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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NADK2-BAZ2B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NADK2-BAZ2B
FusionPDB ID: 57099
FusionGDB2.0 ID: 57099
HgeneTgene
Gene symbol

NADK2

BAZ2B

Gene ID

133686

29994

Gene nameNAD kinase 2, mitochondrialbromodomain adjacent to zinc finger domain 2B
SynonymsC5orf33|DECRD|MNADK|NADKD1WALp4
Cytomap

5p13.2

2q24.2

Type of geneprotein-codingprotein-coding
DescriptionNAD kinase 2, mitochondrialNAD kinase domain-containing protein 1, mitochondrialbromodomain adjacent to zinc finger domain protein 2B
Modification date2020031320200313
UniProtAcc

Q4G0N4

Q9UIF8

Ensembl transtripts involved in fusion geneENST idsENST00000282512, ENST00000381937, 
ENST00000397338, ENST00000506945, 
ENST00000514504, ENST00000511613, 
ENST00000483316, ENST00000343439, 
ENST00000355831, ENST00000392782, 
ENST00000392783, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 4=2249 X 10 X 5=450
# samples 811
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NADK2 [Title/Abstract] AND BAZ2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NADK2(36225644)-BAZ2B(160206868), # samples:1
Anticipated loss of major functional domain due to fusion event.NADK2-BAZ2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NADK2-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNADK2

GO:0019674

NAD metabolic process

23212377


check buttonFusion gene breakpoints across NADK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BAZ2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IP-7968-11ANADK2chr5

36225644

-BAZ2Bchr2

160206868

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282512NADK2chr536225644-ENST00000355831BAZ2Bchr2160206868-38873072942600768
ENST00000282512NADK2chr536225644-ENST00000343439BAZ2Bchr2160206868-38873072942600768
ENST00000282512NADK2chr536225644-ENST00000392782BAZ2Bchr2160206868-38873072942600768
ENST00000282512NADK2chr536225644-ENST00000392783BAZ2Bchr2160206868-38873072942600768
ENST00000506945NADK2chr536225644-ENST00000355831BAZ2Bchr2160206868-40244444312737768
ENST00000506945NADK2chr536225644-ENST00000343439BAZ2Bchr2160206868-40244444312737768
ENST00000506945NADK2chr536225644-ENST00000392782BAZ2Bchr2160206868-40244444312737768
ENST00000506945NADK2chr536225644-ENST00000392783BAZ2Bchr2160206868-40244444312737768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282512ENST00000355831NADK2chr536225644-BAZ2Bchr2160206868-0.0001918550.99980813
ENST00000282512ENST00000343439NADK2chr536225644-BAZ2Bchr2160206868-0.0001918550.99980813
ENST00000282512ENST00000392782NADK2chr536225644-BAZ2Bchr2160206868-0.0001918550.99980813
ENST00000282512ENST00000392783NADK2chr536225644-BAZ2Bchr2160206868-0.0001918550.99980813
ENST00000506945ENST00000355831NADK2chr536225644-BAZ2Bchr2160206868-0.0001948760.99980515
ENST00000506945ENST00000343439NADK2chr536225644-BAZ2Bchr2160206868-0.0001948760.99980515
ENST00000506945ENST00000392782NADK2chr536225644-BAZ2Bchr2160206868-0.0001948760.99980515
ENST00000506945ENST00000392783NADK2chr536225644-BAZ2Bchr2160206868-0.0001948760.99980515

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57099_57099_1_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000282512_BAZ2B_chr2_160206868_ENST00000343439_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_2_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000282512_BAZ2B_chr2_160206868_ENST00000355831_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_3_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000282512_BAZ2B_chr2_160206868_ENST00000392782_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_4_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000282512_BAZ2B_chr2_160206868_ENST00000392783_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_5_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000506945_BAZ2B_chr2_160206868_ENST00000343439_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_6_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000506945_BAZ2B_chr2_160206868_ENST00000355831_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_7_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000506945_BAZ2B_chr2_160206868_ENST00000392782_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

--------------------------------------------------------------

>57099_57099_8_NADK2-BAZ2B_NADK2_chr5_36225644_ENST00000506945_BAZ2B_chr2_160206868_ENST00000392783_length(amino acids)=768AA_BP=4
MIQNGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPN
AGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMST
ASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLT
SNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACL
KNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGE
FTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKG
DNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGN
KDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36225644/chr2:160206868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NADK2

Q4G0N4

BAZ2B

Q9UIF8

FUNCTION: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}.FUNCTION: Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000303|PubMed:10662543}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000034343925361334_13751304.33333333333332069.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000034343925362077_21471304.33333333333332069.0DomainBromo
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000035583125362077_21471370.33333333333332135.0DomainBromo
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278225362077_21471368.33333333333332133.0DomainBromo
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278326372077_21471404.33333333333332169.0DomainBromo
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000034343925361931_19811304.33333333333332069.0Zinc fingerPHD-type
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000035583125361931_19811370.33333333333332135.0Zinc fingerPHD-type
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278225361931_19811368.33333333333332133.0Zinc fingerPHD-type
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278326371931_19811404.33333333333332169.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536883_10611304.33333333333332069.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000035583125361334_13751370.33333333333332135.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536883_10611370.33333333333332135.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278225361334_13751368.33333333333332133.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536883_10611368.33333333333332133.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278326371334_13751404.33333333333332169.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637883_10611404.33333333333332169.0Coiled coilOntology_term=ECO:0000255
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000034343925361296_13391304.33333333333332069.0Compositional biasNote=Asp-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536149_2651304.33333333333332069.0Compositional biasNote=Ser-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536269_2751304.33333333333332069.0Compositional biasNote=Poly-Glu
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536595_6661304.33333333333332069.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536837_8681304.33333333333332069.0Compositional biasNote=Arg-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536902_10611304.33333333333332069.0Compositional biasNote=Lys-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000035583125361296_13391370.33333333333332135.0Compositional biasNote=Asp-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536149_2651370.33333333333332135.0Compositional biasNote=Ser-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536269_2751370.33333333333332135.0Compositional biasNote=Poly-Glu
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536595_6661370.33333333333332135.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536837_8681370.33333333333332135.0Compositional biasNote=Arg-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536902_10611370.33333333333332135.0Compositional biasNote=Lys-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278225361296_13391368.33333333333332133.0Compositional biasNote=Asp-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536149_2651368.33333333333332133.0Compositional biasNote=Ser-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536269_2751368.33333333333332133.0Compositional biasNote=Poly-Glu
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536595_6661368.33333333333332133.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536837_8681368.33333333333332133.0Compositional biasNote=Arg-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536902_10611368.33333333333332133.0Compositional biasNote=Lys-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278326371296_13391404.33333333333332169.0Compositional biasNote=Asp-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637149_2651404.33333333333332169.0Compositional biasNote=Ser-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637269_2751404.33333333333332169.0Compositional biasNote=Poly-Glu
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637595_6661404.33333333333332169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637837_8681404.33333333333332169.0Compositional biasNote=Arg-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637902_10611404.33333333333332169.0Compositional biasNote=Lys-rich
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000034343925361087_11521304.33333333333332069.0DomainDDT
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003434392536739_8101304.33333333333332069.0DomainMBD
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000035583125361087_11521370.33333333333332135.0DomainDDT
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003558312536739_8101370.33333333333332135.0DomainMBD
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278225361087_11521368.33333333333332133.0DomainDDT
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927822536739_8101368.33333333333332133.0DomainMBD
TgeneBAZ2Bchr5:36225644chr2:160206868ENST0000039278326371087_11521404.33333333333332169.0DomainDDT
TgeneBAZ2Bchr5:36225644chr2:160206868ENST000003927832637739_8101404.33333333333332169.0DomainMBD


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NADK2
BAZ2B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NADK2-BAZ2B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NADK2-BAZ2B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource