UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NADSYN1-TRIM9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NADSYN1-TRIM9
	FusionPDB ID: 57136
	FusionGDB2.0 ID: 57136
		Hgene	Tgene
	Gene symbol	NADSYN1	TRIM9
	Gene ID	55191	114088
	Gene name	NAD synthetase 1	tripartite motif containing 9
	Synonyms	-	RNF91\|SPRING
	Cytomap	11q13.4	14q22.1
	Type of gene	protein-coding	protein-coding
	Description	glutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetase	E3 ubiquitin-protein ligase TRIM9RING finger protein 91RING-type E3 ubiquitin transferase TRIM9SNAP-25-interacting RING finger proteinhomolog of rat RING finger Springtripartite motif-containing protein 9
	Modification date	20200313	20200313
	UniProtAcc	Q6IA69	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000319023, ENST00000539574, ENST00000526039, ENST00000530055,	ENST00000557456, ENST00000298355, ENST00000338969, ENST00000360392,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 7=1274	5 X 4 X 5=100
	# samples	17	5
	** MAII score	log2(17/1274*10)=-2.9057586261186 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NADSYN1 [Title/Abstract] AND TRIM9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NADSYN1(71189515)-TRIM9(51492078), # samples:4
Anticipated loss of major functional domain due to fusion event.	NADSYN1-TRIM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-TRIM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-TRIM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-TRIM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRIM9	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20085810

Fusion gene breakpoints across NADSYN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0D4-01A	NADSYN1	chr11	71189515	-	TRIM9	chr14	51492078	-
ChimerDB4	BRCA	TCGA-A2-A0D4-01A	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-
ChimerDB4	BRCA	TCGA-A2-A0D4	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000319023	NADSYN1	chr11	71189515	+	ENST00000298355	TRIM9	chr14	51492078	-	4401	1061	188	2371	727
ENST00000319023	NADSYN1	chr11	71189515	+	ENST00000338969	TRIM9	chr14	51492078	-	3161	1061	188	2647	819
ENST00000319023	NADSYN1	chr11	71189515	+	ENST00000360392	TRIM9	chr14	51492078	-	3828	1061	188	1891	567
ENST00000539574	NADSYN1	chr11	71189515	+	ENST00000298355	TRIM9	chr14	51492078	-	4215	875	782	2185	467
ENST00000539574	NADSYN1	chr11	71189515	+	ENST00000338969	TRIM9	chr14	51492078	-	2975	875	782	2461	559
ENST00000539574	NADSYN1	chr11	71189515	+	ENST00000360392	TRIM9	chr14	51492078	-	3642	875	782	1705	307

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319023	ENST00000298355	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.000800101	0.9991999
ENST00000319023	ENST00000338969	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.002485172	0.99751484
ENST00000319023	ENST00000360392	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.001203323	0.9987967
ENST00000539574	ENST00000298355	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.000645236	0.9993548
ENST00000539574	ENST00000338969	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.003359012	0.99664104
ENST00000539574	ENST00000360392	NADSYN1	chr11	71189515	+	TRIM9	chr14	51492078	-	0.001133679	0.9988663

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57136_57136_1_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000319023_TRIM9_chr14_51492078_ENST00000298355_length(amino acids)=727AA_BP=289
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHE
HKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQ
VKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSP
YSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDD
KAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFY

--------------------------------------------------------------

>57136_57136_2_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000319023_TRIM9_chr14_51492078_ENST00000338969_length(amino acids)=819AA_BP=289
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHE
HKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQ
VKVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKT
LVLQTSEDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSAPYSQLVDIKKL
LAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDN
NRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVSTLPLRLNSCCWLPVQRLPRA

--------------------------------------------------------------

>57136_57136_3_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000319023_TRIM9_chr14_51492078_ENST00000360392_length(amino acids)=567AA_BP=289
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHE
HKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQ
VKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSP

--------------------------------------------------------------

>57136_57136_4_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000539574_TRIM9_chr14_51492078_ENST00000298355_length(amino acids)=467AA_BP=29
MGISGQEVLTATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQ
LLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLL
QSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARV
KAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDV
MKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTL

--------------------------------------------------------------

>57136_57136_5_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000539574_TRIM9_chr14_51492078_ENST00000338969_length(amino acids)=559AA_BP=29
MGISGQEVLTATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQ
LLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLL
QSIHQLDFVQVKVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFN
KTGVSPYSKTLVLQTSEDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSAP
YSQLVDIKKLLAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKD
DKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVSTLPLRLNSCC

--------------------------------------------------------------

>57136_57136_6_NADSYN1-TRIM9_NADSYN1_chr11_71189515_ENST00000539574_TRIM9_chr14_51492078_ENST00000360392_length(amino acids)=307AA_BP=29
MGISGQEVLTATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQ
LLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLL
QSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71189515/chr14:51492078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NADSYN1 Q6IA69	.
FUNCTION: Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source. {ECO:0000269\|PubMed:12547821, ECO:0000269\|PubMed:31883644}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NADSYN1

chr11:71189515

chr14:51492078

ENST00000319023

5_275

291.0

707.0

Domain

CN hydrolase

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

273_340

274.0

711.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

273_340

274.0

803.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

273_340

274.0

551.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

374_432

274.0

711.0

Domain

COS

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

440_535

274.0

711.0

Domain

Fibronectin type-III

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

533_702

274.0

711.0

Domain

B30.2/SPRY

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

374_432

274.0

803.0

Domain

COS

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

440_535

274.0

803.0

Domain

Fibronectin type-III

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

533_702

274.0

803.0

Domain

B30.2/SPRY

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

374_432

274.0

551.0

Domain

COS

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

440_535

274.0

551.0

Domain

Fibronectin type-III

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

533_702

274.0

551.0

Domain

B30.2/SPRY

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NADSYN1

chr11:71189515

chr14:51492078

ENST00000319023

355_362

291.0

707.0

Nucleotide binding

ATP

Hgene

NADSYN1

chr11:71189515

chr14:51492078

ENST00000319023

325_706

291.0

707.0

Region

Ligase

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

10_50

274.0

711.0

Zinc finger

RING-type

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

163_212

274.0

711.0

Zinc finger

B box-type 1

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000298355

224_266

274.0

711.0

Zinc finger

B box-type 2

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

10_50

274.0

803.0

Zinc finger

RING-type

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

163_212

274.0

803.0

Zinc finger

B box-type 1

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000338969

224_266

274.0

803.0

Zinc finger

B box-type 2

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

10_50

274.0

551.0

Zinc finger

RING-type

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

163_212

274.0

551.0

Zinc finger

B box-type 1

Tgene

TRIM9

chr11:71189515

chr14:51492078

ENST00000360392

224_266

274.0

551.0

Zinc finger

B box-type 2

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1598_NADSYN1_71189515_TRIM9_51492078_ranked_0.pdb	NADSYN1	71189515	71189515	ENST00000360392	TRIM9	chr14	51492078	-	MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT ATLDLEDVRSYRAEISSRNLASQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHE HKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQ VKVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKT LVLQTSEDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSAPYSQLVDIKKL LAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDN NRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVSTLPLRLNSCCWLPVQRLPRA	819

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NADSYN1_pLDDT.png

TRIM9_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NADSYN1
TRIM9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NADSYN1-TRIM9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NADSYN1-TRIM9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source