UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:NAALADL2-DRD3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NAALADL2-DRD3
FusionPDB ID: 57029
FusionGDB2.0 ID: 57029
HgeneTgene
Gene symbol

NAALADL2

DRD3

Gene ID

254827

1814

Gene nameN-acetylated alpha-linked acidic dipeptidase like 2dopamine receptor D3
Synonyms-D3DR|ETM1|FET1
Cytomap

3q26.31

3q13.31

Type of geneprotein-codingprotein-coding
Descriptioninactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologueD(3) dopamine receptoressential tremor 1
Modification date2020031320200315
UniProtAcc

Q58DX5

.
Ensembl transtripts involved in fusion geneENST idsENST00000454872, ENST00000473253, 
ENST00000295881, ENST00000383673, 
ENST00000460779, ENST00000467632, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 19 X 9=47882 X 2 X 2=8
# samples 292
** MAII scorelog2(29/4788*10)=-4.04529834692857
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: NAALADL2 [Title/Abstract] AND DRD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NAALADL2(175455187)-DRD3(113858543), # samples:1
Anticipated loss of major functional domain due to fusion event.NAALADL2-DRD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NAALADL2-DRD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDRD3

GO:0002031

G protein-coupled receptor internalization

18424554

TgeneDRD3

GO:0006874

cellular calcium ion homeostasis

7911712

TgeneDRD3

GO:0007186

G protein-coupled receptor signaling pathway

7911712

TgeneDRD3

GO:0007191

adenylate cyclase-activating dopamine receptor signaling pathway

18424554

TgeneDRD3

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

7907363|8666994|18424554

TgeneDRD3

GO:0034776

response to histamine

16839358

TgeneDRD3

GO:0050482

arachidonic acid secretion

8301582

TgeneDRD3

GO:0050709

negative regulation of protein secretion

16839358


check buttonFusion gene breakpoints across NAALADL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DRD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01ANAALADL2chr3

175455187

-DRD3chr3

113858543

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000454872NAALADL2chr3175455187-ENST00000460779DRD3chr3113858543-285921181282794888
ENST00000454872NAALADL2chr3175455187-ENST00000467632DRD3chr3113858543-280121181282794888
ENST00000454872NAALADL2chr3175455187-ENST00000295881DRD3chr3113858543-270221181282695855
ENST00000454872NAALADL2chr3175455187-ENST00000383673DRD3chr3113858543-280121181282794888

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000454872ENST00000460779NAALADL2chr3175455187-DRD3chr3113858543-0.000482440.99951756
ENST00000454872ENST00000467632NAALADL2chr3175455187-DRD3chr3113858543-0.0004573630.9995427
ENST00000454872ENST00000295881NAALADL2chr3175455187-DRD3chr3113858543-0.0004241240.9995759
ENST00000454872ENST00000383673NAALADL2chr3175455187-DRD3chr3113858543-0.0004573630.9995427

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57029_57029_1_NAALADL2-DRD3_NAALADL2_chr3_175455187_ENST00000454872_DRD3_chr3_113858543_ENST00000295881_length(amino acids)=855AA_BP=646
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCN
SVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHC

--------------------------------------------------------------

>57029_57029_2_NAALADL2-DRD3_NAALADL2_chr3_175455187_ENST00000454872_DRD3_chr3_113858543_ENST00000383673_length(amino acids)=888AA_BP=646
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCN
SVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL

--------------------------------------------------------------

>57029_57029_3_NAALADL2-DRD3_NAALADL2_chr3_175455187_ENST00000454872_DRD3_chr3_113858543_ENST00000460779_length(amino acids)=888AA_BP=646
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCN
SVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL

--------------------------------------------------------------

>57029_57029_4_NAALADL2-DRD3_NAALADL2_chr3_175455187_ENST00000454872_DRD3_chr3_113858543_ENST00000467632_length(amino acids)=888AA_BP=646
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCN
SVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:175455187/chr3:113858543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAALADL2

Q58DX5

.
FUNCTION: May be catalytically inactive.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175455187chr3:113858543ENST00000454872-12141_121663.3333333333334796.0Topological domainCytoplasmic
HgeneNAALADL2chr3:175455187chr3:113858543ENST00000454872-1214122_142663.3333333333334796.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337189_196175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337342_350175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948189_196175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948342_350175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248189_196175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248342_350175.33333333333334401.0RegionNote=Agonist binding
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337210_329175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337352_366175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337387_400175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948210_329175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948352_366175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948387_400175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248210_329175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248352_366175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248387_400175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337188_209175.33333333333334401.0TransmembraneHelical%3B Name%3D5
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337330_351175.33333333333334401.0TransmembraneHelical%3B Name%3D6
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337367_386175.33333333333334401.0TransmembraneHelical%3B Name%3D7
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948188_209175.33333333333334401.0TransmembraneHelical%3B Name%3D5
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948330_351175.33333333333334401.0TransmembraneHelical%3B Name%3D6
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948367_386175.33333333333334401.0TransmembraneHelical%3B Name%3D7
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248188_209175.33333333333334401.0TransmembraneHelical%3B Name%3D5
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248330_351175.33333333333334401.0TransmembraneHelical%3B Name%3D6
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248367_386175.33333333333334401.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175455187chr3:113858543ENST00000454872-1214143_795663.3333333333334796.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337127_149175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337171_187175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST00000383673371_32175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST000003836733756_65175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST000003836733789_104175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948127_149175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948171_187175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST00000460779481_32175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST000004607794856_65175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST000004607794889_104175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248127_149175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248171_187175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST00000467632481_32175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST000004676324856_65175.33333333333334401.0Topological domainCytoplasmic
TgeneDRD3chr3:175455187chr3:113858543ENST000004676324889_104175.33333333333334401.0Topological domainExtracellular
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337105_126175.33333333333334401.0TransmembraneHelical%3B Name%3D3
TgeneDRD3chr3:175455187chr3:113858543ENST0000038367337150_170175.33333333333334401.0TransmembraneHelical%3B Name%3D4
TgeneDRD3chr3:175455187chr3:113858543ENST000003836733733_55175.33333333333334401.0TransmembraneHelical%3B Name%3D1
TgeneDRD3chr3:175455187chr3:113858543ENST000003836733766_88175.33333333333334401.0TransmembraneHelical%3B Name%3D2
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948105_126175.33333333333334401.0TransmembraneHelical%3B Name%3D3
TgeneDRD3chr3:175455187chr3:113858543ENST0000046077948150_170175.33333333333334401.0TransmembraneHelical%3B Name%3D4
TgeneDRD3chr3:175455187chr3:113858543ENST000004607794833_55175.33333333333334401.0TransmembraneHelical%3B Name%3D1
TgeneDRD3chr3:175455187chr3:113858543ENST000004607794866_88175.33333333333334401.0TransmembraneHelical%3B Name%3D2
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248105_126175.33333333333334401.0TransmembraneHelical%3B Name%3D3
TgeneDRD3chr3:175455187chr3:113858543ENST0000046763248150_170175.33333333333334401.0TransmembraneHelical%3B Name%3D4
TgeneDRD3chr3:175455187chr3:113858543ENST000004676324833_55175.33333333333334401.0TransmembraneHelical%3B Name%3D1
TgeneDRD3chr3:175455187chr3:113858543ENST000004676324866_88175.33333333333334401.0TransmembraneHelical%3B Name%3D2


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NAALADL2
DRD3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to NAALADL2-DRD3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to NAALADL2-DRD3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource