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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MSI2-TEX2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MSI2-TEX2
FusionPDB ID: 55334
FusionGDB2.0 ID: 55334
HgeneTgene
Gene symbol

MSI2

TEX2

Gene ID

124540

55852

Gene namemusashi RNA binding protein 2testis expressed 2
SynonymsMSI2HHT008|TMEM96
Cytomap

17q22

17q23.3

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2testis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96
Modification date2020031320200313
UniProtAcc

Q96DH6

.
Ensembl transtripts involved in fusion geneENST idsENST00000579505, ENST00000284073, 
ENST00000322684, ENST00000416426, 
ENST00000442934, ENST00000579180, 
ENST00000258991, ENST00000583097, 
ENST00000584379, ENST00000581812, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 16 X 16=1024012 X 12 X 5=720
# samples 4518
** MAII scorelog2(45/10240*10)=-4.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MSI2 [Title/Abstract] AND TEX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MSI2(55607085)-TEX2(62272455), # samples:4
MSI2(55339553)-TEX2(62291602), # samples:4
Anticipated loss of major functional domain due to fusion event.MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MSI2-TEX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MSI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TEX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27N-01AMSI2chr17

55478832

+TEX2chr17

62272455

-
ChimerDB4BRCATCGA-D8-A27N-01AMSI2chr17

55607085

-TEX2chr17

62272455

-
ChimerDB4BRCATCGA-D8-A27N-01AMSI2chr17

55607085

+TEX2chr17

62272455

-
ChimerDB4BRCATCGA-D8-A27NMSI2chr17

55607085

+TEX2chr17

62272455

-
ChimerDB4BRCATCGA-E9-A228-01AMSI2chr17

55339553

-TEX2chr17

62291602

-
ChimerDB4BRCATCGA-E9-A228-01AMSI2chr17

55339553

+TEX2chr17

62291602

-
ChimerDB4BRCATCGA-E9-A228MSI2chr17

55339553

+TEX2chr17

62291602

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416426MSI2chr1755478832+ENST00000258991TEX2chr1762272455-3977474932234713
ENST00000416426MSI2chr1755478832+ENST00000583097TEX2chr1762272455-3509474932213706
ENST00000416426MSI2chr1755478832+ENST00000584379TEX2chr1762272455-3496474932213706
ENST00000284073MSI2chr1755478832+ENST00000258991TEX2chr1762272455-41176141792374731
ENST00000284073MSI2chr1755478832+ENST00000583097TEX2chr1762272455-36496141792353724
ENST00000284073MSI2chr1755478832+ENST00000584379TEX2chr1762272455-36366141792353724
ENST00000322684MSI2chr1755478832+ENST00000258991TEX2chr1762272455-3931428352188717
ENST00000322684MSI2chr1755478832+ENST00000583097TEX2chr1762272455-3463428352167710
ENST00000322684MSI2chr1755478832+ENST00000584379TEX2chr1762272455-3450428352167710
ENST00000442934MSI2chr1755478832+ENST00000258991TEX2chr1762272455-3765262402022660
ENST00000442934MSI2chr1755478832+ENST00000583097TEX2chr1762272455-3297262402001653
ENST00000442934MSI2chr1755478832+ENST00000584379TEX2chr1762272455-3284262402001653
ENST00000579180MSI2chr1755478832+ENST00000258991TEX2chr1762272455-37011981051958617
ENST00000579180MSI2chr1755478832+ENST00000583097TEX2chr1762272455-32331981051937610
ENST00000579180MSI2chr1755478832+ENST00000584379TEX2chr1762272455-32201981051937610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416426ENST00000258991MSI2chr1755478832+TEX2chr1762272455-0.0023630040.99763703
ENST00000416426ENST00000583097MSI2chr1755478832+TEX2chr1762272455-0.0019833390.9980166
ENST00000416426ENST00000584379MSI2chr1755478832+TEX2chr1762272455-0.0020212130.99797875
ENST00000284073ENST00000258991MSI2chr1755478832+TEX2chr1762272455-0.0008116160.99918836
ENST00000284073ENST00000583097MSI2chr1755478832+TEX2chr1762272455-0.0011274820.99887246
ENST00000284073ENST00000584379MSI2chr1755478832+TEX2chr1762272455-0.0011480070.998852
ENST00000322684ENST00000258991MSI2chr1755478832+TEX2chr1762272455-0.0004257710.99957424
ENST00000322684ENST00000583097MSI2chr1755478832+TEX2chr1762272455-0.0005583650.99944156
ENST00000322684ENST00000584379MSI2chr1755478832+TEX2chr1762272455-0.0005625080.9994375
ENST00000442934ENST00000258991MSI2chr1755478832+TEX2chr1762272455-0.0002626980.9997373
ENST00000442934ENST00000583097MSI2chr1755478832+TEX2chr1762272455-0.0003470860.99965286
ENST00000442934ENST00000584379MSI2chr1755478832+TEX2chr1762272455-0.0003510710.9996489
ENST00000579180ENST00000258991MSI2chr1755478832+TEX2chr1762272455-0.0002619990.99973804
ENST00000579180ENST00000583097MSI2chr1755478832+TEX2chr1762272455-0.0003245720.9996754
ENST00000579180ENST00000584379MSI2chr1755478832+TEX2chr1762272455-0.0003295630.9996705

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55334_55334_1_MSI2-TEX2_MSI2_chr17_55478832_ENST00000284073_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=731AA_BP=145
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSK
PNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPR
PQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIM
SQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVS
KKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGC
RPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVE
VQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLL

--------------------------------------------------------------

>55334_55334_2_MSI2-TEX2_MSI2_chr17_55478832_ENST00000284073_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=724AA_BP=145
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSK
PNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPR
PQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKE
LAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKL
SKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCL
ADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGT
LAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEA

--------------------------------------------------------------

>55334_55334_3_MSI2-TEX2_MSI2_chr17_55478832_ENST00000284073_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=724AA_BP=145
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSK
PNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPR
PQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKE
LAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKL
SKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCL
ADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGT
LAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEA

--------------------------------------------------------------

>55334_55334_4_MSI2-TEX2_MSI2_chr17_55478832_ENST00000322684_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=717AA_BP=131
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEP
KPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQIL
YLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQ
KMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPY
FMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEES
SSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPP

--------------------------------------------------------------

>55334_55334_5_MSI2-TEX2_MSI2_chr17_55478832_ENST00000322684_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=710AA_BP=131
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEP
KPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQIL
YLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYS
VYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTL
TELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSE
EDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVW

--------------------------------------------------------------

>55334_55334_6_MSI2-TEX2_MSI2_chr17_55478832_ENST00000322684_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=710AA_BP=131
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEP
KPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQIL
YLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYS
VYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTL
TELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSE
EDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVW

--------------------------------------------------------------

>55334_55334_7_MSI2-TEX2_MSI2_chr17_55478832_ENST00000416426_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=713AA_BP=127
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEV
TYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFG
RTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLL
DYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNE
LTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAG
SSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTD

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>55334_55334_8_MSI2-TEX2_MSI2_chr17_55478832_ENST00000416426_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=706AA_BP=127
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEV
TYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFG
RTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMG
RCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELD
MGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDA
PEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFR

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>55334_55334_9_MSI2-TEX2_MSI2_chr17_55478832_ENST00000416426_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=706AA_BP=127
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEV
TYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFG
RTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMG
RCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELD
MGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDA
PEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFR

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>55334_55334_10_MSI2-TEX2_MSI2_chr17_55478832_ENST00000442934_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=660AA_BP=74
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHA
TLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKE
TSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSP
SGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNAL
LGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKL
GKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETE
FIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDD

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>55334_55334_11_MSI2-TEX2_MSI2_chr17_55478832_ENST00000442934_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=653AA_BP=74
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHA
TLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKE
TSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHS
RSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWD
FLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVE
ALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIE
EVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMH

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>55334_55334_12_MSI2-TEX2_MSI2_chr17_55478832_ENST00000442934_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=653AA_BP=74
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHA
TLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKE
TSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHS
RSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWD
FLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVE
ALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIE
EVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMH

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>55334_55334_13_MSI2-TEX2_MSI2_chr17_55478832_ENST00000579180_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=617AA_BP=31
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQK
IYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREK
EEWFRRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYM
GRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTEL
DMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDD
APEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGF

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>55334_55334_14_MSI2-TEX2_MSI2_chr17_55478832_ENST00000579180_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=610AA_BP=31
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQK
IYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREK
EEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQE
SRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVP
KILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGG
DKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVE

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>55334_55334_15_MSI2-TEX2_MSI2_chr17_55478832_ENST00000579180_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=610AA_BP=31
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQK
IYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREK
EEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQE
SRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVP
KILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGG
DKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55607085/chr17:62272455)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSI2

Q96DH6

.
FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSI2chr17:55478832chr17:62272455ENST00000284073+61421_111135.01951.0DomainRRM 1
HgeneMSI2chr17:55478832chr17:62272455ENST00000322684+51021_111131.0252.0DomainRRM 1
TgeneTEX2chr17:55478832chr17:62272455ENST000002589911121039_1042548.01135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112816_821548.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST000005830971121039_1042548.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112816_821548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST000005843791121039_1042548.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112816_821548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112816_1101548.01135.0DomainSMP-LTD
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112816_1101548.01128.0DomainSMP-LTD
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112816_1101548.01128.0DomainSMP-LTD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSI2chr17:55478832chr17:62272455ENST00000284073+614253_260135.01951.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55478832chr17:62272455ENST00000322684+510253_260131.0252.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55478832chr17:62272455ENST00000579180+27253_26031.0152.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55478832chr17:62272455ENST00000284073+614110_187135.01951.0DomainRRM 2
HgeneMSI2chr17:55478832chr17:62272455ENST00000322684+510110_187131.0252.0DomainRRM 2
HgeneMSI2chr17:55478832chr17:62272455ENST00000579180+27110_18731.0152.0DomainRRM 2
HgeneMSI2chr17:55478832chr17:62272455ENST00000579180+2721_11131.0152.0DomainRRM 1
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112138_141548.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112159_162548.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST0000025899111243_51548.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112138_141548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112159_162548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST0000058309711243_51548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112138_141548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112159_162548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:55478832chr17:62272455ENST0000058437911243_51548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112475_495548.01135.0TransmembraneHelical
TgeneTEX2chr17:55478832chr17:62272455ENST00000258991112497_517548.01135.0TransmembraneHelical
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112475_495548.01128.0TransmembraneHelical
TgeneTEX2chr17:55478832chr17:62272455ENST00000583097112497_517548.01128.0TransmembraneHelical
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112475_495548.01128.0TransmembraneHelical
TgeneTEX2chr17:55478832chr17:62272455ENST00000584379112497_517548.01128.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MSI2
TEX2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MSI2-TEX2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MSI2-TEX2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource