UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:NCOA1-GOLGB1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NCOA1-GOLGB1
FusionPDB ID: 57684
FusionGDB2.0 ID: 57684
HgeneTgene
Gene symbol

NCOA1

GOLGB1

Gene ID

8648

2804

Gene namenuclear receptor coactivator 1golgin B1
SynonymsF-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74GCP|GCP372|GOLIM1
Cytomap

2p23.3

3q13.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1golgin subfamily B member 1372 kDa Golgi complex-associated proteingiantingolgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1golgi integral membrane protein 1golgin B1, golgi integral membrane protein
Modification date2020031320200313
UniProtAcc

Q15788

Q14789

Ensembl transtripts involved in fusion geneENST idsENST00000288599, ENST00000348332, 
ENST00000395856, ENST00000405141, 
ENST00000406961, ENST00000538539, 
ENST00000407230, ENST00000469850, 
ENST00000472829, ENST00000340645, 
ENST00000393667, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 13 X 8=166412 X 11 X 4=528
# samples 1713
** MAII scorelog2(17/1664*10)=-3.29104878200339
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NCOA1 [Title/Abstract] AND GOLGB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NCOA1(24896332)-GOLGB1(121388202), # samples:4
Anticipated loss of major functional domain due to fusion event.NCOA1-GOLGB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA1-GOLGB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA1-GOLGB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA1-GOLGB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

HgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

HgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

HgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check buttonFusion gene breakpoints across NCOA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLGB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5RW-01ANCOA1chr2

24896332

-GOLGB1chr3

121388202

-
ChimerDB4BRCATCGA-OL-A5RW-01ANCOA1chr2

24896332

+GOLGB1chr3

121388202

-
ChimerDB4BRCATCGA-OL-A5RWNCOA1chr2

24896332

+GOLGB1chr3

121388202

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406961NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-290510064901623377
ENST00000406961NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-291610064901638382
ENST00000405141NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-296410655491682377
ENST00000405141NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-297510655491697382
ENST00000538539NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-25416421261259377
ENST00000538539NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-25526421261274382
ENST00000288599NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-2511612961229377
ENST00000288599NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-2522612961244382
ENST00000348332NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-2511612961229377
ENST00000348332NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-2522612961244382
ENST00000395856NCOA1chr224896332+ENST00000340645GOLGB1chr3121388202-2447548321165377
ENST00000395856NCOA1chr224896332+ENST00000393667GOLGB1chr3121388202-2458548321180382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406961ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.0022612370.9977387
ENST00000406961ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0027452350.9972548
ENST00000405141ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.002115720.9978842
ENST00000405141ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0026513160.99734867
ENST00000538539ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.0021176510.9978823
ENST00000538539ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0025784160.9974216
ENST00000288599ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.0023131820.99768686
ENST00000288599ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0027855040.9972145
ENST00000348332ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.0023131820.99768686
ENST00000348332ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0027855040.9972145
ENST00000395856ENST00000340645NCOA1chr224896332+GOLGB1chr3121388202-0.0023474330.9976526
ENST00000395856ENST00000393667NCOA1chr224896332+GOLGB1chr3121388202-0.0027733940.99722654

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57684_57684_1_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000288599_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_2_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000288599_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

>57684_57684_3_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000348332_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_4_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000348332_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

>57684_57684_5_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000395856_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_6_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000395856_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

>57684_57684_7_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000405141_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_8_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000405141_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

>57684_57684_9_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000406961_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_10_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000406961_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

>57684_57684_11_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000538539_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=377AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE
LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAI

--------------------------------------------------------------

>57684_57684_12_NCOA1-GOLGB1_NCOA1_chr2_24896332_ENST00000538539_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=382AA_BP=172
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:24896332/chr3:121388202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA1

Q15788

GOLGB1

Q14789

FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.FUNCTION: May participate in forming intercisternal cross-bridges of the Golgi complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+52223_80118.02199.3333333333335DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+52123_80118.01442.0DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+52123_80118.01441.0DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+82523_80118.02183.6666666666665DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+72323_80118.01442.0DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+62323_80118.01422.6666666666667DomainbHLH
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522112_116118.02199.3333333333335MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+52246_50118.02199.3333333333335MotifNote=LXXLL motif 1
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521112_116118.01442.0MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+52146_50118.01442.0MotifNote=LXXLL motif 1
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521112_116118.01441.0MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+52146_50118.01441.0MotifNote=LXXLL motif 1
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825112_116118.02183.6666666666665MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+82546_50118.02183.6666666666665MotifNote=LXXLL motif 1
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723112_116118.01442.0MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+72346_50118.01442.0MotifNote=LXXLL motif 1
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623112_116118.01422.6666666666667MotifNote=LXXLL motif 2
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+62346_50118.01422.6666666666667MotifNote=LXXLL motif 1
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516223257_32593054.03260.0Topological domainLumenal
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716223257_32593059.03270.0Topological domainLumenal
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516223236_32563054.03260.0TransmembraneHelical
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716223236_32563059.03270.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+5221053_1138118.02199.3333333333335Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522389_682118.02199.3333333333335Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+5211053_1138118.01442.0Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521389_682118.01442.0Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+5211053_1138118.01441.0Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521389_682118.01441.0Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+8251053_1138118.02183.6666666666665Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825389_682118.02183.6666666666665Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+7231053_1138118.01442.0Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723389_682118.01442.0Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+6231053_1138118.01422.6666666666667Compositional biasNote=Gln-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623389_682118.01422.6666666666667Compositional biasNote=Ser-rich
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522109_180118.02199.3333333333335DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521109_180118.01442.0DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521109_180118.01441.0DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825109_180118.02183.6666666666665DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723109_180118.01442.0DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623109_180118.01422.6666666666667DomainPAS
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+5221435_1439118.02199.3333333333335MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522633_637118.02199.3333333333335MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522690_694118.02199.3333333333335MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522749_753118.02199.3333333333335MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522913_917118.02199.3333333333335MotifNote=LXXLL motif 6
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+5211435_1439118.01442.0MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521633_637118.01442.0MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521690_694118.01442.0MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521749_753118.01442.0MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521913_917118.01442.0MotifNote=LXXLL motif 6
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+5211435_1439118.01441.0MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521633_637118.01441.0MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521690_694118.01441.0MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521749_753118.01441.0MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521913_917118.01441.0MotifNote=LXXLL motif 6
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+8251435_1439118.02183.6666666666665MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825633_637118.02183.6666666666665MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825690_694118.02183.6666666666665MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825749_753118.02183.6666666666665MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825913_917118.02183.6666666666665MotifNote=LXXLL motif 6
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+7231435_1439118.01442.0MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723633_637118.01442.0MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723690_694118.01442.0MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723749_753118.01442.0MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723913_917118.01442.0MotifNote=LXXLL motif 6
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+6231435_1439118.01422.6666666666667MotifNote=LXXLL motif 7
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623633_637118.01422.6666666666667MotifNote=LXXLL motif 3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623690_694118.01422.6666666666667MotifNote=LXXLL motif 4
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623749_753118.01422.6666666666667MotifNote=LXXLL motif 5
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623913_917118.01422.6666666666667MotifNote=LXXLL motif 6
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516221062_12453054.03260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516221301_17793054.03260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516221828_31853054.03260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST00000340645162248_5933054.03260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST000003406451622677_10283054.03260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716221062_12453059.03270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716221301_17793059.03270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716221828_31853059.03270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST00000393667162248_5933059.03270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST000003936671622677_10283059.03270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516222420_24233054.03260.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516222993_29963054.03260.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716222420_24233059.03270.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716222993_29963059.03270.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000034064516221_32353054.03260.0Topological domainCytoplasmic
TgeneGOLGB1chr2:24896332chr3:121388202ENST0000039366716221_32353059.03270.0Topological domainCytoplasmic


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>762_NCOA1_24896332_GOLGB1_121388202_ranked_0.pdbNCOA12489633224896332ENST00000393667GOLGB1chr3121388202-
MALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTISVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRR
EQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEFSQLLEEK
NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR
QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVP
382


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NCOA1_pLDDT.png
all structure
all structure
GOLGB1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NCOA1all structure
GOLGB1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522781_988118.02199.3333333333335CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521781_988118.01442.0CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521781_988118.01441.0CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825781_988118.02183.6666666666665CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723781_988118.01442.0CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623781_988118.01422.6666666666667CREBBP
HgeneNCOA1chr2:24896332chr3:121388202ENST00000288599+522361_567118.02199.3333333333335STAT3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000348332+521361_567118.01442.0STAT3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000395856+521361_567118.01441.0STAT3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000405141+825361_567118.02183.6666666666665STAT3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000406961+723361_567118.01442.0STAT3
HgeneNCOA1chr2:24896332chr3:121388202ENST00000538539+623361_567118.01422.6666666666667STAT3


Top

Related Drugs to NCOA1-GOLGB1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to NCOA1-GOLGB1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA1C0006142Malignant neoplasm of breast1CTD_human
HgeneNCOA1C0014175Endometriosis1CTD_human
HgeneNCOA1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneNCOA1C0027627Neoplasm Metastasis1CTD_human
HgeneNCOA1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOA1C0269102Endometrioma1CTD_human
HgeneNCOA1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNCOA1C0678222Breast Carcinoma1CTD_human
HgeneNCOA1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNCOA1C1458155Mammary Neoplasms1CTD_human
HgeneNCOA1C4704874Mammary Carcinoma, Human1CTD_human