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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MTUS1-PDCD4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MTUS1-PDCD4
FusionPDB ID: 55938
FusionGDB2.0 ID: 55938
HgeneTgene
Gene symbol

MTUS1

PDCD4

Gene ID

57509

27250

Gene namemicrotubule associated scaffold protein 1programmed cell death 4
SynonymsATBP|ATIP|ATIP3|ICIS|MP44|MTSG1H731
Cytomap

8p22

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mitprogrammed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a
Modification date2020031320200329
UniProtAcc

Q9ULD2

.
Ensembl transtripts involved in fusion geneENST idsENST00000262102, ENST00000297488, 
ENST00000381861, ENST00000381869, 
ENST00000400046, ENST00000519263, 
ENST00000544260, ENST00000518713, 
ENST00000381862, 
ENST00000481353, 
ENST00000280154, ENST00000393104, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 5=7805 X 6 X 5=150
# samples 156
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MTUS1 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MTUS1(17532695)-PDCD4(112640991), # samples:1
Anticipated loss of major functional domain due to fusion event.MTUS1-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTUS1-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTUS1-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
MTUS1-PDCD4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDCD4

GO:0007569

cell aging

12054647

TgenePDCD4

GO:0030509

BMP signaling pathway

18548003

TgenePDCD4

GO:0045892

negative regulation of transcription, DNA-templated

16357133

TgenePDCD4

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

18548003


check buttonFusion gene breakpoints across MTUS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDCD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3362-01AMTUS1chr8

17532695

-PDCD4chr10

112640991

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000544260MTUS1chr817532695-ENST00000280154PDCD4chr10112640991+38966112351977580
ENST00000544260MTUS1chr817532695-ENST00000393104PDCD4chr10112640991+38956112351977580
ENST00000381861MTUS1chr817532695-ENST00000280154PDCD4chr10112640991+42519663202332670
ENST00000381861MTUS1chr817532695-ENST00000393104PDCD4chr10112640991+42509663202332670
ENST00000519263MTUS1chr817532695-ENST00000280154PDCD4chr10112640991+6202291717442831369
ENST00000519263MTUS1chr817532695-ENST00000393104PDCD4chr10112640991+6201291717442831369
ENST00000400046MTUS1chr817532695-ENST00000280154PDCD4chr10112640991+340612101487495
ENST00000400046MTUS1chr817532695-ENST00000393104PDCD4chr10112640991+340512101487495
ENST00000297488MTUS1chr817532695-ENST00000280154PDCD4chr10112640991+39816962932062589
ENST00000297488MTUS1chr817532695-ENST00000393104PDCD4chr10112640991+39806962932062589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544260ENST00000280154MTUS1chr817532695-PDCD4chr10112640991+0.0001915390.9998085
ENST00000544260ENST00000393104MTUS1chr817532695-PDCD4chr10112640991+0.0001918580.99980813
ENST00000381861ENST00000280154MTUS1chr817532695-PDCD4chr10112640991+0.0001774650.99982256
ENST00000381861ENST00000393104MTUS1chr817532695-PDCD4chr10112640991+0.0001780950.99982196
ENST00000519263ENST00000280154MTUS1chr817532695-PDCD4chr10112640991+8.39E-050.9999161
ENST00000519263ENST00000393104MTUS1chr817532695-PDCD4chr10112640991+8.40E-050.99991596
ENST00000400046ENST00000280154MTUS1chr817532695-PDCD4chr10112640991+5.06E-050.99994934
ENST00000400046ENST00000393104MTUS1chr817532695-PDCD4chr10112640991+5.07E-050.99994934
ENST00000297488ENST00000280154MTUS1chr817532695-PDCD4chr10112640991+0.0002855890.99971443
ENST00000297488ENST00000393104MTUS1chr817532695-PDCD4chr10112640991+0.0002858830.9997141

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55938_55938_1_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000297488_PDCD4_chr10_112640991_ENST00000280154_length(amino acids)=589AA_BP=134
MLLSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTVVFHTVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQ
LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAK
RRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENC
VYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSF
DKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKE
IDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVP

--------------------------------------------------------------

>55938_55938_2_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000297488_PDCD4_chr10_112640991_ENST00000393104_length(amino acids)=589AA_BP=134
MLLSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTVVFHTVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQ
LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAK
RRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENC
VYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSF
DKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKE
IDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVP

--------------------------------------------------------------

>55938_55938_3_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000381861_PDCD4_chr10_112640991_ENST00000280154_length(amino acids)=670AA_BP=215
MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFY
LKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF
EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSR
DSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPL
DERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPE
LALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYL
LSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERF

--------------------------------------------------------------

>55938_55938_4_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000381861_PDCD4_chr10_112640991_ENST00000393104_length(amino acids)=670AA_BP=215
MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFY
LKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF
EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSR
DSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPL
DERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPE
LALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYL
LSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERF

--------------------------------------------------------------

>55938_55938_5_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000400046_PDCD4_chr10_112640991_ENST00000280154_length(amino acids)=495AA_BP=40
MGCPSSKLCLYSPCAATRREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLR
KNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYET
VVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLL
KDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDML
LKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYS

--------------------------------------------------------------

>55938_55938_6_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000400046_PDCD4_chr10_112640991_ENST00000393104_length(amino acids)=495AA_BP=40
MGCPSSKLCLYSPCAATRREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLR
KNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYET
VVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLL
KDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDML
LKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYS

--------------------------------------------------------------

>55938_55938_7_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000519263_PDCD4_chr10_112640991_ENST00000280154_length(amino acids)=1369AA_BP=914
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFI
SKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGK
SQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGK
VTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKS
EAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK
CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSAS
SPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSV
SALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLR
QIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSAGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPS
RKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
KTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLT
VPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGD
TNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVG
DGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFH
HELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR

--------------------------------------------------------------

>55938_55938_8_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000519263_PDCD4_chr10_112640991_ENST00000393104_length(amino acids)=1369AA_BP=914
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFI
SKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGK
SQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGK
VTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKS
EAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK
CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSAS
SPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSV
SALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLR
QIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSAGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPS
RKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
KTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLT
VPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGD
TNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVG
DGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFH
HELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR

--------------------------------------------------------------

>55938_55938_9_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000544260_PDCD4_chr10_112640991_ENST00000280154_length(amino acids)=580AA_BP=125
MKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF
EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSR
DSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPL
DERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPE
LALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYL
LSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERF

--------------------------------------------------------------

>55938_55938_10_MTUS1-PDCD4_MTUS1_chr8_17532695_ENST00000544260_PDCD4_chr10_112640991_ENST00000393104_length(amino acids)=580AA_BP=125
MKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF
EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSR
DSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPL
DERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPE
LALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYL
LSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17532695/chr10:112640991)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTUS1

Q9ULD2

.
FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDCD4chr8:17532695chr10:112640991ENST00000280154112163_28414.333333333333334470.0DomainMI 1
TgenePDCD4chr8:17532695chr10:112640991ENST00000280154112326_44914.333333333333334470.0DomainMI 2
TgenePDCD4chr8:17532695chr10:112640991ENST00000393104213163_2843.3333333333333335459.0DomainMI 1
TgenePDCD4chr8:17532695chr10:112640991ENST00000393104213326_4493.3333333333333335459.0DomainMI 2
TgenePDCD4chr8:17532695chr10:112640991ENST00000280154112241_25014.333333333333334470.0MotifNuclear localization signal
TgenePDCD4chr8:17532695chr10:112640991ENST0000028015411258_6414.333333333333334470.0MotifNuclear localization signal
TgenePDCD4chr8:17532695chr10:112640991ENST0000028015411270_7614.333333333333334470.0MotifNote=Phosphodegron
TgenePDCD4chr8:17532695chr10:112640991ENST00000393104213241_2503.3333333333333335459.0MotifNuclear localization signal
TgenePDCD4chr8:17532695chr10:112640991ENST0000039310421358_643.3333333333333335459.0MotifNuclear localization signal
TgenePDCD4chr8:17532695chr10:112640991ENST0000039310421370_763.3333333333333335459.0MotifNote=Phosphodegron

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTUS1chr8:17532695chr10:112640991ENST00000262102-815940_1231968.33333333333341271.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000297488-310940_1231134.33333333333334437.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000381861-512940_1231215.33333333333334518.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000381862-14940_12310771.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000381869-714940_1231914.33333333333341217.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000400046-29940_123140.333333333333336343.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000519263-613940_1231914.33333333333341217.0Coiled coilOntology_term=ECO:0000255
HgeneMTUS1chr8:17532695chr10:112640991ENST00000544260-512940_1231113.33333333333333416.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MTUS1
PDCD4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MTUS1-PDCD4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MTUS1-PDCD4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource