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Fusion Protein:NCKIPSD-RIMKLB |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NCKIPSD-RIMKLB | FusionPDB ID: 57650 | FusionGDB2.0 ID: 57650 | Hgene | Tgene | Gene symbol | NCKIPSD | RIMKLB | Gene ID | 51517 | 57494 |
| Gene name | NCK interacting protein with SH3 domain | ribosomal modification protein rimK like family member B | |
| Synonyms | AF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISH | FAM80B|NAAGS|NAAGS-I | |
| Cytomap | 3p21.31 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NCK-interacting protein with SH3 domain54 kDa VacA-interacting protein54 kDa vimentin-interacting protein90 kDa SH3 protein interacting with NckSH3 adapter protein SPIN90SH3 protein interacting with Nck, 90 kDaWASP-interacting SH3-domain proteindia | beta-citrylglutamate synthase BN-acetyl-aspartyl-glutamate synthetase BN-acetyl-aspartylglutamate synthetase BN-acetylaspartyl-glutamate synthetase BNAAG synthetase Bbeta-citryl-glutamate synthase Bfamily with sequence similarity 80, member Briboso | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NZQ3 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000294129, ENST00000341520, ENST00000416649, | ENST00000299673, ENST00000538135, ENST00000357529, ENST00000535829, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 4 X 4 X 4=64 | 7 X 7 X 5=245 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/245*10)=-1.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NCKIPSD [Title/Abstract] AND RIMKLB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NCKIPSD(48719477)-RIMKLB(8904552), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | NCKIPSD-RIMKLB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCKIPSD-RIMKLB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCKIPSD-RIMKLB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NCKIPSD-RIMKLB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across NCKIPSD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RIMKLB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 135N | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000341520 | NCKIPSD | chr3 | 48719477 | - | ENST00000535829 | RIMKLB | chr12 | 8904552 | + | 2068 | 692 | 82 | 1446 | 454 |
| ENST00000341520 | NCKIPSD | chr3 | 48719477 | - | ENST00000357529 | RIMKLB | chr12 | 8904552 | + | 4854 | 692 | 82 | 1446 | 454 |
| ENST00000416649 | NCKIPSD | chr3 | 48719477 | - | ENST00000535829 | RIMKLB | chr12 | 8904552 | + | 2030 | 654 | 65 | 1408 | 447 |
| ENST00000416649 | NCKIPSD | chr3 | 48719477 | - | ENST00000357529 | RIMKLB | chr12 | 8904552 | + | 4816 | 654 | 65 | 1408 | 447 |
| ENST00000294129 | NCKIPSD | chr3 | 48719477 | - | ENST00000535829 | RIMKLB | chr12 | 8904552 | + | 2094 | 718 | 108 | 1472 | 454 |
| ENST00000294129 | NCKIPSD | chr3 | 48719477 | - | ENST00000357529 | RIMKLB | chr12 | 8904552 | + | 4880 | 718 | 108 | 1472 | 454 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000341520 | ENST00000535829 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.002164732 | 0.99783534 |
| ENST00000341520 | ENST00000357529 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.00024867 | 0.99975127 |
| ENST00000416649 | ENST00000535829 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.001875677 | 0.9981243 |
| ENST00000416649 | ENST00000357529 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.000206236 | 0.9997938 |
| ENST00000294129 | ENST00000535829 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.001964837 | 0.99803513 |
| ENST00000294129 | ENST00000357529 | NCKIPSD | chr3 | 48719477 | - | RIMKLB | chr12 | 8904552 | + | 0.000233766 | 0.9997663 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >57650_57650_1_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=454AA_BP=203 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK -------------------------------------------------------------- >57650_57650_2_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=454AA_BP=203 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK -------------------------------------------------------------- >57650_57650_3_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=454AA_BP=203 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK -------------------------------------------------------------- >57650_57650_4_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=454AA_BP=203 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK -------------------------------------------------------------- >57650_57650_5_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=447AA_BP=196 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPP PPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVV GGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGII -------------------------------------------------------------- >57650_57650_6_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=447AA_BP=196 MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPP PPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVV GGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGII -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48719477/chr12:8904552) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCKIPSD | . |
| FUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 1_58 | 199.33333333333334 | 723.0 | Domain | SH3 |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 1_58 | 199.33333333333334 | 723.0 | Domain | SH3 |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 1_58 | 192.33333333333334 | 716.0 | Domain | SH3 |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 175_192 | 199.33333333333334 | 723.0 | Motif | Nuclear localization signal |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 175_192 | 199.33333333333334 | 723.0 | Motif | Nuclear localization signal |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 175_192 | 192.33333333333334 | 716.0 | Motif | Nuclear localization signal |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000357529 | 3 | 7 | 193_203 | 135.33333333333334 | 387.0 | Nucleotide binding | ATP | |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000535829 | 2 | 6 | 193_203 | 135.33333333333334 | 387.0 | Nucleotide binding | ATP | |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000538135 | 2 | 6 | 193_203 | 135.33333333333334 | 387.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 171_275 | 199.33333333333334 | 723.0 | Compositional bias | Note=Pro-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 197_240 | 199.33333333333334 | 723.0 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 442_487 | 199.33333333333334 | 723.0 | Compositional bias | Note=Leu-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000294129 | - | 4 | 13 | 534_601 | 199.33333333333334 | 723.0 | Compositional bias | Note=Leu-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 171_275 | 199.33333333333334 | 723.0 | Compositional bias | Note=Pro-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 197_240 | 199.33333333333334 | 723.0 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 442_487 | 199.33333333333334 | 723.0 | Compositional bias | Note=Leu-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000341520 | - | 4 | 13 | 534_601 | 199.33333333333334 | 723.0 | Compositional bias | Note=Leu-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 171_275 | 192.33333333333334 | 716.0 | Compositional bias | Note=Pro-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 197_240 | 192.33333333333334 | 716.0 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 442_487 | 192.33333333333334 | 716.0 | Compositional bias | Note=Leu-rich |
| Hgene | NCKIPSD | chr3:48719477 | chr12:8904552 | ENST00000416649 | - | 4 | 13 | 534_601 | 192.33333333333334 | 716.0 | Compositional bias | Note=Leu-rich |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000357529 | 3 | 7 | 119_304 | 135.33333333333334 | 387.0 | Domain | ATP-grasp | |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000535829 | 2 | 6 | 119_304 | 135.33333333333334 | 387.0 | Domain | ATP-grasp | |
| Tgene | RIMKLB | chr3:48719477 | chr12:8904552 | ENST00000538135 | 2 | 6 | 119_304 | 135.33333333333334 | 387.0 | Domain | ATP-grasp |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NCKIPSD |  |
| RIMKLB |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to NCKIPSD-RIMKLB |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to NCKIPSD-RIMKLB |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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