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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MYLK-USP48

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MYLK-USP48
FusionPDB ID: 56530
FusionGDB2.0 ID: 56530
HgeneTgene
Gene symbol

MYLK

USP48

Gene ID

4638

84196

Gene namemyosin light chain kinaseubiquitin specific peptidase 48
SynonymsAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCKRAP1GA1|USP31
Cytomap

3q21.1

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokinubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48
Modification date2020032020200313
UniProtAcc

Q86YV6

.
Ensembl transtripts involved in fusion geneENST idsENST00000346322, ENST00000359169, 
ENST00000360304, ENST00000360772, 
ENST00000475616, ENST00000354792, 
ENST00000418370, ENST00000510775, 
ENST00000578202, ENST00000583087, 
ENST00000421625, ENST00000479177, 
ENST00000308271, ENST00000374732, 
ENST00000400301, ENST00000529637, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 15 X 7=178514 X 12 X 8=1344
# samples 1816
** MAII scorelog2(18/1785*10)=-3.30985526258679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1344*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MYLK [Title/Abstract] AND USP48 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYLK(123512524)-USP48(22016592), # samples:2
Anticipated loss of major functional domain due to fusion event.MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MYLK-USP48 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MYLK-USP48 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

HgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

HgeneMYLK

GO:0071476

cellular hypotonic response

11976941

HgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across MYLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP48 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-WP-A9GB-01AMYLKchr3

123512524

-USP48chr1

22016592

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360772MYLKchr3123512524-ENST00000400301USP48chr122016592-188854455768237
ENST00000360772MYLKchr3123512524-ENST00000308271USP48chr122016592-160754455768237
ENST00000360772MYLKchr3123512524-ENST00000374732USP48chr122016592-128354455768237
ENST00000360772MYLKchr3123512524-ENST00000529637USP48chr122016592-81954455768237
ENST00000475616MYLKchr3123512524-ENST00000400301USP48chr122016592-15091650389129
ENST00000475616MYLKchr3123512524-ENST00000308271USP48chr122016592-12281650389129
ENST00000475616MYLKchr3123512524-ENST00000374732USP48chr122016592-9041650389129
ENST00000475616MYLKchr3123512524-ENST00000529637USP48chr122016592-4401650389129

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360772ENST00000400301MYLKchr3123512524-USP48chr122016592-0.003280130.9967199
ENST00000360772ENST00000308271MYLKchr3123512524-USP48chr122016592-0.0038555390.9961444
ENST00000360772ENST00000374732MYLKchr3123512524-USP48chr122016592-0.0045047690.9954952
ENST00000360772ENST00000529637MYLKchr3123512524-USP48chr122016592-0.0078978220.9921022
ENST00000475616ENST00000400301MYLKchr3123512524-USP48chr122016592-0.0032731410.9967269
ENST00000475616ENST00000308271MYLKchr3123512524-USP48chr122016592-0.0027594170.99724054
ENST00000475616ENST00000374732MYLKchr3123512524-USP48chr122016592-0.0022512410.9977488
ENST00000475616ENST00000529637MYLKchr3123512524-USP48chr122016592-0.0017289580.998271

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56530_56530_1_MYLK-USP48_MYLK_chr3_123512524_ENST00000360772_USP48_chr1_22016592_ENST00000308271_length(amino acids)=237AA_BP=163
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSID

--------------------------------------------------------------

>56530_56530_2_MYLK-USP48_MYLK_chr3_123512524_ENST00000360772_USP48_chr1_22016592_ENST00000374732_length(amino acids)=237AA_BP=163
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSID

--------------------------------------------------------------

>56530_56530_3_MYLK-USP48_MYLK_chr3_123512524_ENST00000360772_USP48_chr1_22016592_ENST00000400301_length(amino acids)=237AA_BP=163
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSID

--------------------------------------------------------------

>56530_56530_4_MYLK-USP48_MYLK_chr3_123512524_ENST00000360772_USP48_chr1_22016592_ENST00000529637_length(amino acids)=237AA_BP=163
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSID

--------------------------------------------------------------

>56530_56530_5_MYLK-USP48_MYLK_chr3_123512524_ENST00000475616_USP48_chr1_22016592_ENST00000308271_length(amino acids)=129AA_BP=55
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIP

--------------------------------------------------------------

>56530_56530_6_MYLK-USP48_MYLK_chr3_123512524_ENST00000475616_USP48_chr1_22016592_ENST00000374732_length(amino acids)=129AA_BP=55
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIP

--------------------------------------------------------------

>56530_56530_7_MYLK-USP48_MYLK_chr3_123512524_ENST00000475616_USP48_chr1_22016592_ENST00000400301_length(amino acids)=129AA_BP=55
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIP

--------------------------------------------------------------

>56530_56530_8_MYLK-USP48_MYLK_chr3_123512524_ENST00000475616_USP48_chr1_22016592_ENST00000529637_length(amino acids)=129AA_BP=55
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:123512524/chr1:22016592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYLK

Q86YV6

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUSP48chr3:123512524chr1:22016592ENST000004003012126929_1009909.0984.0DomainUbiquitin-like
TgeneUSP48chr3:123512524chr1:22016592ENST00000421625011460_5540486.0DomainDUSP 1
TgeneUSP48chr3:123512524chr1:22016592ENST00000421625011569_6910486.0DomainDUSP 2
TgeneUSP48chr3:123512524chr1:22016592ENST00000421625011711_8240486.0DomainDUSP 3
TgeneUSP48chr3:123512524chr1:22016592ENST0000042162501189_4210486.0DomainNote=USP
TgeneUSP48chr3:123512524chr1:22016592ENST00000421625011929_10090486.0DomainUbiquitin-like

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331906_191455.01846.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331906_191455.01864.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341906_191455.01915.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341906_191455.01864.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131906_19140155.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311906_191455.01915.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141906_19140155.0Compositional biasNote=Poly-Glu
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331098_118655.01846.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331238_132655.01846.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331334_142655.01846.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331464_171955.01846.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433161_24955.01846.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331809_189855.01846.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-43333_12255.01846.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433414_50355.01846.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433514_59955.01846.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433620_71155.01846.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433721_82155.01846.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331098_118655.01864.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331238_132655.01864.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331334_142655.01864.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331464_171955.01864.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433161_24955.01864.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331809_189855.01864.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-43333_12255.01864.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433414_50355.01864.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433514_59955.01864.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433620_71155.01864.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433721_82155.01864.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341098_118655.01915.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341238_132655.01915.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341334_142655.01915.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341464_171955.01915.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434161_24955.01915.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341809_189855.01915.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-43433_12255.01915.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434414_50355.01915.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434514_59955.01915.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434620_71155.01915.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434721_82155.01915.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341098_118655.01864.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341238_132655.01864.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341334_142655.01864.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341464_171955.01864.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534161_24955.01864.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341809_189855.01864.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-53433_12255.01864.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534414_50355.01864.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534514_59955.01864.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534620_71155.01864.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534721_82155.01864.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131098_11860155.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131238_13260155.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131334_14260155.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131464_17190155.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13161_2490155.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131809_18980155.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-1333_1220155.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13414_5030155.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13514_5990155.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13620_7110155.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13721_8210155.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311098_118655.01915.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311238_132655.01915.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311334_142655.01915.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311464_171955.01915.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131161_24955.01915.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311809_189855.01915.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-13133_12255.01915.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131414_50355.01915.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131514_59955.01915.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131620_71155.01915.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131721_82155.01915.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141098_11860155.0DomainNote=Ig-like C2-type 7
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141238_13260155.0DomainNote=Ig-like C2-type 8
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141334_14260155.0DomainFibronectin type-III
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141464_17190155.0DomainProtein kinase
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14161_2490155.0DomainNote=Ig-like C2-type 2
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141809_18980155.0DomainNote=Ig-like C2-type 9
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-1433_1220155.0DomainNote=Ig-like C2-type 1
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14414_5030155.0DomainNote=Ig-like C2-type 3
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14514_5990155.0DomainNote=Ig-like C2-type 4
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14620_7110155.0DomainNote=Ig-like C2-type 5
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14721_8210155.0DomainNote=Ig-like C2-type 6
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331470_147855.01846.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331470_147855.01864.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341470_147855.01915.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341470_147855.01864.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131470_14780155.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311470_147855.01915.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141470_14780155.0Nucleotide bindingATP
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331061_146055.01846.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331711_177455.01846.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433868_99855.01846.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433923_96355.01846.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433948_96355.01846.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433999_106355.01846.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331061_146055.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331711_177455.01864.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433868_99855.01864.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433923_96355.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433948_96355.01864.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433999_106355.01864.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341061_146055.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341711_177455.01915.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434868_99855.01915.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434923_96355.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434948_96355.01915.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434999_106355.01915.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341061_146055.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341711_177455.01864.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534868_99855.01864.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534923_96355.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534948_96355.01864.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534999_106355.01864.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131711_17740155.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13948_9630155.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311061_146055.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311711_177455.01915.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131868_99855.01915.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131923_96355.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131948_96355.01915.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131999_106355.01915.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141711_17740155.0RegionNote=Calmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14948_9630155.0RegionCalmodulin-binding
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331004_101555.01846.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331016_102755.01846.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331028_103955.01846.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331040_105155.01846.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-4331052_106355.01846.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433868_89555.01846.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433896_92355.01846.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433924_95155.01846.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433952_97955.01846.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433980_99855.01846.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000346322-433999_100355.01846.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331004_101555.01864.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331016_102755.01864.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331028_103955.01864.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331040_105155.01864.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-4331052_106355.01864.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433868_89555.01864.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433896_92355.01864.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433924_95155.01864.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433952_97955.01864.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433980_99855.01864.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000359169-433999_100355.01864.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341004_101555.01915.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341016_102755.01915.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341028_103955.01915.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341040_105155.01915.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-4341052_106355.01915.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434868_89555.01915.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434896_92355.01915.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434924_95155.01915.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434952_97955.01915.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434980_99855.01915.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000360304-434999_100355.01915.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341004_101555.01864.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341016_102755.01864.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341028_103955.01864.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341040_105155.01864.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-5341052_106355.01864.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534868_89555.01864.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534896_92355.01864.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534924_95155.01864.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534952_97955.01864.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534980_99855.01864.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000360772-534999_100355.01864.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131004_10150155.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131016_10270155.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131028_10390155.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131040_10510155.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-131052_10630155.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13868_8950155.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13896_9230155.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13924_9510155.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13952_9790155.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13980_9980155.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000418370-13999_10030155.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311004_101555.01915.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311016_102755.01915.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311028_103955.01915.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311040_105155.01915.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-1311052_106355.01915.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131868_89555.01915.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131896_92355.01915.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131924_95155.01915.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131952_97955.01915.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131980_99855.01915.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000475616-131999_100355.01915.0RepeatNote=2-1%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141004_10150155.0RepeatNote=2-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141016_10270155.0RepeatNote=2-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141028_10390155.0RepeatNote=2-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141040_10510155.0RepeatNote=2-5
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-141052_10630155.0RepeatNote=2-6
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14868_8950155.0RepeatNote=1-1
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14896_9230155.0RepeatNote=1-2
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14924_9510155.0RepeatNote=1-3
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14952_9790155.0RepeatNote=1-4
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14980_9980155.0RepeatNote=1-5%3B truncated
HgeneMYLKchr3:123512524chr1:22016592ENST00000583087-14999_10030155.0RepeatNote=2-1%3B truncated
TgeneUSP48chr3:123512524chr1:22016592ENST000003082712227460_554961.01036.0DomainDUSP 1
TgeneUSP48chr3:123512524chr1:22016592ENST000003082712227569_691961.01036.0DomainDUSP 2
TgeneUSP48chr3:123512524chr1:22016592ENST000003082712227711_824961.01036.0DomainDUSP 3
TgeneUSP48chr3:123512524chr1:22016592ENST00000308271222789_421961.01036.0DomainNote=USP
TgeneUSP48chr3:123512524chr1:22016592ENST000003082712227929_1009961.01036.0DomainUbiquitin-like
TgeneUSP48chr3:123512524chr1:22016592ENST000004003012126460_554909.0984.0DomainDUSP 1
TgeneUSP48chr3:123512524chr1:22016592ENST000004003012126569_691909.0984.0DomainDUSP 2
TgeneUSP48chr3:123512524chr1:22016592ENST000004003012126711_824909.0984.0DomainDUSP 3
TgeneUSP48chr3:123512524chr1:22016592ENST00000400301212689_421909.0984.0DomainNote=USP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MYLK
USP48


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MYLK-USP48


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MYLK-USP48


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource