UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:APP-TSPEAR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: APP-TSPEAR
FusionPDB ID: 5711
FusionGDB2.0 ID: 5711
HgeneTgene
Gene symbol

APP

TSPEAR

Gene ID

351

54084

Gene nameamyloid beta precursor proteinthrombospondin type laminin G domain and EAR repeats
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4C21orf29|DFNB98|ECTD14|TSP-EAR
Cytomap

21q21.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteithrombospondin-type laminin G domain and EAR repeat-containing proteinthrombospondin-type laminin G domain and EAR repeats-containing protein
Modification date2020032920200313
UniProtAcc

Q8NEU8

P59090

Ensembl transtripts involved in fusion geneENST idsENST00000346798, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000439274, ENST00000440126, 
ENST00000448388, ENST00000474136, 
ENST00000397916, ENST00000323084, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 25 X 12=93004 X 3 X 4=48
# samples 335
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: APP [Title/Abstract] AND TSPEAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)APP(27326904)-TSPEAR(45987889), # samples:2
Anticipated loss of major functional domain due to fusion event.APP-TSPEAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-TSPEAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-TSPEAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-TSPEAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSPEAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-DC-4745-01AAPPchr21

27326904

-TSPEARchr21

45987889

-
ChimerDB4READTCGA-DC-4745APPchr21

27326904

-TSPEARchr21

45987889

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127326904-ENST00000323084TSPEARchr2145987889-554017213436481204
ENST00000354192APPchr2127326904-ENST00000323084TSPEARchr2145987889-5240142112733481073
ENST00000348990APPchr2127326904-ENST00000323084TSPEARchr2145987889-5428160914735361129
ENST00000357903APPchr2127326904-ENST00000323084TSPEARchr2145987889-5616179716737241185
ENST00000358918APPchr2127326904-ENST00000323084TSPEARchr2145987889-5706188720038141204
ENST00000359726APPchr2127326904-ENST00000323084TSPEARchr2145987889-5538171920036461148
ENST00000448388APPchr2127326904-ENST00000323084TSPEARchr2145987889-5368154916834761102
ENST00000440126APPchr2127326904-ENST00000323084TSPEARchr2145987889-5700188123938081189
ENST00000439274APPchr2127326904-ENST00000323084TSPEARchr2145987889-537215533434801148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0014423640.9985576
ENST00000354192ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0016081210.9983918
ENST00000348990ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.001860090.99813986
ENST00000357903ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0011130340.998887
ENST00000358918ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0018435360.9981565
ENST00000359726ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0026194080.99738055
ENST00000448388ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0019266530.99807334
ENST00000440126ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0009062850.9990938
ENST00000439274ENST00000323084APPchr2127326904-TSPEARchr2145987889-0.0012805250.99871945

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5711_5711_1_APP-TSPEAR_APP_chr21_27326904_ENST00000346798_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1204AA_BP=562
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER
QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRV
PNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADV
PFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQP
PCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQ
NIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVI
YKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANS
HSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTV

--------------------------------------------------------------

>5711_5711_2_APP-TSPEAR_APP_chr21_27326904_ENST00000348990_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1129AA_BP=487
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ
IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQC
DLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFS
LTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLK
YPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKAT
SAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAV
ANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWE
VFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRW

--------------------------------------------------------------

>5711_5711_3_APP-TSPEAR_APP_chr21_27326904_ENST00000354192_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1073AA_BP=431
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATS
GIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLRED
TAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDAT
PRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVE
EHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKW
SHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTF
NGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSA

--------------------------------------------------------------

>5711_5711_4_APP-TSPEAR_APP_chr21_27326904_ENST00000357903_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1185AA_BP=543
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL
ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR
RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
DEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEES
DLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRR
RAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGL
YLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKI
FLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATS
GAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSV
IYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYS

--------------------------------------------------------------

>5711_5711_5_APP-TSPEAR_APP_chr21_27326904_ENST00000358918_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1204AA_BP=562
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER
QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRV
PNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADV
PFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQP
PCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQ
NIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVI
YKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANS
HSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTV

--------------------------------------------------------------

>5711_5711_6_APP-TSPEAR_APP_chr21_27326904_ENST00000359726_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1148AA_BP=506
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQL
SVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPA
LVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLS
IPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIE
VFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIAT
HSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRL
LGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLV

--------------------------------------------------------------

>5711_5711_7_APP-TSPEAR_APP_chr21_27326904_ENST00000439274_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1148AA_BP=506
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQL
SVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPA
LVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLS
IPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIE
VFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIAT
HSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRL
LGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLV

--------------------------------------------------------------

>5711_5711_8_APP-TSPEAR_APP_chr21_27326904_ENST00000440126_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1189AA_BP=547
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEAT
ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAV
DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAML
NDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA
EEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVV
AEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFV
GSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDAS
RKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTI
GKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQT
IATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYV
INSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAY

--------------------------------------------------------------

>5711_5711_9_APP-TSPEAR_APP_chr21_27326904_ENST00000448388_TSPEAR_chr21_45987889_ENST00000323084_length(amino acids)=1102AA_BP=460
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP
DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVE
AMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP
AVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLL
TVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGAR
FFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWF
DASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRH
FTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEA
NQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQND
SYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27326904/chr21:45987889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APP

