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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MYO1C-SMG6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MYO1C-SMG6
	FusionPDB ID: 56637
	FusionGDB2.0 ID: 56637
		Hgene	Tgene
	Gene symbol	MYO1C	SMG6
	Gene ID	4643	23293
	Gene name	myosin IE	SMG6 nonsense mediated mRNA decay factor
	Synonyms	FSGS6\|HuncM-IC\|MYO1C	C17orf31\|EST1A\|SMG-6\|hSMG5/7a
	Cytomap	15q22.2	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1E	telomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A
	Modification date	20200313	20200320
	UniProtAcc	O00159	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000359786, ENST00000361007, ENST00000438665, ENST00000545534, ENST00000575158, ENST00000573198,	ENST00000573166, ENST00000263073, ENST00000354901, ENST00000536871, ENST00000544865,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 8 X 5=240	21 X 16 X 8=2688
	# samples	7	22
	** MAII score	log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2688*10)=-3.6109577092541 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MYO1C [Title/Abstract] AND SMG6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MYO1C(1377904)-SMG6(1989195), # samples:3
Anticipated loss of major functional domain due to fusion event.	MYO1C-SMG6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1C-SMG6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1C-SMG6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1C-SMG6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1C-SMG6 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. MYO1C-SMG6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MYO1C-SMG6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SMG6	GO:1904354	negative regulation of telomere capping	12676087

Fusion gene breakpoints across MYO1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMG6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-94-8491-01A	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-
ChimerDB4	LUSC	TCGA-94-8491	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000359786	MYO1C	chr17	1377904	-	ENST00000544865	SMG6	chr17	1989195	-	4678	2122	277	3024	915
ENST00000359786	MYO1C	chr17	1377904	-	ENST00000263073	SMG6	chr17	1989195	-	4674	2122	277	3024	915
ENST00000359786	MYO1C	chr17	1377904	-	ENST00000354901	SMG6	chr17	1989195	-	4667	2122	277	3024	915
ENST00000359786	MYO1C	chr17	1377904	-	ENST00000536871	SMG6	chr17	1989195	-	3112	2122	277	3024	915
ENST00000438665	MYO1C	chr17	1377904	-	ENST00000544865	SMG6	chr17	1989195	-	4519	1963	40	2865	941
ENST00000438665	MYO1C	chr17	1377904	-	ENST00000263073	SMG6	chr17	1989195	-	4515	1963	40	2865	941
ENST00000438665	MYO1C	chr17	1377904	-	ENST00000354901	SMG6	chr17	1989195	-	4508	1963	40	2865	941
ENST00000438665	MYO1C	chr17	1377904	-	ENST00000536871	SMG6	chr17	1989195	-	2953	1963	40	2865	941
ENST00000361007	MYO1C	chr17	1377904	-	ENST00000544865	SMG6	chr17	1989195	-	4357	1801	82	2703	873
ENST00000361007	MYO1C	chr17	1377904	-	ENST00000263073	SMG6	chr17	1989195	-	4353	1801	82	2703	873
ENST00000361007	MYO1C	chr17	1377904	-	ENST00000354901	SMG6	chr17	1989195	-	4346	1801	82	2703	873
ENST00000361007	MYO1C	chr17	1377904	-	ENST00000536871	SMG6	chr17	1989195	-	2791	1801	82	2703	873
ENST00000545534	MYO1C	chr17	1377904	-	ENST00000544865	SMG6	chr17	1989195	-	4524	1968	243	2870	875
ENST00000545534	MYO1C	chr17	1377904	-	ENST00000263073	SMG6	chr17	1989195	-	4520	1968	243	2870	875
ENST00000545534	MYO1C	chr17	1377904	-	ENST00000354901	SMG6	chr17	1989195	-	4513	1968	243	2870	875
ENST00000545534	MYO1C	chr17	1377904	-	ENST00000536871	SMG6	chr17	1989195	-	2958	1968	243	2870	875

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359786	ENST00000544865	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.005173719	0.99482626
ENST00000359786	ENST00000263073	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.005193303	0.9948067
ENST00000359786	ENST00000354901	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.005156811	0.9948431
ENST00000359786	ENST00000536871	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.010708613	0.98929137
ENST00000438665	ENST00000544865	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.004437008	0.99556303
ENST00000438665	ENST00000263073	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.004450932	0.9955491
ENST00000438665	ENST00000354901	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.004418121	0.9955819
ENST00000438665	ENST00000536871	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.008914038	0.99108595
ENST00000361007	ENST00000544865	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.003690649	0.99630934
ENST00000361007	ENST00000263073	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.003706954	0.996293
ENST00000361007	ENST00000354901	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.003664412	0.9963356
ENST00000361007	ENST00000536871	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.00835376	0.99164623
ENST00000545534	ENST00000544865	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.002018789	0.99798125
ENST00000545534	ENST00000263073	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.002029263	0.99797076
ENST00000545534	ENST00000354901	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.002006078	0.99799395
ENST00000545534	ENST00000536871	MYO1C	chr17	1377904	-	SMG6	chr17	1989195	-	0.00486239	0.99513763

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56637_56637_1_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000359786_SMG6_chr17_1989195_ENST00000263073_length(amino acids)=915AA_BP=615
MLTGRGAQAAGSPQGGMALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFREN
LIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP
ERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR
LGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSV
EGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFE
QFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFL
THKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYF
LEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQE
KIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL
EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV

--------------------------------------------------------------

>56637_56637_2_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000359786_SMG6_chr17_1989195_ENST00000354901_length(amino acids)=915AA_BP=615
MLTGRGAQAAGSPQGGMALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFREN
LIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP
ERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR
LGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSV
EGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFE
QFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFL
THKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYF
LEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQE
KIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL
EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV

--------------------------------------------------------------

>56637_56637_3_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000359786_SMG6_chr17_1989195_ENST00000536871_length(amino acids)=915AA_BP=615
MLTGRGAQAAGSPQGGMALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFREN
LIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP
ERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR
LGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSV
EGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFE
QFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFL
THKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYF
LEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQE
KIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL
EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV

--------------------------------------------------------------

>56637_56637_4_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000359786_SMG6_chr17_1989195_ENST00000544865_length(amino acids)=915AA_BP=615
MLTGRGAQAAGSPQGGMALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFREN
LIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP
ERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR
LGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSV
EGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFE
QFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFL
THKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYF
LEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQE
KIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL
EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV

--------------------------------------------------------------

>56637_56637_5_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000361007_SMG6_chr17_1989195_ENST00000263073_length(amino acids)=873AA_BP=573
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY
SRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNN
KIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLL
FRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLE
DEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLL
ESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLI

--------------------------------------------------------------

>56637_56637_6_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000361007_SMG6_chr17_1989195_ENST00000354901_length(amino acids)=873AA_BP=573
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY
SRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNN
KIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLL
FRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLE
DEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLL
ESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLI

--------------------------------------------------------------

>56637_56637_7_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000361007_SMG6_chr17_1989195_ENST00000536871_length(amino acids)=873AA_BP=573
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY
SRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNN
KIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLL
FRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLE
DEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLL
ESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLI

--------------------------------------------------------------

>56637_56637_8_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000361007_SMG6_chr17_1989195_ENST00000544865_length(amino acids)=873AA_BP=573
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY
SRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNN
KIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLL
FRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLE
DEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLL
ESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLI

--------------------------------------------------------------

>56637_56637_9_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000438665_SMG6_chr17_1989195_ENST00000263073_length(amino acids)=941AA_BP=641
MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV
QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI
SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV
HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH
FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES
PSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEEC
LRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR
SELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGG
EDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAK
GQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE

--------------------------------------------------------------

>56637_56637_10_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000438665_SMG6_chr17_1989195_ENST00000354901_length(amino acids)=941AA_BP=641
MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV
QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI
SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV
HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH
FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES
PSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEEC
LRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR
SELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGG
EDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAK
GQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE

--------------------------------------------------------------

>56637_56637_11_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000438665_SMG6_chr17_1989195_ENST00000536871_length(amino acids)=941AA_BP=641
MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV
QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI
SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV
HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH
FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES
PSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEEC
LRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR
SELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGG
EDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAK
GQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE

--------------------------------------------------------------

>56637_56637_12_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000438665_SMG6_chr17_1989195_ENST00000544865_length(amino acids)=941AA_BP=641
MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV
QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI
SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV
HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH
FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES
PSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEEC
LRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR
SELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGG
EDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAK
GQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE

--------------------------------------------------------------

>56637_56637_13_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000545534_SMG6_chr17_1989195_ENST00000263073_length(amino acids)=875AA_BP=575
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP
HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDV
QFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI
DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKA
VYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYF
NNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNND
LLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTR
LEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLAR
LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDD

--------------------------------------------------------------

>56637_56637_14_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000545534_SMG6_chr17_1989195_ENST00000354901_length(amino acids)=875AA_BP=575
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP
HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDV
QFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI
DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKA
VYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYF
NNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNND
LLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTR
LEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLAR
LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDD

--------------------------------------------------------------

>56637_56637_15_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000545534_SMG6_chr17_1989195_ENST00000536871_length(amino acids)=875AA_BP=575
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP
HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDV
QFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI
DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKA
VYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYF
NNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNND
LLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTR
LEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLAR
LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDD

--------------------------------------------------------------

>56637_56637_16_MYO1C-SMG6_MYO1C_chr17_1377904_ENST00000545534_SMG6_chr17_1989195_ENST00000544865_length(amino acids)=875AA_BP=575
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP
HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDV
QFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI
DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKA
VYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYF
NNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNND
LLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTR
LEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLAR
LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1377904/chr17:1989195)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO1C O00159	.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269\|PubMed:24636949}.; FUNCTION: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

139_148

599.0

1064.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

192_196

599.0

1064.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

139_148

564.0

1029.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

192_196

564.0

1029.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

139_148

580.0

1045.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

192_196

580.0

1045.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

139_148

564.0

1029.0

Nucleotide binding

Note=ATP

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

192_196

564.0

1029.0

Nucleotide binding

Note=ATP

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000263073

1197_1239

1119.0

1420.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000354901

1197_1239

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000354901

567_625

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000536871

1197_1239

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000536871

567_625

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000544865

1197_1239

1088.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000263073

1246_1397

1119.0

1420.0

Domain

Note=PINc

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000354901

1246_1397

211.0

512.0

Domain

Note=PINc

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000536871

1246_1397

211.0

512.0

Domain

Note=PINc

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000544865

1246_1397

1088.0

1389.0

Domain

Note=PINc

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

47_731

599.0

1064.0

Domain

Myosin motor

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

734_757

599.0

1064.0

Domain

IQ 1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

758_786

599.0

1064.0

Domain

IQ 2

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

885_1059

599.0

1064.0

Domain

TH1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

47_731

564.0

1029.0

Domain

Myosin motor

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

734_757

564.0

1029.0

Domain

IQ 1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

758_786

564.0

1029.0

Domain

IQ 2

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

885_1059

564.0

1029.0

Domain

TH1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

47_731

580.0

1045.0

Domain

Myosin motor

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

734_757

580.0

1045.0

Domain

IQ 1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

758_786

580.0

1045.0

Domain

IQ 2

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

885_1059

580.0

1045.0

Domain

TH1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

47_731

564.0

1029.0

Domain

Myosin motor

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

734_757

564.0

1029.0

Domain

IQ 1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

758_786

564.0

1029.0

Domain

IQ 2

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

885_1059

564.0

1029.0

Domain

TH1

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000359786

608_630

599.0

1064.0

Region

Actin-binding

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000361007

608_630

564.0

1029.0

Region

Actin-binding

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000438665

608_630

580.0

1045.0

Region

Actin-binding

Hgene

MYO1C

chr17:1377904

chr17:1989195

ENST00000575158

608_630

564.0

1029.0

Region

Actin-binding

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000263073

163_193

1119.0

1420.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000263073

567_625

1119.0

1420.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000354901

163_193

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000536871

163_193

211.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000544865

163_193

1088.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMG6

chr17:1377904

chr17:1989195

ENST00000544865

567_625

1088.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1737_MYO1C_1377904_SMG6_1989195_ranked_0.pdb	MYO1C	1377904	1377904	ENST00000536871	SMG6	chr17	1989195	-	MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES PSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEEC LRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR SELSDKKRPETVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGG EDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAK GQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE	941

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MYO1C_pLDDT.png

SMG6_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MYO1C
SMG6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SMG6	chr17:1377904	chr17:1989195	ENST00000263073		12	19	114_503	1119.0	1420.0	telomeric DNA
Tgene	SMG6	chr17:1377904	chr17:1989195	ENST00000354901		5	12	114_503	211.0	512.0	telomeric DNA
Tgene	SMG6	chr17:1377904	chr17:1989195	ENST00000536871		4	11	114_503	211.0	512.0	telomeric DNA
Tgene	SMG6	chr17:1377904	chr17:1989195	ENST00000544865		12	19	114_503	1088.0	1389.0	telomeric DNA

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Related Drugs to MYO1C-SMG6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MYO1C-SMG6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source