UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NAB1-GULP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NAB1-GULP1
	FusionPDB ID: 57052
	FusionGDB2.0 ID: 57052
		Hgene	Tgene
	Gene symbol	NAB1	GULP1
	Gene ID	4664	51454
	Gene name	NGFI-A binding protein 1	GULP PTB domain containing engulfment adaptor 1
	Synonyms	-	CED-6\|CED6\|GULP
	Cytomap	2q32.2	2q32.1-q32.2
	Type of gene	protein-coding	protein-coding
	Description	NGFI-A-binding protein 1EGR-1-binding protein 1EGR1 binding protein 1transcriptional regulatory protein p54	PTB domain-containing engulfment adapter protein 1GULP, engulfment adaptor PTB domain containing 1PTB domain adapter protein CED-6PTB domain adaptor protein CED-6cell death protein 6 homologengulfment adapter protein
	Modification date	20200313	20200313
	UniProtAcc	Q13506	Q9UBP9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000337386, ENST00000357215, ENST00000409581, ENST00000409641, ENST00000545490, ENST00000484774,	ENST00000359135, ENST00000409580, ENST00000409609, ENST00000409637, ENST00000409805, ENST00000410051, ENST00000479019, ENST00000409830, ENST00000409843,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 5=315	10 X 12 X 6=720
	# samples	10	10
	** MAII score	log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/720*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NAB1 [Title/Abstract] AND GULP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NAB1(191537878)-GULP1(189448992), # samples:3
Anticipated loss of major functional domain due to fusion event.	NAB1-GULP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAB1-GULP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAB1-GULP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NAB1-GULP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GULP1	GO:0006911	phagocytosis, engulfment	11729193

Fusion gene breakpoints across NAB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GULP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-NC-A5HE-01A	NAB1	chr2	191537878	-	GULP1	chr2	189448992	+
ChimerDB4	LUSC	TCGA-NC-A5HE-01A	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+
ChimerDB4	LUSC	TCGA-NC-A5HE	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000409581	NAB1	chr2	191537878	+	ENST00000409843	GULP1	chr2	189448992	+	2680	1315	274	1581	435
ENST00000409581	NAB1	chr2	191537878	+	ENST00000409830	GULP1	chr2	189448992	+	1621	1315	274	1620	449
ENST00000337386	NAB1	chr2	191537878	+	ENST00000409843	GULP1	chr2	189448992	+	2831	1466	461	1732	423
ENST00000337386	NAB1	chr2	191537878	+	ENST00000409830	GULP1	chr2	189448992	+	1772	1466	461	1771	437
ENST00000357215	NAB1	chr2	191537878	+	ENST00000409843	GULP1	chr2	189448992	+	2480	1115	74	1381	435
ENST00000357215	NAB1	chr2	191537878	+	ENST00000409830	GULP1	chr2	189448992	+	1421	1115	74	1420	449
ENST00000409641	NAB1	chr2	191537878	+	ENST00000409843	GULP1	chr2	189448992	+	2488	1123	118	1389	423
ENST00000409641	NAB1	chr2	191537878	+	ENST00000409830	GULP1	chr2	189448992	+	1429	1123	118	1428	437
ENST00000545490	NAB1	chr2	191537878	+	ENST00000409843	GULP1	chr2	189448992	+	1717	352	7	618	203
ENST00000545490	NAB1	chr2	191537878	+	ENST00000409830	GULP1	chr2	189448992	+	658	352	7	657	217

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409581	ENST00000409843	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.000363533	0.9996364
ENST00000409581	ENST00000409830	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.00493285	0.9950671
ENST00000337386	ENST00000409843	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.000218663	0.9997813
ENST00000337386	ENST00000409830	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.002675908	0.9973241
ENST00000357215	ENST00000409843	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.000226717	0.9997733
ENST00000357215	ENST00000409830	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.003501909	0.9964981
ENST00000409641	ENST00000409843	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.000148683	0.99985135
ENST00000409641	ENST00000409830	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.001919698	0.99808025
ENST00000545490	ENST00000409843	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.001093877	0.99890614
ENST00000545490	ENST00000409830	NAB1	chr2	191537878	+	GULP1	chr2	189448992	+	0.005866974	0.99413306

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57052_57052_1_NAB1-GULP1_NAB1_chr2_191537878_ENST00000337386_GULP1_chr2_189448992_ENST00000409830_length(amino acids)=437AA_BP=335
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLP
VSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGS
PASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLT
LHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQ

--------------------------------------------------------------

>57052_57052_2_NAB1-GULP1_NAB1_chr2_191537878_ENST00000337386_GULP1_chr2_189448992_ENST00000409843_length(amino acids)=423AA_BP=335
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLP
VSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGS
PASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLT
LHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQ

--------------------------------------------------------------

>57052_57052_3_NAB1-GULP1_NAB1_chr2_191537878_ENST00000357215_GULP1_chr2_189448992_ENST00000409830_length(amino acids)=449AA_BP=347
MQPLAELNPSRVMAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTN
PGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATE
SEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGR
FDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDI

--------------------------------------------------------------

>57052_57052_4_NAB1-GULP1_NAB1_chr2_191537878_ENST00000357215_GULP1_chr2_189448992_ENST00000409843_length(amino acids)=435AA_BP=347
MQPLAELNPSRVMAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTN
PGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATE
SEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGR
FDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDI

--------------------------------------------------------------

>57052_57052_5_NAB1-GULP1_NAB1_chr2_191537878_ENST00000409581_GULP1_chr2_189448992_ENST00000409830_length(amino acids)=449AA_BP=347
MQPLAELNPSRVMAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTN
PGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATE
SEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGR
FDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDI

--------------------------------------------------------------

>57052_57052_6_NAB1-GULP1_NAB1_chr2_191537878_ENST00000409581_GULP1_chr2_189448992_ENST00000409843_length(amino acids)=435AA_BP=347
MQPLAELNPSRVMAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTN
PGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATE
SEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGR
FDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDI

--------------------------------------------------------------

>57052_57052_7_NAB1-GULP1_NAB1_chr2_191537878_ENST00000409641_GULP1_chr2_189448992_ENST00000409830_length(amino acids)=437AA_BP=335
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLP
VSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGS
PASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLT
LHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQ

--------------------------------------------------------------

>57052_57052_8_NAB1-GULP1_NAB1_chr2_191537878_ENST00000409641_GULP1_chr2_189448992_ENST00000409843_length(amino acids)=423AA_BP=335
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLP
VSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGS
PASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLT
LHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQ

--------------------------------------------------------------

>57052_57052_9_NAB1-GULP1_NAB1_chr2_191537878_ENST00000545490_GULP1_chr2_189448992_ENST00000409830_length(amino acids)=217AA_BP=115
MLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTY
KYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAAD

--------------------------------------------------------------

>57052_57052_10_NAB1-GULP1_NAB1_chr2_191537878_ENST00000545490_GULP1_chr2_189448992_ENST00000409843_length(amino acids)=203AA_BP=115
MLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTY
KYTYRTTKSKCGERDELSPKRIKVEAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAAD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:191537878/chr2:189448992)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NAB1 Q13506	GULP1 Q9UBP9
FUNCTION: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}.	FUNCTION: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269\|PubMed:10574763, ECO:0000269\|PubMed:10574771, ECO:0000269\|PubMed:16497666, ECO:0000269\|PubMed:17398097}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000337386

221_310

335.0

488.0

Region

Note=NCD2

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000337386

307_338

335.0

488.0

Region

Necessary for nuclear localization

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000337386

4_82

335.0

488.0

Region

Note=NCD1

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000409581

221_310

335.0

488.0

Region

Note=NCD2

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000409581

307_338

335.0

488.0

Region

Necessary for nuclear localization

Hgene

NAB1

chr2:191537878

chr2:189448992

ENST00000409581

4_82

335.0

488.0

Region

Note=NCD1

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409637

158_202

168.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409805

158_202

100.0

202.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000410051

158_202

168.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409637

21_176

168.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000410051

21_176

168.0

Domain

PID

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000359135

158_202

203.0

305.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409580

158_202

203.0

305.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409609

158_202

203.0

305.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409830

158_202

203.0

305.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409843

158_202

203.0

292.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000359135

21_176

203.0

305.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409580

21_176

203.0

305.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409609

21_176

203.0

305.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409805

21_176

100.0

202.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409830

21_176

203.0

305.0

Domain

PID

Tgene

GULP1

chr2:191537878

chr2:189448992

ENST00000409843

21_176

203.0

292.0

Domain

PID

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NAB1_pLDDT.png

GULP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NAB1
GULP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NAB1-GULP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NAB1-GULP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source