Q8NEU8

TSPEAR

P59090

FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318230_260562.3333333333334771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318274_280562.3333333333334771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116230_260487.3333333333333696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116274_280487.3333333333333696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015230_260431.3333333333333640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015274_280431.3333333333333640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217230_260543.3333333333334752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217274_280543.3333333333334752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317230_260562.3333333333334753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317274_280562.3333333333334753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217230_260506.3333333333333715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217274_280506.3333333333333715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217230_260538.3333333333334747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217274_280538.3333333333334747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-131828_189562.3333333333334771.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318374_565562.3333333333334771.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-111628_189487.3333333333333696.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-101528_189431.3333333333333640.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-121728_189543.3333333333334752.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-131728_189562.3333333333334753.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317374_565562.3333333333334753.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-121728_189506.3333333333333715.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-121728_189538.3333333333334747.0DomainE1
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318344_365562.3333333333334771.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116344_365487.3333333333333696.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015344_365431.3333333333333640.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217344_365543.3333333333334752.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317344_365562.3333333333334753.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217344_365506.3333333333333715.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217344_365538.3333333333334747.0MotifOX-2
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318131_189562.3333333333334771.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318181_188562.3333333333334771.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-131828_123562.3333333333334771.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318391_423562.3333333333334771.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318491_522562.3333333333334771.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318523_540562.3333333333334771.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-131896_110562.3333333333334771.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116131_189487.3333333333333696.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116181_188487.3333333333333696.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-111628_123487.3333333333333696.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116391_423487.3333333333333696.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-111696_110487.3333333333333696.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015131_189431.3333333333333640.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015181_188431.3333333333333640.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-101528_123431.3333333333333640.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015391_423431.3333333333333640.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-101596_110431.3333333333333640.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217131_189543.3333333333334752.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217181_188543.3333333333334752.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-121728_123543.3333333333334752.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217391_423543.3333333333334752.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217491_522543.3333333333334752.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217523_540543.3333333333334752.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-121796_110543.3333333333334752.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317131_189562.3333333333334753.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317181_188562.3333333333334753.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-131728_123562.3333333333334753.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317391_423562.3333333333334753.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317491_522562.3333333333334753.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317523_540562.3333333333334753.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-131796_110562.3333333333334753.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217131_189506.3333333333333715.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217181_188506.3333333333333715.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-121728_123506.3333333333333715.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217391_423506.3333333333333715.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-121796_110506.3333333333333715.0RegionHeparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217131_189538.3333333333334747.0RegionCuBD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217181_188538.3333333333334747.0RegionNote=Zinc-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-121728_123538.3333333333334747.0RegionGFLD subdomain
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217391_423538.3333333333334747.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217491_522538.3333333333334747.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217523_540538.3333333333334747.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-121796_110538.3333333333334747.0RegionHeparin-binding
TgeneTSPEARchr21:27326904chr21:45987889ENST0000032308401258_27727.333333333333332670.0DomainNote=Laminin G-like
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012313_35827.333333333333332670.0RepeatEAR 1
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012360_40827.333333333333332670.0RepeatEAR 2
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012412_46027.333333333333332670.0RepeatEAR 3
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012464_50627.333333333333332670.0RepeatEAR 4
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012514_57027.333333333333332670.0RepeatEAR 5
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012574_62227.333333333333332670.0RepeatEAR 6
TgeneTSPEARchr21:27326904chr21:45987889ENST00000323084012625_66827.333333333333332670.0RepeatEAR 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116374_565487.3333333333333696.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015374_565431.3333333333333640.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217374_565543.3333333333334752.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217374_565506.3333333333333715.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217374_565538.3333333333334747.0DomainE2
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318724_734562.3333333333334771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116724_734487.3333333333333696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015724_734431.3333333333333640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217724_734543.3333333333334752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317724_734562.3333333333334753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217724_734506.3333333333333715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217724_734538.3333333333334747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116491_522487.3333333333333696.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116523_540487.3333333333333696.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015491_522431.3333333333333640.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015523_540431.3333333333333640.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217491_522506.3333333333333715.0RegionNote=Heparin-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217523_540506.3333333333333715.0RegionCollagen-binding
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-131818_701562.3333333333334771.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318723_770562.3333333333334771.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-111618_701487.3333333333333696.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116723_770487.3333333333333696.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-101518_701431.3333333333333640.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015723_770431.3333333333333640.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-121718_701543.3333333333334752.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217723_770543.3333333333334752.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-131718_701562.3333333333334753.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317723_770562.3333333333334753.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-121718_701506.3333333333333715.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217723_770506.3333333333333715.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-121718_701538.3333333333334747.0Topological domainExtracellular
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217723_770538.3333333333334747.0Topological domainCytoplasmic
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318702_722562.3333333333334771.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116702_722487.3333333333333696.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015702_722431.3333333333333640.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217702_722543.3333333333334752.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317702_722562.3333333333334753.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217702_722506.3333333333333715.0TransmembraneHelical
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217702_722538.3333333333334747.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
APP_pLDDT.png
all structure
all structure
TSPEAR_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
APP
TSPEAR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318732_751562.3333333333334771.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116732_751487.3333333333333696.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015732_751431.3333333333333640.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217732_751543.3333333333334752.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317732_751562.3333333333334753.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217732_751506.3333333333333715.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217732_751538.3333333333334747.0G(o)-alpha
HgeneAPPchr21:27326904chr21:45987889ENST00000346798-1318695_722562.3333333333334771.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000348990-1116695_722487.3333333333333696.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000354192-1015695_722431.3333333333333640.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000357903-1217695_722543.3333333333334752.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000358918-1317695_722562.3333333333334753.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000359726-1217695_722506.3333333333333715.0PSEN1
HgeneAPPchr21:27326904chr21:45987889ENST00000440126-1217695_722538.3333333333334747.0PSEN1


Top

Related Drugs to APP-TSPEAR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to APP-TSPEAR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource