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Fusion Protein:MTR-IFI16 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MTR-IFI16 | FusionPDB ID: 55866 | FusionGDB2.0 ID: 55866 | Hgene | Tgene | Gene symbol | MTR | IFI16 | Gene ID | 4548 | 3428 |
| Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase | interferon gamma inducible protein 16 | |
| Synonyms | HMAG|MS|cblG | IFNGIP1|PYHIN2 | |
| Cytomap | 1q43 | 1q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase | gamma-interferon-inducible protein 16IFI16 beta isoforminterferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9UBK8 | Q16666 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000366577, ENST00000535889, ENST00000418145, ENST00000470570, | ENST00000295809, ENST00000340979, ENST00000359709, ENST00000368131, ENST00000368132, ENST00000430894, ENST00000448393, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 3=108 | 12 X 13 X 7=1092 |
| # samples | 7 | 15 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1092*10)=-2.86393845042397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MTR [Title/Abstract] AND IFI16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MTR(237001899)-IFI16(159019222), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MTR-IFI16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTR-IFI16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTR-IFI16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTR-IFI16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IFI16 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12894224|24413532 |
| Tgene | IFI16 | GO:0002218 | activation of innate immune response | 21575908 |
| Tgene | IFI16 | GO:0030224 | monocyte differentiation | 9766636 |
| Tgene | IFI16 | GO:0032731 | positive regulation of interleukin-1 beta production | 21575908 |
| Tgene | IFI16 | GO:0042149 | cellular response to glucose starvation | 21573174 |
| Tgene | IFI16 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 14654789 |
| Tgene | IFI16 | GO:0043392 | negative regulation of DNA binding | 22291595 |
| Tgene | IFI16 | GO:0045071 | negative regulation of viral genome replication | 22291595 |
| Tgene | IFI16 | GO:0045824 | negative regulation of innate immune response | 22046441 |
| Tgene | IFI16 | GO:0045892 | negative regulation of transcription, DNA-templated | 9642285 |
| Tgene | IFI16 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11146555 |
| Tgene | IFI16 | GO:0051607 | defense response to virus | 21478870 |
| Tgene | IFI16 | GO:0071479 | cellular response to ionizing radiation | 14654789 |
| Tgene | IFI16 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 22046441 |
| Fusion gene breakpoints across MTR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IFI16 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A8-A07O-01A | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
| ChimerDB4 | BRCA | TCGA-A8-A07O-01A | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + |
| ChimerDB4 | BRCA | TCGA-A8-A07O | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159015086 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000340979 | IFI16 | chr1 | 159021469 | + | 2854 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000368131 | IFI16 | chr1 | 159021469 | + | 2856 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000368132 | IFI16 | chr1 | 159021469 | + | 2852 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000295809 | IFI16 | chr1 | 159021469 | + | 2856 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000430894 | IFI16 | chr1 | 159021469 | + | 2849 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000359709 | IFI16 | chr1 | 159021469 | + | 2849 | 1909 | 301 | 2601 | 766 |
| ENST00000366577 | MTR | chr1 | 237001899 | - | ENST00000448393 | IFI16 | chr1 | 159021469 | + | 2825 | 1909 | 301 | 2601 | 766 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000340979 | IFI16 | chr1 | 159021469 | + | 2482 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000368131 | IFI16 | chr1 | 159021469 | + | 2484 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000368132 | IFI16 | chr1 | 159021469 | + | 2480 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000295809 | IFI16 | chr1 | 159021469 | + | 2484 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000430894 | IFI16 | chr1 | 159021469 | + | 2477 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000359709 | IFI16 | chr1 | 159021469 | + | 2477 | 1537 | 22 | 2229 | 735 |
| ENST00000535889 | MTR | chr1 | 237001899 | - | ENST00000448393 | IFI16 | chr1 | 159021469 | + | 2453 | 1537 | 22 | 2229 | 735 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000366577 | ENST00000340979 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000975812 | 0.99902415 |
| ENST00000366577 | ENST00000368131 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000979442 | 0.9990206 |
| ENST00000366577 | ENST00000368132 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000982096 | 0.99901783 |
| ENST00000366577 | ENST00000295809 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000979442 | 0.9990206 |
| ENST00000366577 | ENST00000430894 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000983399 | 0.99901664 |
| ENST00000366577 | ENST00000359709 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000983399 | 0.99901664 |
| ENST00000366577 | ENST00000448393 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.001117378 | 0.9988826 |
| ENST00000535889 | ENST00000340979 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000877791 | 0.9991222 |
| ENST00000535889 | ENST00000368131 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000882524 | 0.99911743 |
| ENST00000535889 | ENST00000368132 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000883561 | 0.9991165 |
| ENST00000535889 | ENST00000295809 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000882524 | 0.99911743 |
| ENST00000535889 | ENST00000430894 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000880699 | 0.99911934 |
| ENST00000535889 | ENST00000359709 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.000880699 | 0.99911934 |
| ENST00000535889 | ENST00000448393 | MTR | chr1 | 237001899 | - | IFI16 | chr1 | 159021469 | + | 0.001002231 | 0.99899775 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >55866_55866_1_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000295809_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_2_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000340979_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_3_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000359709_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_4_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000368131_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_5_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000368132_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_6_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000430894_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_7_MTR-IFI16_MTR_chr1_237001899_ENST00000366577_IFI16_chr1_159021469_ENST00000448393_length(amino acids)=766AA_BP=536 MALAGVALGRRHLWRARLLCRALCARRRLDNMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDH ARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPT NKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQ TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPD HIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDD GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPR LKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTL VADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFE -------------------------------------------------------------- >55866_55866_8_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000295809_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_9_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000340979_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_10_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000359709_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_11_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000368131_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_12_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000368132_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_13_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000430894_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- >55866_55866_14_MTR-IFI16_MTR_chr1_237001899_ENST00000535889_IFI16_chr1_159021469_ENST00000448393_length(amino acids)=735AA_BP=505 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGA DIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPF IEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFV YEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCS QTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDI -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:237001899/chr1:159019222) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTR | IFI16 |
| FUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250|UniProtKB:Q8C1A3, ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17892308, ECO:0000269|PubMed:27771510, ECO:0000305|PubMed:19243433}. | FUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 19_338 | 505.0 | 1266.0 | Domain | Hcy-binding |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 382_384 | 505.0 | 1266.0 | Region | Substrate binding |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 562_761 | 555.0 | 786.0 | Domain | HIN-200 2 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 562_761 | 443.0 | 674.0 | Domain | HIN-200 2 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 562_761 | 499.0 | 730.0 | Domain | HIN-200 2 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 562_761 | 499.0 | 730.0 | Domain | HIN-200 2 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 562_761 | 499.0 | 730.0 | Domain | HIN-200 2 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 562_761 | 443.0 | 674.0 | Domain | HIN-200 2 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 371_632 | 505.0 | 1266.0 | Domain | Pterin-binding |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 662_759 | 505.0 | 1266.0 | Domain | B12-binding N-terminal |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 772_907 | 505.0 | 1266.0 | Domain | B12-binding |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 923_1265 | 505.0 | 1266.0 | Domain | AdoMet activation |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 1227_1228 | 505.0 | 1266.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | MTR | chr1:237001899 | chr1:159021469 | ENST00000366577 | - | 15 | 33 | 782_786 | 505.0 | 1266.0 | Region | Methylcob(III)alamin binding |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 1_150 | 555.0 | 786.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 258_261 | 555.0 | 786.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 1_150 | 443.0 | 674.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 258_261 | 443.0 | 674.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 1_150 | 499.0 | 730.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 258_261 | 499.0 | 730.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 1_150 | 499.0 | 730.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 258_261 | 499.0 | 730.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 1_150 | 499.0 | 730.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 258_261 | 499.0 | 730.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 1_150 | 443.0 | 674.0 | Compositional bias | Note=Lys-rich | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 258_261 | 443.0 | 674.0 | Compositional bias | Note=Poly-Ile | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 189_389 | 555.0 | 786.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 1_88 | 555.0 | 786.0 | Domain | Pyrin | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 189_389 | 443.0 | 674.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 1_88 | 443.0 | 674.0 | Domain | Pyrin | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 189_389 | 499.0 | 730.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 1_88 | 499.0 | 730.0 | Domain | Pyrin | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 189_389 | 499.0 | 730.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 1_88 | 499.0 | 730.0 | Domain | Pyrin | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 189_389 | 499.0 | 730.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 1_88 | 499.0 | 730.0 | Domain | Pyrin | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 189_389 | 443.0 | 674.0 | Domain | HIN-200 1 | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 1_88 | 443.0 | 674.0 | Domain | Pyrin |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MTR | |
| IFI16 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000295809 | 8 | 12 | 192_393 | 555.0 | 786.0 | TP53 C-terminus | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000340979 | 6 | 10 | 192_393 | 443.0 | 674.0 | TP53 C-terminus | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000359709 | 7 | 11 | 192_393 | 499.0 | 730.0 | TP53 C-terminus | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368131 | 7 | 11 | 192_393 | 499.0 | 730.0 | TP53 C-terminus | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000368132 | 7 | 11 | 192_393 | 499.0 | 730.0 | TP53 C-terminus | |
| Tgene | IFI16 | chr1:237001899 | chr1:159021469 | ENST00000448393 | 5 | 9 | 192_393 | 443.0 | 674.0 | TP53 C-terminus |
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Related Drugs to MTR-IFI16 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MTR-IFI16 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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