UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ABR-YWHAE

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABR-YWHAE
FusionPDB ID: 564
FusionGDB2.0 ID: 564
HgeneTgene
Gene symbol

ABR

YWHAE

Gene ID

29

7531

Gene nameABR activator of RhoGEF and GTPasetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
SynonymsMDB14-3-3E|HEL2|KCIP-1|MDCR|MDS
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine
Modification date2020031320200327
UniProtAcc

Q15018

P62258

Ensembl transtripts involved in fusion geneENST idsENST00000291107, ENST00000302538, 
ENST00000544583, ENST00000574437, 
ENST00000536794, ENST00000543210, 
ENST00000572441, ENST00000573895, 
ENST00000571732, ENST00000498643, 
ENST00000573026, ENST00000575977, 
ENST00000264335, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 15 X 14=483025 X 13 X 12=3900
# samples 3632
** MAII scorelog2(36/4830*10)=-3.74595437739346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3900*10)=-3.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABR [Title/Abstract] AND YWHAE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABR(1132087)-YWHAE(1268352), # samples:9
YWHAE(1303340)-ABR(1028702), # samples:2
Anticipated loss of major functional domain due to fusion event.ABR-YWHAE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-YWHAE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABR-YWHAE seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABR-YWHAE seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ABR-YWHAE seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YWHAE-ABR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
YWHAE-ABR seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YWHAE-ABR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABR

GO:0090630

activation of GTPase activity

7479768

TgeneYWHAE

GO:0000165

MAPK cascade

12917326

TgeneYWHAE

GO:0034605

cellular response to heat

12917326

TgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

TgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

TgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

TgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

TgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

TgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

TgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YWHAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A106-01AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4COADTCGA-A6-2686-01AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4COADTCGA-G4-6294-01AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4GBMTCGA-27-1831-01AABRchr17

1082961

-YWHAEchr17

1273035

-
ChimerDB4LAMLTCGA-AB-2832-03AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4LAMLTCGA-AB-2884-03AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4LAMLTCGA-AB-2920-03BABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4LAMLTCGA-AB-2984-03AABRchr17

1132087

-YWHAEchr17

1268352

-
ChimerDB4LGGTCGA-DU-6404-01AABRchr17

1132087

-YWHAEchr17

1248793

-
ChimerDB4LGGTCGA-HT-7693-01AABRchr17

982570

-YWHAEchr17

1268352

-
ChimerDB4LGGTCGA-HT-7693ABRchr17

982569

-YWHAEchr17

1268352

-
ChimerDB4LGGTCGA-HT-7693ABRchr17

982570

-YWHAEchr17

1268352

-
ChimerDB4LGGTCGA-RY-A847-01AABRchr17

1082961

-YWHAEchr17

1268352

-
ChimerDB4LUADTCGA-55-7576-01AABRchr17

953290

-YWHAEchr17

1257641

-
ChimerDB4SKCMTCGA-EE-A2GN-06AABRchr17

1082961

-YWHAEchr17

1268352

-
ChimerDB4STADTCGA-FP-8631-01AABRchr17

1132087

-YWHAEchr17

1268352

-
ChiTaRS5.0N/AAV710702ABRchr17

1000591

+YWHAEchr17

1258737

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302538ABRchr17982570-ENST00000264335YWHAEchr171268352-27268471471550467
ENST00000574437ABRchr17982570-ENST00000264335YWHAEchr171268352-290610271231730535
ENST00000291107ABRchr17982570-ENST00000264335YWHAEchr171268352-2500621321324430
ENST00000302538ABRchr17982569-ENST00000264335YWHAEchr171268352-27268471471550467
ENST00000574437ABRchr17982569-ENST00000264335YWHAEchr171268352-290610271231730535
ENST00000291107ABRchr17982569-ENST00000264335YWHAEchr171268352-2500621321324430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302538ENST00000264335ABRchr17982570-YWHAEchr171268352-0.0005294690.99947053
ENST00000574437ENST00000264335ABRchr17982570-YWHAEchr171268352-0.0005785770.9994215
ENST00000291107ENST00000264335ABRchr17982570-YWHAEchr171268352-0.0005854990.99941456
ENST00000302538ENST00000264335ABRchr17982569-YWHAEchr171268352-0.0005294690.99947053
ENST00000574437ENST00000264335ABRchr17982569-YWHAEchr171268352-0.0005785770.9994215
ENST00000291107ENST00000264335ABRchr17982569-YWHAEchr171268352-0.0005854990.99941456

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>564_564_1_ABR-YWHAE_ABR_chr17_982569_ENST00000291107_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=430AA_BP=196
MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS
QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKV
KGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKL
ICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEIL

--------------------------------------------------------------

>564_564_2_ABR-YWHAE_ABR_chr17_982569_ENST00000302538_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=467AA_BP=233
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRA
SWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENS
LVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGD

--------------------------------------------------------------

>564_564_3_ABR-YWHAE_ABR_chr17_982569_ENST00000574437_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=535AA_BP=301
MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF
SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA
LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCS
QSNNQFQKISEELKVKGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLK
MIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIR

--------------------------------------------------------------

>564_564_4_ABR-YWHAE_ABR_chr17_982570_ENST00000291107_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=430AA_BP=196
MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS
QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKV
KGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKL
ICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEIL

--------------------------------------------------------------

>564_564_5_ABR-YWHAE_ABR_chr17_982570_ENST00000302538_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=467AA_BP=233
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRA
SWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENS
LVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGD

--------------------------------------------------------------

>564_564_6_ABR-YWHAE_ABR_chr17_982570_ENST00000574437_YWHAE_chr17_1268352_ENST00000264335_length(amino acids)=535AA_BP=301
MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF
SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA
LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCS
QSNNQFQKISEELKVKGPKDSKDSHTSVTMEEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLK
MIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1132087/chr17:1268352)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABR

Q15018

YWHAE

P62258

FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABRchr17:982569chr17:1268352ENST00000291107-522417_420196.33333333333334823.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982569chr17:1268352ENST00000302538-623417_420233.33333333333334860.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982569chr17:1268352ENST00000543210-18417_4200311.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982569chr17:1268352ENST00000544583-623417_420187.33333333333334814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982569chr17:1268352ENST00000574437-522417_420187.33333333333334814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982570chr17:1268352ENST00000291107-522417_420196.33333333333334823.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982570chr17:1268352ENST00000302538-623417_420233.33333333333334860.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982570chr17:1268352ENST00000543210-18417_4200311.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982570chr17:1268352ENST00000544583-623417_420187.33333333333334814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982570chr17:1268352ENST00000574437-522417_420187.33333333333334814.0Compositional biasNote=Poly-Leu
HgeneABRchr17:982569chr17:1268352ENST00000291107-522301_459196.33333333333334823.0DomainPH
HgeneABRchr17:982569chr17:1268352ENST00000291107-522484_613196.33333333333334823.0DomainC2
HgeneABRchr17:982569chr17:1268352ENST00000291107-522647_845196.33333333333334823.0DomainRho-GAP
HgeneABRchr17:982569chr17:1268352ENST00000291107-52291_284196.33333333333334823.0DomainDH
HgeneABRchr17:982569chr17:1268352ENST00000302538-623301_459233.33333333333334860.0DomainPH
HgeneABRchr17:982569chr17:1268352ENST00000302538-623484_613233.33333333333334860.0DomainC2
HgeneABRchr17:982569chr17:1268352ENST00000302538-623647_845233.33333333333334860.0DomainRho-GAP
HgeneABRchr17:982569chr17:1268352ENST00000302538-62391_284233.33333333333334860.0DomainDH
HgeneABRchr17:982569chr17:1268352ENST00000543210-18301_4590311.0DomainPH
HgeneABRchr17:982569chr17:1268352ENST00000543210-18484_6130311.0DomainC2
HgeneABRchr17:982569chr17:1268352ENST00000543210-18647_8450311.0DomainRho-GAP
HgeneABRchr17:982569chr17:1268352ENST00000543210-1891_2840311.0DomainDH
HgeneABRchr17:982569chr17:1268352ENST00000544583-623301_459187.33333333333334814.0DomainPH
HgeneABRchr17:982569chr17:1268352ENST00000544583-623484_613187.33333333333334814.0DomainC2
HgeneABRchr17:982569chr17:1268352ENST00000544583-623647_845187.33333333333334814.0DomainRho-GAP
HgeneABRchr17:982569chr17:1268352ENST00000544583-62391_284187.33333333333334814.0DomainDH
HgeneABRchr17:982569chr17:1268352ENST00000574437-522301_459187.33333333333334814.0DomainPH
HgeneABRchr17:982569chr17:1268352ENST00000574437-522484_613187.33333333333334814.0DomainC2
HgeneABRchr17:982569chr17:1268352ENST00000574437-522647_845187.33333333333334814.0DomainRho-GAP
HgeneABRchr17:982569chr17:1268352ENST00000574437-52291_284187.33333333333334814.0DomainDH
HgeneABRchr17:982570chr17:1268352ENST00000291107-522301_459196.33333333333334823.0DomainPH
HgeneABRchr17:982570chr17:1268352ENST00000291107-522484_613196.33333333333334823.0DomainC2
HgeneABRchr17:982570chr17:1268352ENST00000291107-522647_845196.33333333333334823.0DomainRho-GAP
HgeneABRchr17:982570chr17:1268352ENST00000291107-52291_284196.33333333333334823.0DomainDH
HgeneABRchr17:982570chr17:1268352ENST00000302538-623301_459233.33333333333334860.0DomainPH
HgeneABRchr17:982570chr17:1268352ENST00000302538-623484_613233.33333333333334860.0DomainC2
HgeneABRchr17:982570chr17:1268352ENST00000302538-623647_845233.33333333333334860.0DomainRho-GAP
HgeneABRchr17:982570chr17:1268352ENST00000302538-62391_284233.33333333333334860.0DomainDH
HgeneABRchr17:982570chr17:1268352ENST00000543210-18301_4590311.0DomainPH
HgeneABRchr17:982570chr17:1268352ENST00000543210-18484_6130311.0DomainC2
HgeneABRchr17:982570chr17:1268352ENST00000543210-18647_8450311.0DomainRho-GAP
HgeneABRchr17:982570chr17:1268352ENST00000543210-1891_2840311.0DomainDH
HgeneABRchr17:982570chr17:1268352ENST00000544583-623301_459187.33333333333334814.0DomainPH
HgeneABRchr17:982570chr17:1268352ENST00000544583-623484_613187.33333333333334814.0DomainC2
HgeneABRchr17:982570chr17:1268352ENST00000544583-623647_845187.33333333333334814.0DomainRho-GAP
HgeneABRchr17:982570chr17:1268352ENST00000544583-62391_284187.33333333333334814.0DomainDH
HgeneABRchr17:982570chr17:1268352ENST00000574437-522301_459187.33333333333334814.0DomainPH
HgeneABRchr17:982570chr17:1268352ENST00000574437-522484_613187.33333333333334814.0DomainC2
HgeneABRchr17:982570chr17:1268352ENST00000574437-522647_845187.33333333333334814.0DomainRho-GAP
HgeneABRchr17:982570chr17:1268352ENST00000574437-52291_284187.33333333333334814.0DomainDH


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
YWHAEIGF1R, GPRIN2, SORBS2, GRAP2, MAPK7, NDEL1, HDAC4, HDAC5, REM1, BAD, MAP3K10, CDC25C, MAP3K3, MAP3K1, MAP3K2, IRS1, NGFRAP1, SYN2, KCNH2, TNFAIP3, RAF1, CDC25B, TOP2A, TGFB1, CDC25A, Usp8, USP43, POLR3H, HDAC7, MDM4, FOXO3, HIVEP2, LRMP, COX2, MYH10, PNLIP, SSFA2, YWHAB, YWHAZ, YWHAG, ARAF, YWHAH, HDAC9, KIAA0232, TLK1, CHAF1A, CAP2, YWHAQ, RAP1GAP2, SH3BP4, WWTR1, FAM13B, MSL2, ZNF839, RASAL3, WNK1, ENKD1, TBC1D3F, CGNL1, CEP95, ANKHD1-EIF4EBP3, ING1, SRRM2, FAN1, EMD, SAMSN1, EXO1, H2AFX, MYC, PRKAA1, PARD6G, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, DISC1, UBE3A, GAPDH, KAT8, HIST1H3A, HIST1H4A, TCEB3, BRD4, CALM1, FBXO4, CDKN1B, TRAT1, RARRES3, ARRB1, ARRB2, CBL, ACD, POT1, CUL3, CDK2, CUL1, DCUN1D1, NEDD8, PTPN14, MARK3, MARK2, MEX3B, LRRK2, AKT1, ACTA2, CBX3, HNF1A, HSP90AB1, NPM1, ATP5B, ATP5A1, STOML2, CLNS1A, IPO8, KPNB1, RPLP0, RPL6, RPL4, RPS3, RPS8, DNAJA1, EIF4B, EIF3E, EEF1G, EEF1A2, HNRNPA2B1, ILF2, RUVBL2, RCN2, TUBB, TUBB4B, TUBB2B, PRPSAP1, TUBA3E, DDX21, ADH1B, ADH4, AGXT, HIST2H4B, HNRNPA3, HNRNPC, RBMY1A1, SF3B1, PCBP1, RBM10, MAP3K7, TBK1, PPM1B, SPIN1, CDC37, PHB, PRPSAP2, PRPS1, QPCTL, TMPO, C11orf84, HDX, CFAP43, VCP, ATXN1, FN1, VCAM1, BRAF, MAP2K1, PARD3, KIF5B, KLC2, LMO7, TBC1D4, HSPA1A, KLC3, KLC4, KLC1, CLASP2, LIMA1, TSC2, CLASP1, HSPA8, PAK4, RAB11FIP2, MAST3, TBC1D1, KIF1C, OSBPL3, TIAM1, ABLIM1, LARP1, BAIAP2, IRS2, SHROOM2, LSR, KIF1B, RAB11FIP1, MLLT4, MAST2, PFKFB2, CDK18, PKP2, DENND4A, TP53BP2, CGN, ZFP36L2, TUBA1A, KSR1, RABEP1, EIF4E2, CSNK1A1, PDZD11, PRKCI, DCAF7, NADK, USP8, C1QBP, TSC1, REEP1, KIF23, SLC25A6, SRGAP2, FAM53C, TRIP11, BCAR1, CRTC1, RASSF8, CEP250, VAMP8, GRB2, TRIM32, NOS2, IL7R, UBL4A, ITGA4, gag-pol, CBX4, ABL1, MST1R, PAN2, RAD52, BAG3, UL46, GSTA1, FTH1, Wwtr1, Yap1, CDK11B, SRSF1, SRSF6, SRSF4, NOLC1, TRA2B, PLEKHO2, HMHA1, SRSF7, NCBP1, DOK3, VASP, KIAA0930, GAB2, KIAA0226, PIK3R4, SGK223, RCHY1, IGHG1, UVRAG, SRSF2, FBXO6, RASSF2, SAV1, YAP1, PARK2, PAFAH1B2, PPP1R2, PROSC, RAP1GDS1, TMOD3, TNFAIP8, TUBB2A, UBXN1, VCL, XPO1, ALDH7A1, ASNS, ATIC, CAPN2, CAPNS1, EIF5, FERMT2, G6PD, GSS, ISOC1, MCTS1, STK26, OGFOD1, PAK2, PDHB, PDIA4, PTMA, SCPEP1, TBCB, TWF2, UBE2R2, IRS4, SIK3, SIK2, CEP57, TP53, GRB10, DTL, HUWE1, FBXW11, Mdm4, CUL7, OBSL1, CCDC8, MAST1, CDK16, TNK1, BTRC, NKD2, DMTN, TEX33, Numb, EPB41L3, WWC1, HNRNPA1, HSPB1, UNK, ACAT2, CALR, CENPE, MACF1, MAPK14, MCFD2, POLR2D, PSMB2, SHMT2, SNRPD1, ACTR6, HNRNPL, NPM3, PGK1, PSMC1, ZPR1, NTRK1, LCA5, CENPJ, PRICKLE3, MYH11, TSNAX, CCDC88A, CRY1, CRY2, MCM2, Ksr1, CDC5L, ERRFI1, U2AF2, PRDX6, NFATC2, SNF8, ANKZF1, SMAGP, TCEANC, LCP2, METAP2, MAGEB4, CHST11, ZC3HC1, MCM10, DDX54, C8orf59, NAF1, FGF12, GSTM3, STAC, FAM64A, ATP6V0B, FLJ25758, CDC73, WWP2, CDH1, CEP131, PCM1, PPM1H, PTPN3, SSH1, TENC1, SMTNL2, PLEKHG5, SAMD4A, SPATA13, RIN1, TFEB, TESPA1, SAMD4B, FAM163A, CRTC2, FAM189A2, PAK6, RBM3, RAB3IP, CBY1, CEP170, INPP5E, SLC9A1, CYLD, COX15, DLD, DLST, DNM1L, SDHA, SOAT1, VDAC1, TRIM25, BRCA1, BRD1, BRMS1, YLR177W, ACM1, IFNAR1, CFTR, TARDBP, ZNF598, CTNNB1, MEX3C, EGLN3, RIPK4, PTPN4, API5, KRAS, PPP6C, COPE, GRHPR, JUP, PPIE, YAF2, PARD3B, RPA2, NIN, AKAP9, CASK, PRC1, RBM14, UBE2M, RAD18, EFTUD2, AAR2, PIH1D1, TNIP2, RNF31, HAVCR1, BPLF1, ESR2, HEXIM1, MEPCE, PPT1, AGR2, EZH2, RECQL4, KANK1, STUB1, BAP1, PIK3R1, GPC1, Prkaa1, Nav2, KIAA1429, RC3H1, RC3H2, ATG16L1, ACTC1, FAF1, CLIC4, FHL1, FHL2, FHL3, LMO1, LMO2, LMO3, TET2, KCTD15, GBF1, AGRN, BMH1, BMH2, ATXN3, HIBADH, DIABLO, NDUFAB1, ALDH1B1, ALDH2, COQ9, FH, HEXA, HSP90AA1, LDHB, MMP20, RAD23A, TIMM44, UBA1, VBP1, AARS2, ECH1, GRPEL1, IARS2, PAFAH2, PFDN4, SSBP1, DYRK1A, MAPT, CD74, SLC15A3, GEM, DUSP16, MTMR4, PTPDC1, ITFG1, BIRC3, NFX1, nsp7ab, ORF3a, CCDC125, PLEKHA4, PINK1, FANCD2, NGB, ZC3H18, CSK, PDPK1, PRKCE, PRKD1, SHC1, SHOC2, SFN, PHACTR4, MAP3K5, CHAF1B, CAMSAP3, LRCH1, SH2B3, CDK12, TANC2, EPN3, PANK2, MAP3K15, CEP89, FRMD6, THAP11, TTC17, CCNY, ARHGEF19, FAM122B, DAB2IP, FAM110C, LPIN1, PRR5, DNMT1, CDK11A, SRSF10, TBC1D7, NEDD4L, FAM117B, KANK2, DENND4C, RGS12, YWHAE, EMC4, ERC2, APPL2, ANKRD55, ESR1, SNAPIN, EDC3, NEK4, CHMP4C, CCR9, CYSLTR2, RXFP3, KIF14, RMDN3, HNRNPH1, INS, Rnf183, NUPR1, CIC, CCAR2, Apc2, RBM39, LGALS9, ACTN4, BTF3, CAD, CALD1, CDKN2A, COPA, DDB1, DDX6, DHX9, EIF2B1, GOLGA3, HDAC1, JAK1, LTBP1, PPP1R12A, NONO, PA2G4, PAWR, PRPS2, RBBP4, ROCK1, SMARCC2, TRIM21, TAF4, EIF3A, PABPC4, LRRFIP2, MTA2, VPRBP, EIF4A3, MATR3, HDAC6, SAE1, G3BP1, SMC2, IVNS1ABP, SF3B2, FASTKD2, NT5C2, STK38L, MGA, UBR2, CAND1, EFHD2, SHCBP1, SFPQ, TAB3, TAB1, ACAP2, INSIG1, NEDD4, SOD1, IL1B, UFL1, DDRGK1, KRT8, VAPA, FZR1, PAGE4, NUDCD2, LNP1, SNX33, FAM53B, SYNGAP1, CDR2L, GUCA1B, KIAA1211, ARHGEF4, FAM124A, EPB41L1, AFAP1L1, MIIP, PLEKHA3, GAREM, CD28, GPSM3, SIPA1L3, PDE7B, C19orf26, C6orf222, PSD4, MACC1, ZNF395, FAM86C1, SH2D3A, NCKIPSD, KSR2, SPRTN, TRIM26, FBXW7, FGD5, CCNF, HECTD1, NBR1, SQSTM1, MAP1LC3B, SLFN11, RIPK2, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABR
YWHAEall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ABR-YWHAE


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ABR-YWHAE


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYWHAEC0036341Schizophrenia4PSYGENET
TgeneYWHAEC0005586Bipolar Disorder2PSYGENET
TgeneYWHAEC0206630Endometrial Stromal Sarcoma2ORPHANET
TgeneYWHAEC0027627Neoplasm Metastasis1CTD_human
TgeneYWHAEC0265219Miller Dieker syndrome1ORPHANET
TgeneYWHAEC0334488Clear cell sarcoma of kidney1ORPHANET
TgeneYWHAEC2750748Chromosome 17p13.3 Duplication Syndrome1ORPHANET
TgeneYWHAEC4707092Distal 17p13.3 microdeletion syndrome1ORPHANET