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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NCOA4-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NCOA4-RET
FusionPDB ID: 57772
FusionGDB2.0 ID: 57772
HgeneTgene
Gene symbol

NCOA4

RET

Gene ID

8031

5979

Gene namenuclear receptor coactivator 4ret proto-oncogene
SynonymsARA70|ELE1|PTC3|RFGCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

10q11.22

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 470 kDa AR-activator70 kDa androgen receptor coactivatorNCoA-4RET-activating gene ELE1androgen receptor-associated protein of 70 kDaret fusedproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc

Q13772

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000498586, ENST00000414907, 
ENST00000344348, ENST00000374082, 
ENST00000374087, ENST00000430396, 
ENST00000438493, ENST00000443446, 
ENST00000452682, 		ENST00000340058, 
ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 11=247532 X 31 X 11=10912
# samples 2148
** MAII scorelog2(21/2475*10)=-3.55896729218821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NCOA4 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NCOA4(51582939)-RET(43612032), # samples:12
RET(43610184)-NCOA4(51584616), # samples:3
Anticipated loss of major functional domain due to fusion event.NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RET-NCOA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RET-NCOA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCOA4-RET seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NCOA4-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NCOA4-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NCOA4-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA4

GO:0006622

protein targeting to lysosome

25327288

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across NCOA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-CE-A482-01ANCOA4chr10

51582939

-RETchr10

43612032

+
ChimerDB4THCATCGA-CE-A482-01ANCOA4chr10

51582939

+RETchr10

43612032

+
ChimerDB4THCATCGA-CE-A482NCOA4chr10

51582939

+RETchr10

43612031

+
ChimerDB4THCATCGA-DE-A3KN-01ANCOA4chr10

51582939

-RETchr10

43612032

+
ChimerDB4THCATCGA-DE-A3KN-01ANCOA4chr10

51582939

+RETchr10

43612032

+
ChimerDB4THCATCGA-DE-A3KNNCOA4chr10

51582939

+RETchr10

43612031

+
ChimerDB4THCATCGA-EL-A3H3-01ANCOA4chr10

51582939

-RETchr10

43612032

+
ChimerDB4THCATCGA-EL-A3H3-01ANCOA4chr10

51582939

+RETchr10

43612032

+
ChimerDB4THCATCGA-EL-A3H3NCOA4chr10

51582939

+RETchr10

43612031

+
ChimerDB4THCATCGA-EM-A2CU-01ANCOA4chr10

51582939

-RETchr10

43612032

+
ChimerDB4THCATCGA-EM-A2CU-01ANCOA4chr10

51582939

+RETchr10

43612032

+
ChimerDB4THCATCGA-EM-A2CUNCOA4chr10

51582939

+RETchr10

43612031

+
ChimerKB3..NCOA4chr10

51252946

+RETchr10

42932035

+
ChimerKB3..NCOA4chr10

51581378

+RETchr10

43612031

+
ChimerKB3..NCOA4chr10

51582272

+RETchr10

43612031

+
ChimerKB3..NCOA4chr10

51582939

+RETchr10

43609927

+
ChimerKB3..NCOA4chr10

51582939

+RETchr10

43612031

+
ChiTaRS5.0N/AS71225NCOA4chr10

51582940

-RETchr10

43612030

+
ChiTaRS5.0N/AS74821NCOA4chr10

51584251

-RETchr10

43610593

+
ChiTaRS5.0N/AS82976NCOA4chr10

51584125

-RETchr10

43610089

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000438493NCOA4chr1051581378+ENST00000355710RETchr1043612031+40717802521988578
ENST00000438493NCOA4chr1051581378+ENST00000340058RETchr1043612031+26137802521862536
ENST00000452682NCOA4chr1051581378+ENST00000355710RETchr1043612031+40717802521988578
ENST00000452682NCOA4chr1051581378+ENST00000340058RETchr1043612031+26137802521862536
ENST00000430396NCOA4chr1051581378+ENST00000355710RETchr1043612031+36313401601548462
ENST00000430396NCOA4chr1051581378+ENST00000340058RETchr1043612031+21733401601422420
ENST00000374087NCOA4chr1051581378+ENST00000355710RETchr1043612031+3855564841772562
ENST00000374087NCOA4chr1051581378+ENST00000340058RETchr1043612031+2397564841646520
ENST00000344348NCOA4chr1051581378+ENST00000355710RETchr1043612031+39116201401828562
ENST00000344348NCOA4chr1051581378+ENST00000340058RETchr1043612031+24536201401702520
ENST00000374082NCOA4chr1051581378+ENST00000355710RETchr1043612031+3851560801768562
ENST00000374082NCOA4chr1051581378+ENST00000340058RETchr1043612031+2393560801642520
ENST00000443446NCOA4chr1051581378+ENST00000355710RETchr1043612031+40007091271917596
ENST00000443446NCOA4chr1051581378+ENST00000340058RETchr1043612031+25427091271791554
ENST00000438493NCOA4chr1051582272+ENST00000355710RETchr1043612031+41618702522078608
ENST00000438493NCOA4chr1051582272+ENST00000340058RETchr1043612031+27038702521952566
ENST00000452682NCOA4chr1051582272+ENST00000355710RETchr1043612031+41618702522078608
ENST00000452682NCOA4chr1051582272+ENST00000340058RETchr1043612031+27038702521952566
ENST00000430396NCOA4chr1051582272+ENST00000355710RETchr1043612031+37214301601638492
ENST00000430396NCOA4chr1051582272+ENST00000340058RETchr1043612031+22634301601512450
ENST00000374087NCOA4chr1051582272+ENST00000355710RETchr1043612031+3945654841862592
ENST00000374087NCOA4chr1051582272+ENST00000340058RETchr1043612031+2487654841736550
ENST00000414907NCOA4chr1051582272+ENST00000355710RETchr1043612031+3557266681474468
ENST00000414907NCOA4chr1051582272+ENST00000340058RETchr1043612031+2099266681348426
ENST00000344348NCOA4chr1051582272+ENST00000355710RETchr1043612031+40017101401918592
ENST00000344348NCOA4chr1051582272+ENST00000340058RETchr1043612031+25437101401792550
ENST00000374082NCOA4chr1051582272+ENST00000355710RETchr1043612031+3941650801858592
ENST00000374082NCOA4chr1051582272+ENST00000340058RETchr1043612031+2483650801732550
ENST00000443446NCOA4chr1051582272+ENST00000355710RETchr1043612031+40907991272007626
ENST00000443446NCOA4chr1051582272+ENST00000340058RETchr1043612031+26327991271881584
ENST00000438493NCOA4chr1051582939+ENST00000355710RETchr1043612031+430510142522222656
ENST00000438493NCOA4chr1051582939+ENST00000340058RETchr1043612031+284710142522096614
ENST00000452682NCOA4chr1051582939+ENST00000355710RETchr1043612031+430510142522222656
ENST00000452682NCOA4chr1051582939+ENST00000340058RETchr1043612031+284710142522096614
ENST00000430396NCOA4chr1051582939+ENST00000355710RETchr1043612031+38655741601782540
ENST00000430396NCOA4chr1051582939+ENST00000340058RETchr1043612031+24075741601656498
ENST00000374087NCOA4chr1051582939+ENST00000355710RETchr1043612031+4089798842006640
ENST00000374087NCOA4chr1051582939+ENST00000340058RETchr1043612031+2631798841880598
ENST00000414907NCOA4chr1051582939+ENST00000355710RETchr1043612031+3701410681618516
ENST00000414907NCOA4chr1051582939+ENST00000340058RETchr1043612031+2243410681492474
ENST00000344348NCOA4chr1051582939+ENST00000355710RETchr1043612031+41458541402062640
ENST00000344348NCOA4chr1051582939+ENST00000340058RETchr1043612031+26878541401936598
ENST00000374082NCOA4chr1051582939+ENST00000355710RETchr1043612031+4085794802002640
ENST00000374082NCOA4chr1051582939+ENST00000340058RETchr1043612031+2627794801876598
ENST00000443446NCOA4chr1051582939+ENST00000355710RETchr1043612031+42349431272151674
ENST00000443446NCOA4chr1051582939+ENST00000340058RETchr1043612031+27769431272025632
ENST00000438493NCOA4chr1051582939-ENST00000355710RETchr1043612032+430510142522222656
ENST00000438493NCOA4chr1051582939-ENST00000340058RETchr1043612032+284710142522096614
ENST00000452682NCOA4chr1051582939-ENST00000355710RETchr1043612032+430510142522222656
ENST00000452682NCOA4chr1051582939-ENST00000340058RETchr1043612032+284710142522096614
ENST00000430396NCOA4chr1051582939-ENST00000355710RETchr1043612032+38655741601782540
ENST00000430396NCOA4chr1051582939-ENST00000340058RETchr1043612032+24075741601656498
ENST00000374087NCOA4chr1051582939-ENST00000355710RETchr1043612032+4089798842006640
ENST00000374087NCOA4chr1051582939-ENST00000340058RETchr1043612032+2631798841880598
ENST00000414907NCOA4chr1051582939-ENST00000355710RETchr1043612032+3701410681618516
ENST00000414907NCOA4chr1051582939-ENST00000340058RETchr1043612032+2243410681492474
ENST00000344348NCOA4chr1051582939-ENST00000355710RETchr1043612032+41458541402062640
ENST00000344348NCOA4chr1051582939-ENST00000340058RETchr1043612032+26878541401936598
ENST00000374082NCOA4chr1051582939-ENST00000355710RETchr1043612032+4085794802002640
ENST00000374082NCOA4chr1051582939-ENST00000340058RETchr1043612032+2627794801876598
ENST00000443446NCOA4chr1051582939-ENST00000355710RETchr1043612032+42349431272151674
ENST00000443446NCOA4chr1051582939-ENST00000340058RETchr1043612032+27769431272025632
ENST00000438493NCOA4chr1051582939+ENST00000355710RETchr1043612031+430510142522222656
ENST00000438493NCOA4chr1051582939+ENST00000340058RETchr1043612031+284710142522096614
ENST00000452682NCOA4chr1051582939+ENST00000355710RETchr1043612031+430510142522222656
ENST00000452682NCOA4chr1051582939+ENST00000340058RETchr1043612031+284710142522096614
ENST00000430396NCOA4chr1051582939+ENST00000355710RETchr1043612031+38655741601782540
ENST00000430396NCOA4chr1051582939+ENST00000340058RETchr1043612031+24075741601656498
ENST00000374087NCOA4chr1051582939+ENST00000355710RETchr1043612031+4089798842006640
ENST00000374087NCOA4chr1051582939+ENST00000340058RETchr1043612031+2631798841880598
ENST00000414907NCOA4chr1051582939+ENST00000355710RETchr1043612031+3701410681618516
ENST00000414907NCOA4chr1051582939+ENST00000340058RETchr1043612031+2243410681492474
ENST00000344348NCOA4chr1051582939+ENST00000355710RETchr1043612031+41458541402062640
ENST00000344348NCOA4chr1051582939+ENST00000340058RETchr1043612031+26878541401936598
ENST00000374082NCOA4chr1051582939+ENST00000355710RETchr1043612031+4085794802002640
ENST00000374082NCOA4chr1051582939+ENST00000340058RETchr1043612031+2627794801876598
ENST00000443446NCOA4chr1051582939+ENST00000355710RETchr1043612031+42349431272151674
ENST00000443446NCOA4chr1051582939+ENST00000340058RETchr1043612031+27769431272025632
ENST00000438493NCOA4chr1051582940-ENST00000355710RETchr1043612030+430510142522222656
ENST00000438493NCOA4chr1051582940-ENST00000340058RETchr1043612030+284710142522096614
ENST00000452682NCOA4chr1051582940-ENST00000355710RETchr1043612030+430510142522222656
ENST00000452682NCOA4chr1051582940-ENST00000340058RETchr1043612030+284710142522096614
ENST00000430396NCOA4chr1051582940-ENST00000355710RETchr1043612030+38655741601782540
ENST00000430396NCOA4chr1051582940-ENST00000340058RETchr1043612030+24075741601656498
ENST00000374087NCOA4chr1051582940-ENST00000355710RETchr1043612030+4089798842006640
ENST00000374087NCOA4chr1051582940-ENST00000340058RETchr1043612030+2631798841880598
ENST00000414907NCOA4chr1051582940-ENST00000355710RETchr1043612030+3701410681618516
ENST00000414907NCOA4chr1051582940-ENST00000340058RETchr1043612030+2243410681492474
ENST00000344348NCOA4chr1051582940-ENST00000355710RETchr1043612030+41458541402062640
ENST00000344348NCOA4chr1051582940-ENST00000340058RETchr1043612030+26878541401936598
ENST00000374082NCOA4chr1051582940-ENST00000355710RETchr1043612030+4085794802002640
ENST00000374082NCOA4chr1051582940-ENST00000340058RETchr1043612030+2627794801876598
ENST00000443446NCOA4chr1051582940-ENST00000355710RETchr1043612030+42349431272151674
ENST00000443446NCOA4chr1051582940-ENST00000340058RETchr1043612030+27769431272025632

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000438493ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0011300460.99886996
ENST00000438493ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0060803660.9939196
ENST00000452682ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0011300460.99886996
ENST00000452682ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0060803660.9939196
ENST00000430396ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0056913630.99430865
ENST00000430396ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.018757970.98124206
ENST00000374087ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.003984550.99601537
ENST00000374087ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0158243830.9841756
ENST00000414907ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0008968480.9991032
ENST00000414907ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0037227040.9962773
ENST00000344348ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0041740320.995826
ENST00000344348ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0160427970.9839572
ENST00000374082ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0040238840.99597615
ENST00000374082ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0159225220.98407745
ENST00000443446ENST00000355710NCOA4chr1051582939-RETchr1043612032+0.0040464730.99595356
ENST00000443446ENST00000340058NCOA4chr1051582939-RETchr1043612032+0.0150609730.984939
ENST00000438493ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0011300460.99886996
ENST00000438493ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0060803660.9939196
ENST00000452682ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0011300460.99886996
ENST00000452682ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0060803660.9939196
ENST00000430396ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0056913630.99430865
ENST00000430396ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.018757970.98124206
ENST00000374087ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.003984550.99601537
ENST00000374087ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0158243830.9841756
ENST00000414907ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0008968480.9991032
ENST00000414907ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0037227040.9962773
ENST00000344348ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0041740320.995826
ENST00000344348ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0160427970.9839572
ENST00000374082ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0040238840.99597615
ENST00000374082ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0159225220.98407745
ENST00000443446ENST00000355710NCOA4chr1051582939+RETchr1043612031+0.0040464730.99595356
ENST00000443446ENST00000340058NCOA4chr1051582939+RETchr1043612031+0.0150609730.984939
ENST00000438493ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0011300460.99886996
ENST00000438493ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0060803660.9939196
ENST00000452682ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0011300460.99886996
ENST00000452682ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0060803660.9939196
ENST00000430396ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0056913630.99430865
ENST00000430396ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.018757970.98124206
ENST00000374087ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.003984550.99601537
ENST00000374087ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0158243830.9841756
ENST00000414907ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0008968480.9991032
ENST00000414907ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0037227040.9962773
ENST00000344348ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0041740320.995826
ENST00000344348ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0160427970.9839572
ENST00000374082ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0040238840.99597615
ENST00000374082ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0159225220.98407745
ENST00000443446ENST00000355710NCOA4chr1051582940-RETchr1043612030+0.0040464730.99595356
ENST00000443446ENST00000340058NCOA4chr1051582940-RETchr1043612030+0.0150609730.984939

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57772_57772_1_NCOA4-RET_NCOA4_chr10_51581378_ENST00000344348_RET_chr10_43612031_ENST00000340058_length(amino acids)=520AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS

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>57772_57772_2_NCOA4-RET_NCOA4_chr10_51581378_ENST00000344348_RET_chr10_43612031_ENST00000355710_length(amino acids)=562AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPN

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>57772_57772_3_NCOA4-RET_NCOA4_chr10_51581378_ENST00000374082_RET_chr10_43612031_ENST00000340058_length(amino acids)=520AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS

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>57772_57772_4_NCOA4-RET_NCOA4_chr10_51581378_ENST00000374082_RET_chr10_43612031_ENST00000355710_length(amino acids)=562AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPN

--------------------------------------------------------------

>57772_57772_5_NCOA4-RET_NCOA4_chr10_51581378_ENST00000374087_RET_chr10_43612031_ENST00000340058_length(amino acids)=520AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS

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>57772_57772_6_NCOA4-RET_NCOA4_chr10_51581378_ENST00000374087_RET_chr10_43612031_ENST00000355710_length(amino acids)=562AA_BP=158
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGE
GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR
IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPN

--------------------------------------------------------------

>57772_57772_7_NCOA4-RET_NCOA4_chr10_51581378_ENST00000430396_RET_chr10_43612031_ENST00000340058_length(amino acids)=420AA_BP=58
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKAT
AFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGS
RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR

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>57772_57772_8_NCOA4-RET_NCOA4_chr10_51581378_ENST00000430396_RET_chr10_43612031_ENST00000355710_length(amino acids)=462AA_BP=58
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKAT
AFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGS
RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR
RDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLS

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>57772_57772_9_NCOA4-RET_NCOA4_chr10_51581378_ENST00000438493_RET_chr10_43612031_ENST00000340058_length(amino acids)=536AA_BP=174
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPK
WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ

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>57772_57772_10_NCOA4-RET_NCOA4_chr10_51581378_ENST00000438493_RET_chr10_43612031_ENST00000355710_length(amino acids)=578AA_BP=174
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPK
WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ
CWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVP

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>57772_57772_11_NCOA4-RET_NCOA4_chr10_51581378_ENST00000443446_RET_chr10_43612031_ENST00000340058_length(amino acids)=554AA_BP=192
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI
KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAAR
NILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH
RMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE

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>57772_57772_12_NCOA4-RET_NCOA4_chr10_51581378_ENST00000443446_RET_chr10_43612031_ENST00000355710_length(amino acids)=596AA_BP=192
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI
KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAAR
NILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH
RMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE

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>57772_57772_13_NCOA4-RET_NCOA4_chr10_51581378_ENST00000452682_RET_chr10_43612031_ENST00000340058_length(amino acids)=536AA_BP=174
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPK
WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ

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>57772_57772_14_NCOA4-RET_NCOA4_chr10_51581378_ENST00000452682_RET_chr10_43612031_ENST00000355710_length(amino acids)=578AA_BP=174
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPK
WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ
CWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVP

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>57772_57772_15_NCOA4-RET_NCOA4_chr10_51582272_ENST00000344348_RET_chr10_43612031_ENST00000340058_length(amino acids)=550AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_16_NCOA4-RET_NCOA4_chr10_51582272_ENST00000344348_RET_chr10_43612031_ENST00000355710_length(amino acids)=592AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_17_NCOA4-RET_NCOA4_chr10_51582272_ENST00000374082_RET_chr10_43612031_ENST00000340058_length(amino acids)=550AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_18_NCOA4-RET_NCOA4_chr10_51582272_ENST00000374082_RET_chr10_43612031_ENST00000355710_length(amino acids)=592AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_19_NCOA4-RET_NCOA4_chr10_51582272_ENST00000374087_RET_chr10_43612031_ENST00000340058_length(amino acids)=550AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_20_NCOA4-RET_NCOA4_chr10_51582272_ENST00000374087_RET_chr10_43612031_ENST00000355710_length(amino acids)=592AA_BP=185
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG
ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV
AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLY

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>57772_57772_21_NCOA4-RET_NCOA4_chr10_51582272_ENST00000414907_RET_chr10_43612031_ENST00000340058_length(amino acids)=426AA_BP=61
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFG
KVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY
LGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK
WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE

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>57772_57772_22_NCOA4-RET_NCOA4_chr10_51582272_ENST00000414907_RET_chr10_43612031_ENST00000355710_length(amino acids)=468AA_BP=61
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFG
KVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY
LGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK
WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE
KMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVY

--------------------------------------------------------------

>57772_57772_23_NCOA4-RET_NCOA4_chr10_51582272_ENST00000430396_RET_chr10_43612031_ENST00000340058_length(amino acids)=450AA_BP=85
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF

--------------------------------------------------------------

>57772_57772_24_NCOA4-RET_NCOA4_chr10_51582272_ENST00000430396_RET_chr10_43612031_ENST00000355710_length(amino acids)=492AA_BP=85
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE

--------------------------------------------------------------

>57772_57772_25_NCOA4-RET_NCOA4_chr10_51582272_ENST00000438493_RET_chr10_43612031_ENST00000340058_length(amino acids)=566AA_BP=201
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA
EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA

--------------------------------------------------------------

>57772_57772_26_NCOA4-RET_NCOA4_chr10_51582272_ENST00000438493_RET_chr10_43612031_ENST00000355710_length(amino acids)=608AA_BP=201
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA
EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA

--------------------------------------------------------------

>57772_57772_27_NCOA4-RET_NCOA4_chr10_51582272_ENST00000443446_RET_chr10_43612031_ENST00000340058_length(amino acids)=584AA_BP=219
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK
MLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM
GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFG
VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLI

--------------------------------------------------------------

>57772_57772_28_NCOA4-RET_NCOA4_chr10_51582272_ENST00000443446_RET_chr10_43612031_ENST00000355710_length(amino acids)=626AA_BP=219
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK
MLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM
GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFG
VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLI

--------------------------------------------------------------

>57772_57772_29_NCOA4-RET_NCOA4_chr10_51582272_ENST00000452682_RET_chr10_43612031_ENST00000340058_length(amino acids)=566AA_BP=201
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA
EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA

--------------------------------------------------------------

>57772_57772_30_NCOA4-RET_NCOA4_chr10_51582272_ENST00000452682_RET_chr10_43612031_ENST00000355710_length(amino acids)=608AA_BP=201
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA
EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA

--------------------------------------------------------------

>57772_57772_31_NCOA4-RET_NCOA4_chr10_51582939_ENST00000344348_RET_chr10_43612031_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_32_NCOA4-RET_NCOA4_chr10_51582939_ENST00000344348_RET_chr10_43612031_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_33_NCOA4-RET_NCOA4_chr10_51582939_ENST00000344348_RET_chr10_43612032_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_34_NCOA4-RET_NCOA4_chr10_51582939_ENST00000344348_RET_chr10_43612032_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_35_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374082_RET_chr10_43612031_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_36_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374082_RET_chr10_43612031_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_37_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374082_RET_chr10_43612032_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_38_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374082_RET_chr10_43612032_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_39_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374087_RET_chr10_43612031_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_40_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374087_RET_chr10_43612031_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_41_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374087_RET_chr10_43612032_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_42_NCOA4-RET_NCOA4_chr10_51582939_ENST00000374087_RET_chr10_43612032_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_43_NCOA4-RET_NCOA4_chr10_51582939_ENST00000414907_RET_chr10_43612031_ENST00000340058_length(amino acids)=474AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_44_NCOA4-RET_NCOA4_chr10_51582939_ENST00000414907_RET_chr10_43612031_ENST00000355710_length(amino acids)=516AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_45_NCOA4-RET_NCOA4_chr10_51582939_ENST00000414907_RET_chr10_43612032_ENST00000340058_length(amino acids)=474AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_46_NCOA4-RET_NCOA4_chr10_51582939_ENST00000414907_RET_chr10_43612032_ENST00000355710_length(amino acids)=516AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_47_NCOA4-RET_NCOA4_chr10_51582939_ENST00000430396_RET_chr10_43612031_ENST00000340058_length(amino acids)=498AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS

--------------------------------------------------------------

>57772_57772_48_NCOA4-RET_NCOA4_chr10_51582939_ENST00000430396_RET_chr10_43612031_ENST00000355710_length(amino acids)=540AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS

--------------------------------------------------------------

>57772_57772_49_NCOA4-RET_NCOA4_chr10_51582939_ENST00000430396_RET_chr10_43612032_ENST00000340058_length(amino acids)=498AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS

--------------------------------------------------------------

>57772_57772_50_NCOA4-RET_NCOA4_chr10_51582939_ENST00000430396_RET_chr10_43612032_ENST00000355710_length(amino acids)=540AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS

--------------------------------------------------------------

>57772_57772_51_NCOA4-RET_NCOA4_chr10_51582939_ENST00000438493_RET_chr10_43612031_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_52_NCOA4-RET_NCOA4_chr10_51582939_ENST00000438493_RET_chr10_43612031_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------

>57772_57772_53_NCOA4-RET_NCOA4_chr10_51582939_ENST00000438493_RET_chr10_43612032_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_54_NCOA4-RET_NCOA4_chr10_51582939_ENST00000438493_RET_chr10_43612032_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------

>57772_57772_55_NCOA4-RET_NCOA4_chr10_51582939_ENST00000443446_RET_chr10_43612031_ENST00000340058_length(amino acids)=632AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT

--------------------------------------------------------------

>57772_57772_56_NCOA4-RET_NCOA4_chr10_51582939_ENST00000443446_RET_chr10_43612031_ENST00000355710_length(amino acids)=674AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP

--------------------------------------------------------------

>57772_57772_57_NCOA4-RET_NCOA4_chr10_51582939_ENST00000443446_RET_chr10_43612032_ENST00000340058_length(amino acids)=632AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT

--------------------------------------------------------------

>57772_57772_58_NCOA4-RET_NCOA4_chr10_51582939_ENST00000443446_RET_chr10_43612032_ENST00000355710_length(amino acids)=674AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP

--------------------------------------------------------------

>57772_57772_59_NCOA4-RET_NCOA4_chr10_51582939_ENST00000452682_RET_chr10_43612031_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_60_NCOA4-RET_NCOA4_chr10_51582939_ENST00000452682_RET_chr10_43612031_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------

>57772_57772_61_NCOA4-RET_NCOA4_chr10_51582939_ENST00000452682_RET_chr10_43612032_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_62_NCOA4-RET_NCOA4_chr10_51582939_ENST00000452682_RET_chr10_43612032_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------

>57772_57772_63_NCOA4-RET_NCOA4_chr10_51582940_ENST00000344348_RET_chr10_43612030_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_64_NCOA4-RET_NCOA4_chr10_51582940_ENST00000344348_RET_chr10_43612030_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_65_NCOA4-RET_NCOA4_chr10_51582940_ENST00000374082_RET_chr10_43612030_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_66_NCOA4-RET_NCOA4_chr10_51582940_ENST00000374082_RET_chr10_43612030_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_67_NCOA4-RET_NCOA4_chr10_51582940_ENST00000374087_RET_chr10_43612030_ENST00000340058_length(amino acids)=598AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD

--------------------------------------------------------------

>57772_57772_68_NCOA4-RET_NCOA4_chr10_51582940_ENST00000374087_RET_chr10_43612030_ENST00000355710_length(amino acids)=640AA_BP=233
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQ
QLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF
HLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN
SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD
YLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS

--------------------------------------------------------------

>57772_57772_69_NCOA4-RET_NCOA4_chr10_51582940_ENST00000414907_RET_chr10_43612030_ENST00000340058_length(amino acids)=474AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_70_NCOA4-RET_NCOA4_chr10_51582940_ENST00000414907_RET_chr10_43612030_ENST00000355710_length(amino acids)=516AA_BP=109
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGY
QAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV
LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL

--------------------------------------------------------------

>57772_57772_71_NCOA4-RET_NCOA4_chr10_51582940_ENST00000430396_RET_chr10_43612030_ENST00000340058_length(amino acids)=498AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS

--------------------------------------------------------------

>57772_57772_72_NCOA4-RET_NCOA4_chr10_51582940_ENST00000430396_RET_chr10_43612030_ENST00000355710_length(amino acids)=540AA_BP=133
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQ
KSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT
VAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER
ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV
WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS

--------------------------------------------------------------

>57772_57772_73_NCOA4-RET_NCOA4_chr10_51582940_ENST00000438493_RET_chr10_43612030_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_74_NCOA4-RET_NCOA4_chr10_51582940_ENST00000438493_RET_chr10_43612030_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------

>57772_57772_75_NCOA4-RET_NCOA4_chr10_51582940_ENST00000443446_RET_chr10_43612030_ENST00000340058_length(amino acids)=632AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT

--------------------------------------------------------------

>57772_57772_76_NCOA4-RET_NCOA4_chr10_51582940_ENST00000443446_RET_chr10_43612030_ENST00000355710_length(amino acids)=674AA_BP=267
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCI
SRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTIT
LRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLEN
SQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP

--------------------------------------------------------------

>57772_57772_77_NCOA4-RET_NCOA4_chr10_51582940_ENST00000452682_RET_chr10_43612030_ENST00000340058_length(amino acids)=614AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------

>57772_57772_78_NCOA4-RET_NCOA4_chr10_51582940_ENST00000452682_RET_chr10_43612030_ENST00000355710_length(amino acids)=656AA_BP=249
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQV
DLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPE
HLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:51582939/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA4

Q13772

RET

RTL1

FUNCTION: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. {ECO:0000269|PubMed:10347167}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRETchr10:51582939chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:51582939chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:51582939chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:51582939chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:51582940chr10:43612030ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:51582940chr10:43612030ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:51582939chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:51582939chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:51582939chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:51582939chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:51582940chr10:43612030ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:51582940chr10:43612030ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:51582939chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:51582939chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr10:51582939chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:51582939chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr10:51582940chr10:43612030ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:51582940chr10:43612030ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRETchr10:51582939chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:51582939chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:51582939chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:51582939chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:51582940chr10:43612030ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:51582940chr10:43612030ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:51582939chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:51582939chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:51582939chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:51582939chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:51582939chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:51582939chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:51582939chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:51582939chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:51582940chr10:43612030ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:51582940chr10:43612030ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:51582940chr10:43612030ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:51582940chr10:43612030ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:51582939chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:51582939chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr10:51582939chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:51582939chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr10:51582940chr10:43612030ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:51582940chr10:43612030ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (179) >>>179.pdbFusion protein BP residue: 58
CIF file (179) >>>179.cif		NCOA4chr1051581378+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
420
3D view using mol* of 179 (AA BP:58)
PDB file (187) >>>187.pdbFusion protein BP residue: 61
CIF file (187) >>>187.cif		NCOA4chr1051582272+RETchr1043612031+
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSAN
IGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQ
DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERAL
TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT
LGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRP
VFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA
426
3D view using mol* of 187 (AA BP:61)
PDB file (218) >>>218.pdbFusion protein BP residue: 85
CIF file (218) >>>218.cif		NCOA4chr1051582272+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL
LSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAST
PSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF
450
3D view using mol* of 218 (AA BP:85)
PDB file (236) >>>236.pdbFusion protein BP residue: 58
CIF file (236) >>>236.cif		NCOA4chr1051581378+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
PSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLS
462
3D view using mol* of 236 (AA BP:58)
PDB file (246) >>>246.pdbFusion protein BP residue: 61
CIF file (246) >>>246.cif		NCOA4chr1051582272+RETchr1043612031+
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSAN
IGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQ
DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERAL
TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS
RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT
LGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRP
VFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNA
PLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVY
468
3D view using mol* of 246 (AA BP:61)
PDB file (253) >>>253.pdbFusion protein BP residue: 109
CIF file (253) >>>253.cif		NCOA4chr1051582939+RETchr1043612031+
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSAN
IGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDP
QDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKG
RAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG
PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM
GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD
VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG
GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL
474
3D view using mol* of 253 (AA BP:109)
PDB file (287) >>>287.pdbFusion protein BP residue: 85
CIF file (287) >>>287.cif		NCOA4chr1051582272+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL
LSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAST
PSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE
492
3D view using mol* of 287 (AA BP:85)
PDB file (296) >>>296.pdbFusion protein BP residue: 133
CIF file (296) >>>296.cif		NCOA4chr1051582939+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVP
FSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
498
3D view using mol* of 296 (AA BP:133)
PDB file (331) >>>331.pdbFusion protein BP residue: 109
CIF file (331) >>>331.cif		NCOA4chr1051582939+RETchr1043612031+
MGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSAN
IGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDP
QDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKG
RAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG
PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM
GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD
VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG
GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL
PRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN
516
3D view using mol* of 331 (AA BP:109)
PDB file (336) >>>336.pdbFusion protein BP residue: 158
CIF file (336) >>>336.cif		NCOA4chr1051581378+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
520
3D view using mol* of 336 (AA BP:158)
PDB file (366) >>>366.pdbFusion protein BP residue: 174
CIF file (366) >>>366.cif		NCOA4chr1051581378+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFG
KVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPH
VIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR
KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWS
FGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ
CWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE
536
3D view using mol* of 366 (AA BP:174)
PDB file (377) >>>377.pdbFusion protein BP residue: 133
CIF file (377) >>>377.cif		NCOA4chr1051582939+RETchr1043612031+
MNRWTLFISLKRRHFNSRLSSSTRLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVP
FSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESP
540
3D view using mol* of 377 (AA BP:133)
PDB file (391) >>>391.pdbFusion protein BP residue: 185
CIF file (391) >>>391.cif		NCOA4chr1051582272+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL
LSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAST
PSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF
550
3D view using mol* of 391 (AA BP:185)
PDB file (398) >>>398.pdbFusion protein BP residue: 192
CIF file (398) >>>398.cif		NCOA4chr1051581378+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWE
FPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE
LRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH
RMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL
AASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHA
554
3D view using mol* of 398 (AA BP:192)
PDB file (413) >>>413.pdbFusion protein BP residue: 158
CIF file (413) >>>413.cif		NCOA4chr1051581378+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
PSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLS
562
3D view using mol* of 413 (AA BP:158)
PDB file (417) >>>417.pdbFusion protein BP residue: 201
CIF file (417) >>>417.cif		NCOA4chr1051582272+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGC
ISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVA
VKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAW
QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV
KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE
KMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTW
566
3D view using mol* of 417 (AA BP:201)
PDB file (443) >>>443.pdbFusion protein BP residue: 174
CIF file (443) >>>443.cif		NCOA4chr1051581378+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIEDPKWEFPRKNLVLGKTLGEGEFG
KVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPH
VIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR
KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWS
FGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ
CWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE
ETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTG
578
3D view using mol* of 443 (AA BP:174)
PDB file (448) >>>448.pdbFusion protein BP residue: 219
CIF file (448) >>>448.cif		NCOA4chr1051582272+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHL
MAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI
KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSL
DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM
KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFG
VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW
KQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEET
584
3D view using mol* of 448 (AA BP:219)
PDB file (457) >>>457.pdbFusion protein BP residue: 185
CIF file (457) >>>457.cif		NCOA4chr1051582272+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL
LSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV
GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAST
PSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE
592
3D view using mol* of 457 (AA BP:185)
PDB file (466) >>>466.pdbFusion protein BP residue: 192
CIF file (466) >>>466.cif		NCOA4chr1051581378+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIEDPKWE
FPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE
LRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH
RMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL
AASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPN
596
3D view using mol* of 466 (AA BP:192)
PDB file (470) >>>470.pdbFusion protein BP residue: 233
CIF file (470) >>>470.cif		NCOA4chr1051582939+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVP
FSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
598
3D view using mol* of 470 (AA BP:233)
PDB file (480) >>>480.pdbFusion protein BP residue: 201
CIF file (480) >>>480.cif		NCOA4chr1051582272+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGC
ISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVA
VKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAW
QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV
KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP
PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE
KMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTW
IENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA
608
3D view using mol* of 480 (AA BP:201)
PDB file (485) >>>485.pdbFusion protein BP residue: 249
CIF file (485) >>>485.cif		NCOA4chr1051582939+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGC
ISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTL
ENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK
MLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAK
YGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQI
SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE
614
3D view using mol* of 485 (AA BP:249)
PDB file (499) >>>499.pdbFusion protein BP residue: 219
CIF file (499) >>>499.cif		NCOA4chr1051582272+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHL
MAHASSANIGPFLEKRGCISMPEQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI
KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSL
DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM
KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFG
VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW
KQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEET
PLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP
626
3D view using mol* of 499 (AA BP:219)
PDB file (503) >>>503.pdbFusion protein BP residue: 267
CIF file (503) >>>503.cif		NCOA4chr1051582939+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHL
MAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQA
PYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVK
ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKL
YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVL
LWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ
EPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPL
632
3D view using mol* of 503 (AA BP:267)
PDB file (513) >>>513.pdbFusion protein BP residue: 233
CIF file (513) >>>513.cif		NCOA4chr1051582939+RETchr1043612031+
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKA
QIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFN
CLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQT
ITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVP
FSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESP
640
3D view using mol* of 513 (AA BP:233)
PDB file (534) >>>534.pdbFusion protein BP residue: 249
CIF file (534) >>>534.cif		NCOA4chr1051582939+RETchr1043612031+
MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGV
LRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEET
LQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPED
STVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGC
ISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTL
ENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK
MLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAK
YGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQI
SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE
RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE
NKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKL
656
3D view using mol* of 534 (AA BP:249)
PDB file (547) >>>547.pdbFusion protein BP residue: 267
CIF file (547) >>>547.cif		NCOA4chr1051582939+RETchr1043612031+
MHDWPKCKVKQPITLQLSKSEPAFHPCDTGAVRRMNTFQDQSGSSSNREP
LLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSR
EVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLAN
QVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHL
MAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQA
PYIPSTDPQDWLTQKQTLENSQEDPKWEFPRKNLVLGKTLGEGEFGKVVK
ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKL
YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVL
LWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ
EPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPL
VDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRY
674
3D view using mol* of 547 (AA BP:267)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NCOA4_pLDDT.png
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RET_pLDDT.png
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check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NCOA4_RET_179_PAE.png (AA BP:58)
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NCOA4_RET_179_pLDDT.png (AA BP:58)
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NCOA4_RET_179_pLDDT_and_active_sites.png (AA BP:58)
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NCOA4_RET_187_pLDDT.png (AA BP:61)
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NCOA4_RET_187_pLDDT_and_active_sites.png (AA BP:61)
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NCOA4_RET_187_violinplot.png (AA BP:61)
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NCOA4_RET_218_PAE.png (AA BP:85)
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NCOA4_RET_218_pLDDT.png (AA BP:85)
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NCOA4_RET_218_pLDDT_and_active_sites.png (AA BP:85)
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NCOA4_RET_218_violinplot.png (AA BP:85)
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NCOA4_RET_236_PAE.png (AA BP:58)
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NCOA4_RET_236_pLDDT.png (AA BP:58)
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NCOA4_RET_236_pLDDT_and_active_sites.png (AA BP:58)
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NCOA4_RET_236_violinplot.png (AA BP:58)
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NCOA4_RET_246_PAE.png (AA BP:61)
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NCOA4_RET_246_pLDDT.png (AA BP:61)
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NCOA4_RET_246_pLDDT_and_active_sites.png (AA BP:61)
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NCOA4_RET_246_violinplot.png (AA BP:61)
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NCOA4_RET_253_PAE.png (AA BP:109)
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NCOA4_RET_253_pLDDT.png (AA BP:109)
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NCOA4_RET_253_pLDDT_and_active_sites.png (AA BP:109)
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NCOA4_RET_253_violinplot.png (AA BP:109)
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NCOA4_RET_287_pLDDT.png (AA BP:85)
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NCOA4_RET_287_pLDDT_and_active_sites.png (AA BP:85)
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NCOA4_RET_287_violinplot.png (AA BP:85)
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NCOA4_RET_296_pLDDT.png (AA BP:133)
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NCOA4_RET_296_pLDDT_and_active_sites.png (AA BP:133)
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NCOA4_RET_296_violinplot.png (AA BP:133)
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NCOA4_RET_331_pLDDT.png (AA BP:109)
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NCOA4_RET_331_pLDDT_and_active_sites.png (AA BP:109)
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NCOA4_RET_331_violinplot.png (AA BP:109)
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NCOA4_RET_336_pLDDT.png (AA BP:158)
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NCOA4_RET_336_pLDDT_and_active_sites.png (AA BP:158)
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NCOA4_RET_336_violinplot.png (AA BP:158)
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NCOA4_RET_366_pLDDT.png (AA BP:174)
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NCOA4_RET_366_pLDDT_and_active_sites.png (AA BP:174)
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NCOA4_RET_366_violinplot.png (AA BP:174)
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NCOA4_RET_377_pLDDT.png (AA BP:133)
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NCOA4_RET_377_pLDDT_and_active_sites.png (AA BP:133)
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NCOA4_RET_377_violinplot.png (AA BP:133)
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NCOA4_RET_391_pLDDT.png (AA BP:185)
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NCOA4_RET_391_pLDDT_and_active_sites.png (AA BP:185)
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NCOA4_RET_391_violinplot.png (AA BP:185)
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NCOA4_RET_398_pLDDT.png (AA BP:192)
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NCOA4_RET_398_pLDDT_and_active_sites.png (AA BP:192)
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NCOA4_RET_398_violinplot.png (AA BP:192)
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NCOA4_RET_413_pLDDT.png (AA BP:158)
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NCOA4_RET_413_pLDDT_and_active_sites.png (AA BP:158)
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NCOA4_RET_413_violinplot.png (AA BP:158)
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NCOA4_RET_417_pLDDT.png (AA BP:201)
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NCOA4_RET_417_pLDDT_and_active_sites.png (AA BP:201)
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NCOA4_RET_417_violinplot.png (AA BP:201)
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NCOA4_RET_443_pLDDT.png (AA BP:174)
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NCOA4_RET_443_pLDDT_and_active_sites.png (AA BP:174)
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NCOA4_RET_443_violinplot.png (AA BP:174)
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NCOA4_RET_448_pLDDT.png (AA BP:219)
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NCOA4_RET_448_pLDDT_and_active_sites.png (AA BP:219)
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NCOA4_RET_448_violinplot.png (AA BP:219)
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NCOA4_RET_457_pLDDT.png (AA BP:185)
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NCOA4_RET_457_pLDDT_and_active_sites.png (AA BP:185)
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NCOA4_RET_457_violinplot.png (AA BP:185)
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NCOA4_RET_466_pLDDT.png (AA BP:192)
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NCOA4_RET_466_pLDDT_and_active_sites.png (AA BP:192)
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NCOA4_RET_466_violinplot.png (AA BP:192)
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NCOA4_RET_470_pLDDT.png (AA BP:233)
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NCOA4_RET_470_pLDDT_and_active_sites.png (AA BP:233)
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NCOA4_RET_470_violinplot.png (AA BP:233)
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NCOA4_RET_480_pLDDT.png (AA BP:201)
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NCOA4_RET_480_pLDDT_and_active_sites.png (AA BP:201)
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NCOA4_RET_480_violinplot.png (AA BP:201)
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NCOA4_RET_485_pLDDT.png (AA BP:249)
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NCOA4_RET_485_pLDDT_and_active_sites.png (AA BP:249)
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NCOA4_RET_485_violinplot.png (AA BP:249)
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NCOA4_RET_499_pLDDT.png (AA BP:219)
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NCOA4_RET_499_pLDDT_and_active_sites.png (AA BP:219)
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NCOA4_RET_499_violinplot.png (AA BP:219)
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NCOA4_RET_503_pLDDT.png (AA BP:267)
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NCOA4_RET_503_pLDDT_and_active_sites.png (AA BP:267)
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NCOA4_RET_503_violinplot.png (AA BP:267)
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NCOA4_RET_513_pLDDT.png (AA BP:233)
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NCOA4_RET_513_pLDDT_and_active_sites.png (AA BP:233)
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NCOA4_RET_513_violinplot.png (AA BP:233)
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NCOA4_RET_534_pLDDT.png (AA BP:249)
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NCOA4_RET_534_pLDDT_and_active_sites.png (AA BP:249)
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NCOA4_RET_534_violinplot.png (AA BP:249)
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NCOA4_RET_547_pLDDT.png (AA BP:267)
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NCOA4_RET_547_pLDDT_and_active_sites.png (AA BP:267)
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NCOA4_RET_547_violinplot.png (AA BP:267)
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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NCOA4_RET_179.png
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NCOA4_RET_187.png
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NCOA4_RET_218.png
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NCOA4_RET_236.png
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NCOA4_RET_246.png
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NCOA4_RET_253.png
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NCOA4_RET_287.png
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NCOA4_RET_296.png
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NCOA4_RET_331.png
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NCOA4_RET_336.png
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NCOA4_RET_366.png
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NCOA4_RET_377.png
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NCOA4_RET_391.png
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NCOA4_RET_398.png
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NCOA4_RET_413.png
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NCOA4_RET_417.png
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NCOA4_RET_443.png
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NCOA4_RET_448.png
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NCOA4_RET_457.png
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NCOA4_RET_466.png
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NCOA4_RET_470.png
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NCOA4_RET_480.png
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NCOA4_RET_485.png
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NCOA4_RET_499.png
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NCOA4_RET_503.png
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NCOA4_RET_513.png
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NCOA4_RET_534.png
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NCOA4_RET_547.png
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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
1871.0722291.141728.8750.5080.70.9321.2460.6721.8541.38Chain A: 4,5,6,7,8,10,11,12,13,14,15,16,17,18,20,2
2,23,24,26,27,30,32,33,34,35,36,37,38,39,42,43,45,
46,51,54,55,58
2180.9953540.9861070.8460.6110.690.8980.5151.1280.4560.744Chain A: 111,112,113,136,138,143,145,146,148,149,1
50,153,191,195,249,251,252,254,255,256,257,270,272
,273,275,276,277,279,280,281,282,283,284,285,286,2
87,288,289,290,291,292,293,294,295,296,301,303,304
,305,306,307,321,326,327,328,329,334,335,336,339,4
33,434,435,436,437,438,439,440,441
2361.0362170.992582.0710.4730.7511.0180.5831.2240.4771.1Chain A: 80,81,82,83,84,106,108,109,112,113,115,11
6,119,120,123,161,222,226,227,240,242,243,253,255,
257,258,259,260,261,262,263,264,265,446,447,448,44
9,450,451,454
2461.0034021.0331074.2760.5820.6810.8840.670.9690.6920.691Chain A: 52,55,56,59,61,62,64,88,89,112,114,119,12
0,121,122,124,125,126,127,128,129,131,132,135,167,
171,222,224,225,226,227,228,230,231,232,233,246,24
7,248,249,250,251,252,253,255,256,257,258,259,260,
261,262,263,264,265,266,267,268,269,270,271,272,27
7,280,281,282,297,302,303,304,305,311,312,314,315
2530.9863120.977774.8370.5910.6770.8870.4851.1340.4280.89Chain A: 94,96,97,98,99,100,102,103,106,107,110,13
6,137,167,168,169,170,171,172,173,176,179,180,183,
272,273,275,276,280,281,296,297,298,299,300,301,30
3,305,306,307,308,309,310,311,312,313,314,315,316,
317,318,319,320,328,329,330,359
2870.9892911.012754.60.5040.6760.90.4251.0250.4150.631Chain A: 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17
,18,19,20,21,22,23,24,28,38,40,42,45,62,63,64,65,6
6,67,69,70,71,73
2960.9774720.9971220.0510.590.6640.8510.4361.0480.4160.997Chain A: 97,98,99,100,103,104,107,108,110,114,115,
116,117,118,120,121,124,126,127,130,131,134,159,16
0,161,187,189,190,191,192,193,194,195,196,197,200,
203,204,207,294,296,299,300,304,320,321,322,323,32
4,325,327,328,329,330,331,332,333,334,335,337,338,
339,340,341,342,343,344,351,352,353,354,376,377,38
3
3311.0422821.104752.1990.5390.6720.8711.040.7321.4211.02Chain A: 14,16,33,34,35,36,37,38,39,40,41,43,46,47
,52,55,56,60,61,62,63,64,65,66,67,68,71,72,73,74,7
5,76,77,79,80,81,82,83,84,86
3361.0114241.0361050.2660.5680.7010.8930.8190.9950.8230.955Chain A: 51,52,55,56,59,60,63,147,150,151,153,154,
155,156,157,158,181,182,183,206,208,213,215,216,21
8,219,220,221,222,223,225,226,228,229,261,316,318,
320,321,322,323,326,327,340,341,342,343,344,345,34
6,349,350,351,352,353,354,355,356,357,359,360,361,
362,363,365,366,367,370,371,374,376,380,384,406,40
9
3660.93612321.0474744.9960.7010.44250.39960.28280.4850.58310.918Chain A: 157,158,159,161,162,192,194,195,196,197,1
98,199,200,201,202,220,222,235,239,243,252,266,268
,270,271,272,273,274,275,277,278,279,281,282,283,2
86,287,288,289,291,292,293,294,295,296,297,298,299
,300,301,302,304,305,306,307,308,309,310,311,338,3
40,342,343,345,350,355,356,359,370,371,372,373,375
,376,377,378,379,380,381,382,387,388,389,390,392,4
07,412,413,414,415,417,418,421,422,423,424,425,426

3770.92351311.05386.7790.75790.39240.3770.36010.37570.95840.7774Chain A: 1,3,8,10,25,26,27,28,30,38,40,41,42,43,46
,50,54
3911.035701.0831551.3890.620.6720.8750.8280.7971.0381.025Chain A: 52,53,55,56,57,59,60,61,62,63,64,67,68,71
,72,75,144,147,148,150,151,152,154,155,156,157,178
,179,180,181,182,184,185,186,187,188,189,190,191,1
92,195,196,208,209,210,211,212,213,214,216,234,236
,237,238,239,240,242,243,244,245,246,247,248,249,2
50,251,253,254,255,258,271,273,274,276,277,278,282
,283,284,285,288,289,351,352,356,357,359,369,370,3
72,373,383,384,385,386,387,388,389,390,391,392,393
,394,395,396,401,404,406,414
3981.0961141.146295.6660.4770.7680.9561.5170.7821.941.041Chain A: 212,213,214,215,216,217,218,220,238,240,2
57,261,270,284,286,287,288,289,290,292,293,356,360
,361,363,373,374
4131.1326991.204262.7380.48170.77630.99751.74330.60442.88441.4088Chain A: 178,179,180,181,183,184,186,204,206,223,2
27,236,252,253,254,255,258,326,327,329,339,340
4170.9412591.101155.7220.8280.3570.2930.6280.1653.812.232Chain A: 90,93,94,97,98,101,102,104,105,108,109,11
1,112,115,118,119,122,123,125,126,127,128,130,131,
134,141,146,148,150,151,152,153,154
4431.0031641.064447.9580.6750.6230.7860.8550.7651.1171.484Chain A: 67,68,71,72,75,76,78,79,163,166,167,168,1
69,170,171,172,173,175,176,177,178,181,182,190,196
,201,203,223,224,225,226,227,233,237,240,244,259,2
62,263,264
4481.0223501.0711026.5990.6090.6710.8170.6870.8330.8241.033Chain A: 92,95,96,99,100,102,103,106,107,109,110,1
13,242,243,244,245,246,247,248,249,250,268,270,273
,279,280,282,283,287,291,300,314,316,317,318,319,3
22,323,385,386,390,391,393,403,404,407,409,417,418
,419,420,421,422,423,424,425,426,427,428,429,430,4
34,436,437,438,440,473,474,477,478
4571.06271511.1139438.0110.57820.720.89640.89290.79171.12791.1202Chain A: 208,209,210,211,212,213,214,216,234,236,2
53,266,280,282,283,284,285,286,287,288,352,356,357
,359,369,370,373,385,390,391,392,393,394,395,435
4661.10081491.1562440.0690.4790.76170.9841.14380.73851.54881.1108Chain A: 212,213,214,215,216,217,218,220,238,240,2
57,261,270,284,286,287,288,289,292,293,295,356,360
,361,363,373,374,377,389,394,395,396,398,399
4701.1251151.1791279.5450.4250.79571.01891.61240.73122.20521.1993Chain A: 256,257,258,259,261,262,264,282,284,301,3
05,314,330,331,332,333,334,336,337,404,405,407,417
,418
4801.0771411.128433.5520.570.7390.9761.0470.7841.3341.249Chain A: 222,224,225,226,227,228,229,230,232,250,2
52,265,269,282,296,298,300,301,303,304,305,308,368
,372,373,375,385,386,389,401,406,407,408,409,410,4
11,422,451
4851.1011001.159289.4920.5390.7560.9461.4090.721.9561.692Chain A: 272,273,274,275,277,278,279,280,298,300,3
17,321,344,346,348,349,352,353,420,421,423,433,434

4991.0224221.0481047.5220.5280.7130.9220.7470.980.7620.84Chain A: 92,95,96,97,99,100,102,103,106,107,110,24
5,246,247,248,270,272,273,276,277,278,279,280,282,
283,284,286,287,289,290,293,382,385,386,387,390,39
1,404,406,407,408,409,410,413,415,416,417,418,419,
420,421,422,423,424,425,426,427,429,430,435,436,43
7,438,440,448,469,470,471,473,474
5031.0751251.125311.1010.4980.7380.9171.4350.791.8161.043Chain A: 290,291,292,293,294,295,296,297,298,316,3
17,318,335,339,348,362,364,365,366,367,368,370,371
,438,439,441,451,452
5131.11111.16275.4290.5840.750.9411.280.7041.8181.087Chain A: 67,69,70,71,72,73,74,75,76,77,80,138,139,
140,141,399,421,432,433,436,439,440,441,444,448,44
9,452,454,483,484,487
5341.0681181.175513.4710.7080.6230.7941.4280.4273.3440.647Chain A: 1,2,5,50,53,54,56,57,58,60,61,64,65,67,68
,71,72,75,76,79,163,164,166,167,168,170,171,172,17
3,176,177,178,182,183,186,191,218,221,222
5471.0492901.074804.3350.5420.7520.9630.7850.9720.8080.86Chain A: 103,106,107,109,110,111,113,114,116,117,1
20,121,123,124,127,294,295,434,438,439,455,467,470
,471,472,473,474,475,476,477,478,482,483,486,517,5
18,521,655,656,657,658,659,660,661,662,663

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
398ZINC000019632917DB00475Chlordiazepoxide-9.36199-9.40989
398ZINC000003938686DB09073Palbociclib-7.99145-8.39835
398BaricitinibDB09073-7.96969-7.96969
398ZINC000000897089DB00358Mefloquine-7.93151-7.93401
398ZINC000085537017DB06441Cangrelor-7.8364-7.8504
398ZINC000028108825DB06705Gadofosveset trisodium-6.27694-7.66854
398ZINC000001534965DB08860Pitavastatin-7.61179-7.62129
398ZINC000085540215DB09135Ioxilan-7.50627-7.50627
398ZINC000000537964DB00358Mefloquine-7.27085-7.27335
398ZINC000060183170DB01421Paromomycin-5.5025-7.2419
398ZINC000003874185DB00358Mefloquine-7.2081-7.2106
398ZINC000022059930DB01155Gemifloxacin-7.11242-7.15332
398ZINC000003810860DB00973Ezetimibe-7.14711-7.14771
398ZINC000000897085DB00358Mefloquine-7.10079-7.10329
398ZINC000003830339DB01210Levobunolol-7.09355-7.09465
398ZINC000000020220DB00537Ciprofloxacin-6.93927-7.03907
398ZINC000022059926DB01155Gemifloxacin-6.97437-7.01527
398ZINC000001996117DB00496Darifenacin-7.00588-7.00748
398ZINC000000020243DB00861Diflunisal-6.91725-6.91725
398ZINC000053683151DB01200Bromocriptine-6.73711-6.91611

