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Fusion Protein:MTUS1-FBXO38 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MTUS1-FBXO38 | FusionPDB ID: 55935 | FusionGDB2.0 ID: 55935 | Hgene | Tgene | Gene symbol | MTUS1 | FBXO38 | Gene ID | 57509 | 81545 |
| Gene name | microtubule associated scaffold protein 1 | F-box protein 38 | |
| Synonyms | ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1 | Fbx38|HMN2D|MOKA|SP329 | |
| Cytomap | 8p22 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit | F-box only protein 38modulator of KLF7 activity homolog | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9ULD2 | Q6PIJ6 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262102, ENST00000381861, ENST00000381869, ENST00000519263, ENST00000544260, ENST00000297488, ENST00000381862, ENST00000400046, ENST00000518713, | ENST00000509699, ENST00000513826, ENST00000296701, ENST00000340253, ENST00000394370, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 12 X 13 X 5=780 | 8 X 6 X 7=336 |
| # samples | 15 | 8 | |
| ** MAII score | log2(15/780*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MTUS1 [Title/Abstract] AND FBXO38 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MTUS1(17570723)-FBXO38(147812987), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MTUS1-FBXO38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTUS1-FBXO38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTUS1-FBXO38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTUS1-FBXO38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTUS1-FBXO38 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. MTUS1-FBXO38 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXO38 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell | 30487606 |
| Tgene | FBXO38 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 30487606 |
| Tgene | FBXO38 | GO:0070936 | protein K48-linked ubiquitination | 30487606 |
| Fusion gene breakpoints across MTUS1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FBXO38 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-8534-01A | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000544260 | MTUS1 | chr8 | 17570723 | - | ENST00000340253 | FBXO38 | chr5 | 147812987 | + | 1932 | 329 | 235 | 1242 | 335 |
| ENST00000544260 | MTUS1 | chr8 | 17570723 | - | ENST00000296701 | FBXO38 | chr5 | 147812987 | + | 1923 | 329 | 235 | 1242 | 335 |
| ENST00000544260 | MTUS1 | chr8 | 17570723 | - | ENST00000394370 | FBXO38 | chr5 | 147812987 | + | 1932 | 329 | 235 | 1242 | 335 |
| ENST00000381861 | MTUS1 | chr8 | 17570723 | - | ENST00000340253 | FBXO38 | chr5 | 147812987 | + | 2287 | 684 | 320 | 1597 | 425 |
| ENST00000381861 | MTUS1 | chr8 | 17570723 | - | ENST00000296701 | FBXO38 | chr5 | 147812987 | + | 2278 | 684 | 320 | 1597 | 425 |
| ENST00000381861 | MTUS1 | chr8 | 17570723 | - | ENST00000394370 | FBXO38 | chr5 | 147812987 | + | 2287 | 684 | 320 | 1597 | 425 |
| ENST00000519263 | MTUS1 | chr8 | 17570723 | - | ENST00000340253 | FBXO38 | chr5 | 147812987 | + | 4238 | 2635 | 174 | 3548 | 1124 |
| ENST00000519263 | MTUS1 | chr8 | 17570723 | - | ENST00000296701 | FBXO38 | chr5 | 147812987 | + | 4229 | 2635 | 174 | 3548 | 1124 |
| ENST00000519263 | MTUS1 | chr8 | 17570723 | - | ENST00000394370 | FBXO38 | chr5 | 147812987 | + | 4238 | 2635 | 174 | 3548 | 1124 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000544260 | ENST00000340253 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000220429 | 0.9997795 |
| ENST00000544260 | ENST00000296701 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000229947 | 0.9997701 |
| ENST00000544260 | ENST00000394370 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000220429 | 0.9997795 |
| ENST00000381861 | ENST00000340253 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000295841 | 0.9997042 |
| ENST00000381861 | ENST00000296701 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000304222 | 0.9996958 |
| ENST00000381861 | ENST00000394370 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000295841 | 0.9997042 |
| ENST00000519263 | ENST00000340253 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000273966 | 0.999726 |
| ENST00000519263 | ENST00000296701 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000277612 | 0.9997224 |
| ENST00000519263 | ENST00000394370 | MTUS1 | chr8 | 17570723 | - | FBXO38 | chr5 | 147812987 | + | 0.000273966 | 0.999726 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >55935_55935_1_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000381861_FBXO38_chr5_147812987_ENST00000296701_length(amino acids)=425AA_BP=121 MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFY LKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- >55935_55935_2_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000381861_FBXO38_chr5_147812987_ENST00000340253_length(amino acids)=425AA_BP=121 MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFY LKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- >55935_55935_3_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000381861_FBXO38_chr5_147812987_ENST00000394370_length(amino acids)=425AA_BP=121 MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFY LKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- >55935_55935_4_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000519263_FBXO38_chr5_147812987_ENST00000296701_length(amino acids)=1124AA_BP=820 MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFI SKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGK SQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGK VTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKS EAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSAS SPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSV SALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLR QIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSAGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPS RKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKV ENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIAN INQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSAD -------------------------------------------------------------- >55935_55935_5_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000519263_FBXO38_chr5_147812987_ENST00000340253_length(amino acids)=1124AA_BP=820 MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFI SKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGK SQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGK VTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKS EAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSAS SPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSV SALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLR QIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSAGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPS RKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKV ENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIAN INQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSAD -------------------------------------------------------------- >55935_55935_6_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000519263_FBXO38_chr5_147812987_ENST00000394370_length(amino acids)=1124AA_BP=820 MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFI SKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGK SQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGK VTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKS EAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSAS SPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSV SALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLR QIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSAGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPS RKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKV ENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIAN INQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSAD -------------------------------------------------------------- >55935_55935_7_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000544260_FBXO38_chr5_147812987_ENST00000296701_length(amino acids)=335AA_BP=31 MKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- >55935_55935_8_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000544260_FBXO38_chr5_147812987_ENST00000340253_length(amino acids)=335AA_BP=31 MKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- >55935_55935_9_MTUS1-FBXO38_MTUS1_chr8_17570723_ENST00000544260_FBXO38_chr5_147812987_ENST00000394370_length(amino acids)=335AA_BP=31 MKPLVSRAHVHLMKTPPKGPSRKNLFTALNAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17570723/chr5:147812987) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTUS1 | FBXO38 |
| FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 896_899 | 639.3333333333334 | 944.0 | Motif | Nuclear localization signal | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 896_899 | 884.3333333333334 | 1189.0 | Motif | Nuclear localization signal | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 896_899 | 809.3333333333334 | 1114.0 | Motif | Nuclear localization signal | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 896_899 | 639.3333333333334 | 944.0 | Motif | Nuclear localization signal |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000262102 | - | 6 | 15 | 940_1231 | 874.3333333333334 | 1271.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000297488 | - | 1 | 10 | 940_1231 | 0 | 437.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000381861 | - | 3 | 12 | 940_1231 | 121.33333333333333 | 518.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000381862 | - | 1 | 4 | 940_1231 | 0 | 771.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000381869 | - | 5 | 14 | 940_1231 | 820.3333333333334 | 1217.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000400046 | - | 1 | 9 | 940_1231 | 0.0 | 343.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000519263 | - | 4 | 13 | 940_1231 | 820.3333333333334 | 1217.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS1 | chr8:17570723 | chr5:147812987 | ENST00000544260 | - | 3 | 12 | 940_1231 | 19.333333333333332 | 416.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 30_75 | 639.3333333333334 | 944.0 | Domain | F-box | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 30_75 | 884.3333333333334 | 1189.0 | Domain | F-box | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 30_75 | 809.3333333333334 | 1114.0 | Domain | F-box | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 30_75 | 639.3333333333334 | 944.0 | Domain | F-box | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 194_201 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 1 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 307_316 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 2 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 451_460 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 3 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 194_201 | 884.3333333333334 | 1189.0 | Motif | Nuclear export signal 1 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 307_316 | 884.3333333333334 | 1189.0 | Motif | Nuclear export signal 2 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 451_460 | 884.3333333333334 | 1189.0 | Motif | Nuclear export signal 3 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 194_201 | 809.3333333333334 | 1114.0 | Motif | Nuclear export signal 1 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 307_316 | 809.3333333333334 | 1114.0 | Motif | Nuclear export signal 2 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 451_460 | 809.3333333333334 | 1114.0 | Motif | Nuclear export signal 3 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 194_201 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 1 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 307_316 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 2 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 451_460 | 639.3333333333334 | 944.0 | Motif | Nuclear export signal 3 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MTUS1 | |
| FBXO38 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000296701 | 13 | 21 | 59_119 | 639.3333333333334 | 944.0 | KLF7 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000340253 | 14 | 22 | 59_119 | 884.3333333333334 | 1189.0 | KLF7 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000394370 | 14 | 22 | 59_119 | 809.3333333333334 | 1114.0 | KLF7 | |
| Tgene | FBXO38 | chr8:17570723 | chr5:147812987 | ENST00000513826 | 12 | 20 | 59_119 | 639.3333333333334 | 944.0 | KLF7 |
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Related Drugs to MTUS1-FBXO38 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MTUS1-FBXO38 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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