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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MYLK-PLXND1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MYLK-PLXND1
FusionPDB ID: 56527
FusionGDB2.0 ID: 56527
HgeneTgene
Gene symbol

MYLK

PLXND1

Gene ID

4638

23129

Gene namemyosin light chain kinaseplexin D1
SynonymsAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCKPLEXD1
Cytomap

3q21.1

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokinplexin-D1
Modification date2020032020200313
UniProtAcc

Q86YV6

Q9Y4D7

Ensembl transtripts involved in fusion geneENST idsENST00000346322, ENST00000354792, 
ENST00000359169, ENST00000360304, 
ENST00000360772, ENST00000475616, 
ENST00000418370, ENST00000510775, 
ENST00000578202, ENST00000583087, 
ENST00000504689, ENST00000324093, 
ENST00000393239, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 15 X 7=17853 X 3 X 3=27
# samples 183
** MAII scorelog2(18/1785*10)=-3.30985526258679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MYLK [Title/Abstract] AND PLXND1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYLK(123345665)-PLXND1(129297276), # samples:3
Anticipated loss of major functional domain due to fusion event.MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MYLK-PLXND1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

HgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

HgeneMYLK

GO:0071476

cellular hypotonic response

11976941

HgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across MYLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLXND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A496-01AMYLKchr3

123345665

-PLXND1chr3

129297276

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360772MYLKchr3123345665-ENST00000324093PLXND1chr3129297276-1013854645590002981
ENST00000360772MYLKchr3123345665-ENST00000393239PLXND1chr3129297276-1014554645585802841
ENST00000354792MYLKchr3123345665-ENST00000324093PLXND1chr3129297276-644417701853061762
ENST00000354792MYLKchr3123345665-ENST00000393239PLXND1chr3129297276-645117701848861622
ENST00000475616MYLKchr3123345665-ENST00000324093PLXND1chr3129297276-99125238087742924
ENST00000475616MYLKchr3123345665-ENST00000393239PLXND1chr3129297276-99195238083542784

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360772ENST00000324093MYLKchr3123345665-PLXND1chr3129297276-0.0052443440.9947556
ENST00000360772ENST00000393239MYLKchr3123345665-PLXND1chr3129297276-0.0056613630.9943387
ENST00000354792ENST00000324093MYLKchr3123345665-PLXND1chr3129297276-0.0034264570.99657357
ENST00000354792ENST00000393239MYLKchr3123345665-PLXND1chr3129297276-0.0034904640.9965095
ENST00000475616ENST00000324093MYLKchr3123345665-PLXND1chr3129297276-0.0038618520.99613816
ENST00000475616ENST00000393239MYLKchr3123345665-PLXND1chr3129297276-0.0041033770.9958967

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56527_56527_1_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000354792_PLXND1_chr3_129297276_ENST00000324093_length(amino acids)=1762AA_BP=583
MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG
ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD
IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK
DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV
QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL
ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK
DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLE
EIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQP
MAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSR
DRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTF
WYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVA
EELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAA
VGQLPITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDM
TDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFL
IVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEP
FFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA
EDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQS
HRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVF
DIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVA

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>56527_56527_2_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000354792_PLXND1_chr3_129297276_ENST00000393239_length(amino acids)=1622AA_BP=583
MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG
ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD
IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK
DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV
QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL
ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK
DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLE
EIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQP
MAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSR
DRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTF
WYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVA
EELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAA
VGQLPITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDM
TDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFL
IVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEP
FFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA
EDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQS
HRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNRWRPSSPVLGEHPEEPPV

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>56527_56527_3_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000360772_PLXND1_chr3_129297276_ENST00000324093_length(amino acids)=2981AA_BP=1802
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP
ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK
FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG
LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS
SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK
FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD
CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL
LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG
EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY
EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH
TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA
SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL
CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ
FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD
PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT
TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI
MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK
LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR
KWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPAR
FLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVA
HGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQV
LVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV
HHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEP
LTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLL
LSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLP
SQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMK
ELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAK
PRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKI
PEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPP
LAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLY
AKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALM

--------------------------------------------------------------

>56527_56527_4_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000360772_PLXND1_chr3_129297276_ENST00000393239_length(amino acids)=2841AA_BP=1802
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP
ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK
FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG
LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS
SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK
FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD
CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL
LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG
EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY
EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH
TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA
SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL
CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ
FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD
PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT
TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI
MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK
LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR
KWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPAR
FLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVA
HGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQV
LVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV
HHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEP
LTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLL
LSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLP
SQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMK
ELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAK
PRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKI
PEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPP

--------------------------------------------------------------

>56527_56527_5_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000475616_PLXND1_chr3_129297276_ENST00000324093_length(amino acids)=2924AA_BP=1745
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS
LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF
SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD
VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG
LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE
GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT
PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS
DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ
PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM
LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL
LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK
LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG
HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC
VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK
VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL
SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD
DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE
KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV
LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC
TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWV
NESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAP
EIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLP
LVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVI
TAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEE
AQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITI
QVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELN
RSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALE
QQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAI
KQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWF
ASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPE
IYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHI
DACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYA

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>56527_56527_6_MYLK-PLXND1_MYLK_chr3_123345665_ENST00000475616_PLXND1_chr3_129297276_ENST00000393239_length(amino acids)=2784AA_BP=1745
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS
LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF
SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD
VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG
LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE
GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT
PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS
DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ
PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM
LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL
LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK
LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG
HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC
VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK
VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL
SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD
DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE
KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV
LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC
TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWV
NESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAP
EIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLP
LVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVI
TAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEE
AQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITI
QVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELN
RSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALE
QQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAI
KQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWF
ASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:123345665/chr3:129297276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYLK

Q86YV6

PLXND1

Q9Y4D7

FUNCTION: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331098_11861677.01846.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331238_13261677.01846.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331334_14261677.01846.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033161_2491677.01846.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-303333_1221677.01846.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033414_5031677.01846.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033514_5991677.01846.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033620_7111677.01846.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033721_8211677.01846.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331098_11861695.01864.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331238_13261695.01864.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331334_14261695.01864.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033161_2491695.01864.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-303333_1221695.01864.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033414_5031695.01864.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033514_5991695.01864.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033620_7111695.01864.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033721_8211695.01864.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341098_11861746.01915.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341238_13261746.01915.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341334_14261746.01915.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341464_17191746.01915.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134161_2491746.01915.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-313433_1221746.01915.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134414_5031746.01915.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134514_5991746.01915.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134620_7111746.01915.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134721_8211746.01915.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341098_11861695.01864.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341238_13261695.01864.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341334_14261695.01864.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134161_2491695.01864.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-313433_1221695.01864.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134414_5031695.01864.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134514_5991695.01864.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134620_7111695.01864.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134721_8211695.01864.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311098_11861746.01915.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311238_13261746.01915.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311334_14261746.01915.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311464_17191746.01915.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831161_2491746.01915.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-283133_1221746.01915.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831414_5031746.01915.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831514_5991746.01915.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831620_7111746.01915.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831721_8211746.01915.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331470_14781677.01846.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331470_14781695.01864.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341470_14781746.01915.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341470_14781695.01864.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311470_14781746.01915.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331061_14601677.01846.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033868_9981677.01846.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033923_9631677.01846.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033948_9631677.01846.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033999_10631677.01846.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331061_14601695.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033868_9981695.01864.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033923_9631695.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033948_9631695.01864.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033999_10631695.01864.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341061_14601746.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134868_9981746.01915.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134923_9631746.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134948_9631746.01915.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134999_10631746.01915.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341061_14601695.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134868_9981695.01864.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134923_9631695.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134948_9631695.01864.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134999_10631695.01864.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311061_14601746.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831868_9981746.01915.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831923_9631746.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831948_9631746.01915.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831999_10631746.01915.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331004_10151677.01846.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331016_10271677.01846.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331028_10391677.01846.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331040_10511677.01846.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331052_10631677.01846.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033868_8951677.01846.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033896_9231677.01846.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033924_9511677.01846.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033952_9791677.01846.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033980_9981677.01846.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-3033999_10031677.01846.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331004_10151695.01864.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331016_10271695.01864.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331028_10391695.01864.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331040_10511695.01864.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331052_10631695.01864.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033868_8951695.01864.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033896_9231695.01864.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033924_9511695.01864.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033952_9791695.01864.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033980_9981695.01864.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-3033999_10031695.01864.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341004_10151746.01915.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341016_10271746.01915.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341028_10391746.01915.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341040_10511746.01915.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341052_10631746.01915.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134868_8951746.01915.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134896_9231746.01915.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134924_9511746.01915.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134952_9791746.01915.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134980_9981746.01915.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-3134999_10031746.01915.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341004_10151695.01864.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341016_10271695.01864.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341028_10391695.01864.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341040_10511695.01864.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341052_10631695.01864.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134868_8951695.01864.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134896_9231695.01864.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134924_9511695.01864.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134952_9791695.01864.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134980_9981695.01864.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-3134999_10031695.01864.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311004_10151746.01915.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311016_10271746.01915.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311028_10391746.01915.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311040_10511746.01915.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311052_10631746.01915.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831868_8951746.01915.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831896_9231746.01915.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831924_9511746.01915.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831952_9791746.01915.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831980_9981746.01915.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-2831999_10031746.01915.0RepeatNote=2-1%3B truncated
TgenePLXND1chr3:123345665chr3:129297276ENST000003240937361069_1160747.01926.0DomainNote=IPT/TIG 3
TgenePLXND1chr3:123345665chr3:129297276ENST00000324093736891_979747.01926.0DomainNote=IPT/TIG 1
TgenePLXND1chr3:123345665chr3:129297276ENST00000324093736981_1066747.01926.0DomainNote=IPT/TIG 2
TgenePLXND1chr3:123345665chr3:129297276ENST000003932397361069_1160747.01692.0DomainNote=IPT/TIG 3
TgenePLXND1chr3:123345665chr3:129297276ENST00000393239736891_979747.01692.0DomainNote=IPT/TIG 1
TgenePLXND1chr3:123345665chr3:129297276ENST00000393239736981_1066747.01692.0DomainNote=IPT/TIG 2
TgenePLXND1chr3:123345665chr3:129297276ENST000003240937361293_1925747.01926.0Topological domainCytoplasmic
TgenePLXND1chr3:123345665chr3:129297276ENST000003932397361293_1925747.01692.0Topological domainCytoplasmic
TgenePLXND1chr3:123345665chr3:129297276ENST000003240937361272_1292747.01926.0TransmembraneHelical
TgenePLXND1chr3:123345665chr3:129297276ENST000003932397361272_1292747.01692.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331906_19141677.01846.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331906_19141695.01864.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341906_19141746.01915.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341906_19141695.01864.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131906_19140155.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311906_19141746.01915.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141906_19140155.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331464_17191677.01846.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331809_18981677.01846.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331464_17191695.01864.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331809_18981695.01864.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341809_18981746.01915.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341464_17191695.01864.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341809_18981695.01864.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131098_11860155.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131238_13260155.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131334_14260155.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131464_17190155.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13161_2490155.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131809_18980155.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-1333_1220155.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13414_5030155.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13514_5990155.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13620_7110155.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13721_8210155.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311809_18981746.01915.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141098_11860155.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141238_13260155.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141334_14260155.0DomainFibronectin type-III
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141464_17190155.0DomainProtein kinase
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14161_2490155.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141809_18980155.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-1433_1220155.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14414_5030155.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14514_5990155.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14620_7110155.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14721_8210155.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131470_14780155.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141470_14780155.0Nucleotide bindingATP
HgeneMYLKchr3:123345665chr3:129297276ENST00000346322-30331711_17741677.01846.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000359169-30331711_17741695.01864.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000360304-31341711_17741746.01915.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000360772-31341711_17741695.01864.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131711_17740155.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13948_9630155.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000475616-28311711_17741746.01915.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141711_17740155.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14948_9630155.0RegionCalmodulin-binding
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131004_10150155.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131016_10270155.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131028_10390155.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131040_10510155.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-131052_10630155.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13868_8950155.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13896_9230155.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13924_9510155.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13952_9790155.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13980_9980155.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000418370-13999_10030155.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141004_10150155.0RepeatNote=2-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141016_10270155.0RepeatNote=2-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141028_10390155.0RepeatNote=2-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141040_10510155.0RepeatNote=2-5
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-141052_10630155.0RepeatNote=2-6
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14868_8950155.0RepeatNote=1-1
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14896_9230155.0RepeatNote=1-2
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14924_9510155.0RepeatNote=1-3
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14952_9790155.0RepeatNote=1-4
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14980_9980155.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123345665chr3:129297276ENST00000583087-14999_10030155.0RepeatNote=2-1%3B truncated
TgenePLXND1chr3:123345665chr3:129297276ENST0000032409373647_546747.01926.0DomainSema
TgenePLXND1chr3:123345665chr3:129297276ENST0000039323973647_546747.01692.0DomainSema
TgenePLXND1chr3:123345665chr3:129297276ENST0000032409373647_1271747.01926.0Topological domainExtracellular
TgenePLXND1chr3:123345665chr3:129297276ENST0000039323973647_1271747.01692.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MYLK
PLXND1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MYLK-PLXND1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MYLK-PLXND1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLXND1C0041207Truncus Arteriosus, Persistent2GENOMICS_ENGLAND;ORPHANET
TgenePLXND1C0221060Mobius Syndrome2GENOMICS_ENGLAND;ORPHANET
TgenePLXND1C0853240Mobius II syndrome1ORPHANET
TgenePLXND1C1135196Heart Failure, Diastolic1CTD_human