62081324	-	1173	520	105	1019	304
ENST00000579180	MSI2	chr17	55704664	+	ENST00000449662	ICAM2	chr17	62081324	-	1172	520	105	1019	304
ENST00000579180	MSI2	chr17	55704664	+	ENST00000579788	ICAM2	chr17	62081324	-	1171	520	105	1019	304
ENST00000579180	MSI2	chr17	55704664	+	ENST00000418105	ICAM2	chr17	62081324	-	1171	520	105	1019	304
ENST00000579180	MSI2	chr17	55704664	+	ENST00000412356	ICAM2	chr17	62081324	-	1171	520	105	1019	304

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000416426	ENST00000578892	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004614106	0.99538594
ENST00000416426	ENST00000578379	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004614106	0.99538594
ENST00000416426	ENST00000449662	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004619445	0.9953805
ENST00000416426	ENST00000579788	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004756958	0.995243
ENST00000416426	ENST00000418105	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004756958	0.995243
ENST00000416426	ENST00000412356	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.004756958	0.995243
ENST00000284073	ENST00000578892	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006661508	0.99333847
ENST00000284073	ENST00000578379	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006661508	0.99333847
ENST00000284073	ENST00000449662	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006665442	0.99333453
ENST00000284073	ENST00000579788	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006847785	0.99315226
ENST00000284073	ENST00000418105	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006847785	0.99315226
ENST00000284073	ENST00000412356	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.006847785	0.99315226
ENST00000322684	ENST00000578892	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001684478	0.9983156
ENST00000322684	ENST00000578379	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001684478	0.9983156
ENST00000322684	ENST00000449662	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001690643	0.9983094
ENST00000322684	ENST00000579788	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001737181	0.9982628
ENST00000322684	ENST00000418105	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001737181	0.9982628
ENST00000322684	ENST00000412356	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001737181	0.9982628
ENST00000442934	ENST00000578892	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001874542	0.9981255
ENST00000442934	ENST00000578379	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001874542	0.9981255
ENST00000442934	ENST00000449662	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.001874576	0.9981254
ENST00000442934	ENST00000579788	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.00192672	0.9980732
ENST00000442934	ENST00000418105	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.00192672	0.9980732
ENST00000442934	ENST00000412356	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.00192672	0.9980732
ENST00000579180	ENST00000578892	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002841801	0.99715817
ENST00000579180	ENST00000578379	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002841801	0.99715817
ENST00000579180	ENST00000449662	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002878296	0.99712163
ENST00000579180	ENST00000579788	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002900044	0.9971
ENST00000579180	ENST00000418105	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002900044	0.9971
ENST00000579180	ENST00000412356	MSI2	chr17	55704664	+	ICAM2	chr17	62081324	-	0.002900044	0.9971

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55319_55319_1_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000412356_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_2_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000418105_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_3_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000449662_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_4_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000578379_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_5_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000578892_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_6_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000284073_ICAM2_chr17_62081324_ENST00000579788_length(amino acids)=418AA_BP=252
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI
HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG
KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE

--------------------------------------------------------------

>55319_55319_7_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000412356_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_8_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000418105_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_9_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000449662_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_10_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000578379_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_11_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000578892_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_12_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000322684_ICAM2_chr17_62081324_ENST00000579788_length(amino acids)=404AA_BP=238
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKK
AQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEP
LDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVV

--------------------------------------------------------------

>55319_55319_13_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000412356_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_14_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000418105_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_15_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000449662_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_16_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000578379_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_17_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000578892_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_18_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000416426_ICAM2_chr17_62081324_ENST00000579788_length(amino acids)=400AA_BP=234
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK
EVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSL
TLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLL

--------------------------------------------------------------

>55319_55319_19_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000412356_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_20_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000418105_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_21_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000449662_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_22_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000578379_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_23_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000578892_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_24_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000442934_ICAM2_chr17_62081324_ENST00000579788_length(amino acids)=347AA_BP=181
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHR
GFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQF
PEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMS

--------------------------------------------------------------

>55319_55319_25_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000412356_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

>55319_55319_26_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000418105_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

>55319_55319_27_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000449662_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

>55319_55319_28_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000578379_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

>55319_55319_29_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000578892_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

>55319_55319_30_MSI2-ICAM2_MSI2_chr17_55704664_ENST00000579180_ICAM2_chr17_62081324_ENST00000579788_length(amino acids)=304AA_BP=138
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPP
GTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFR
GNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55704664/chr17:62081324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MSI2 Q96DH6	ICAM2 P13598
FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.	FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000284073

110_187

242.33333333333334

1951.0

Domain

RRM 2

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000284073

21_111

242.33333333333334

1951.0

Domain

RRM 1

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000322684

110_187

238.33333333333334

252.0

Domain

RRM 2

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000322684

21_111

238.33333333333334

252.0

Domain

RRM 1

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000579180

21_111

138.33333333333334

152.0

Domain

RRM 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000412356

127_197

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000418105

127_197

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000449662

127_197

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579687

127_197

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579788

127_197

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000412356

249_275

109.33333333333333

276.0

Topological domain

Cytoplasmic

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000418105

249_275

109.33333333333333

276.0

Topological domain

Cytoplasmic

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000449662

249_275

109.33333333333333

276.0

Topological domain

Cytoplasmic

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579687

249_275

109.33333333333333

276.0

Topological domain

Cytoplasmic

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579788

249_275

109.33333333333333

276.0

Topological domain

Cytoplasmic

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000412356

224_248

109.33333333333333

276.0

Transmembrane

Helical

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000418105

224_248

109.33333333333333

276.0

Transmembrane

Helical

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000449662

224_248

109.33333333333333

276.0

Transmembrane

Helical

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579687

224_248

109.33333333333333

276.0

Transmembrane

Helical

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579788

224_248

109.33333333333333

276.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000284073

253_260

242.33333333333334

1951.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000322684

253_260

238.33333333333334

252.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000579180

253_260

138.33333333333334

152.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55704664

chr17:62081324

ENST00000579180

110_187

138.33333333333334

152.0

Domain

RRM 2

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000412356

41_98

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000418105

41_98

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000449662

41_98

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579687

41_98

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579788

41_98

109.33333333333333

276.0

Domain

Note=Ig-like C2-type 1

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000412356

25_223

109.33333333333333

276.0

Topological domain

Extracellular

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000418105

25_223

109.33333333333333

276.0

Topological domain

Extracellular

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000449662

25_223

109.33333333333333

276.0

Topological domain

Extracellular

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579687

25_223

109.33333333333333

276.0

Topological domain

Extracellular

Tgene

ICAM2

chr17:55704664

chr17:62081324

ENST00000579788

25_223

109.33333333333333

276.0

Topological domain

Extracellular

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>863_MSI2_55704664_ICAM2_62081324_863_MSI2_55704664_ICAM2_62081324_ranked_0.pdb	MSI2	55704664	55704664	ENST00000412356	ICAM2	chr17	62081324	-	MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEI HFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPEPPRQVILTLQPTLVAVG KSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE	418

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MSI2_pLDDT.png

ICAM2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MSI2
ICAM2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MSI2-ICAM2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MSI2-ICAM2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source