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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MYH10-CDKN2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MYH10-CDKN2A
FusionPDB ID: 56273
FusionGDB2.0 ID: 56273
HgeneTgene
Gene symbol

MYH10

CDKN2A

Gene ID

4628

1029

Gene namemyosin heavy chain 10cyclin dependent kinase inhibitor 2A
SynonymsNMMHC-IIB|NMMHCBARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16
Cytomap

17p13.1

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionmyosin-10cellular myosin heavy chain, type Bmyosin heavy chain, nonmuscle type Bmyosin, heavy chain 10, non-musclemyosin, heavy polypeptide 10, non-musclenonmuscle myosin II heavy chain-Bnonmuscle myosin heavy chain IIBcyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1
Modification date2020031320200329
UniProtAcc

P35580

Q96HQ2

Ensembl transtripts involved in fusion geneENST idsENST00000269243, ENST00000360416, 
ENST00000379980, ENST00000396239, 
ENST00000446177, ENST00000479692, 
ENST00000494262, ENST00000497750, 
ENST00000498124, ENST00000498628, 
ENST00000530628, ENST00000578845, 
ENST00000470819, ENST00000304494, 
ENST00000579122, ENST00000361570, 
ENST00000579755, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 15 X 5=90013 X 5 X 10=650
# samples 1516
** MAII scorelog2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/650*10)=-2.02236781302845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MYH10 [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDKN2A(21994138)-MYH10(8508300), # samples:2
MYH10(8526220)-CDKN2A(21971207), # samples:2
Anticipated loss of major functional domain due to fusion event.CDKN2A-MYH10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2A-MYH10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYH10

GO:0000281

mitotic cytokinesis

15774463

HgeneMYH10

GO:0030048

actin filament-based movement

15845534

TgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

TgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

TgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

TgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

TgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

TgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

TgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215


check buttonFusion gene breakpoints across MYH10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDKN2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-A71P-01AMYH10chr17

8526220

-CDKN2Achr9

21971207

-
ChimerDB4SARCTCGA-SI-A71PMYH10chr17

8526219

-CDKN2Achr9

21971207

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360416MYH10chr178526220-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000360416MYH10chr178526220-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000379980MYH10chr178526220-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000379980MYH10chr178526220-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000396239MYH10chr178526220-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000396239MYH10chr178526220-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000269243MYH10chr178526220-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000269243MYH10chr178526220-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000360416MYH10chr178526219-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000360416MYH10chr178526219-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000379980MYH10chr178526219-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000379980MYH10chr178526219-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000396239MYH10chr178526219-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000396239MYH10chr178526219-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000269243MYH10chr178526219-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000269243MYH10chr178526219-ENST00000579755CDKN2Achr921971207-1281484139804221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360416ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0023159420.997684
ENST00000360416ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0023075390.99769247
ENST00000379980ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0021275340.9978725
ENST00000379980ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0021185770.99788135
ENST00000396239ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0021275340.9978725
ENST00000396239ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0021185770.99788135
ENST00000269243ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0023159420.997684
ENST00000269243ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0023075390.99769247
ENST00000360416ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0023159420.997684
ENST00000360416ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0023075390.99769247
ENST00000379980ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0021275340.9978725
ENST00000379980ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0021185770.99788135
ENST00000396239ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0021275340.9978725
ENST00000396239ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0021185770.99788135
ENST00000269243ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0023159420.997684
ENST00000269243ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0023075390.99769247

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56273_56273_1_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_2_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_3_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_4_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_5_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_6_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_7_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_8_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_9_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_10_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_11_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_12_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_13_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_14_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_15_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

>56273_56273_16_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:21994138/chr9:8508300)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH10

P35580

CDKN2A

Q96HQ2

FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-24131_81115.01977.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-24331_81115.02008.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-24231_81115.01998.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-24131_81115.01977.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-24331_81115.02008.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-24231_81115.01998.0DomainMyosin N-terminal SH3-like
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000030449403110_13950.0157.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940377_10650.0157.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000044617703110_13950.0168.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770377_10650.0168.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049426214110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621411_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621444_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621477_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049812404110_13950.0130.66666666666666RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240477_10650.0130.66666666666666RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049862803110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280311_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280344_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280377_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000057884502110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450211_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450244_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450277_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000030449403110_13950.0157.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940377_10650.0157.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000044617703110_13950.0168.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770377_10650.0168.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049426214110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621411_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621444_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621477_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049812404110_13950.0130.66666666666666RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240477_10650.0130.66666666666666RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049862803110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280311_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280344_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280377_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000057884502110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450211_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450244_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450277_1060106.0RepeatNote=ANK 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241845_1976115.01977.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243845_1976115.02008.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242845_1976115.01998.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241845_1976115.01977.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243845_1976115.02008.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242845_1976115.01998.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241786_815115.01977.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-24185_783115.01977.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243786_815115.02008.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-24385_783115.02008.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242786_815115.01998.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-24285_783115.01998.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241786_815115.01977.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-24185_783115.01977.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243786_815115.02008.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-24385_783115.02008.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242786_815115.01998.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-24285_783115.01998.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241178_185115.01977.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243178_185115.02008.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242178_185115.01998.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241178_185115.01977.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243178_185115.02008.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242178_185115.01998.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241661_683115.01977.0RegionActin-binding
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243661_683115.02008.0RegionActin-binding
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242661_683115.01998.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241661_683115.01977.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243661_683115.02008.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242661_683115.01998.0RegionActin-binding
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940311_4050.0157.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940344_7250.0157.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770311_4050.0168.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770344_7250.0168.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240411_4050.0130.66666666666666RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240444_7250.0130.66666666666666RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940311_4050.0157.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940344_7250.0157.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770311_4050.0168.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770344_7250.0168.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240411_4050.0130.66666666666666RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240444_7250.0130.66666666666666RepeatNote=ANK 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MYH10
CDKN2A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000361570031_64105.33333333333333220.0CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000530628031_6464.33333333333333122.66666666666667CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000579755031_6464.33333333333333134.33333333333334CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000361570031_64105.33333333333333220.0CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000530628031_6464.33333333333333122.66666666666667CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000579755031_6464.33333333333333134.33333333333334CDK5RAP3 and MDM2


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Related Drugs to MYH10-CDKN2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MYH10-CDKN2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource