UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:APTX-NOL6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: APTX-NOL6
FusionPDB ID: 5722
FusionGDB2.0 ID: 5722
HgeneTgene
Gene symbol

APTX

NOL6

Gene ID

54840

65083

Gene nameaprataxinnucleolar protein 6
SynonymsAOA|AOA1|AXA1|EAOH|EOAHA|FHA-HITNRAP|UTP22|bA311H10.1
Cytomap

9p21.1

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionaprataxinforkhead-associated domain histidine triad-like proteinnucleolar protein 6nucleolar RNA-associated proteinnucleolar protein 6 (RNA-associated)nucleolar protein family 6 (RNA-associated)
Modification date2020032020200313
UniProtAcc

Q7Z2E3

Q9H6R4

Ensembl transtripts involved in fusion geneENST idsENST00000309615, ENST00000379819, 
ENST00000379825, ENST00000397172, 
ENST00000476858, ENST00000379813, 
ENST00000379817, ENST00000436040, 
ENST00000463596, ENST00000468275, 
ENST00000473270, 		ENST00000455041, 
ENST00000464829, ENST00000379471, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 6=5406 X 5 X 4=120
# samples 127
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: APTX [Title/Abstract] AND NOL6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)APTX(33001565)-NOL6(33472410), # samples:3
Anticipated loss of major functional domain due to fusion event.APTX-NOL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APTX-NOL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPTX

GO:0000012

single strand break repair

17519253

HgeneAPTX

GO:0042542

response to hydrogen peroxide

15044383


check buttonFusion gene breakpoints across APTX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7376-01AAPTXchr9

33001565

-NOL6chr9

33472410

-
ChimerDB4HNSCTCGA-CR-7376APTXchr9

33001564

-NOL6chr9

33472410

-
ChimerDB4HNSCTCGA-CR-7376APTXchr9

33001565

-NOL6chr9

33472410

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379825APTXchr933001565-ENST00000379471NOL6chr933472410-376262563031991
ENST00000309615APTXchr933001565-ENST00000379471NOL6chr933472410-376262563031991
ENST00000397172APTXchr933001565-ENST00000379471NOL6chr933472410-374141353010991
ENST00000379819APTXchr933001565-ENST00000379471NOL6chr933472410-373838323007991
ENST00000476858APTXchr933001565-ENST00000379471NOL6chr933472410-377575693044991
ENST00000379825APTXchr933001564-ENST00000379471NOL6chr933472410-376262563031991
ENST00000309615APTXchr933001564-ENST00000379471NOL6chr933472410-376262563031991
ENST00000397172APTXchr933001564-ENST00000379471NOL6chr933472410-374141353010991
ENST00000379819APTXchr933001564-ENST00000379471NOL6chr933472410-373838323007991
ENST00000476858APTXchr933001564-ENST00000379471NOL6chr933472410-377575693044991

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379825ENST00000379471APTXchr933001565-NOL6chr933472410-0.0011524960.9988475
ENST00000309615ENST00000379471APTXchr933001565-NOL6chr933472410-0.0011524960.9988475
ENST00000397172ENST00000379471APTXchr933001565-NOL6chr933472410-0.001162820.9988372
ENST00000379819ENST00000379471APTXchr933001565-NOL6chr933472410-0.0011591650.99884087
ENST00000476858ENST00000379471APTXchr933001565-NOL6chr933472410-0.0011744040.9988256
ENST00000379825ENST00000379471APTXchr933001564-NOL6chr933472410-0.0011524960.9988475
ENST00000309615ENST00000379471APTXchr933001564-NOL6chr933472410-0.0011524960.9988475
ENST00000397172ENST00000379471APTXchr933001564-NOL6chr933472410-0.001162820.9988372
ENST00000379819ENST00000379471APTXchr933001564-NOL6chr933472410-0.0011591650.99884087
ENST00000476858ENST00000379471APTXchr933001564-NOL6chr933472410-0.0011744040.9988256

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5722_5722_1_APTX-NOL6_APTX_chr9_33001564_ENST00000309615_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_2_APTX-NOL6_APTX_chr9_33001564_ENST00000379819_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_3_APTX-NOL6_APTX_chr9_33001564_ENST00000379825_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_4_APTX-NOL6_APTX_chr9_33001564_ENST00000397172_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_5_APTX-NOL6_APTX_chr9_33001564_ENST00000476858_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_6_APTX-NOL6_APTX_chr9_33001565_ENST00000309615_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_7_APTX-NOL6_APTX_chr9_33001565_ENST00000379819_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_8_APTX-NOL6_APTX_chr9_33001565_ENST00000379825_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_9_APTX-NOL6_APTX_chr9_33001565_ENST00000397172_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

>5722_5722_10_APTX-NOL6_APTX_chr9_33001565_ENST00000476858_NOL6_chr9_33472410_ENST00000379471_length(amino acids)=991AA_BP=2
MEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRID
AFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLN
QRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAG
DGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLR
SVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPM
IRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLL
RPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQ
GLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMT
VVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLR
LERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNP
LFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRWDPAKMWP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33001565/chr9:33472410)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APTX

Q7Z2E3

NOL6

Q9H6R4

FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNOL6chr9:33001564chr9:33472410ENST0000037947102483_11418.01008.0Coiled coilOntology_term=ECO:0000255
TgeneNOL6chr9:33001565chr9:33472410ENST0000037947102483_11418.01008.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18182_28712.666666666666666307.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-1838_8712.666666666666666307.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17182_2870343.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-1738_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18182_28712.666666666666666357.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-1838_8712.666666666666666357.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18182_28712.666666666666666307.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-1838_8712.666666666666666307.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18182_28712.666666666666666285.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-1838_8712.666666666666666285.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16182_2870445.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-1638_870445.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17182_28712.666666666666666303.0DomainHIT
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-1738_8712.666666666666666303.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18182_28712.666666666666666307.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-1838_8712.666666666666666307.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17182_2870343.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-1738_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18182_28712.666666666666666357.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-1838_8712.666666666666666357.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18182_28712.666666666666666307.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-1838_8712.666666666666666307.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18182_28712.666666666666666285.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-1838_8712.666666666666666285.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16182_2870445.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-1638_870445.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18182_2870343.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17182_28712.666666666666666303.0DomainHIT
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-1738_8712.666666666666666303.0DomainNote=FHA-like
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18126_13112.666666666666666307.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18272_27612.666666666666666307.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18126_13112.666666666666666357.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18272_27612.666666666666666357.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18126_13112.666666666666666307.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18272_27612.666666666666666307.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18126_13112.666666666666666285.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18272_27612.666666666666666285.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16126_1310445.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16272_2760445.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17126_13112.666666666666666303.0MotifNuclear localization signal
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17272_27612.666666666666666303.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18126_13112.666666666666666307.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18272_27612.666666666666666307.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18126_13112.666666666666666357.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18272_27612.666666666666666357.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18126_13112.666666666666666307.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18272_27612.666666666666666307.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18126_13112.666666666666666285.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18272_27612.666666666666666285.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16126_1310445.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16272_2760445.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17126_13112.666666666666666303.0MotifNuclear localization signal
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17272_27612.666666666666666303.0MotifHistidine triad motif
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18331_35312.666666666666666307.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18331_35312.666666666666666357.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18331_35312.666666666666666307.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18331_35312.666666666666666285.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16331_3530445.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17331_35312.666666666666666303.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18331_35312.666666666666666307.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18331_35312.666666666666666357.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18331_35312.666666666666666307.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18331_35312.666666666666666285.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16331_3530445.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17331_35312.666666666666666303.0Zinc fingerC2H2-type


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
APTX_pLDDT.png
all structure
all structure
NOL6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
APTX
NOL6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18207_21112.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000309615-18269_27012.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379813-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17207_2110343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379817-17269_2700343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18207_21112.666666666666666357.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379819-18269_27012.666666666666666357.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18207_21112.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000379825-18269_27012.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18207_21112.666666666666666285.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000397172-18269_27012.666666666666666285.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16207_2110445.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000436040-16269_2700445.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000463596-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000468275-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17207_21112.666666666666666303.0DNA substrate
HgeneAPTXchr9:33001564chr9:33472410ENST00000476858-17269_27012.666666666666666303.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18207_21112.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000309615-18269_27012.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379813-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17207_2110343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379817-17269_2700343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18207_21112.666666666666666357.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379819-18269_27012.666666666666666357.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18207_21112.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000379825-18269_27012.666666666666666307.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18207_21112.666666666666666285.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000397172-18269_27012.666666666666666285.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16207_2110445.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000436040-16269_2700445.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000463596-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18207_2110343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000468275-18269_2700343.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17207_21112.666666666666666303.0DNA substrate
HgeneAPTXchr9:33001565chr9:33472410ENST00000476858-17269_27012.666666666666666303.0DNA substrate


Top

Related Drugs to APTX-NOL6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to APTX-NOL6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource