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Fusion Protein:APOO-CNKSR2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: APOO-CNKSR2 | FusionPDB ID: 5632 | FusionGDB2.0 ID: 5632 | Hgene | Tgene | Gene symbol | APOO | CNKSR2 | Gene ID | 79135 | 22866 |
| Gene name | apolipoprotein O | connector enhancer of kinase suppressor of Ras 2 | |
| Synonyms | FAM121B|MIC26|MICOS26|Mic23|My025 | CNK2|KSR2|MAGUIN|MRXSHG | |
| Cytomap | Xp22.11 | Xp22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MICOS complex subunit MIC26MICOS complex subunit MIC23brain my025family with sequence similarity 121Bmitochondrial contact site and cristae organizing system subunit 26 | connector enhancer of kinase suppressor of ras 2CNK homolog protein 2connector enhancer of KSR2membrane-associated guanylate kinase-interacting protein | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q9BUR5 | Q8WXI2 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000379220, ENST00000379226, ENST00000476598, | ENST00000485012, ENST00000279451, ENST00000379510, ENST00000425654, ENST00000543067, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 10 X 4=360 | 6 X 9 X 4=216 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: APOO [Title/Abstract] AND CNKSR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | APOO(23897032)-CNKSR2(21488884), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CNKSR2 | GO:0035556 | intracellular signal transduction | 14597674 |
| Fusion gene breakpoints across APOO (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CNKSR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-66-2790-01A | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| ChimerDB4 | LUSC | TCGA-66-2790 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000543067 | CNKSR2 | chrX | 21488884 | + | 3825 | 469 | 232 | 2499 | 755 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000425654 | CNKSR2 | chrX | 21488884 | + | 5138 | 469 | 232 | 2964 | 910 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000279451 | CNKSR2 | chrX | 21488884 | + | 3972 | 469 | 232 | 2646 | 804 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000379510 | CNKSR2 | chrX | 21488884 | + | 5229 | 469 | 232 | 3054 | 940 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000543067 | CNKSR2 | chrX | 21488884 | + | 3831 | 475 | 238 | 2505 | 755 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000425654 | CNKSR2 | chrX | 21488884 | + | 5144 | 475 | 238 | 2970 | 910 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000279451 | CNKSR2 | chrX | 21488884 | + | 3978 | 475 | 238 | 2652 | 804 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000379510 | CNKSR2 | chrX | 21488884 | + | 5235 | 475 | 238 | 3060 | 940 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000379226 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000421735 | 0.9995783 |
| ENST00000379226 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00011226 | 0.9998877 |
| ENST00000379226 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000349089 | 0.99965096 |
| ENST00000379226 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000134512 | 0.9998654 |
| ENST00000379220 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000423335 | 0.9995766 |
| ENST00000379220 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000112491 | 0.99988747 |
| ENST00000379220 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00034998 | 0.99965 |
| ENST00000379220 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00013488 | 0.99986506 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >5632_5632_1_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK -------------------------------------------------------------- >5632_5632_2_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL -------------------------------------------------------------- >5632_5632_3_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA -------------------------------------------------------------- >5632_5632_4_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS -------------------------------------------------------------- >5632_5632_5_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK -------------------------------------------------------------- >5632_5632_6_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL -------------------------------------------------------------- >5632_5632_7_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA -------------------------------------------------------------- >5632_5632_8_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:23897032/chrX:21488884) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOO | CNKSR2 |
| FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}. | FUNCTION: May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 875_904 | 173.0 | 899.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 875_904 | 173.0 | 1035.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 875_904 | 173.0 | 1005.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 875_904 | 173.0 | 850.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 354_357 | 173.0 | 899.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 703_706 | 173.0 | 899.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 875_888 | 173.0 | 899.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 354_357 | 173.0 | 1035.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 703_706 | 173.0 | 1035.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 875_888 | 173.0 | 1035.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 354_357 | 173.0 | 1005.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 703_706 | 173.0 | 1005.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 875_888 | 173.0 | 1005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 354_357 | 173.0 | 850.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 703_706 | 173.0 | 850.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 875_888 | 173.0 | 850.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 215_297 | 173.0 | 899.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 332_515 | 173.0 | 899.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 570_669 | 173.0 | 899.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 215_297 | 173.0 | 1035.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 332_515 | 173.0 | 1035.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 570_669 | 173.0 | 1035.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 215_297 | 173.0 | 1005.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 332_515 | 173.0 | 1005.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 570_669 | 173.0 | 1005.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 215_297 | 173.0 | 850.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 332_515 | 173.0 | 850.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 570_669 | 173.0 | 850.0 | Domain | PH |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APOO | chrX:23897032 | chrX:21488884 | ENST00000379226 | - | 3 | 9 | 108_128 | 79.0 | 191.0 | Transmembrane | Helical |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 11_76 | 173.0 | 899.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 84_178 | 173.0 | 899.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 11_76 | 173.0 | 1035.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 84_178 | 173.0 | 1035.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 11_76 | 173.0 | 1005.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 84_178 | 173.0 | 1005.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 11_76 | 173.0 | 850.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 84_178 | 173.0 | 850.0 | Domain | CRIC |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1732_APOO_23897032_CNKSR2_21488884_ranked_0.pdb | APOO | 23897032 | 23897032 | ENST00000379510 | CNKSR2 | chrX | 21488884 | + | MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL | 940 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
APOO_pLDDT.png  |
CNKSR2_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| APOO | |
| CNKSR2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to APOO-CNKSR2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to APOO-CNKSR2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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