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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MTMR2-MAML2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MTMR2-MAML2
FusionPDB ID: 55750
FusionGDB2.0 ID: 55750
HgeneTgene
Gene symbol

MTMR2

MAML2

Gene ID

8898

84441

Gene namemyotubularin related protein 2mastermind like transcriptional coactivator 2
SynonymsCMT4B|CMT4B1MAM-3|MAM2|MAM3|MLL-MAML2
Cytomap

11q21

11q21

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatasemastermind-like protein 2mam-2mastermind-like 2
Modification date2020032820200313
UniProtAcc

Q13614

Q8IZL2

Ensembl transtripts involved in fusion geneENST idsENST00000352297, ENST00000393223, 
ENST00000409459, ENST00000484818, 
ENST00000346299, 		ENST00000524717, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 7=50414 X 24 X 9=3024
# samples 1321
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3024*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MTMR2 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MTMR2(95657039)-MAML2(95724887), # samples:2
MTMR2(95598765)-MAML2(95724887), # samples:2
Anticipated loss of major functional domain due to fusion event.MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR2

GO:0046856

phosphatidylinositol dephosphorylation

12668758

HgeneMTMR2

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

TgeneMAML2

GO:0007219

Notch signaling pathway

12370315

TgeneMAML2

GO:0045944

positive regulation of transcription by RNA polymerase II

12370315


check buttonFusion gene breakpoints across MTMR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAML2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18V-01AMTMR2chr11

95657039

-MAML2chr11

95724887

-
ChimerDB4BRCATCGA-E9-A244-01AMTMR2chr11

95598765

-MAML2chr11

95724887

-
ChimerDB4LGGTCGA-HT-7477-01BMTMR2chr11

95621320

-MAML2chr11

95826681

-
ChimerDB4STADTCGA-BR-8678-01AMTMR2chr11

95578117

-MAML2chr11

95724887

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393223MTMR2chr1195598765-ENST00000524717MAML2chr1195724887-43917097932040415
ENST00000352297MTMR2chr1195598765-ENST00000524717MAML2chr1195724887-41614795631810415
ENST00000346299MTMR2chr1195578117-ENST00000524717MAML2chr1195724887-540917272453058937
ENST00000409459MTMR2chr1195578117-ENST00000524717MAML2chr1195724887-535416724753003842
ENST00000346299MTMR2chr1195621320-ENST00000524717MAML2chr1195826681-583552724534841079

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393223ENST00000524717MTMR2chr1195598765-MAML2chr1195724887-0.000267470.99973255
ENST00000352297ENST00000524717MTMR2chr1195598765-MAML2chr1195724887-0.0002183240.99978167
ENST00000346299ENST00000524717MTMR2chr1195578117-MAML2chr1195724887-0.0004659560.999534
ENST00000409459ENST00000524717MTMR2chr1195578117-MAML2chr1195724887-0.0003672990.9996327
ENST00000346299ENST00000524717MTMR2chr1195621320-MAML2chr1195826681-0.0010687010.9989312

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55750_55750_1_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000346299_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=937AA_BP=494
MRPRSVALRPPLLPPCSREDCFSLSLCCPCRAMEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFS
PDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENS
YGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCD
TYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAV
ANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCS
DGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQT
LQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLL
STSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPN
LTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPM
NQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMG

--------------------------------------------------------------

>55750_55750_2_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000409459_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=842AA_BP=399
MRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLET
VCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPAL
LVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAK
GGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDR
TAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQI
MEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHG
TRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSM
ASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQ
TLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNS

--------------------------------------------------------------

>55750_55750_3_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000352297_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=415AA_BP=
MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQA
LANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ
RAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD

--------------------------------------------------------------

>55750_55750_4_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000393223_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=415AA_BP=
MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQA
LANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ
RAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD

--------------------------------------------------------------

>55750_55750_5_MTMR2-MAML2_MTMR2_chr11_95621320_ENST00000346299_MAML2_chr11_95826681_ENST00000524717_length(amino acids)=1079AA_BP=94
MRPRSVALRPPLLPPCSREDCFSLSLCCPCRAMEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFS
PDLRLQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGL
FNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQ
SQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLK
QIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLD
VLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
QQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQV
SQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRP
PPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGM
NQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQE
ALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:95657039/chr11:95724887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR2

Q13614

MAML2

Q8IZL2

FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139}.FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-11154_53462.0644.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-12164_53390.0572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-13174_53390.0572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-13174_53390.0572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-3154_5387.33333333333333644.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-2154_5362.0644.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-111568_139462.0644.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-121668_139390.0572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-131768_139390.0572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-131768_139390.0572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115330_333462.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115355_356462.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115417_423462.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216330_333390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216355_356390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317330_333390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317355_356390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317330_333390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317355_356390.0572.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115593_627462.0644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216593_627390.0572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317593_627390.0572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317593_627390.0572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315593_62787.33333333333333644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416593_62715.333333333333334572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517593_62715.333333333333334572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517593_62715.333333333333334572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215593_62762.0644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115593_62726.666666666666668644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-4164_5315.333333333333334572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-5174_5315.333333333333334572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-5174_5315.333333333333334572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-3164_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-3174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-3174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-1154_5326.666666666666668644.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-1164_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-1174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-1174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115205_580462.0644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216205_580390.0572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317205_580390.0572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317205_580390.0572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315205_58087.33333333333333644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-31568_13987.33333333333333644.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416205_58015.333333333333334572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-41668_13915.333333333333334572.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517205_58015.333333333333334572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-51768_13915.333333333333334572.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517205_58015.333333333333334572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-51768_13915.333333333333334572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215205_58062.0644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-21568_13962.0644.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-31668_1390572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-31768_1390572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-31768_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115205_58026.666666666666668644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-11568_13926.666666666666668644.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-11668_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-11768_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-11768_1390572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216417_423390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317417_423390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317417_423390.0572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315330_33387.33333333333333644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315355_35687.33333333333333644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315417_42387.33333333333333644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416330_33315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416355_35615.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416417_42315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517330_33315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517355_35615.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517417_42315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517330_33315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517355_35615.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517417_42315.333333333333334572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215330_33362.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215355_35662.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215417_42362.0644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115330_33326.666666666666668644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115355_35626.666666666666668644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115417_42326.666666666666668644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117417_4230572.0RegionSubstrate binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MTMR2
MAML2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MTMR2-MAML2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MTMR2-MAML2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAML2C0087031Juvenile-Onset Still Disease1CTD_human
TgeneMAML2C3495559Juvenile arthritis1CTD_human
TgeneMAML2C3714758Juvenile psoriatic arthritis1CTD_human
TgeneMAML2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneMAML2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human