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000019632917DB00475ChlordiazepoxideSmall moleculeCNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1Approved|Illicit|Investigational
ZINC000003938686DB09073PalbociclibSmall moleculeCC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=OApproved|Investigational
ZINC000085537017DB06441CangrelorSmall moleculeCSCCNC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC(F)(F)F)=N1Approved
ZINC000001534965DB08860PitavastatinSmall moleculeO[C@H](C[C@H](O)C=CC1=C(N=C2C=CC=CC2=C1C1=CC=C(F)C=C1)C1CC1)CC(O)=OApproved
ZINC000000537964DB00358MefloquineSmall moleculeOC(C1CCCCN1)C1=CC(=NC2=C1C=CC=C2C(F)(F)F)C(F)(F)FApproved|Investigational
ZINC000060183170DB01421ParomomycinSmall moleculeNC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1OApproved|Investigational
ZINC000022059930DB01155GemifloxacinSmall moleculeCON=C1/CN(CC1CN)C1=NC2=C(C=C1F)C(=O)C(=CN2C1CC1)C(O)=OApproved|Investigational
ZINC000003810860DB00973EzetimibeSmall molecule[H][C@]1(CC[C@H](O)C2=CC=C(F)C=C2)C(=O)N(C2=CC=C(F)C=C2)[C@]1([H])C1=CC=C(O)C=C1Approved
ZINC000003830339DB01210LevobunololSmall moleculeCC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCCC2=OApproved
ZINC000000020220DB00537CiprofloxacinSmall moleculeOC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=OApproved|Investigational
ZINC000001996117DB00496DarifenacinSmall moleculeNC(=O)C([C@@H]1CCN(CCC2=CC3=C(OCC3)C=C2)C1)(C1=CC=CC=C1)C1=CC=CC=C1Approved|Investigational
ZINC000000020243DB00861DiflunisalSmall moleculeOC(=O)C1=C(O)C=CC(=C1)C1=C(F)C=C(F)C=C1Approved|Investigational
ZINC000053683151DB01200BromocriptineSmall molecule[H][C@@]12CCCN1C(=O)[C@H](CC(C)C)N1C(=O)[C@](NC(=O)[C@H]3CN(C)[C@]4([H])CC5=C(Br)NC6=CC=CC(=C56)C4=C3)(O[C@@]21O)C(C)CApproved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000019632917299.7594.645553.04137.02264.707279.78871.524941.819138.565310000
ZINC000019632917299.7595.502549.003118.96574.766283.8271.453935.577138.408310000
ZINC000003938686447.5398.82766.315477.598137.176151.54101402.5882118.081376.62700
ZINC000003938686447.5398.648773.964490.638134.585148.74101410.0512118.181377.38600
ZINC000003938686447.5399.527761.155473.791137.885149.47801397.3732118.061376.300
ZINC000000897089378.3177.024589.936192.76554.441122.198220.5321034.58724.29.632310000
ZINC000085537017776.3537.43927.054287.655393.58554.42191.3941783.369320.68.4621031
ZINC000085537017776.3535.036918.307262.294312.53251.82291.6611775.566320.68.6031031
ZINC000028108825737.6969.678994.117223.532449.46319.6451.4792004.2186219.5011032
ZINC000028108825737.6962.2981041.332267.666452.611319.7841.2712036.9586219.0721032
ZINC000028108825737.69611.17929.353238.432413.58273.1054.2361934.9836219.1561032
ZINC000001534965421.4679.407688.637204.403154.1283.41446.7211285.22225.49.203390.33400
ZINC000001534965421.4678.087702.616214.015173.729273.09241.781310.67925.49.099386.94101
ZINC000085540215791.11610.896769.61332.376308.4229.811119.0021424.341716.59.57913.14231
ZINC000000537964378.3177.123588.841200.22446.124121.748220.7441035.6624.29.366310000
ZINC000060183170615.6346.469852.379333.487518.892001659.2811828.89.3491032
ZINC000060183170615.6343.96880.798394.277486.521001692.3141828.89.3051032
ZINC000060183170615.6345.103837.174322.647514.527001660.7851828.89.2221032
ZINC000060183170615.6342.705864.842336.076528.766001662.1151828.89.4241032
ZINC000060183170615.6345.505857.834356.773501.061001653.7311828.89.0251032
ZINC000060183170615.6344.108857.637355.734501.903001653.7891828.89.1071032
ZINC000060183170615.6347.059842.213356.118486.095001655.7631828.89.11032
ZINC000060183170615.6347.013831.783339.851491.933001655.6381828.89.1961032
ZINC000060183170615.6349.322830.127345.166484.961001649.2491828.89.4381032
ZINC000060183170615.6346.26774.039316.84457.199001589.5781828.89.1661032
ZINC000060183170615.6347.054839.2337.172502.027001650.0581828.89.3551032
ZINC000003874185378.3177.567591.505189.63358.939124.18218.7531037.43524.29.501310000
ZINC000022059930389.3855.771675.499333.722232.90267.77341.1011199.67128.79.049236.48201
ZINC000022059930389.3857.083660.215323.57227.18268.27141.1911181.71728.79.157237.11301
ZINC000003810860409.4325.656707.47174.233136.697402.90893.6341265.98724.458.806191.96111
ZINC000000897085378.3177.557589.939192.62654.6122.313220.4011034.64724.29.439310000
ZINC000003830339291.3894.063611.955402.6193.154116.19101057.8625.459.203386.07900
ZINC000000020220331.3468.67578.412299.833178.53968.48731.5531017.371168.925248.3301
ZINC000000020220331.3468.111575.511298.04176.66769.24631.5581012.813168.79248.64801
ZINC000022059926389.3855.386675.076333.398232.63867.9641.081199.52228.79.053236.53501
ZINC000022059926389.3854.357656.741321.575225.55768.44141.1671178.17628.79.183237.34601
ZINC000001996117426.5575.155723.497247.17267.742408.58401355.66725.258.883310000
ZINC000001996117426.5576.468726.97236.5678.556411.85401352.99125.258.861394.6400
ZINC000000020243250.2018.261459.0810144.436231.00583.64751.87911.759.879386.60100
ZINC000053683151654.60211.311884.761559.878100.028147.41277.4431759.2122.2510.758.488273.87210
ZINC000053683151654.6024.267910.671542.638130.584160.05377.3961770.52.2510.758.201265.90610
ZINC000053683151654.6025.119805.567489.353124.173114.63677.4041680.3042.2510.758.492363.12110
ZINC000053683151654.6023.434928.964578.515115.293157.74977.4071791.1032.2510.758.157270.96611


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000019632917CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C10.1473206730.447326601
ZINC000003938686CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O0.1541407730.105977064
ZINC000000897089O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000085537017CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)(O)O[P@](=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O0.0178895410.259362736
ZINC000028108825O=C(O)CN(CCN(CC(=O)O)C[C@H](CO[P@](=O)(O)OC1CCC(c2ccccc2)(c2ccccc2)CC1)N(CC(=O)O)CC(=O)O)CC(=O)O0.0431071060.443371273
ZINC000001534965O=C(O)C[C@H](O)C[C@H](O)/C=C/c1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc10.1003276950.163808993
ZINC000085540215CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000000537964O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN10.0827248270.290697747
ZINC000060183170NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O0.0109957710.270848186
ZINC000003874185O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000022059930CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1CN0.0776115140.258972331
ZINC000003810860O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc10.1137834410.30369071
ZINC000000897085O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN10.0827248270.290697747
ZINC000003830339CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O0.1733436360.14827061
ZINC000000020220O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O0.2310316290.323908212
ZINC000022059926CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN0.0776115140.258972331
ZINC000001996117NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C10.1513084920.279833775
ZINC000000020243O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O0.4404093730.371648269
ZINC000053683151CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N120.0178511490.327929451


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NCOA4AR, PPARG, ESR1, Nr3c1, GTF2B, KAT2B, NR3C1, VDR, AKT1, ATXN2, RXRA, HERC2, XPO1, GRIA2, KDR, KIFC3, PSMC1, XRCC3, HUWE1, PSMD14, TFG, KIF21A, USP43, Bmpr1a, Kif1b, Cdc23, Wdr61, Psmd6, FTH1, FTL, GMCL1, NEURL4, TAX1BP1, EGLN3, MAPK6, MID2, ORF3a, nsp13, nsp16, RNF10, PRELID2, PIPSL, BTF3, MAP1LC3B, NBR1, CALCOCO2, OPTN, SQSTM1,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NCOA4
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NCOA4-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NCOA4-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
NCOA4RETThyroid Gland Papillary CarcinomaMyCancerGenome
NCOA4RETLung AdenocarcinomaMyCancerGenome
NCOA4RETBreast Invasive Ductal CarcinomaMyCancerGenome
NCOA4RETColon AdenocarcinomaMyCancerGenome
NCOA4RETAdenocarcinoma Of Unknown PrimaryMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA4C0238463Papillary thyroid carcinoma2ORPHANET
HgeneNCOA4C0040136Thyroid Neoplasm1CTD_human
HgeneNCOA4C0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneNCOA4C0549473Thyroid carcinoma1CTD_human
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human