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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NAP1L4-CFTR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NAP1L4-CFTR
FusionPDB ID: 57200
FusionGDB2.0 ID: 57200
HgeneTgene
Gene symbol

NAP1L4

CFTR

Gene ID

4676

1080

Gene namenucleosome assembly protein 1 like 4CF transmembrane conductance regulator
SynonymsNAP1L4b|NAP2|NAP2L|hNAP2ABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1
Cytomap

11p15.4

7q31.2

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2cystic fibrosis transmembrane conductance regulatorcAMP-dependent chloride channelchannel conductance-controlling ATPasecystic fibrosis transmembrane conductance regulatingcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-f
Modification date2020032220200329
UniProtAcc

Q99733

P13569

Ensembl transtripts involved in fusion geneENST idsENST00000380542, ENST00000526115, 
ENST00000469089, 		ENST00000608965, 
ENST00000003084, ENST00000454343, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 18 X 7=163813 X 15 X 10=1950
# samples 1813
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1950*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NAP1L4 [Title/Abstract] AND CFTR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NAP1L4(2972489)-CFTR(117227793), # samples:2
Anticipated loss of major functional domain due to fusion event.NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NAP1L4-CFTR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAP1L4

GO:0006334

nucleosome assembly

9325046

TgeneCFTR

GO:0015701

bicarbonate transport

15010471|19019741

TgeneCFTR

GO:0034976

response to endoplasmic reticulum stress

21884936|28067262

TgeneCFTR

GO:1902476

chloride transmembrane transport

11524016|11707463|19019741

TgeneCFTR

GO:1902943

positive regulation of voltage-gated chloride channel activity

22006324

TgeneCFTR

GO:1904322

cellular response to forskolin

15010471|19621064


check buttonFusion gene breakpoints across NAP1L4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CFTR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1417-01ANAP1L4chr11

2972489

-CFTRchr7

117227793

+
ChimerDB4OVTCGA-24-1417NAP1L4chr11

2972488

-CFTRchr7

117227792

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000526115NAP1L4chr112972489-ENST00000003084CFTRchr7117227793+5818140628442641326
ENST00000526115NAP1L4chr112972489-ENST00000454343CFTRchr7117227793+5822140628442641326
ENST00000526115NAP1L4chr112972488-ENST00000003084CFTRchr7117227792+5818140628442641326
ENST00000526115NAP1L4chr112972488-ENST00000454343CFTRchr7117227792+5822140628442641326

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000526115ENST00000003084NAP1L4chr112972489-CFTRchr7117227793+0.0002271570.99977285
ENST00000526115ENST00000454343NAP1L4chr112972489-CFTRchr7117227793+0.0002258560.99977416
ENST00000526115ENST00000003084NAP1L4chr112972488-CFTRchr7117227792+0.0002271570.99977285
ENST00000526115ENST00000454343NAP1L4chr112972488-CFTRchr7117227792+0.0002258560.99977416

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57200_57200_1_NAP1L4-CFTR_NAP1L4_chr11_2972488_ENST00000526115_CFTR_chr7_117227792_ENST00000003084_length(amino acids)=1326AA_BP=374
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQK
HKGRGTVRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGD
EEGEDEDDAEINPKDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFG
EKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIH
RKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEV
AASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTL
NTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTH
LVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQ
WAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSI
SPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGL
RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL

--------------------------------------------------------------

>57200_57200_2_NAP1L4-CFTR_NAP1L4_chr11_2972488_ENST00000526115_CFTR_chr7_117227792_ENST00000454343_length(amino acids)=1326AA_BP=374
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQK
HKGRGTVRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGD
EEGEDEDDAEINPKDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFG
EKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIH
RKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEV
AASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTL
NTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTH
LVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQ
WAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSI
SPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGL
RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL

--------------------------------------------------------------

>57200_57200_3_NAP1L4-CFTR_NAP1L4_chr11_2972489_ENST00000526115_CFTR_chr7_117227793_ENST00000003084_length(amino acids)=1326AA_BP=374
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQK
HKGRGTVRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGD
EEGEDEDDAEINPKDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFG
EKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIH
RKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEV
AASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTL
NTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTH
LVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQ
WAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSI
SPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGL
RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL

--------------------------------------------------------------

>57200_57200_4_NAP1L4-CFTR_NAP1L4_chr11_2972489_ENST00000526115_CFTR_chr7_117227793_ENST00000454343_length(amino acids)=1326AA_BP=374
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQK
HKGRGTVRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGD
EEGEDEDDAEINPKDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFG
EKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIH
RKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEV
AASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTL
NTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTH
LVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQ
WAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSI
SPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGL
RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:2972489/chr7:117227793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L4

Q99733

CFTR

P13569

FUNCTION: Acts as histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAP1L4chr11:2972488chr7:117227792ENST00000380542-1416126_131374.0740.3333333333334Compositional biasNote=Poly-Glu
HgeneNAP1L4chr11:2972488chr7:117227792ENST00000380542-1416301_310374.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2972488chr7:117227792ENST00000380542-1416347_370374.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2972489chr7:117227793ENST00000380542-1416126_131374.0740.3333333333334Compositional biasNote=Poly-Glu
HgeneNAP1L4chr11:2972489chr7:117227793ENST00000380542-1416301_310374.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2972489chr7:117227793ENST00000380542-1416347_370374.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2972488chr7:117227792ENST00000380542-1416265_271374.0740.3333333333334MotifNuclear localization signal
HgeneNAP1L4chr11:2972489chr7:117227793ENST00000380542-1416265_271374.0740.3333333333334MotifNuclear localization signal
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271210_1443528.01481.0DomainABC transporter 2
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027859_1155528.01481.0DomainABC transmembrane type-1 2
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261210_1443467.01420.0DomainABC transporter 2
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926859_1155467.01420.0DomainABC transmembrane type-1 2
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271210_1443528.01481.0DomainABC transporter 2
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027859_1155528.01481.0DomainABC transmembrane type-1 2
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261210_1443467.01420.0DomainABC transporter 2
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926859_1155467.01420.0DomainABC transmembrane type-1 2
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271244_1251528.01481.0Nucleotide bindingATP 2
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261244_1251467.01420.0Nucleotide bindingATP 2
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271244_1251528.01481.0Nucleotide bindingATP 2
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261244_1251467.01420.0Nucleotide bindingATP 2
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027654_831528.01481.0RegionIntrinsically disordered R region
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926654_831467.01420.0RegionIntrinsically disordered R region
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027654_831528.01481.0RegionIntrinsically disordered R region
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926654_831467.01420.0RegionIntrinsically disordered R region
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271012_1013528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271035_1095528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271117_1130528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271152_1480528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027880_918528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027940_990528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261012_1013467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261035_1095467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261117_1130467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261152_1480467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926880_918467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926940_990467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271012_1013528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271035_1095528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271117_1130528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271152_1480528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027880_918528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027940_990528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261012_1013467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261035_1095467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261117_1130467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261152_1480467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926880_918467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926940_990467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271014_1034528.01481.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271096_1116528.01481.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271131_1151528.01481.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027859_879528.01481.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027919_939528.01481.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027991_1011528.01481.0TransmembraneHelical%3B Name%3D9
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261014_1034467.01420.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261096_1116467.01420.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261131_1151467.01420.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926859_879467.01420.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926919_939467.01420.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926991_1011467.01420.0TransmembraneHelical%3B Name%3D9
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271014_1034528.01481.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271096_1116528.01481.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271131_1151528.01481.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027859_879528.01481.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027919_939528.01481.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027991_1011528.01481.0TransmembraneHelical%3B Name%3D9
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261014_1034467.01420.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261096_1116467.01420.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261131_1151467.01420.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926859_879467.01420.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926919_939467.01420.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926991_1011467.01420.0TransmembraneHelical%3B Name%3D9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027423_646528.01481.0DomainABC transporter 1
TgeneCFTRchr11:2972488chr7:117227792ENST00000003084102781_365528.01481.0DomainABC transmembrane type-1 1
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926423_646467.01420.0DomainABC transporter 1
TgeneCFTRchr11:2972488chr7:117227792ENST0000045434392681_365467.01420.0DomainABC transmembrane type-1 1
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027423_646528.01481.0DomainABC transporter 1
TgeneCFTRchr11:2972489chr7:117227793ENST00000003084102781_365528.01481.0DomainABC transmembrane type-1 1
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926423_646467.01420.0DomainABC transporter 1
TgeneCFTRchr11:2972489chr7:117227793ENST0000045434392681_365467.01420.0DomainABC transmembrane type-1 1
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027458_465528.01481.0Nucleotide bindingATP 1
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926458_465467.01420.0Nucleotide bindingATP 1
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027458_465528.01481.0Nucleotide bindingATP 1
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926458_465467.01420.0Nucleotide bindingATP 1
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027147_195528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST0000000308410271_77528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027217_222528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027244_298528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027320_339528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027359_858528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST00000003084102799_122528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926147_195467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST000004543439261_77467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926217_222467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926244_298467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926320_339467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926359_858467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972488chr7:117227792ENST0000045434392699_122467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027147_195528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST0000000308410271_77528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027217_222528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027244_298528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027320_339528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027359_858528.01481.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST00000003084102799_122528.01481.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926147_195467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST000004543439261_77467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926217_222467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926244_298467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926320_339467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926359_858467.01420.0Topological domainCytoplasmic
TgeneCFTRchr11:2972489chr7:117227793ENST0000045434392699_122467.01420.0Topological domainExtracellular
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027123_146528.01481.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027196_216528.01481.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027223_243528.01481.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027299_319528.01481.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr11:2972488chr7:117227792ENST000000030841027340_358528.01481.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr11:2972488chr7:117227792ENST00000003084102778_98528.01481.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926123_146467.01420.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926196_216467.01420.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926223_243467.01420.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926299_319467.01420.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr11:2972488chr7:117227792ENST00000454343926340_358467.01420.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr11:2972488chr7:117227792ENST0000045434392678_98467.01420.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027123_146528.01481.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027196_216528.01481.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027223_243528.01481.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027299_319528.01481.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr11:2972489chr7:117227793ENST000000030841027340_358528.01481.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr11:2972489chr7:117227793ENST00000003084102778_98528.01481.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926123_146467.01420.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926196_216467.01420.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926223_243467.01420.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926299_319467.01420.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr11:2972489chr7:117227793ENST00000454343926340_358467.01420.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr11:2972489chr7:117227793ENST0000045434392678_98467.01420.0TransmembraneHelical%3B Name%3D1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NAP1L4
CFTR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NAP1L4-CFTR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NAP1L4-CFTR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource