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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MTRR-NMD3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MTRR-NMD3
	FusionPDB ID: 55903
	FusionGDB2.0 ID: 55903
		Hgene	Tgene
	Gene symbol	MTRR	NMD3
	Gene ID	4552	51068
	Gene name	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	NMD3 ribosome export adaptor
	Synonyms	MSR\|cblE	CGI-07
	Cytomap	5p15.31	3q26.1
	Type of gene	protein-coding	protein-coding
	Description	methionine synthase reductase[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)methionine synthase reductase, mitochondrial	60S ribosomal export protein NMD3NMD3 homologhNMD3
	Modification date	20200315	20200313
	UniProtAcc	Q9UBK8	Q96D46
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264668, ENST00000440940, ENST00000341013, ENST00000502509,	ENST00000478160, ENST00000351193, ENST00000460469, ENST00000472947,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 2 X 3=18	4 X 4 X 4=64
	# samples	3	4
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MTRR [Title/Abstract] AND NMD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MTRR(7897360)-NMD3(160965046), # samples:3
Anticipated loss of major functional domain due to fusion event.	MTRR-NMD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTRR-NMD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTRR-NMD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTRR-NMD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTRR	GO:0009086	methionine biosynthetic process	11466310
Hgene	MTRR	GO:0043418	homocysteine catabolic process	11466310
Hgene	MTRR	GO:0046655	folic acid metabolic process	11466310
Hgene	MTRR	GO:1904042	negative regulation of cystathionine beta-synthase activity	24416422

Fusion gene breakpoints across MTRR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NMD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-66-2753-01A	MTRR	chr5	7897360	-	NMD3	chr3	160965046	+
ChimerDB4	LUSC	TCGA-66-2753-01A	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+
ChimerDB4	LUSC	TCGA-66-2753	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264668	MTRR	chr5	7897360	+	ENST00000351193	NMD3	chr3	160965046	+	3842	2063	30	2444	804
ENST00000264668	MTRR	chr5	7897360	+	ENST00000472947	NMD3	chr3	160965046	+	3189	2063	30	2522	830
ENST00000264668	MTRR	chr5	7897360	+	ENST00000460469	NMD3	chr3	160965046	+	3539	2063	30	2444	804
ENST00000440940	MTRR	chr5	7897360	+	ENST00000351193	NMD3	chr3	160965046	+	3783	2004	13	2385	790
ENST00000440940	MTRR	chr5	7897360	+	ENST00000472947	NMD3	chr3	160965046	+	3130	2004	13	2463	816
ENST00000440940	MTRR	chr5	7897360	+	ENST00000460469	NMD3	chr3	160965046	+	3480	2004	13	2385	790

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264668	ENST00000351193	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000178343	0.9998217
ENST00000264668	ENST00000472947	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000429777	0.9995702
ENST00000264668	ENST00000460469	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000260731	0.9997392
ENST00000440940	ENST00000351193	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000104013	0.99989593
ENST00000440940	ENST00000472947	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000296202	0.9997038
ENST00000440940	ENST00000460469	MTRR	chr5	7897360	+	NMD3	chr3	160965046	+	0.000154416	0.9998455

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55903_55903_1_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000351193_length(amino acids)=804AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW

--------------------------------------------------------------

>55903_55903_2_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000460469_length(amino acids)=804AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW

--------------------------------------------------------------

>55903_55903_3_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000472947_length(amino acids)=830AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW
KLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEAKSAPEAADLES

--------------------------------------------------------------

>55903_55903_4_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000351193_length(amino acids)=790AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT

--------------------------------------------------------------

>55903_55903_5_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000460469_length(amino acids)=790AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT

--------------------------------------------------------------

>55903_55903_6_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000472947_length(amino acids)=816AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT
DDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEAKSAPEAADLESEVTEGPSVVVDACN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7897360/chr3:160965046)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTRR Q9UBK8	NMD3 Q96D46
FUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250\|UniProtKB:Q8C1A3, ECO:0000269\|PubMed:16769880, ECO:0000269\|PubMed:17892308, ECO:0000269\|PubMed:27771510, ECO:0000305\|PubMed:19243433}.	FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269\|PubMed:12724356, ECO:0000269\|PubMed:12773398}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

271_533

677.6666666666666

726.0

Domain

FAD-binding FR-type

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

5_147

677.6666666666666

726.0

Domain

Flavodoxin-like

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

271_533

650.6666666666666

699.0

Domain

FAD-binding FR-type

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

5_147

650.6666666666666

699.0

Domain

Flavodoxin-like

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

487_490

677.6666666666666

726.0

Nucleotide binding

FAD

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

610_611

677.6666666666666

726.0

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

624_626

677.6666666666666

726.0

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

93_124

677.6666666666666

726.0

Nucleotide binding

FMN

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

487_490

650.6666666666666

699.0

Nucleotide binding

FAD

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

610_611

650.6666666666666

699.0

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

624_626

650.6666666666666

699.0

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

93_124

650.6666666666666

699.0

Nucleotide binding

FMN

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000264668

166_247

677.6666666666666

726.0

Region

Note=Hinge

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000440940

166_247

650.6666666666666

699.0

Region

Note=Hinge

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000351193

405_422

376.6666666666667

504.0

Motif

Note=Nuclear and nucleolar localization signal

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000351193

480_489

376.6666666666667

504.0

Motif

Note=Nuclear export signal

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000460469

405_422

376.6666666666667

504.0

Motif

Note=Nuclear and nucleolar localization signal

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000460469

480_489

376.6666666666667

504.0

Motif

Note=Nuclear export signal

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000351193

425_503

376.6666666666667

504.0

Region

Note=Necessary for the nuclear export of the 60S ribosomal subunit

Tgene

NMD3

chr5:7897360

chr3:160965046

ENST00000460469

425_503

376.6666666666667

504.0

Region

Note=Necessary for the nuclear export of the 60S ribosomal subunit

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

271_533

58.333333333333336

Domain

FAD-binding FR-type

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

5_147

58.333333333333336

Domain

Flavodoxin-like

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

487_490

58.333333333333336

Nucleotide binding

FAD

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

610_611

58.333333333333336

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

624_626

58.333333333333336

Nucleotide binding

NADP

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

93_124

58.333333333333336

Nucleotide binding

FMN

Hgene

MTRR

chr5:7897360

chr3:160965046

ENST00000341013

166_247

58.333333333333336

Region

Note=Hinge

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1617_MTRR_7897360_NMD3_160965046_ranked_0.pdb	MTRR	7897360	7897360	ENST00000460469	NMD3	chr3	160965046	+	MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW KLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEAKSAPEAADLES	830

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MTRR_pLDDT.png

NMD3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MTRR
NMD3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MTRR-NMD3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MTRR-NMD3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source